{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:27:46Z","timestamp":1790458066844,"version":"4.1.0"},"reference-count":80,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"American Academy of Optometry Career Development Award to ABenavente"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>To describe the effect of myopic eye growth on the structure and distribution of astrocytes, vasculature, and retinal nerve fiber layer thickness, which are critical for inner retinal tissue homeostasis and survival. Astrocyte and capillary distribution, retinal nerve fiber (RNFL), and ganglion cell layer (GCL) thicknesses were assessed using immunochemistry and spectral domain optical coherence tomography on eleven retinas of juvenile common marmosets (Callithrix Jacchus), six of which were induced with lens-induced myopia (refraction, Rx: \u22127.01 \u00b1 1.8D). Five untreated age-matched juvenile marmoset retinas were used as controls (Rx: \u22120.74 \u00b1 0.4D). Untreated marmoset eyes grew normally, their RNFL thickened and their astrocyte numbers were associated with RNFL thickness. Marmosets with induced myopia did not show this trend and, on the contrary, had reduced astrocyte numbers, increased GFAP-immunopositive staining, thinner RNFL, lower peripheral capillary branching, and increased numbers of string vessels. The myopic changes in retinal astrocytes, vasculature, and retinal nerve fiber layer thickness suggest a reorganization of the astrocyte and vascular templates during myopia development and progression. Whether these adaptations are beneficial or harmful to the retina remains to be investigated.<\/jats:p>","DOI":"10.3390\/ijms23116202","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T03:33:18Z","timestamp":1654054398000},"page":"6202","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Myopia Alters the Structural Organization of the Retinal Vasculature, GFAP-Positive Glia, and Ganglion Cell Layer Thickness"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-0696","authenticated-orcid":false,"given":"Carol","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, SUNY College of Optometry, New York, NY 10036, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abduqodir","family":"Toychiev","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, SUNY College of Optometry, New York, NY 10036, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8559-6437","authenticated-orcid":false,"given":"Reynolds","family":"Ablordeppey","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, SUNY College of Optometry, New York, NY 10036, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3610-8649","authenticated-orcid":false,"given":"Nefeli","family":"Slavi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, SUNY College of Optometry, New York, NY 10036, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miduturu","family":"Srinivas","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, SUNY College of Optometry, New York, NY 10036, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Benavente-Perez","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, SUNY College of Optometry, New York, NY 10036, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1475-1313.2005.00298.x","article-title":"Myopia and associated pathological complications","volume":"25","author":"Saw","year":"2005","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Curtin, B.J. (1985). The Myopias: Basic Science and Clinical Management, Harper & Row.","DOI":"10.1097\/00006982-198600620-00013"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ophtha.2006.06.050","article-title":"High myopia and glaucoma susceptibility the Beijing Eye Study","volume":"114","author":"Xu","year":"2007","journal-title":"Ophthalmology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/eye.2013.280","article-title":"Epidemiology of myopia","volume":"28","author":"Foster","year":"2014","journal-title":"Eye"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_6","first-page":"415","article-title":"Diagnosis and Treatment of Myopic Maculopathy","volume":"7","author":"Yokoi","year":"2018","journal-title":"Asia Pac. J. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/pr.57.2.4","article-title":"The blood-brain barrier\/neurovascular unit in health and disease","volume":"57","author":"Hawkins","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1006\/exer.1997.0365","article-title":"Development of the human retinal vasculature: Cellular relations and VEGF expression","volume":"65","author":"Provis","year":"1997","journal-title":"Exp. Eye Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.06.003","article-title":"Glia-neuron interactions in the mammalian retina","volume":"51","author":"Vecino","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1182\/blood-2012-04-396846","article-title":"Eyeing central neurons in vascular growth and reparative angiogenesis","volume":"120","author":"Sapieha","year":"2012","journal-title":"Blood"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2174\/1871527311312030004","article-title":"Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases","volume":"12","author":"Maki","year":"2013","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1016\/0042-6989(95)00322-3","article-title":"Structural specializations of human retinal glial cells","volume":"36","author":"Ramirez","year":"1996","journal-title":"Vision Res."