{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:08:41Z","timestamp":1789171721205,"version":"build-2803163510"},"reference-count":162,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T00:00:00Z","timestamp":1656806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1990\/18"],"award-info":[{"award-number":["1990\/18"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["21-303-AI"],"award-info":[{"award-number":["21-303-AI"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001698","name":"Beverley Librach Abshez Initiative for Ovarian and Female Reproductive System Cancers","doi-asserted-by":"publisher","award":["1990\/18"],"award-info":[{"award-number":["1990\/18"]}],"id":[{"id":"10.13039\/100001698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001698","name":"Beverley Librach Abshez Initiative for Ovarian and Female Reproductive System Cancers","doi-asserted-by":"publisher","award":["21-303-AI"],"award-info":[{"award-number":["21-303-AI"]}],"id":[{"id":"10.13039\/100001698","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Len and Susan Mark Phase II initiative for Ovarian and Uterine\/MMMT","award":["1990\/18"],"award-info":[{"award-number":["1990\/18"]}]},{"name":"Len and Susan Mark Phase II initiative for Ovarian and Uterine\/MMMT","award":["21-303-AI"],"award-info":[{"award-number":["21-303-AI"]}]},{"name":"Israel Cancer Association\u2019s USA Board of Directors","award":["1990\/18"],"award-info":[{"award-number":["1990\/18"]}]},{"name":"Israel Cancer Association\u2019s USA Board of Directors","award":["21-303-AI"],"award-info":[{"award-number":["21-303-AI"]}]},{"name":"EU\u2019s Marie Curie Actions (FP7 People)","award":["1990\/18"],"award-info":[{"award-number":["1990\/18"]}]},{"name":"EU\u2019s Marie Curie Actions (FP7 People)","award":["21-303-AI"],"award-info":[{"award-number":["21-303-AI"]}]},{"name":"Women\u2019s Health Fund at the Rambam Health Care Campus","award":["1990\/18"],"award-info":[{"award-number":["1990\/18"]}]},{"name":"Women\u2019s Health Fund at the Rambam Health Care Campus","award":["21-303-AI"],"award-info":[{"award-number":["21-303-AI"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Normal processes of embryonic development and abnormal transformation to cancer have many parallels, and in fact many aberrant cancer cell capabilities are embryonic traits restored in a distorted, unorganized way. Some of these capabilities are cell autonomous, such as proliferation and resisting apoptosis, while others involve a complex interplay with other cells that drives significant changes in neighboring cells. The correlation between embryonic development and cancer is driven by shared proteins. Some embryonic proteins disappear after embryogenesis in adult differentiated cells and are restored in cancer, while others are retained in adult cells, acquiring new functions upon transformation to cancer. Many embryonic factors embraced by cancer cells are transcription factors; some are master regulators that play a major role in determining cell fate. The paired box (PAX) domain family of developmental transcription factors includes nine members involved in differentiation of various organs. All paired box domain proteins are involved in different cancer types carrying pro-tumorigenic or anti-tumorigenic roles. This review focuses on PAX8, a master regulator of transcription in embryonic development of the thyroid, kidney, and male and female genital tracts. We detail the role of PAX8 in each of these organ systems, describe its role during development and in the adult if known, and highlight its pro-tumorigenic role in cancers that emerge from PAX8 expressing organs.<\/jats:p>","DOI":"10.3390\/ijms23137410","type":"journal-article","created":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T22:50:46Z","timestamp":1656888646000},"page":"7410","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["PAX8 in the Junction between Development and Tumorigenesis"],"prefix":"10.3390","volume":"23","author":[{"given":"Reli Rachel","family":"Kakun","sequence":"first","affiliation":[{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion\u2013Israel Institute of Technology, Haifa 3109601, Israel"},{"name":"Clinical Research Institute at Rambam, Rambam Health Care Campus, Haifa 3109601, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohar","family":"Melamed","sequence":"additional","affiliation":[{"name":"Division of Oncology, Rambam Health Care Campus, Haifa 3109601, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Perets","sequence":"additional","affiliation":[{"name":"Bruce and Ruth Rappaport Faculty of Medicine, Technion\u2013Israel Institute of Technology, Haifa 3109601, Israel"},{"name":"Clinical Research Institute at Rambam, Rambam Health Care Campus, Haifa 3109601, Israel"},{"name":"Division of Oncology, Rambam Health Care Campus, Haifa 3109601, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1158\/0008-5472.CAN-15-1382","article-title":"It\u2019s Totally Tubular\u2026Riding The New Wave of Ovarian Cancer Research","volume":"76","author":"Perets","year":"2016","journal-title":"Cancer Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"12372","DOI":"10.1073\/pnas.1109363108","article-title":"Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer","volume":"108","author":"Cheung","year":"2011","journal-title":"Proc. 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