{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:57:34Z","timestamp":1777492654921,"version":"3.51.4"},"reference-count":56,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF) grants funded by the Korean government (MSIT)","award":["NRF-2019R1A5A2027521"],"award-info":[{"award-number":["NRF-2019R1A5A2027521"]}]},{"name":"National Research Foundation of Korea (NRF) grants funded by the Korean government (MSIT)","award":["2021R1A2C1006350"],"award-info":[{"award-number":["2021R1A2C1006350"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Neurogenin 1 (Ngn1) belongs to the basic helix\u2013loop\u2013helix (bHLH) transcription factor family and plays important roles in specifying neuronal differentiation. The present study aimed to determine whether forced Ngn1 expression contributes to bone homeostasis. Ngn1 inhibited the p300\/CREB-binding protein-associated factor (PCAF)-induced acetylation of nuclear factor of activated T cells 1 (NFATc1) and runt-related transcription factor 2 (Runx2) through binding to PCAF, which led to the inhibition of osteoclast and osteoblast differentiation, respectively. In addition, Ngn1 overexpression inhibited the TNF-\u03b1- and IL-17A-mediated enhancement of osteoclast differentiation and IL-17A-induced osteoblast differentiation. These findings indicate that Ngn1 can serve as a novel therapeutic agent for treating ankylosing spondylitis with abnormally increased bone formation and resorption.<\/jats:p>","DOI":"10.3390\/ijms23126708","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T01:48:12Z","timestamp":1655430492000},"page":"6708","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Overexpression of Neurogenin 1 Negatively Regulates Osteoclast and Osteoblast Differentiation"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2543-043X","authenticated-orcid":false,"given":"Jung Ha","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Chonnam National University Medical School, Gwangju 61469, Korea"},{"name":"Hard-Tissue Biointerface Research Center, School of Dentistry, Chonnam National University, Gwangju 61186, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8320-5030","authenticated-orcid":false,"given":"Kabsun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Chonnam National University Medical School, Gwangju 61469, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Chonnam National University Medical School, Gwangju 61469, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6631-7129","authenticated-orcid":false,"given":"Semun","family":"Seong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Chonnam National University Medical School, Gwangju 61469, Korea"},{"name":"Hard-Tissue Biointerface Research Center, School of Dentistry, Chonnam National University, Gwangju 61186, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6279-6487","authenticated-orcid":false,"given":"Jeong-Tae","family":"Koh","sequence":"additional","affiliation":[{"name":"Hard-Tissue Biointerface Research Center, School of Dentistry, Chonnam National University, Gwangju 61186, Korea"},{"name":"Department of Pharmacology and Dental Therapeutics, School of Dentistry, Chonnam National University, Gwangju 61186, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8132-3981","authenticated-orcid":false,"given":"Nacksung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Chonnam National University Medical School, Gwangju 61469, Korea"},{"name":"Hard-Tissue Biointerface Research Center, School of Dentistry, Chonnam National University, Gwangju 61186, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"651161","DOI":"10.3389\/fcell.2021.651161","article-title":"Regulation of Osteoclastogenesis and Bone Resorption by miRNAs","volume":"9","author":"Inoue","year":"2021","journal-title":"Front. 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