},{"key":"ref_13","first-page":"3500","article-title":"Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion","volume":"43","author":"Dorrell","year":"2002","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1242\/dev.01732","article-title":"Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes","volume":"132","author":"West","year":"2005","journal-title":"Development"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/glia.20900","article-title":"Maintaining retinal astrocytes normalizes revascularization and prevents vascular pathology associated with oxygen-induced retinopathy","volume":"58","author":"Dorrell","year":"2010","journal-title":"Glia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1177\/1073858411423441","article-title":"Structural remodeling of astrocytes in the injured CNS","volume":"18","author":"Sun","year":"2012","journal-title":"Neuroscientist"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/glia.20000","article-title":"Muller cell response to laser-induced increase in intraocular pressure in rats","volume":"47","author":"Woldemussie","year":"2004","journal-title":"Glia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1038\/s41467-017-01624-y","article-title":"Muller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture","volume":"8","author":"Wohl","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000328979","article-title":"Muller glial cells in retinal disease","volume":"227","author":"Bringmann","year":"2012","journal-title":"Ophthalmologica"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00417-010-1407-9","article-title":"Ocular blood flow measurements in healthy human myopic eyes","volume":"248","author":"Hosking","year":"2010","journal-title":"Graefes. Arch. Clin. Exp. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3928\/23258160-20181203-03","article-title":"Effect of Age and Myopia on Retinal Microvasculature","volume":"49","author":"Leng","year":"2018","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Golebiewska, J., Biala-Gosek, K., Czeszyk, A., and Hautz, W. (2019). Optical coherence tomography angiography of superficial retinal vessel density and foveal avascular zone in myopic children. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0219785"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1167\/iovs.16-21289","article-title":"Quantitative OCT Angiography of the Retinal Microvasculature and the Choriocapillaris in Myopic Eyes","volume":"58","author":"Phasukkijwatana","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/tvst.9.4.8","article-title":"Characterization of the Three Distinct Retinal Capillary Plexuses Using Optical Coherence Tomography Angiography in Myopic Eyes","volume":"9","author":"Zhu","year":"2020","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/dgd.12109","article-title":"Common marmoset as a new model animal for neuroscience research and genome editing technology","volume":"56","author":"Kishi","year":"2014","journal-title":"Dev. Growth Differ."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.siny.2012.07.002","article-title":"The common marmoset as a novel animal model system for biomedical and neuroscience research applications","volume":"17","author":"Okano","year":"2012","journal-title":"Semin. Fetal. Neonatal. Med."},{"key":"ref_27","first-page":"383","article-title":"Marmoset models commonly used in biomedical research","volume":"53","author":"Mansfield","year":"2003","journal-title":"Comp. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/0042-6989(93)90039-Y","article-title":"Ocular development and visual deprivation myopia in the common marmoset (Callithrix jacchus)","volume":"33","author":"Troilo","year":"1993","journal-title":"Vision Res."},{"key":"ref_29","first-page":"2519","article-title":"Diurnal rhythms in intraocular pressure, axial length, and choroidal thickness in a primate model of eye growth, the common marmoset","volume":"43","author":"Nickla","year":"2002","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6765","DOI":"10.1167\/iovs.14-14524","article-title":"Axial eye growth and refractive error development can be modified by exposing the peripheral retina to relative myopic or hyperopic defocus","volume":"55","author":"Nour","year":"2014","journal-title":"Investig Ophthalmol. Vis. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6479","DOI":"10.1167\/iovs.12-9822","article-title":"The effect of simultaneous negative and positive defocus on eye growth and development of refractive state in marmosets","volume":"53","author":"Nour","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"11459","DOI":"10.1038\/s41598-019-48009-3","article-title":"Short Interruptions of Imposed Hyperopic Defocus Earlier in Treatment are More Effective at Preventing Myopia Development","volume":"9","author":"Nour","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1167\/iovs.16-20007","article-title":"Evaluation of Nonperfused Retinal Vessels in Ischemic Retinopathy","volume":"57","author":"Powner","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/cne.20996","article-title":"Development of the neural retina and its vasculature in the marmoset Callithrix jacchus","volume":"497","author":"Hendrickson","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1242\/dev.097949","article-title":"Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling","volume":"141","author":"Fan","year":"2014","journal-title":"Development"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.mcn.2013.06.001","article-title":"Hyperoxia causes reduced density of retinal astrocytes in the central avascular zone