{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:35:31Z","timestamp":1790904931999,"version":"4.1.0"},"reference-count":65,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Intramural Research Programs of the National Human Genome Research Institute","award":["ASAP-000458"],"award-info":[{"award-number":["ASAP-000458"]}]},{"name":"Michael J. Fox Foundation for Parkinson\u2019s Research (MJFF)","award":["ASAP-000458"],"award-info":[{"award-number":["ASAP-000458"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Deficient acid \u03b2-glucocerebrosidase activity due to biallelic mutations in GBA1 results in Gaucher disease (GD). Patients with this lysosomal storage disorder exhibit a wide range of associated manifestations, spanning from virtually asymptomatic adults to infants with severe neurodegeneration. While type 1 GD (GD1) is considered non-neuronopathic, a small subset of patients develop parkinsonian features. Variants in GBA1 are also an important risk factor for several common Lewy body disorders (LBDs). Neuropathological examinations of patients with GD, including those who developed LBDs, are rare. GD primarily affects macrophages, and perivascular infiltration of Gaucher macrophages is the most common neuropathologic finding. However, the frequency of these clusters and the affected anatomical region varies. GD affects astrocytes, and, in neuronopathic GD, neurons in cerebral cortical layers 3 and 5, layer 4b of the calcarine cortex, and hippocampal regions CA2\u20134. In addition, several reports describe selective degeneration of the cerebellar dentate nucleus in chronic neuronopathic GD. GD1 is characterized by astrogliosis without prominent neuronal loss. In GD-LBD, widespread Lewy body pathology is seen, often involving hippocampal regions CA2\u20134. Additional neuropathological examinations in GD are sorely needed to clarify disease-specific patterns and elucidate causative mechanisms relevant to GD, and potentially to more common neurodegenerative diseases.<\/jats:p>","DOI":"10.3390\/ijms23105842","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T22:57:22Z","timestamp":1653346642000},"page":"5842","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Neuropathological Features of Gaucher Disease and Gaucher Disease with Parkinsonism"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4328-6657","authenticated-orcid":false,"given":"Makaila L.","family":"Furderer","sequence":"first","affiliation":[{"name":"Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 35A Convent Drive-Room 1E623, Bethesda, MD 20892-3708, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0916-3557","authenticated-orcid":false,"given":"Ellen","family":"Hertz","sequence":"additional","affiliation":[{"name":"Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 35A Convent Drive-Room 1E623, Bethesda, MD 20892-3708, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grisel J.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 35A Convent Drive-Room 1E623, Bethesda, MD 20892-3708, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Sidransky","sequence":"additional","affiliation":[{"name":"Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 35A Convent Drive-Room 1E623, Bethesda, MD 20892-3708, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1172\/JCI105417","article-title":"Demonstration of a deficiency of glucocerebroside-cleaving enzyme in Gaucher\u2019s disease","volume":"45","author":"Brady","year":"1966","journal-title":"J. Clin. Investig."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ymgme.2004.08.015","article-title":"Gaucher disease: Complexity in a \u201csimple\u201d disorder","volume":"83","author":"Sidransky","year":"2004","journal-title":"Mol. Genet. Metab."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/jimd.12235","article-title":"The definition of neuronopathic Gaucher disease","volume":"43","author":"Schiffmann","year":"2020","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0140-6736(08)61522-6","article-title":"Phenotype, diagnosis, and treatment of Gaucher\u2019s disease","volume":"372","author":"Grabowski","year":"2008","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.braindev.2005.04.005","article-title":"French Type 2 Gaucher Disease Study G. Type 2 Gaucher disease: 15 new cases and review of the literature","volume":"28","author":"Mignot","year":"2006","journal-title":"Brain Dev."},{"key":"ref_6","first-page":"e2119","article-title":"The natural history of type 2 Gaucher disease in the 21st century: A retrospective study","volume":"95","author":"Seehra","year":"2020","journal-title":"Neurology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ymgme.2020.10.010","article-title":"EEG abnormalities in patients with chronic neuronopathic Gaucher disease: A retrospective review","volume":"131","author":"Poffenberger","year":"2020","journal-title":"Mol. Genet. