{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:01:44Z","timestamp":1792425704539,"version":"4.5.0"},"reference-count":96,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T00:00:00Z","timestamp":1656374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Celiac disease (CD) is an immune-mediated enteropathy triggered in genetically susceptible individuals by gluten-containing cereals. A central role in the pathogenesis of CD is played by the HLA-restricted gliadin-specific intestinal T cell response generated in a pro-inflammatory environment. The mechanisms that generate this pro-inflammatory environment in CD is now starting to be addressed. In vitro study on CD cells and organoids, shows that constant low-grade inflammation is present also in the absence of gluten. In vivo studies on a population at risk, show before the onset of the disease and before the introduction of gluten in the diet, cellular and metabolic alterations in the absence of a T cell-mediated response. Gluten exacerbates these constitutive alterations in vitro and in vivo. Inflammation, may have a main role in CD, adding this disease tout court to the big family of chronic inflammatory diseases. Nutrients can have pro-inflammatory or anti-inflammatory effects, also mediated by intestinal microbiota. The intestine function as a crossroad for the control of inflammation both locally and at distance. The aim of this review is to discuss the recent literature on the main role of inflammation in the natural history of CD, supported by cellular fragility with increased sensitivity to gluten and other pro-inflammatory agents.<\/jats:p>","DOI":"10.3390\/ijms23137177","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T23:59:22Z","timestamp":1656460762000},"page":"7177","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Pivotal Role of Inflammation in Celiac Disease"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-4917","authenticated-orcid":false,"given":"Maria Vittoria","family":"Barone","sequence":"first","affiliation":[{"name":"Department of Translational Medical Science, University Federico II, Via S. Pansini 5, 80131 Naples, Italy"},{"name":"European Laboratory for the Investigation of Food Induced Disease (ELFID), University Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Auricchio","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science, University Federico II, Via S. Pansini 5, 80131 Naples, Italy"},{"name":"European Laboratory for the Investigation of Food Induced Disease (ELFID), University Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2569-4606","authenticated-orcid":false,"given":"Merlin","family":"Nanayakkara","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science, University Federico II, Via S. Pansini 5, 80131 Naples, Italy"},{"name":"European Laboratory for the Investigation of Food Induced Disease (ELFID), University Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science, University Federico II, Via S. Pansini 5, 80131 Naples, Italy"},{"name":"European Laboratory for the Investigation of Food Induced Disease (ELFID), University Federico II, Via S. Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Troncone","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Science, University Federico II, Via S. Pansini 5, 80131 Naples, Italy"},{"name":"European Laboratory for the Investigation of Food Induced Disease (ELFID), University Federico II, Via S. 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Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1053\/j.gastro.2014.12.036","article-title":"Food, immunity, and the microbiome","volume":"148","author":"Tilg","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"k2340","DOI":"10.1136\/bmj.k2340","article-title":"Dietary carbohydrates: Role of quality and quantity in chronic disease","volume":"361","author":"Ludwig","year":"2018","journal-title":"BMJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.freeradbiomed.2019.03.036","article-title":"An update on lipid oxidation and inflammation in cardiovascular diseases","volume":"144","author":"Zhong","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature24628","article-title":"Salt-responsive gut commensal modulates T(H)17 axis and disease","volume":"551","author":"Wilck","year":"2017","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.immuni.2014.05.014","article-title":"Diet, metabolites, and \u201cwestern-lifestyle\u201d inflammatory diseases","volume":"40","author":"Thorburn","year":"2014","journal-title":"Immunity"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/archinternmed.2011.18","article-title":"Dietary fiber intake and mortality in the NIH-AARP diet and health study","volume":"171","author":"Park","year":"2011","journal-title":"Arch. Intern. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1017\/S0007114515002093","article-title":"Low-grade inflammation, diet composition and health: Current research evidence and its translation","volume":"114","author":"Minihane","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.cell.2019.03.037","article-title":"Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10","volume":"177","author":"Rojas","year":"2019","journal-title":"Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cmet.2016.01.003","article-title":"The Intestinal Immune System in Obesity and Insulin Resistance","volume":"23","author":"Winer","year":"2016","journal-title":"Cell Metab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.molmed.2016.12.005","article-title":"Beta-Cell Fragility as a Common Underlying Risk Factor in Type 1 and Type 2 Diabetes","volume":"23","author":"Liston","year":"2017","journal-title":"Trends Mol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/nri3407","article-title":"Triggers and drivers of autoimmunity: Lessons from coeliac disease","volume":"13","author":"Sollid","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41572-018-0054-z","article-title":"Coeliac disease","volume":"5","author":"Lindfors","year":"2019","journal-title":"Nat. Rev. Dis. Primers."