in the mouse model of oxygen-induced retinopathy","volume":"56","author":"Bucher","year":"2013","journal-title":"Mol. Cell Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/s41598-020-80080-z","article-title":"Macular vessel density, branching complexity and foveal avascular zone size in normal tension glaucoma","volume":"11","author":"Cheng","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_38","first-page":"1022","article-title":"Peripheral refraction and ocular shape in children","volume":"41","author":"Mutti","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/02713689308999467","article-title":"Reduction in choroidal blood flow occurs in chicks wearing goggles that induce eye growth toward myopia","volume":"12","author":"Shih","year":"1993","journal-title":"Curr. Eye Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00212949","article-title":"Evaluation of the peripapillary circulation in healthy and glaucoma eyes with scanning laser Doppler flowmetry","volume":"20","author":"Hollo","year":"1996","journal-title":"Int. Ophthalmol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1242\/dev.120.12.3395","article-title":"Apoptosis during macrophage-dependent ocular tissue remodelling","volume":"120","author":"Lang","year":"1994","journal-title":"Development"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0197-4580(89)90048-1","article-title":"Progressive failure of cerebral angiogenesis supporting neural plasticity in aging rats","volume":"10","author":"Black","year":"1989","journal-title":"Neurobiol. Aging"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/978-1-4615-0205-0_55","article-title":"Hypoxia-inducible factor-1alpha accumulation in the rat brain in response to hypoxia and ischemia is attenuated during aging","volume":"510","author":"Chavez","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"29643","DOI":"10.1074\/jbc.M001029200","article-title":"Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity","volume":"275","author":"Rivard","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1161\/01.CIR.99.1.111","article-title":"Age-dependent impairment of angiogenesis","volume":"99","author":"Rivard","year":"1999","journal-title":"Circulation"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/BF00294173","article-title":"Pathological alterations of the cerebral microvasculature in Alzheimer\u2019s disease and related dementing disorders","volume":"87","author":"Buee","year":"1994","journal-title":"Acta Neuropathol."},{"key":"ref_47","first-page":"68","article-title":"Pericyte form and distribution in rat retinal and uveal capillaries","volume":"26","author":"Tilton","year":"1985","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"326","DOI":"10.2337\/diab.30.4.326","article-title":"Pericyte degeneration and basement membrane thickening in skeletal muscle capillaries of human diabetics","volume":"30","author":"Tilton","year":"1981","journal-title":"Diabetes"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1001\/archopht.1961.01840020710019","article-title":"Retinal vascular patterns. III. Age, hypertension, absolute glaucoma, injury","volume":"65","author":"Kuwabara","year":"1961","journal-title":"Arch. Ophthalmol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3109\/02713683.2014.973043","article-title":"Correlation of macular choroidal thickness with concentrations of aqueous vascular endothelial growth factor in high myopia","volume":"40","author":"Chen","year":"2015","journal-title":"Curr. Eye Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.exer.2015.11.016","article-title":"Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA\/2J mouse model of glaucoma","volume":"150","author":"Cooper","year":"2016","journal-title":"Exp. Eye Res."},{"key":"ref_52","first-page":"484","article-title":"Astrocytes and Muller Cell Alterations During Retinal Degeneration in a Transgenic Rat Model of Retinitis Pigmentosa","volume":"9","author":"Lax","year":"2015","journal-title":"Front. Cell Neurosci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00237966","article-title":"The astrocytes in the retina and optic nerve head of mammals: A special glia for the ganglion cell axons","volume":"206","author":"Bussow","year":"1980","journal-title":"Cell Tissue Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/cne.903130405","article-title":"Structure of the macroglia of the retina: Sharing and division of labour between astrocytes and Muller cells","volume":"313","author":"Hollander","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"ref_55","first-page":"2827","article-title":"Astrocytes and blood vessels define the foveal rim during primate retinal development","volume":"41","author":"Provis","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/j.1460-9568.1993.tb00963.x","article-title":"Confocal microscopy and computer-assisted image reconstruction of astrocytes in the mammalian retina","volume":"5","author":"Messerli","year":"1993","journal-title":"Eur. J. Neurosci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF01189801","article-title":"The development of astrocytes and blood vessels in the postnatal rabbit retina","volume":"17","author":"Schnitzer","year":"1988","journal-title":"J. Neurocytol."