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Salamanca","award":["PID2021-122787OB-I00"],"award-info":[{"award-number":["PID2021-122787OB-I00"]}]},{"name":"University of Salamanca","award":["SAF2017-83061-R"],"award-info":[{"award-number":["SAF2017-83061-R"]}]},{"name":"University of Salamanca","award":["ESF\u2014European Social Fund"],"award-info":[{"award-number":["ESF\u2014European Social Fund"]}]},{"name":"University of Salamanca","award":["PRE2019-088887"],"award-info":[{"award-number":["PRE2019-088887"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Leukemia is the most usual childhood cancer, and B-cell acute lymphoblastic leukemia (B-ALL) is its most common presentation. It has been proposed that pediatric leukemogenesis occurs through a \u201cmulti-step\u201d or \u201cmulti-hit\u201d mechanism that includes both in utero and postnatal steps. Many childhood leukemia-initiating events, such as chromosomal translocations, originate in utero, and studies so far suggest that these \u201cfirst-hits\u201d occur at a far higher frequency than the incidence of childhood leukemia itself. The reason why only a small percentage of the children born with such preleukemic \u201chits\u201d will develop full-blown leukemia is still a mystery. In order to better understand childhood leukemia, mouse modeling is essential, but only if the multistage process of leukemia can be recapitulated in the model. Therefore, mouse models naturally reproducing the \u201cmulti-step\u201d process of childhood B-ALL will be essential to identify environmental or other factors that are directly linked to increased risk of disease.<\/jats:p>","DOI":"10.3390\/ijms23147562","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T11:37:08Z","timestamp":1657280228000},"page":"7562","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Childhood B-Cell Preleukemia Mouse Modeling"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8334-4981","authenticated-orcid":false,"given":"Marta","family":"Isidro-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Experimental Therapeutics and Translational Oncology Program, Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-USAL, Campus M. de Unamuno s\/n, 37007 Salamanca, Spain"},{"name":"Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Alem\u00e1n-Arteaga","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and Translational Oncology Program, Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-USAL, Campus M. de Unamuno s\/n, 37007 Salamanca, Spain"},{"name":"Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Casado-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and Translational Oncology Program, Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-USAL, Campus M. de Unamuno s\/n, 37007 Salamanca, Spain"},{"name":"Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n","family":"Ruiz-Corzo","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and Translational Oncology Program, Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, CSIC-USAL, Campus M. de Unamuno s\/n, 37007 Salamanca, Spain"},{"name":"Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Riesco","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"},{"name":"Department of Pediatrics, Hospital Universitario de Salamanca, Paseo de San Vicente, 58-182, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2680-3285","authenticated-orcid":false,"given":"Pablo","family":"Prieto-Matos","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain"},{"name":"Department of Pediatrics, Hospital Universitario de Salamanca, Paseo de San Vicente, 58-182, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-5489","authenticated-orcid":false,"given":"Jorge","family":"Mart\u00ednez-Cano","sequence":"additional","affiliation":[{"name":"Immune System Development and Function Unit, Centro de Biolog\u00eda Molecular Severo Ochoa (Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid), 28049 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"School of Law, University of Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-9204","authenticated-orcid":false,"given":"C\u00e9sar","family":"Cobaleda","sequence":"additional","affiliation":[{"name":"Immune System Development and Function Unit, Centro de Biolog\u00eda Molecular Severo Ochoa (Consejo Superior de Investigaciones Cient\u00edficas-Universidad Aut\u00f3noma de Madrid), 28049 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6989-9905","authenticated-orcid":false,"given":"Isidro","family":"S\u00e1nchez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Experimental Therapeutics and Translational Oncology Program, Instituto de Biolog\u00eda Molecular y Celular del 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