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University BioCenter","award":["FTLDc 01GI1007A"],"award-info":[{"award-number":["FTLDc 01GI1007A"]}]},{"name":"Boehringer Ingelheim Ulm University BioCenter","award":["01EW2008"],"award-info":[{"award-number":["01EW2008"]}]},{"name":"Boehringer Ingelheim Ulm University BioCenter","award":["SFB1279"],"award-info":[{"award-number":["SFB1279"]}]},{"name":"Boehringer Ingelheim Ulm University BioCenter","award":["D.3830"],"award-info":[{"award-number":["D.3830"]}]},{"name":"Boehringer Ingelheim Ulm University BioCenter","award":["D.5009"],"award-info":[{"award-number":["D.5009"]}]},{"name":"Boehringer Ingelheim Ulm University BioCenter","award":["D.2468"],"award-info":[{"award-number":["D.2468"]}]},{"name":"Thierry Latran Foundation","award":["01ED2008A"],"award-info":[{"award-number":["01ED2008A"]}]},{"name":"Thierry Latran Foundation","award":["FTLDc 01GI1007A"],"award-info":[{"award-number":["FTLDc 01GI1007A"]}]},{"name":"Thierry Latran Foundation","award":["01EW2008"],"award-info":[{"award-number":["01EW2008"]}]},{"name":"Thierry Latran Foundation","award":["SFB1279"],"award-info":[{"award-number":["SFB1279"]}]},{"name":"Thierry Latran Foundation","award":["D.3830"],"award-info":[{"award-number":["D.3830"]}]},{"name":"Thierry Latran Foundation","award":["D.5009"],"award-info":[{"award-number":["D.5009"]}]},{"name":"Thierry Latran Foundation","award":["D.2468"],"award-info":[{"award-number":["D.2468"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>SerpinA1 (\u03b11-antitrypsin) is a soluble glycoprotein, the cerebrospinal fluid (CSF) isoforms of which showed disease-specific changes in neurodegenerative disorders that are still unexplored in Alz-heimer\u2019s disease (AD). By means of capillary isoelectric focusing immunoassay, we investigated six serpinA1 isoforms in CSF samples of controls (n = 29), AD-MCI (n = 29), AD-dem (n = 26) and Lewy body disease (LBD, n = 59) patients and correlated the findings with CSF AD core biomarkers (A\u03b242\/40 ratio, p-tau, t-tau). Four CSF serpinA1 isoforms were differently expressed in AD patients compared to controls and LBD patients, especially isoforms 2 and 4. AD-specific changes were found since the MCI stage and significantly correlated with decreased A\u03b242\/40 (p &lt; 0.05) and in-creased p-tau and t-tau levels in CSF (p &lt; 0.001). Analysis of serpinA1 isoform provided good di-agnostic accuracy in discriminating AD patients versus controls (AUC = 0.80) and versus LBD patients (AUC = 0.92), with best results in patients in the dementia stage (AUC = 0.97). SerpinA1 isoform expression is altered in AD patients, suggesting a common, albeit disease-specific, in-volvement of serpinA1 in most neurodegenerative disorders.<\/jats:p>","DOI":"10.3390\/ijms23136922","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T21:31:06Z","timestamp":1655933466000},"page":"6922","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Specific Cerebrospinal Fluid SerpinA1 Isoform Pattern in Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1328-3620","authenticated-orcid":false,"given":"Lorenzo","family":"Barba","sequence":"first","affiliation":[{"name":"Department of Neurology, Martin-Luther-University Halle-Wittenberg, 06120 Halle (Saale), Germany"},{"name":"Department of Neurology, Ulm University Hospital, 89081 Ulm, Germany"},{"name":"Section of Neurology, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Halbgebauer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University Hospital, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9623-1900","authenticated-orcid":false,"given":"Federico","family":"Paolini Paoletti","sequence":"additional","affiliation":[{"name":"Section of Neurology, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-5650","authenticated-orcid":false,"given":"Giovanni","family":"Bellomo","sequence":"additional","affiliation":[{"name":"Section of Neurology, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Abu-Rumeileh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Martin-Luther-University Halle-Wittenberg, 06120 Halle (Saale), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Steinacker","sequence":"additional","affiliation":[{"name":"Department of Neurology, Martin-Luther-University Halle-Wittenberg, 06120 Halle (Saale), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5667-204X","authenticated-orcid":false,"given":"Federico","family":"Massa","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5722-3967","authenticated-orcid":false,"given":"Lucilla","family":"Parnetti","sequence":"additional","affiliation":[{"name":"Section of Neurology, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4273-4267","authenticated-orcid":false,"given":"Markus","family":"Otto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Martin-Luther-University Halle-Wittenberg, 06120 Halle (Saale), Germany"},{"name":"Department of Neurology, Ulm University Hospital, 89081 Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/joim.12239","article-title":"Role of alpha-1 antitrypsin in human health and disease","volume":"276","author":"Blanco","year":"2014","journal-title":"J. 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