},{"key":"ref_58","first-page":"681","article-title":"Electron microscope study on astrocytes in the human retina (author\u2019s transl)","volume":"78","author":"Uga","year":"1974","journal-title":"Nippon. Ganka Gakkai Zasshi"},{"key":"ref_59","first-page":"828","article-title":"Shape and distribution of astrocytes in the cat retina","volume":"27","author":"Karschin","year":"1986","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_60","first-page":"499","article-title":"Nerve fiber layer astrocytes of the primate retina: Morphology, distribution, and density","volume":"17","author":"Ogden","year":"1978","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1167\/iovs.11-9315","article-title":"TMP prevents retinal neovascularization and imparts neuroprotection in an oxygen-induced retinopathy model","volume":"53","author":"Liang","year":"2012","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_62","unstructured":"Kolb, H., Fernandez, E., and Nelson, R. (1995). Glial Cells of the Retina. Webvision: The Organization of the Retina and Visual System, University of Utah Healh Sciences Center."},{"key":"ref_63","first-page":"3442","article-title":"Vascular development in primate retina: Comparison of laminar plexus formation in monkey and human","volume":"35","author":"Gariano","year":"1994","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3109\/02713683.2013.836541","article-title":"From mechanosensitivity to inflammatory responses: New players in the pathology of glaucoma","volume":"39","author":"Krizaj","year":"2014","journal-title":"Curr. Eye Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1167\/iovs.02-1136","article-title":"Immunohistochemical assessment of the glial mitogen-activated protein kinase activation in glaucoma","volume":"44","author":"Tezel","year":"2003","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1084\/jem.20160412","article-title":"Optic nerve astrocyte reactivity protects function in experimental glaucoma and other nerve injuries","volume":"214","author":"Sun","year":"2017","journal-title":"J. Exp. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"E5934","DOI":"10.1073\/pnas.1803907115","article-title":"Suppression of connexin 43 phosphorylation promotes astrocyte survival and vascular regeneration in proliferative retinopathy","volume":"115","author":"Slavi","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/glia.440150102","article-title":"Astrocytes modulate retinal vasculogenesis: Effects on endothelial cell differentiation","volume":"15","author":"Jiang","year":"1995","journal-title":"Glia"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/opo.12223","article-title":"Retinal vessel oxygen saturation and vessel diameter in high myopia","volume":"35","author":"Zheng","year":"2015","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1001\/archophthalmol.2009.145","article-title":"Measurement of local retinal ganglion cell layer thickness in patients with glaucoma using frequency-domain optical coherence tomography","volume":"127","author":"Wang","year":"2009","journal-title":"Arch. Ophthalmol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1167\/iovs.15-17013","article-title":"Ganglion Cell-Inner Plexiform Layer and Peripapillary Retinal Nerve Fiber Layer Thicknesses in Age-Related Macular Degeneration","volume":"56","author":"Lee","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1167\/iovs.15-18736","article-title":"Retinal Ganglion Cell Layer Thinning Within One Month of Presentation for Non-Arteritic Anterior Ischemic Optic Neuropathy","volume":"57","author":"Kupersmith","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Lopez-de-Eguileta, A., Cervero, A., Ruiz de Sabando, A., Sanchez-Juan, P., and Casado, A. (2020). Ganglion Cell Layer Thinning in Alzheimer\u2019s Disease. Medicina, 56.","DOI":"10.3390\/medicina56100553"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cobme.2020.01.001","article-title":"Connective Tissue Remodeling in Myopia and its Potential Role in Increasing Risk of Glaucoma","volume":"15","author":"Grytz","year":"2020","journal-title":"Curr. Opin. Biomed. Eng."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Seo, S., Lee, C.E., Jeong, J.H., Park, K.H., Kim, D.M., and Jeoung, J.W. (2017). Ganglion cell-inner plexiform layer and retinal nerve fiber layer thickness according to myopia and optic disc area: A quantitative and three-dimensional analysis. BMC Ophthalmol., 17.","DOI":"10.1186\/s12886-017-0419-1"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1167\/tvst.9.13.9","article-title":"The Influence of Axial Length Upon the Retinal Ganglion Cell Layer of the Human Eye","volume":"9","author":"Chen","year":"2020","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/APO.0000000000000288","article-title":"High Myopia and Glaucoma-Like Optic Neuropathy","volume":"9","author":"Jonas","year":"2020","journal-title":"Asia Pac. J. Ophthalmol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/term.2168","article-title":"Mechanical elongation of astrocyte processes to create living scaffolds for nervous system regeneration","volume":"11","author":"Katiyar","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1073\/pnas.95.6.3168","article-title":"Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress","volume":"95","author":"Gould","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/11\/6202\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:23:05Z","timestamp":1760138585000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/11\/6202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,31]]},"references-count":80,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["ijms23116202"],"URL":"https:\/\/doi.org\/10.3390\/ijms23116202","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,31]]}}}