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1053\/j.gastro.2020.04.018","article-title":"Evidence That Pathogenic Transglutaminase 2 in Celiac Disease Derives from Enterocytes","volume":"159","author":"Iversen","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1126\/science.aah5298","article-title":"Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease","volume":"356","author":"Bouziat","year":"2017","journal-title":"Science"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1111\/j.1572-0241.2006.00741.x","article-title":"Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: A longitudinal study","volume":"101","author":"Stene","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Porpora, M., Conte, M., Lania, G., Bellomo, C., Rapacciuolo, L., Chirdo, F.G., Auricchio, R., Troncone, R., Auricchio, S., and Barone, M.V. (2022). Inflammation Is Present, Persistent and More Sensitive to Proinflammatory Triggers in Celiac Disease Enterocytes. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23041973"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"672148","DOI":"10.3389\/fimmu.2021.672148","article-title":"Can Celiac Disease Be Prevented?","volume":"12","author":"Auricchio","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"14303","DOI":"10.1038\/s41598-019-50735-7","article-title":"A Phospholipid Profile at 4 Months Predicts the Onset of Celiac Disease in at-Risk Infants","volume":"9","author":"Auricchio","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14309\/ctg.0000000000000044","article-title":"Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated with Progression to Celiac Disease","volume":"10","author":"Sen","year":"2019","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1136\/archdischild-2019-317976","article-title":"Growth rate of coeliac children is compromised before the onset of the disease","volume":"105","author":"Auricchio","year":"2020","journal-title":"Arch. Dis. Child."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8157","DOI":"10.1038\/s41598-022-12636-0","article-title":"Author Correction: Gluten consumption and inflammation affect the development of celiac disease in at-risk children","volume":"12","author":"Auricchio","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/MPG.0000000000001519","article-title":"Presymptomatic Diagnosis of Celiac Disease in Predisposed Children: The Role of Gene Expression Profile","volume":"65","author":"Galatola","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40168-018-0415-6","article-title":"Gut microbiota trajectory in early life may predict development of celiac disease","volume":"6","author":"Olivares","year":"2018","journal-title":"Microbiome"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jcmgh.2020.07.010","article-title":"Genome-Wide Transcriptomic Analysis of Intestinal Mucosa in Celiac Disease Patients on a Gluten-Free Diet and Postgluten Challenge","volume":"11","author":"Dotsenko","year":"2021","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Stamnaes, J., Stray, D., Stensland, M., Sarna, V.K., Nyman, T.A., Lundin, K.E.A., and Sollid, L.M. (2020). Quantitative proteomics of coeliac gut during 14-day gluten challenge: Low-level baseline inflammation despite clinical and histological normality predicts subsequent response. medRxiv.","DOI":"10.1101\/2020.05.04.20090977"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2003526","DOI":"10.1002\/advs.202003526","article-title":"In Well-Treated Celiac Patients Low-Level Mucosal Inflammation Predicts Response to 14-day Gluten Challenge","volume":"8","author":"Stamnaes","year":"2021","journal-title":"Adv. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1136\/gut.2008.169052","article-title":"Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling","volume":"58","author":"Trynka","year":"2009","journal-title":"Gut"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1093\/hmg\/ddt520","article-title":"Coregulation and modulation of NF\u03baB-related genes in celiac disease: Uncovered aspects of gut mucosal inflammation","volume":"23","author":"Irastorza","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/bs.ircmb.2017.07.003","article-title":"Profiling Celiac Disease-Related Transcriptional Changes","volume":"336","author":"Bilbao","year":"2018","journal-title":"Int. Rev. Cell. Mol. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3389\/fimmu.2019.00420","article-title":"Disease-Associated SNPs in Inflammation-Related lncRNAs","volume":"10","author":"Ghosh","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/ncpgasthep0582","article-title":"Mechanisms of disease: Immunopathogenesis of celiac disease","volume":"3","author":"Jabri","year":"2006","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/MPG.0b013e3181ea0092","article-title":"Increased heat shock protein 72 expression in celiac disease","volume":"51","author":"Sziksz","year":"2010","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/imr.12191","article-title":"IL-15: A central regulator of celiac disease immunopathology","volume":"260","author":"Abadie","year":"2014","journal-title":"Immunol. