{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:04:09Z","timestamp":1790838249160,"version":"4.1.0"},"reference-count":134,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"South African Medical Research Council","award":["# 16\/67"],"award-info":[{"award-number":["# 16\/67"]}]},{"name":"Poliomyelitis Research Foundation","award":["# 16\/67"],"award-info":[{"award-number":["# 16\/67"]}]},{"name":"University of KwaZulu-Natal\u2019s College of Health Sciences","award":["# 16\/67"],"award-info":[{"award-number":["# 16\/67"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Once merely thought of as the protein responsible for the overall physical nature of the human immunodeficiency virus type 1 (HIV-1), the Gag polyprotein has since been elucidated to have several roles in viral replication and functionality. Over the years, extensive research into the polyproteins\u2019 structure has revealed that Gag can mediate its own trafficking to the plasma membrane, it can interact with several host factors and can even aid in viral genome packaging. Not surprisingly, Gag has also been associated with HIV-1 drug resistance and even treatment failure. Therefore, this review provides an extensive overview of the structural and functional roles of the HIV-1 Gag domains in virion integrity, functionality and infectivity.<\/jats:p>","DOI":"10.3390\/ijms23147569","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T11:37:08Z","timestamp":1657280228000},"page":"7569","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The HIV-1 Gag Protein Displays Extensive Functional and Structural Roles in Virus Replication and Infectivity"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5010-5076","authenticated-orcid":false,"given":"Veronna","family":"Marie","sequence":"first","affiliation":[{"name":"KwaZulu-Natal Research, Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban 4041, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Lucille","family":"Gordon","sequence":"additional","affiliation":[{"name":"KwaZulu-Natal Research, Innovation and Sequencing Platform, University of KwaZulu-Natal, Durban 4041, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lin, Y.-R., Chu, S.-M., Yu, F.-H., Huang, K.-J., and Wang, C.-T. 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