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This study used an integrated \u201comics\u201d approach (untargeted whole serum lipidomics, targeted proteomics, and lipoprotein lipidomics) to study lipoprotein remodelling and HDL composition in subjects with central obesity diagnosed with MetS (vs. controls). Compared with healthy subjects, MetS patients showed higher free fatty acids, diglycerides, phosphatidylcholines, and triglycerides, particularly those enriched in products of de novo lipogenesis. On the other hand, the \u201clysophosphatidylcholines to phosphatidylcholines\u201d and \u201ccholesteryl ester to free cholesterol\u201d ratios were reduced, pointing to a lower activity of lecithin cholesterol acyltransferase (LCAT) in MetS; LCAT activity (directly measured and predicted by lipidomic ratios) was positively correlated with high-density lipoprotein cholesterol (HDL-C) and negatively correlated with body mass index (BMI) and insulin resistance. Moreover, many phosphatidylcholines and sphingomyelins were significantly lower in the HDL of MetS patients and strongly correlated with BMI and clinical metabolic parameters. These results suggest that MetS is associated with an impairment of phospholipid metabolism in HDL, partially led by LCAT, and associated with obesity and underlying insulin resistance. 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The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: A collaborative analysis of ten large cohort studies. BMC Endocr. Disord., 14.","DOI":"10.1186\/1472-6823-14-9"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.jacc.2010.05.034","article-title":"The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis","volume":"56","author":"Mottillo","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Stadler, J.T., and Marsche, G. (2020). Obesity-Related Changes in High-Density Lipoprotein Metabolism and Function. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21238985"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1177\/204748730000700505","article-title":"The insulin resistance syndrome: Impact on lipoprotein metabolism and atherothrombosis","volume":"7","author":"Ginsberg","year":"2000","journal-title":"J. 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Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.atherosclerosis.2015.12.042","article-title":"Major changes in the sphingophospholipidome of HDL in non-diabetic patients with metabolic syndrome","volume":"246","author":"Denimal","year":"2016","journal-title":"Atherosclerosis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1053\/j.gastro.2019.12.054","article-title":"Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease","volume":"158","author":"Azzu","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Mocciaro, G., and Gastaldelli, A. (2022). Obesity-Related Insulin Resistance: The Central Role of Adipose Tissue Dysfunction. Handbook of Experimental Pharmacology, Springer.","DOI":"10.1007\/164_2021_573"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13059-018-1439-8","article-title":"Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption","volume":"19","author":"Sanders","year":"2018","journal-title":"Genome Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1038\/s41467-019-10684-1","article-title":"Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis","volume":"10","author":"Hackl","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13148-022-01257-z","article-title":"Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes","volume":"14","author":"Seyres","year":"2022","journal-title":"Clin. Epigenetics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3389\/fendo.2020.00616","article-title":"Hypertriglyceridemia-Causes, Significance, and Approaches to Therapy","volume":"11","author":"Ginsberg","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1111\/j.1464-5491.2009.02757.x","article-title":"Parallel increase of plasma apoproteins C-II and C-III in Type 2 diabetic patients","volume":"26","author":"Beliard","year":"2009","journal-title":"Diabet. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/eci.12657","article-title":"Triglyceride-rich lipoprotein metabolism in women: Roles of apoC-II and apoC-III","volume":"46","author":"Ooi","year":"2016","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.atherosclerosis.2017.10.025","article-title":"Apolipoprotein C-II: New findings related to genetics, biochemistry, and role in triglyceride metabolism","volume":"267","author":"Wolska","year":"2017","journal-title":"Atherosclerosis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"159087","DOI":"10.1016\/j.bbalip.2021.159087","article-title":"Abdominal obesity negatively influences key metrics of reverse cholesterol transport","volume":"1867","author":"Hardfeldt","year":"2022","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"14764","DOI":"10.1038\/s41598-018-33116-4","article-title":"Cholesterol is Inefficiently Converted to Cholesteryl Esters in the Blood of Cardiovascular Disease Patients","volume":"8","author":"Gerl","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1161\/ATVBAHA.118.311987","article-title":"Recombinant LCAT (Lecithin:Cholesterol Acyltransferase) Rescues Defective HDL (High-Density Lipoprotein)-Mediated Endothelial Protection in Acute Coronary Syndrome","volume":"39","author":"Ossoli","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.chemphyslip.2014.07.001","article-title":"A fast method for the determination of the PC\/LPC ratio in intact serum by MALDI-TOF MS: An easy-to-follow lipid biomarker of inflammation","volume":"183","author":"Angelini","year":"2014","journal-title":"Chem. Phys. Lipids"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3803\/EnM.2016.31.2.223","article-title":"High-Density Lipoprotein, Lecithin: Cholesterol Acyltransferase, and Atherosclerosis","volume":"31","author":"Ossoli","year":"2016","journal-title":"Endocrinol. Metab."