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1365-2249.2008.03743.x","article-title":"Higher constitutive IL15R alpha expression and lower IL-15 response threshold in coeliac disease patients","volume":"154","author":"Bernardo","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"10821","DOI":"10.1038\/s41598-018-28830-y","article-title":"P31-43, an undigested gliadin peptide, mimics and enhances the innate immune response to viruses and interferes with endocytic trafficking: A role in celiac disease","volume":"8","author":"Nanayakkara","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"155258","DOI":"10.1016\/j.cyto.2020.155258","article-title":"Interleukin-15 in autoimmunity","volume":"136","author":"Mishra","year":"2020","journal-title":"Cytokine"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41586-020-2003-8","article-title":"IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease","volume":"578","author":"Abadie","year":"2020","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s42003-019-0443-1","article-title":"Constitutive alterations in vesicular trafficking increase the sensitivity of cells from celiac disease patients to gliadin","volume":"2","author":"Lania","year":"2019","journal-title":"Commun. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"20518","DOI":"10.3390\/ijms151120518","article-title":"Gliadin peptides as triggers of the proliferative and stress\/innate immune response of the celiac small intestinal mucosa","volume":"15","author":"Barone","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1365-2249.2007.03500.x","article-title":"Gluten affects epithelial differentiation-associated genes in small intestinal mucosa of coeliac patients","volume":"150","author":"Kainulainen","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Nanayakkara, M., Lania, G., Maglio, M., Kosova, R., Sarno, M., Gaito, A., Discepolo, V., Troncone, R., Auricchio, S., and Auricchio, R. (2013). Enterocyte proliferation and signaling are constitutively altered in celiac disease. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076006"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1136\/gut.26.11.1214","article-title":"Intestinal permeability in patients with coeliac disease and dermatitis herpetiformis","volume":"26","author":"Bjarnason","year":"1985","journal-title":"Gut"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1136\/gut.25.2.145","article-title":"In vitro determination of small intestinal permeability: Demonstration of a persistent defect in patients with coeliac disease","volume":"25","author":"Bjarnason","year":"1984","journal-title":"Gut"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1309\/DTYRA91G8R0KTM8M","article-title":"Altered expression, localization, and phosphorylation of epithelial junctional proteins in celiac disease","volume":"125","author":"Ciccocioppo","year":"2006","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1203\/00006450-199804000-00001","article-title":"Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue","volume":"43","author":"Schulzke","year":"1998","journal-title":"Pediatr. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/MPG.0000000000000338","article-title":"Alteration of tight junction gene expression in celiac disease","volume":"58","author":"Irastorza","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"7029","DOI":"10.1038\/s41598-019-43426-w","article-title":"Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease","volume":"9","author":"Freire","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1038\/s41598-020-60521-5","article-title":"Intestinal ex vivo organoid culture reveals altered programmed crypt stem cells in patients with celiac disease","volume":"10","author":"Dieterich","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Nanayakkara, M., Kosova, R., Lania, G., Sarno, M., Gaito, A., Galatola, M., Greco, L., Cuomo, M., Troncone, R., and Auricchio, S. (2013). A celiac cellular phenotype, with altered LPP sub-cellular distribution, is inducible in controls by the toxic gliadin peptide P31-43. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079763"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Paolella, G., Nanayakkara, M., Sposito, S., Lepretti, M., Auricchio, S., Esposito, C., Barone, M.V., Martucciello, S., and Caputo, I. (2020). Constitutive Differential Features of Type 2 Transglutaminase in Cells Derived from Celiac Patients and from Healthy Subjects. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041231"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Discepolo, V., Lania, G., Ten Eikelder, M.L.G., Nanayakkara, M., Sepe, L., Tufano, R., Troncone, R., Auricchio, S., Auricchio, R., and Paolella, G. (2021). Pediatric Celiac Disease Patients Show Alterations of Dendritic Cell Shape and Actin Rearrangement. