{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:52:57Z","timestamp":1790545977553,"version":"4.1.0"},"reference-count":164,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Sim\u00f3n Bol\u00edvar"},{"name":"Vicerrector\u00eda de Investigaci\u00f3n, Extensi\u00f3n e Innovaci\u00f3n, Barranquilla, Colombia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Obesity is a major public health issue worldwide since it is associated with the development of chronic comorbidities such as type 2 diabetes, dyslipidemias, atherosclerosis, some cancer forms and skin diseases, including psoriasis. Scientific evidence has indicated that the possible link between obesity and psoriasis may be multifactorial, highlighting dietary habits, lifestyle, certain genetic factors and the microbiome as leading factors in the progress of both pathologies because they are associated with a chronic pro-inflammatory state. Thus, inflammation management in obesity is a plausible target for psoriasis, not only because of the sick adipose tissue secretome profile but also due to the relationship of obesity with the rest of the immune derangements associated with psoriasis initiation and maintenance. Hence, this review will provide a general and molecular overview of the relationship between both pathologies and present recent therapeutic advances in treating this problem.<\/jats:p>","DOI":"10.3390\/ijms23147499","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T09:41:10Z","timestamp":1657100470000},"page":"7499","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["Exploring the Links between Obesity and Psoriasis: A Comprehensive Review"],"prefix":"10.3390","volume":"23","author":[{"given":"Gabriela","family":"Barros","sequence":"first","affiliation":[{"name":"Departamento de Post-Grado, Universidad Cat\u00f3lica de Cuenca, Ciudad Cuenca 010109, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8030-1780","authenticated-orcid":false,"given":"Pablo","family":"Duran","sequence":"additional","affiliation":[{"name":"Endocrine and Metabolic Diseases Research Center, School of Medicine, The University of Zulia, Maracaibo 4004, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Vera","sequence":"additional","affiliation":[{"name":"Endocrine and Metabolic Diseases Research Center, School of Medicine, The University of Zulia, Maracaibo 4004, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1880-8887","authenticated-orcid":false,"given":"Valmore","family":"Berm\u00fadez","sequence":"additional","affiliation":[{"name":"Departamento de Post-Grado, Universidad Cat\u00f3lica de Cuenca, Ciudad Cuenca 010109, Ecuador"},{"name":"Facultad de Ciencias de la Salud, Universidad Sim\u00f3n Bol\u00edvar, Barranquilla 080002, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1159\/000455840","article-title":"Psoriasis and Obesity","volume":"232","author":"Jensen","year":"2016","journal-title":"Dermatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"593564","DOI":"10.3389\/fimmu.2020.593564","article-title":"The Important Role of Leptin in Modulating the Risk of Dermatological Diseases","volume":"11","author":"Su","year":"2021","journal-title":"Front. 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