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jpeds.2007.12.023","article-title":"Cognitive outcome in treated patients with chronic neuronopathic Gaucher disease","volume":"153","author":"Wiggs","year":"2008","journal-title":"J. Pediatr."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Benko, W., Ries, M., Wiggs, E.A., Brady, R.O., Schiffmann, R., and Fitzgibbon, E.J. (2011). The saccadic and neurological deficits in type 3 Gaucher disease. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0022410"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S1096-7192(03)00071-4","article-title":"Gaucher disease with parkinsonian manifestations: Does glucocerebrosidase deficiency contribute to a vulnerability to parkinsonism?","volume":"79","author":"Tayebi","year":"2003","journal-title":"Mol. Genet. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/qjmed\/89.9.691","article-title":"Occurrence of Parkinson\u2019s syndrome in type I Gaucher disease","volume":"89","author":"Neudorfer","year":"1996","journal-title":"QJM"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1136\/jmg.2004.024455","article-title":"Parkinsonism among Gaucher disease carriers","volume":"41","author":"Schiffmann","year":"2004","journal-title":"J. Med. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ymgme.2003.11.004","article-title":"Glucocerebrosidase mutations in subjects with parkinsonism","volume":"81","author":"Lwin","year":"2004","journal-title":"Mol. Genet. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","article-title":"Multicenter analysis of glucocerebrosidase mutations in Parkinson\u2019s disease","volume":"361","author":"Sidransky","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1001\/jamaneurol.2013.1925","article-title":"A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies","volume":"70","author":"Nalls","year":"2013","journal-title":"JAMA Neurol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bcmd.2010.10.006","article-title":"The incidence of Parkinsonism in patients with type 1 Gaucher disease: Data from the ICGG Gaucher Registry","volume":"46","author":"Rosenbloom","year":"2011","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1001\/jamaneurol.2014.313","article-title":"Comparison of Parkinson risk in Ashkenazi Jewish patients with Gaucher disease and GBA heterozygotes","volume":"71","author":"Alcalay","year":"2014","journal-title":"JAMA Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10545-010-9055-0","article-title":"The risk of Parkinson\u2019s disease in type 1 Gaucher disease","volume":"33","author":"Bultron","year":"2010","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.neuron.2017.01.018","article-title":"The Complicated Relationship between Gaucher Disease and Parkinsonism: Insights from a Rare Disease","volume":"93","author":"Aflaki","year":"2017","journal-title":"Neuron"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ymgme.2013.12.003","article-title":"Neuroinflammation and alpha-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction","volume":"111","author":"Ginns","year":"2014","journal-title":"Mol. Genet. Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2011.06.001","article-title":"Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies","volume":"146","author":"Mazzulli","year":"2011","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ymgme.2004.04.011","article-title":"Neuropathology provides clues to the pathophysiology of Gaucher disease","volume":"82","author":"Wong","year":"2004","journal-title":"Mol. Genet. Metab."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00692212","article-title":"Central nervous system involvement in adult-onset Gaucher\u2019s disease","volume":"49","author":"Soffer","year":"1980","journal-title":"Acta Neuropathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s10545-009-1178-9","article-title":"Autopsy case of Gaucher disease type I in a patient on enzyme replacement therapy. Comments on the dynamics of persistent storage process","volume":"32","author":"Hulkova","year":"2009","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S1096-7192(02)00117-8","article-title":"Glucosylsphingosine accumulation in tissues from patients with Gaucher disease: Correlation with phenotype and genotype","volume":"76","author":"Orvisky","year":"2002","journal-title":"Mol. Genet. