{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:08:06Z","timestamp":1790834886847,"version":"4.1.0"},"reference-count":33,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T00:00:00Z","timestamp":1654992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81773793"],"award-info":[{"award-number":["81773793"]}]},{"name":"National Natural Science Foundation of China","award":["31770814"],"award-info":[{"award-number":["31770814"]}]},{"name":"National Natural Science Foundation of China","award":["20720150052"],"award-info":[{"award-number":["20720150052"]}]},{"name":"National Natural Science Foundation of China","award":["B12001"],"award-info":[{"award-number":["B12001"]}]},{"name":"National Natural Science Foundation of China","award":["J1310027"],"award-info":[{"award-number":["J1310027"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["81773793"],"award-info":[{"award-number":["81773793"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["31770814"],"award-info":[{"award-number":["31770814"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["20720150052"],"award-info":[{"award-number":["20720150052"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["B12001"],"award-info":[{"award-number":["B12001"]}]},{"name":"Fundamental Research Funds for the Central Universities","award":["J1310027"],"award-info":[{"award-number":["J1310027"]}]},{"name":"Programme of Introducing Talents of Discipline to Universities","award":["81773793"],"award-info":[{"award-number":["81773793"]}]},{"name":"Programme of Introducing Talents of Discipline to Universities","award":["31770814"],"award-info":[{"award-number":["31770814"]}]},{"name":"Programme of Introducing Talents of Discipline to Universities","award":["20720150052"],"award-info":[{"award-number":["20720150052"]}]},{"name":"Programme of Introducing Talents of Discipline to Universities","award":["B12001"],"award-info":[{"award-number":["B12001"]}]},{"name":"Programme of Introducing Talents of Discipline to Universities","award":["J1310027"],"award-info":[{"award-number":["J1310027"]}]},{"name":"National Science Foundation of China for Fostering Talents in Basic Research","award":["81773793"],"award-info":[{"award-number":["81773793"]}]},{"name":"National Science Foundation of China for Fostering Talents in Basic Research","award":["31770814"],"award-info":[{"award-number":["31770814"]}]},{"name":"National Science Foundation of China for Fostering Talents in Basic Research","award":["20720150052"],"award-info":[{"award-number":["20720150052"]}]},{"name":"National Science Foundation of China for Fostering Talents in Basic Research","award":["B12001"],"award-info":[{"award-number":["B12001"]}]},{"name":"National Science Foundation of China for Fostering Talents in Basic Research","award":["J1310027"],"award-info":[{"award-number":["J1310027"]}]},{"name":"George &amp; Irina Schaeffer and the John Hench Foundations","award":["81773793"],"award-info":[{"award-number":["81773793"]}]},{"name":"George &amp; Irina Schaeffer and the John Hench Foundations","award":["31770814"],"award-info":[{"award-number":["31770814"]}]},{"name":"George &amp; Irina Schaeffer and the John Hench Foundations","award":["20720150052"],"award-info":[{"award-number":["20720150052"]}]},{"name":"George &amp; Irina Schaeffer and the John Hench Foundations","award":["B12001"],"award-info":[{"award-number":["B12001"]}]},{"name":"George &amp; Irina Schaeffer and the John Hench Foundations","award":["J1310027"],"award-info":[{"award-number":["J1310027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Decidual protein induced by progesterone (DEPP) was originally identified as a modulator in the process of decidualization in the endometrium. Here, we define that DEPP is involved in adipose tissue thermogenesis, which contributes to metabolic regulation. Knockdown of DEPP suppressed adipocyte differentiation and lipid accumulation in 3T3-L1 cells, induced expression of brown adipose tissue (BAT) markers in primary brown adipocyte and induced mouse embryonic fibroblasts (MEFs) differentiation to brown adipocytes. Moreover, DEPP deficiency in mice induced white adipocyte browning and enhanced BAT activity. Cold exposure stimulated more browning of white adipose tissue (WAT) and maintained higher body temperature in DEPP knockout mice compared to that in wild-type control mice. DEPP deficiency also protected mice against high-fat-diet-induced insulin resistance. Mechanistic studies demonstrated that DEPP competitively binds SIRT1, inhibiting the interaction between peroxisome proliferator-activated receptor gamma (PPAR\u03b3) and Sirtuin 1 (SIRT1). Collectively, these findings suggest that DEPP plays a crucial role in orchestrating thermogenesis through regulating adipocyte programs and thus might be a potential target for the treatment of metabolic disorders.<\/jats:p>","DOI":"10.3390\/ijms23126563","type":"journal-article","created":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T09:26:48Z","timestamp":1655026008000},"page":"6563","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["DEPP Deficiency Contributes to Browning of White Adipose Tissue"],"prefix":"10.3390","volume":"23","author":[{"given":"Fusheng","family":"Guo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhui","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifu","family":"Pan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"He","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2685-6048","authenticated-orcid":false,"given":"Lihua","family":"Jin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China"},{"name":"Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev-nutr-072610-145209","article-title":"The implication of brown adipose tissue for humans","volume":"31","author":"Ravussin","year":"2011","journal-title":"Annu. 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