{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:56:13Z","timestamp":1773662173051,"version":"3.50.1"},"reference-count":103,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"INNOLABS\u2013POR Puglia","award":["FESR-FSE 2014-2020"],"award-info":[{"award-number":["FESR-FSE 2014-2020"]}]},{"name":"INNOLABS\u2013POR Puglia","award":["PRIN 20174TB8KW_002"],"award-info":[{"award-number":["PRIN 20174TB8KW_002"]}]},{"name":"Italian University and Research Ministry","award":["FESR-FSE 2014-2020"],"award-info":[{"award-number":["FESR-FSE 2014-2020"]}]},{"name":"Italian University and Research Ministry","award":["PRIN 20174TB8KW_002"],"award-info":[{"award-number":["PRIN 20174TB8KW_002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ion channels are pore-forming proteins that allow ions to flow across plasma membranes and intracellular organelles in both excitable and non-excitable cells. They are involved in the regulation of several biological processes (i.e., proliferation, cell volume and shape, differentiation, migration, and apoptosis). Recently, the aberrant expression of ion channels has emerged as an important step of malignant transformation, tumor progression, and drug resistance, leading to the idea of \u201conco-channelopathy\u201d. Here, we review the contribution of ion channels and transporters in multiple myeloma (MM), a hematological neoplasia characterized by the expansion of tumor plasma cells (MM cells) in the bone marrow (BM). Deregulation of ion channels sustains MM progression by modulating intracellular pathways that promote MM cells\u2019 survival, proliferation, and drug resistance. Finally, we focus on the promising role of ion channels as therapeutic targets for the treatment of MM patients in a combination strategy with currently used anti-MM drugs to improve their cytotoxic activity and reduce adverse effects.<\/jats:p>","DOI":"10.3390\/ijms23137302","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:21:50Z","timestamp":1656634910000},"page":"7302","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ion Channels in Multiple Myeloma: Pathogenic Role and Therapeutic Perspectives"],"prefix":"10.3390","volume":"23","author":[{"given":"Ilaria","family":"Saltarella","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Section of Pharmacology, University of Bari Aldo Moro Medical School, Piazza Giulio Cesare 11, I-70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-9621","authenticated-orcid":false,"given":"Concetta","family":"Altamura","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Section of Pharmacology, University of Bari Aldo Moro Medical School, Piazza Giulio Cesare 11, I-70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelia","family":"Lamanuzzi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine, University of Bari Aldo Moro Medical School, I-70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetta","family":"Apollonio","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine, University of Bari Aldo Moro Medical School, I-70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4567-8216","authenticated-orcid":false,"given":"Angelo","family":"Vacca","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine, University of Bari Aldo Moro Medical School, I-70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Antonia","family":"Frassanito","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Section of General Pathology, University of Bari Aldo Moro Medical School, I-70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8816-9369","authenticated-orcid":false,"given":"Jean-Fran\u00e7ois","family":"Desaphy","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Section of Pharmacology, University of Bari Aldo Moro Medical School, Piazza Giulio Cesare 11, I-70124 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17046","DOI":"10.1038\/nrdp.2017.46","article-title":"Multiple myeloma","volume":"3","author":"Kumar","year":"2017","journal-title":"Nat. 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