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1471-4159.1982.tb07950.x","article-title":"Accumulation of glucosylceramide and glucosylsphingosine (psychosine) in cerebrum and cerebellum in infantile and juvenile Gaucher disease","volume":"39","author":"Nilsson","year":"1982","journal-title":"J. Neurochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/ana.410200208","article-title":"Type 2 and type 3 Gaucher disease: A morphological and biochemical study","volume":"20","author":"Kaye","year":"1986","journal-title":"Ann. Neurol."},{"key":"ref_28","first-page":"177","article-title":"The pathology of Gaucher disease","volume":"95","author":"Lee","year":"1982","journal-title":"Prog. Clin Biol. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ymgme.2014.08.011","article-title":"CNS, lung, and lymph node involvement in Gaucher disease type 3 after 11 years of therapy: Clinical, histopathologic, and biochemical findings","volume":"114","author":"Burrow","year":"2015","journal-title":"Mol. Genet. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/BF00293959","article-title":"Late-infantile Gaucher disease in a child with myoclonus and bulbar signs: Neuropathological and neurochemical findings","volume":"82","author":"Conradi","year":"1991","journal-title":"Acta Neuropathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1017\/S0022215100142483","article-title":"Brainstem pathology of infantile Gaucher\u2019s disease with only wave I and II of auditory brainstem response","volume":"112","author":"Kaga","year":"1998","journal-title":"J. Laryngol. Otol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1001\/archneur.57.3.389","article-title":"Myoclonus from selective dentate nucleus degeneration in type 3 Gaucher disease","volume":"57","author":"Verghese","year":"2000","journal-title":"Arch. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1212\/WNL.33.8.994","article-title":"Non-infantile neuronopathic Gaucher\u2019s disease: A clinicopathologic study","volume":"33","author":"Winkelman","year":"1983","journal-title":"Neurology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF00690463","article-title":"Neuropathology of the Norrbottnian type of Gaucher disease. Morphological and biochemical studies","volume":"65","author":"Conradi","year":"1984","journal-title":"Acta Neuropathol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Civita, P., Valerio, O., Naccarato, A.G., Gumbleton, M., and Pilkington, G.J. (2020). Satellitosis, a Crosstalk between Neurons, Vascular Structures and Neoplastic Cells in Brain Tumours; Early Manifestation of Invasive Behaviour. Cancers, 12.","DOI":"10.20944\/preprints202011.0553.v1"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neuron.2017.12.012","article-title":"Reversible Conformational Conversion of alpha-Synuclein into Toxic Assemblies by Glucosylceramide","volume":"97","author":"Zunke","year":"2018","journal-title":"Neuron"},{"key":"ref_37","first-page":"1353","article-title":"The spectrum of parkinsonian manifestations associated with glucocerebrosidase mutations","volume":"65","author":"Lopez","year":"2008","journal-title":"Arch. Neurol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1016\/j.neurobiolaging.2015.08.027","article-title":"Impact of glucocerebrosidase mutations on motor and nonmotor complications in Parkinson\u2019s disease","volume":"36","author":"Oeda","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1002\/mds.28195","article-title":"GBA-Related Parkinson\u2019s Disease: Dissection of Genotype-Phenotype Correlates in a Large Italian Cohort","volume":"35","author":"Petrucci","year":"2020","journal-title":"Mov. Disord."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1093\/brain\/awp044","article-title":"Glucocerebrosidase mutations in clinical and pathologically proven Parkinson\u2019s disease","volume":"132","author":"Neumann","year":"2009","journal-title":"Brain"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1001\/archneurol.2009.54","article-title":"Association of glucocerebrosidase mutations with dementia with lewy bodies","volume":"66","author":"Clark","year":"2009","journal-title":"Arch. Neurol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1111\/ene.13395","article-title":"GBA mutations in Parkinson disease: Earlier death but similar neuropathological features","volume":"24","author":"Adler","year":"2017","journal-title":"Eur. J. Neurol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/mds.27193","article-title":"Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature","volume":"32","author":"Schneider","year":"2017","journal-title":"Mov. Disord."