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4860","DOI":"10.1210\/jc.2008-1213","article-title":"Plasma lecithin: Cholesterol acyltransferase activity is elevated in metabolic syndrome and is an independent marker of increased carotid artery intima media thickness","volume":"93","author":"Dullaart","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s11745-009-3285-7","article-title":"Plasma lipid transfer enzymes in non-diabetic lean and obese men and women","volume":"44","author":"Magkos","year":"2009","journal-title":"Lipids"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.atherosclerosis.2015.07.019","article-title":"Increased cholesterol efflux capacity in metabolic syndrome: Relation with qualitative alterations in HDL and LCAT","volume":"242","author":"Lucero","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/MAJ.0b013e3181f3ce10","article-title":"Oxidized low-density lipoprotein is negatively correlated with lecithin-cholesterol acyltransferase activity in type 2 diabetes mellitus","volume":"341","author":"Nakhjavani","year":"2011","journal-title":"Am. J. Med. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/j.bbadis.2013.09.006","article-title":"Nuclear receptors expression chart in peripheral blood mononuclear cells identifies patients with Metabolic Syndrome","volume":"1832","author":"Vacca","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"27367","DOI":"10.1038\/srep27367","article-title":"Impaired HDL cholesterol efflux in metabolic syndrome is unrelated to glucose tolerance status: The CODAM study","volume":"6","author":"Annema","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/cvr\/cvy077","article-title":"Identification of miR-9-5p as direct regulator of ABCA1 and HDL-driven reverse cholesterol transport in circulating CD14+ cells of patients with metabolic syndrome","volume":"114","author":"Hardfeldt","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0009-9120(03)00078-X","article-title":"Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: The combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity","volume":"36","author":"Rashid","year":"2003","journal-title":"Clin. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1194\/jlr.M060285","article-title":"The effect of phospholipid composition of reconstituted HDL on its cholesterol efflux and anti-inflammatory properties","volume":"56","author":"Schwendeman","year":"2015","journal-title":"J. Lipid Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1194\/jlr.M700139-JLR200","article-title":"Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1","volume":"48","author":"Sano","year":"2007","journal-title":"J. Lipid Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"36596","DOI":"10.1074\/jbc.M006924200","article-title":"High density lipoprotein phospholipid composition is a major determinant of the bi-directional flux and net movement of cellular free cholesterol mediated by scavenger receptor BI","volume":"275","author":"Yancey","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1681\/ASN.2010111144","article-title":"Uremia alters HDL composition and function","volume":"22","author":"Holzer","year":"2011","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1194\/jlr.M800196-JLR200","article-title":"Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity","volume":"50","author":"Nakanishi","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Ding, M., and Rexrode, K.M. (2020). A Review of Lipidomics of Cardiovascular Disease Highlights the Importance of Isolating Lipoproteins. Metabolites, 10.","DOI":"10.3390\/metabo10040163"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1016\/j.clnu.2021.06.006","article-title":"Association of the odd-chain fatty acid content in lipid groups with type 2 diabetes risk: A targeted analysis of lipidomics data in the EPIC-Potsdam cohort","volume":"40","author":"Prada","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Imamura, F., Sharp, S.J., Koulman, A., Schulze, M.B., Kroger, J., Griffin, J.L., Huerta, J.M., Guevara, M., Sluijs, I., and Agudo, A. (2017). A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study. PLoS Med., 14.","DOI":"10.1371\/journal.pmed.1002409"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1017\/S0007114514003894","article-title":"Recommended dairy product intake modulates circulating fatty acid profile in healthy adults: A multi-centre cross-over study","volume":"113","author":"Abdullah","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.3945\/ajcn.117.152702","article-title":"Odd-chain