{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:23:57Z","timestamp":1791476637329,"version":"4.3.4"},"reference-count":56,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MCIU\/AEI\/FEDER, UE","award":["RTI2018-095021-J-I00"],"award-info":[{"award-number":["RTI2018-095021-J-I00"]}]},{"name":"MCIU\/AEI\/FEDER, UE","award":["AGL2016-78311-R"],"award-info":[{"award-number":["AGL2016-78311-R"]}]},{"DOI":"10.13039\/501100003329","name":"MINECO\/AEI\/FEDER, UE","doi-asserted-by":"publisher","award":["RTI2018-095021-J-I00"],"award-info":[{"award-number":["RTI2018-095021-J-I00"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"MINECO\/AEI\/FEDER, UE","doi-asserted-by":"publisher","award":["AGL2016-78311-R"],"award-info":[{"award-number":["AGL2016-78311-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Inflammatory bowel disease is a chronic disorder including ulcerative colitis and Crohn\u2019s disease (CD). Gut dysbiosis is often associated with CD, and metagenomics allows a better understanding of the microbial communities involved. The objective of this study was to reconstruct in silico carbohydrate metabolic capabilities from metagenome-assembled genomes (MAGs) obtained from healthy and CD individuals. This computational method was developed as a mean to aid rationally designed prebiotic interventions to rebalance CD dysbiosis, with a focus on metabolism of emergent prebiotics derived from arabinoxylan and pectin. Up to 1196 and 1577 MAGs were recovered from CD and healthy people, respectively. MAGs of Akkermansia muciniphila, Barnesiella viscericola DSM 18177 and Paraprevotella xylaniphila YIT 11841 showed a wide range of unique and specific enzymes acting on arabinoxylan and pectin. These glycosidases were also found in MAGs recovered from CD patients. Interestingly, these arabinoxylan and pectin degraders are predicted to exhibit metabolic interactions with other gut microbes reduced in CD. Thus, administration of arabinoxylan and pectin may ameliorate dysbiosis in CD by promoting species with key metabolic functions, capable of cross-feeding other beneficial species. These computational methods may be of special interest for the rational design of prebiotic ingredients targeting at CD.<\/jats:p>","DOI":"10.3390\/ijms23137093","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T09:00:13Z","timestamp":1656234013000},"page":"7093","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Arabinoxylan and Pectin Metabolism in Crohn\u2019s Disease Microbiota: An In Silico Study"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6098-895X","authenticated-orcid":false,"given":"Carlos","family":"Sabater","sequence":"first","affiliation":[{"name":"Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias-Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Paseo R\u00edo Linares s\/n, 33300 Villaviciosa, Asturias, Spain"},{"name":"Functionality and Ecology of Beneficial Microbes (MicroHealth) Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5509-7696","authenticated-orcid":false,"given":"In\u00e9s","family":"Calvete-Torre","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias-Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Paseo R\u00edo Linares s\/n, 33300 Villaviciosa, Asturias, Spain"},{"name":"Functionality and Ecology of Beneficial Microbes (MicroHealth) Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias-Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Paseo R\u00edo Linares s\/n, 33300 Villaviciosa, Asturias, Spain"},{"name":"Functionality and Ecology of Beneficial Microbes (MicroHealth) Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abelardo","family":"Margolles","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias-Consejo Superior de Investigaciones Cient\u00edficas (IPLA-CSIC), Paseo R\u00edo Linares s\/n, 33300 Villaviciosa, Asturias, Spain"},{"name":"Functionality and Ecology of Beneficial Microbes (MicroHealth) Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12328-017-0813-5","article-title":"Gut microbiota in the pathogenesis of inflammatory bowel disease","volume":"11","author":"Nishida","year":"2018","journal-title":"Clin. 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