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22052708"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1056\/NEJMoa1404172","article-title":"Randomized feeding intervention in infants at high risk for celiac disease","volume":"371","author":"Vriezinga","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/bs.ircmb.2020.10.003","article-title":"The gliadin P31-43 peptide: Inducer of multiple proinflammatory effects","volume":"358","author":"Chirdo","year":"2021","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Barone, M.V., Nanayakkara, M., Paolella, G., Maglio, M., Vitale, V., Troiano, R., Ribecco, M.T., Lania, G., Zanzi, D., and Santagata, S. (2010). Gliadin peptide P31-43 localises to endocytic vesicles and interferes with their maturation. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0012246"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.cell.2010.11.033","article-title":"Lipidomics: New tools and applications","volume":"143","author":"Wenk","year":"2010","journal-title":"Cell"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1084\/jem.20081800","article-title":"Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes","volume":"205","author":"Oresic","year":"2008","journal-title":"J. Exp. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"10635","DOI":"10.1038\/s41598-018-28907-8","article-title":"Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes\u2014Type 1 Diabetes Prediction and Prevention Study (DIPP)","volume":"8","author":"Lamichhane","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Perochon, J., Carroll, L.R., and Cordero, J.B. (2018). Wnt Signalling in Intestinal Stem Cells: Lessons from Mice and Flies. Genes, 9.","DOI":"10.3390\/genes9030138"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/cr.2011.13","article-title":"NF-\u03baB in immunobiology","volume":"21","author":"Hayden","year":"2011","journal-title":"Cell. Res."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Barone, M.V., and Auricchio, S. (2021). A Cumulative Effect of Food and Viruses to Trigger Celiac Disease (CD): A Commentary on the Recent Literature. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22042027"},{"key":"ref_62","first-page":"667","article-title":"Time\/dose responses of coeliac mucosae to graded oral challenges with Frazer\u2019s fraction III of gliadin","volume":"4","author":"Marsh","year":"1992","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1136\/gut.34.12.1740-a","article-title":"Clinical and pathological spectrum of coeliac disease","volume":"34","author":"Mulder","year":"1993","journal-title":"Gut"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0950-3528(95)90032-2","article-title":"Morphology of the mucosal lesion in gluten sensitivity","volume":"9","author":"Marsh","year":"1995","journal-title":"Baillieres Clin. Gastroenterol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/gut.2005.086637","article-title":"Growth factor-like activity of gliadin, an alimentary protein: Implications for coeliac disease","volume":"56","author":"Barone","year":"2007","journal-title":"Gut"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Taavela, J., Viiri, K., Popp, A., Oittinen, M., Dotsenko, V., Per\u00e4aho, M., Staff, S., Sarin, J., Leon, F., and M\u00e4ki, M. (2019). Histological, immunohistochemical and mRNA gene expression responses in coeliac disease patients challenged with gluten using PAXgene fixed paraffin-embedded duodenal biopsies. BMC Gastroenterol., 19.","DOI":"10.1186\/s12876-019-1089-7"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1053\/j.gastro.2007.04.070","article-title":"Sera of patients with celiac disease and neurologic disorders evoke a mitochondrial-dependent apoptosis in vitro","volume":"133","author":"Cervio","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.dld.2005.11.013","article-title":"Anti-ganglioside antibodies in coeliac disease with neurological disorders","volume":"38","author":"Volta","year":"2006","journal-title":"Dig. Liver. Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1053\/j.gastro.2007.01.030","article-title":"Humoral immune response to tissue transglutaminase is related to epithelial cell proliferation in celiac disease","volume":"132","author":"Barone","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1365-2249.2004.02541.x","article-title":"Anti-actin IgA antibodies in severe coeliac disease","volume":"137","author":"Granito","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S1590-8658(00)80354-0","article-title":"Prevalence of silent coeliac disease in atopics","volume":"32","author":"Zauli","year":"2000","journal-title":"Dig. Liver Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/gut.2007.133132","article-title":"Associations with tight junction genes PARD3 and MAGI2 in Dutch patients point to a common barrier defect for coeliac disease and ulcerative colitis","volume":"57","author":"Wapenaar","year":"2008","journal-title":"Gut"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ng.998","article-title":"Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease","volume":"43","author":"Trynka","year":"2011","journal-title":"Nat. Genet."