{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T03:41:04Z","timestamp":1762054864829,"version":"build-2065373602"},"reference-count":77,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund FWF","doi-asserted-by":"publisher","award":["V 530"],"award-info":[{"award-number":["V 530"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Many cardiac insults causing atrial remodeling are linked to either stretch or tachycardia, but a comparative characterization of their effects on early remodeling events in human myocardium is lacking. Here, we applied isometric stretch or sustained tachycardia at 2.5 Hz in human atrial trabeculae for 6 h followed by microarray gene expression profiling. Among largely independent expression patterns, we found a small common fraction with the microRNA miR-1183 as the highest up-regulated transcript (up to 4-fold). Both, acute stretch and tachycardia induced down-regulation of the predicted miR-1183 target genes ADAM20 and PLA2G7. Furthermore, miR-1183 was also significantly up-regulated in chronically remodeled atrial samples from patients with persistent atrial fibrillation (3-fold up-regulation versus sinus rhythm samples), and in ventricular myocardium from dilative cardiomyopathy hearts (2-fold up-regulation) as compared to non-failing controls. In sum, although stretch and tachycardia show distinct transcriptomic signatures in human atrial myocardium, both cardiac insults consistently regulate the expression of miR-1183 and its downstream targets in acute and chronic remodeling. Thus, elevated expression of miR-1183 might serve as a tissue biomarker for atrial remodeling and might be of potential functional significance in cardiac disease.<\/jats:p>","DOI":"10.3390\/ijms23136962","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T21:25:00Z","timestamp":1656019500000},"page":"6962","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium"],"prefix":"10.3390","volume":"23","author":[{"given":"Natasa","family":"Djalinac","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria"},{"name":"Unit of Human Molecular Genetics and Functional Genomics, Department of Biology, University of Padua, 35121 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9349-8068","authenticated-orcid":false,"given":"Ewald","family":"Kolesnik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Maechler","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Scheruebel-Posch","sequence":"additional","affiliation":[{"name":"Gottfried Schatz Research Center, Institute of Biophysics, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Pelzmann","sequence":"additional","affiliation":[{"name":"Gottfried Schatz Research Center, Institute of Biophysics, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2840-6454","authenticated-orcid":false,"given":"Peter P.","family":"Rainer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria"},{"name":"BioTechMed Graz, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Foessl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7692-892X","authenticated-orcid":false,"given":"Markus","family":"Wallner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria"},{"name":"Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Scherr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8554-2372","authenticated-orcid":false,"given":"Akos","family":"Heinemann","sequence":"additional","affiliation":[{"name":"Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4419-6821","authenticated-orcid":false,"given":"Simon","family":"Sedej","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria"},{"name":"BioTechMed Graz, 8036 Graz, Austria"},{"name":"Institute of Physiology, Faculty of Medicine, University of Maribor, 2000 Maribor, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6994-9976","authenticated-orcid":false,"given":"Senka","family":"Ljubojevic-Holzer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria"},{"name":"BioTechMed Graz, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"von Lewinski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egbert","family":"Bisping","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, 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