fatty acids as a biomarker for dietary fiber intake: A novel pathway for endogenous production from propionate","volume":"105","author":"Weitkunat","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"44845","DOI":"10.1038\/srep44845","article-title":"Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance","volume":"7","author":"Jenkins","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/s41589-018-0132-2","article-title":"Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues","volume":"14","author":"Wallace","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.clnu.2019.06.013","article-title":"Metabolomics reveals plausible interactive effects between dairy product consumption and metabolic syndrome in humans","volume":"39","author":"Capel","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s11745-013-3781-7","article-title":"Variability in associations of phosphatidylcholine molecular species with metabolic syndrome in Mexican-American families","volume":"48","author":"Kulkarni","year":"2013","journal-title":"Lipids"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.jdiacomp.2018.05.014","article-title":"Exploratory lipidomics in patients with nascent Metabolic Syndrome","volume":"32","author":"Ramakrishanan","year":"2018","journal-title":"J. Diabetes Complicat."},{"key":"ref_54","first-page":"23","article-title":"Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease","volume":"15","author":"Surowiec","year":"2019","journal-title":"Metab. Off. J. Metab. Soc."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"102520","DOI":"10.1016\/j.ebiom.2019.10.046","article-title":"Lipidomic profiling identifies signatures of metabolic risk","volume":"51","author":"Yin","year":"2020","journal-title":"EBioMedicine"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1194\/jlr.R036095","article-title":"Unraveling the complexities of the HDL lipidome","volume":"54","author":"Kontush","year":"2013","journal-title":"J. Lipid Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"7716","DOI":"10.3390\/ijms14047716","article-title":"Sphingomyelin in high-density lipoproteins: Structural role and biological function","volume":"14","author":"Osada","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_58","first-page":"5163","article-title":"Plasma lipidomics discloses metabolic syndrome with a specific HDL phenotype","volume":"28","author":"Jove","year":"2014","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1194\/jlr.S087163","article-title":"MS-based lipidomics of human blood plasma: A community-initiated position paper to develop accepted guidelines","volume":"59","author":"Burla","year":"2018","journal-title":"J. Lipid Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10059-009-0037-8","article-title":"Synthesis of reconstituted high density lipoprotein (rHDL) containing apoA-I and apoC-III: The functional role of apoC-III in rHDL","volume":"27","author":"Cho","year":"2009","journal-title":"Mol. Cells"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1161\/CIRCRESAHA.119.312617","article-title":"HDL and Reverse Cholesterol Transport","volume":"124","author":"Ouimet","year":"2019","journal-title":"Circ. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1194\/jlr.S120000720","article-title":"Lecithin:cholesterol acyltransferase: Symposium on 50 years of biomedical research from its discovery to latest findings","volume":"61","author":"Norum","year":"2020","journal-title":"J. Lipid Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41569-021-00538-z","article-title":"High-density lipoproteins, reverse cholesterol transport and atherogenesis","volume":"18","author":"Pownall","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s00125-009-1282-2","article-title":"Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations","volume":"52","author":"Kotronen","year":"2009","journal-title":"Diabetologia"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.jhep.2021.04.013","article-title":"Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis","volume":"75","author":"Ooi","year":"2021","journal-title":"J. Hepatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0022-2275(20)33305-8","article-title":"An efficient chromatographic system for lipoprotein fractionation using whole plasma","volume":"39","author":"Li","year":"1998","journal-title":"J. Lipid Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"8025","DOI":"10.1021\/acs.analchem.8b04615","article-title":"A Comprehensive UHPLC Ion Mobility Quadrupole Time-of-Flight Method for Profiling and Quantification of Eicosanoids, Other Oxylipins, and Fatty Acids","volume":"91","author":"Hinz","year":"2019","journal-title":"Anal. Chem."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/12\/6786\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:34:18Z","timestamp":1760139258000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/12\/6786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,17]]},"references-count":69,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["ijms23126786"],"URL":"https:\/\/doi.org\/10.3390\/ijms23126786","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,17]]}}}