{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:57:00Z","timestamp":1791928620998,"version":"4.3.4"},"reference-count":44,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Joint Region Innovation Development Scheme, National Natural Science Foundation of Chin","award":["U19A2010"],"award-info":[{"award-number":["U19A2010"]}]},{"name":"Joint Region Innovation Development Scheme, National Natural Science Foundation of Chin","award":["CXTD2018012"],"award-info":[{"award-number":["CXTD2018012"]}]},{"name":"Joint Region Innovation Development Scheme, National Natural Science Foundation of Chin","award":["030058179"],"award-info":[{"award-number":["030058179"]}]},{"name":"Xinglin Scholars Discipline Talent Research Promotion Plan","award":["U19A2010"],"award-info":[{"award-number":["U19A2010"]}]},{"name":"Xinglin Scholars Discipline Talent Research Promotion Plan","award":["CXTD2018012"],"award-info":[{"award-number":["CXTD2018012"]}]},{"name":"Xinglin Scholars Discipline Talent Research Promotion Plan","award":["030058179"],"award-info":[{"award-number":["030058179"]}]},{"name":"Xinglin Scholar Research Promotion Project of Chengdu University of TCM","award":["U19A2010"],"award-info":[{"award-number":["U19A2010"]}]},{"name":"Xinglin Scholar Research Promotion Project of Chengdu University of TCM","award":["CXTD2018012"],"award-info":[{"award-number":["CXTD2018012"]}]},{"name":"Xinglin Scholar Research Promotion Project of Chengdu University of TCM","award":["030058179"],"award-info":[{"award-number":["030058179"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>(1) Background: Curcumin (CUR) and tetrandrine (TET) are natural compounds with various bioactivities, but have problems with low solubility, stability, and absorption rate, resulting in low bioavailability, and limited applications in food, medicine, and other fields. It is very important to improve the solubility while maintaining the high activity of drugs. Liposomes are micro\u2013vesicles synthesized from cholesterol and lecithin. With high biocompatibility and biodegradability, liposomes can significantly improve drug solubility, efficacy, and bioavailability. (2) Methods: In this work, CUR and TET were encapsulated with nano\u2013liposomes and g DSPE\u2013MPEG 2000 (DP)was added as a stabilizer to achieve better physicochemical properties, biosafety, and anti\u2013tumor effects. (3) Results: The nano\u2013liposome (CT\u2013DP\u2013Lip) showed stable particle size (under 100 nm) under different conditions, high solubility, drug encapsulation efficiency (EE), loading capacity (LC), release rate in vitro, and stability. In addition, in vivo studies demonstrated CT\u2013DP\u2013Lip had no significant toxicity on zebrafish. Tumor cytotoxicity test showed that CT\u2013DP\u2013Lip had a strong inhibitory effect on a variety of cancer cells. (4) Conclusions: This work showed that nano\u2013liposomes can significantly improve the physical and chemical properties of CUR and TET and make them safer and more efficient.<\/jats:p>","DOI":"10.3390\/ijms23126858","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T01:43:27Z","timestamp":1655775807000},"page":"6858","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Nano\u2013Liposomes Double Loaded with Curcumin and Tetrandrine: Preparation, Characterization, Hepatotoxicity and Anti\u2013Tumor Effects"],"prefix":"10.3390","volume":"23","author":[{"given":"Jia-Wen","family":"Song","sequence":"first","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"},{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Shi","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"},{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Rou","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Xiao","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5989-2125","authenticated-orcid":false,"given":"Yi-Ping","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"},{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7445-5257","authenticated-orcid":false,"given":"Li","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"},{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2174\/138945011794815356","article-title":"The targets of curcumin","volume":"12","author":"Zhou","year":"2011","journal-title":"Curr Drug Targets"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9183","DOI":"10.3390\/molecules20059183","article-title":"Curcumin, inflammation, and chronic diseases: How are they linked?","volume":"20","author":"He","year":"2015","journal-title":"Molecules"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"112124","DOI":"10.1016\/j.jphotobiol.2021.112124","article-title":"Self-assembled Camptothecin derivatives\u2014Curcuminoids conjugate for combinatorial chemo-photodynamic therapy to enhance anti-tumor efficacy","volume":"215","author":"Guo","year":"2021","journal-title":"J. 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