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"767456","DOI":"10.3389\/fimmu.2021.767456","article-title":"IL-1\u03b2 and the Intestinal Epithelial Tight Junction Barrier","volume":"12","author":"Kaminsky","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1056\/NEJMra0910494","article-title":"Mendelian disorders of membrane trafficking","volume":"365","author":"Luini","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nature12599","article-title":"Paneth cells as a site of origin for intestinal inflammation","volume":"503","author":"Adolph","year":"2013","journal-title":"Nature"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ng.3279","article-title":"COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis","volume":"47","author":"Watkin","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1038\/s41598-018-37746-6","article-title":"The methylome of the celiac intestinal epithelium harbours genotype-independent alterations in the HLA region","volume":"9","author":"Legarda","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Pietz, G., De, R., Hedberg, M., Sj\u00f6berg, V., Sandstr\u00f6m, O., Hernell, O., Hammarstr\u00f6m, S., and Hammarstr\u00f6m, M.L. (2017). Immunopathology of childhood celiac disease-Key role of intestinal epithelial cells. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0185025"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41575-020-00391-4","article-title":"Modelling intestinal inflammation and infection using \u2018mini-gut\u2019 organoids","volume":"18","author":"Li","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"66737","DOI":"10.3389\/fnut.2021.667370","article-title":"Wheat ATIs: Characteristics and Role in Human Disease","volume":"8","author":"Geisslitz","year":"2021","journal-title":"Front. Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1053\/j.gastro.2018.02.024","article-title":"Dietary Patterns After the Weaning and Lactation Period Are Associated with Celiac Disease Autoimmunity in Children","volume":"154","author":"Barroso","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/nure.12035","article-title":"Dietary pattern analysis and biomarkers of low-grade inflammation: A systematic literature review","volume":"71","author":"Barbaresko","year":"2013","journal-title":"Nutr. Rev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.immuni.2019.02.014","article-title":"A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult","volume":"50","author":"Dulauroy","year":"2019","journal-title":"Immunity"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.cgh.2016.10.033","article-title":"Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life","volume":"15","author":"Kemppainen","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/ajg.2015.287","article-title":"Infections and risk of celiac disease in childhood: A prospective nationwide cohort study","volume":"110","author":"Kahrs","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/INF.0000000000002281","article-title":"Rotavirus Vaccination Does Not Increase Type 1 Diabetes and May Decrease Celiac Disease in Children and Adolescents","volume":"38","author":"Vesikari","year":"2019","journal-title":"Pediatr. Infect Dis. J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"l231","DOI":"10.1136\/bmj.l231","article-title":"Enterovirus as trigger of coeliac disease: Nested case-control study within prospective birth cohort","volume":"364","author":"Kahrs","year":"2019","journal-title":"BMJ"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"G161","DOI":"10.1152\/ajpgi.00099.2019","article-title":"Celiac disease: Should we care about microbes?","volume":"317","author":"Caminero","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1136\/gut.28.8.995","article-title":"Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease","volume":"28","author":"Kagnoff","year":"1987","journal-title":"Gut"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1159\/000236457","article-title":"Antipeptide antibodies to adenovirus E1b protein indicate enhanced risk of celiac disease and dermatitis herpetiformis","volume":"101","author":"Lehtinen","year":"1993","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1136\/gutjnl-2019-319809","article-title":"Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: The TEDDY study","volume":"69","author":"Lindfors","year":"2020","journal-title":"Gut"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41575-022-00593-y","article-title":"Multiomics to elucidate inflammatory bowel disease risk factors and pathways","volume":"19","author":"Agrawal","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1053\/j.gastro.2021.07.026","article-title":"Systemic Inflammation in Preclinical Ulcerative Colitis","volume":"161","author":"Bergemalm","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Vrdoljak, J., Vilovi\u0107, M., \u017divkovi\u0107, P.M., Tadin Hadjina, I., Ru\u0161i\u0107, D., Buki\u0107, J., Borovac, J.A., and Bo\u017ei\u0107, J. (2020). Mediterranean Diet Adherence and Dietary Attitudes in Patients with Inflammatory Bowel Disease. Nutrients, 12.","DOI":"10.3390\/nu12113429"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1136\/gutjnl-2019-319505","article-title":"Adherence to a Mediterranean diet is associated with a lower risk of later-onset Crohn\u2019s disease: Results from two large prospective cohort studies","volume":"69","author":"Khalili","year":"2020","journal-title":"Gut"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/13\/7177\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:39:45Z","timestamp":1760139585000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/13\/7177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,28]]},"references-count":96,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["ijms23137177"],"URL":"https:\/\/doi.org\/10.3390\/ijms23137177","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,28]]}}}