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s12035-012-8280-y","article-title":"The Lewy body in Parkinson\u2019s disease and related neurodegenerative disorders","volume":"47","author":"Wakabayashi","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/s41593-019-0423-2","article-title":"Lewy pathology in Parkinson\u2019s disease consists of crowded organelles and lipid membranes","volume":"22","author":"Shahmoradian","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13024-021-00501-z","article-title":"Neuropathology and molecular diagnosis of Synucleinopathies","volume":"16","author":"Koga","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"214.e1","DOI":"10.1016\/j.neurobiolaging.2018.11.007","article-title":"Genetic analysis of neurodegenerative diseases in a pathology cohort","volume":"76","author":"Blauwendraat","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/mdc3.12481","article-title":"Frequency of GBA variants in autopsy-proven multiple system atrophy","volume":"4","author":"Sklerov","year":"2017","journal-title":"Mov. Disord. Clin Pract."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-019-0306-8","article-title":"Dementia with Lewy bodies: An update and outlook","volume":"14","author":"Outeiro","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/jnc.14698","article-title":"Clinical and neuropathological differences between Parkinson\u2019s disease, Parkinson\u2019s disease dementia and dementia with Lewy bodies\u2014Current issues and future directions","volume":"150","author":"Walker","year":"2019","journal-title":"J. Neurochem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.parkreldis.2010.09.009","article-title":"Glucocerebrosidase mutations in diffuse Lewy body disease","volume":"17","author":"Nishioka","year":"2011","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00401-006-0088-2","article-title":"Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies?","volume":"112","author":"Jellinger","year":"2006","journal-title":"Acta Neuropathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s40478-019-0717-3","article-title":"Hippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson\u2019s disease with cognitive decline","volume":"7","author":"Liu","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ymgme.2011.04.015","article-title":"Glucocerebrosidase mutations do not cause increased Lewy body pathology in Parkinson\u2019s disease","volume":"103","author":"Parkkinen","year":"2011","journal-title":"Mol. Genet. Metab."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"122","DOI":"10.5414\/NP300901","article-title":"Gaucher cells are not associated with alpha-synuclein neuropathology in infants","volume":"35","author":"Lutz","year":"2016","journal-title":"Clin Neuropathol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/jnnp.51.6.745","article-title":"The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson\u2019s disease","volume":"51","author":"Gibb","year":"1988","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00401-010-0741-7","article-title":"Glucocerebrosidase is present in alpha-synuclein inclusions in Lewy body disorders","volume":"120","author":"Stubblefield","year":"2010","journal-title":"Acta Neuropathol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/mds.26278","article-title":"No evidence for substrate accumulation in Parkinson brains with GBA mutations","volume":"30","author":"Gegg","year":"2015","journal-title":"Mov. Disord."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13024-019-0339-z","article-title":"Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson\u2019s disease","volume":"14","author":"Huebecker","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.parkreldis.2020.06.007","article-title":"GBA variation and susceptibility to multiple system atrophy","volume":"77","author":"Wernick","year":"2020","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/acn3.185","article-title":"Variants associated with Gaucher disease in multiple system atrophy","volume":"2","author":"Mitsui","year":"2015","journal-title":"Ann. Clin Transl. Neurol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00702-018-1898-9","article-title":"Is Braak staging valid for all types of Parkinson\u2019s disease?","volume":"126","author":"Jellinger","year":"2019","journal-title":"J. Neural. Transm."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/neup.12597","article-title":"Neuropathology of Lewy body disease: Clinicopathological crosstalk between typical and atypical cases","volume":"40","author":"Kon","year":"2020","journal-title":"Neuropathology"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/10\/5842\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:17:10Z","timestamp":1760138230000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/10\/5842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,23]]},"references-count":65,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["ijms23105842"],"URL":"https:\/\/doi.org\/10.3390\/ijms23105842","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,23]]}}}