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Untreated infections can lead to sequelae, such as infertility and ectopic pregnancy in women and blindness. We previously enhanced the antichlamydial activity of the fluoroquinolone ciprofloxacin by grafting a metal chelating moiety onto it. In the present study, we pursued this pharmacomodulation and obtained nanomolar active molecules (EC50) against this pathogen. This gain in activity prompted us to evaluate the antibacterial activity of this family of molecules against other pathogenic bacteria, such as Neisseria gonorrhoeae and bacteria from the ESKAPE group. The results show that the novel molecules have selectively improved activity against C. trachomatis and demonstrate how the antichlamydial effect of fluoroquinolones can be enhanced.<\/jats:p>","DOI":"10.3390\/ijms23126741","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T01:48:12Z","timestamp":1655430492000},"page":"6741","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modified Fluoroquinolones as Antimicrobial Compounds Targeting Chlamydia trachomatis"],"prefix":"10.3390","volume":"23","author":[{"given":"Thi Huyen","family":"Vu","sequence":"first","affiliation":[{"name":"University of Engineering and Technology, Vietnam National University, Hanoi (VNUH), Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6019-6389","authenticated-orcid":false,"given":"Erika","family":"Adhel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, ITODYS, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Vielfort","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Ume\u00e5 University, SE-901 87 Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0954-9193","authenticated-orcid":false,"given":"Ng\u00fbyet-Thanh","family":"Ha Duong","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, ITODYS, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Anquetin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, ITODYS, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4634-8550","authenticated-orcid":false,"given":"Katy","family":"Jeannot","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence de la R\u00e9sistance aux Antibiotiques, Centre Hospitalier Universitaire de Besan\u00e7on, F-25030 Besan\u00e7on, France"},{"name":"Chrono-Environnement, UMR 6249, CNRS Facult\u00e9 de M\u00e9decine-Pharmacie, Universit\u00e9 Bourgogne-Franche Comt\u00e9, F-25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Verbeke","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine Xavier Bichat, Universit\u00e9 Paris Cit\u00e9, INSERM U1149, F-75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Hjalmar","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Ume\u00e5 University, SE-901 85 Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8632-7087","authenticated-orcid":false,"given":"\u00c5sa","family":"Gylfe","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Ume\u00e5 University, SE-901 85 Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2799-1209","authenticated-orcid":false,"given":"Nawal","family":"Serradji","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, ITODYS, F-75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"851635","DOI":"10.3389\/fmed.2022.851635","article-title":"Incidence Trends of Five Common Sexually Transmitted Infections Excluding HIV From 1990 to 2019 at the Global, Regional, and National Levels: Results from the Global Burden of Disease Study 2019","volume":"9","author":"Fu","year":"2022","journal-title":"Front. 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