{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:19:04Z","timestamp":1790853544537,"version":"4.1.0"},"reference-count":132,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","award":["#2019\/26268-6"],"award-info":[{"award-number":["#2019\/26268-6"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","award":["#2019\/21745-0"],"award-info":[{"award-number":["#2019\/21745-0"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","award":["#2019\/27080-0"],"award-info":[{"award-number":["#2019\/27080-0"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","award":["#2013\/07467-1"],"award-info":[{"award-number":["#2013\/07467-1"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","award":["#2019\/15320-7"],"award-info":[{"award-number":["#2019\/15320-7"]}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)","award":["#2019\/19435-3"],"award-info":[{"award-number":["#2019\/19435-3"]}]},{"name":"CAPES","award":["#2019\/26268-6"],"award-info":[{"award-number":["#2019\/26268-6"]}]},{"name":"CAPES","award":["#2019\/21745-0"],"award-info":[{"award-number":["#2019\/21745-0"]}]},{"name":"CAPES","award":["#2019\/27080-0"],"award-info":[{"award-number":["#2019\/27080-0"]}]},{"name":"CAPES","award":["#2013\/07467-1"],"award-info":[{"award-number":["#2013\/07467-1"]}]},{"name":"CAPES","award":["#2019\/15320-7"],"award-info":[{"award-number":["#2019\/15320-7"]}]},{"name":"CAPES","award":["#2019\/19435-3"],"award-info":[{"award-number":["#2019\/19435-3"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["#2019\/26268-6"],"award-info":[{"award-number":["#2019\/26268-6"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["#2019\/21745-0"],"award-info":[{"award-number":["#2019\/21745-0"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["#2019\/27080-0"],"award-info":[{"award-number":["#2019\/27080-0"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["#2013\/07467-1"],"award-info":[{"award-number":["#2013\/07467-1"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["#2019\/15320-7"],"award-info":[{"award-number":["#2019\/15320-7"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["#2019\/19435-3"],"award-info":[{"award-number":["#2019\/19435-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Glioblastoma multiforme is a lethal disease and represents the most common and severe type of glioma. Drug resistance and the evasion of cell death are the main characteristics of its malignancy, leading to a high percentage of disease recurrence and the patients\u2019 low survival rate. Exploiting the modulation of cell death mechanisms could be an important strategy to prevent tumor development and reverse the high mortality and morbidity rates in glioblastoma patients. Ferroptosis is a recently described type of cell death, which is characterized by iron accumulation, high levels of polyunsaturated fatty acid (PUFA)-containing phospholipids, and deficiency in lipid peroxidation repair. Several studies have demonstrated that ferroptosis has a potential role in cancer treatment and could be a promising approach for glioblastoma patients. Thus, here, we present an overview of the mechanisms of the iron-dependent cell death and summarize the current findings of ferroptosis modulation on glioblastoma including its non-canonical pathway. Moreover, we focused on new ferroptosis-inducing compounds for glioma treatment, and we highlight the key ferroptosis-related genes to glioma prognosis, which could be further explored. Thereby, understanding how to trigger ferroptosis in glioblastoma may provide promising pharmacological targets and indicate new therapeutic approaches to increase the survival of glioblastoma patients.<\/jats:p>","DOI":"10.3390\/ijms23136879","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T04:39:55Z","timestamp":1655786395000},"page":"6879","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Ferroptosis Modulation: Potential Therapeutic Target for Glioblastoma Treatment"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6935-7521","authenticated-orcid":false,"given":"Izadora","family":"de Souza","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Oncology, Federal University of Sao Paulo (UNIFESP), Sao Paulo 04037-003, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carolina Clares","family":"Ramalho","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Cycle, Center of Toxins, Immune Response and Cell Signaling (CeTICS), Butantan Institute, Sao Paulo 05503-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5261-1055","authenticated-orcid":false,"given":"Camila Banca","family":"Guedes","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Oncology, Federal University of Sao Paulo (UNIFESP), Sao Paulo 04037-003, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabeli Yumi Ara\u00fajo","family":"Osawa","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Cycle, Center of Toxins, Immune Response and Cell Signaling (CeTICS), Butantan Institute, Sao Paulo 05503-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda Karolynne Seregni","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Oncology, Federal University of Sao Paulo (UNIFESP), Sao Paulo 04037-003, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Rodrigues","family":"Gomes","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Cycle, Center of Toxins, Immune Response and Cell Signaling (CeTICS), Butantan Institute, Sao Paulo 05503-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa Ribeiro Reily","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Oncology, Federal University of Sao Paulo (UNIFESP), Sao Paulo 04037-003, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1188\/16.CJON.S1.2-8","article-title":"Glioblastoma: Overview of Disease and Treatment","volume":"20","author":"Davis","year":"2016","journal-title":"Clin. 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