{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:46:08Z","timestamp":1791927968160,"version":"4.3.4"},"reference-count":70,"publisher":null,"issue":"14","license":[{"start":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T00:00:00Z","timestamp":1657411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The equipment of innovative laboratories doing research on new medicines used in the therapy of civilization and neoplastic diseases"},{"DOI":"10.13039\/501100005632","name":"National Centre for Research and Development","doi-asserted-by":"crossref","award":["STRATEGMED III (STRATEGMED3\/303570\/7\/NCBR\/2017)"],"award-info":[{"award-number":["STRATEGMED III (STRATEGMED3\/303570\/7\/NCBR\/2017)"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>SOX2 is a recognized pluripotent transcription factor involved in stem cell homeostasis, self-renewal and reprogramming. It belongs to, one of the SRY-related HMG-box (SOX) family of transcription factors, taking part in the regulation of embryonic development and determination of cell fate. Among other functions, SOX2 promotes proliferation, survival, invasion, metastasis, cancer stemness, and drug resistance. SOX2 interacts with other transcription factors in multiple signaling pathways to control growth and survival. The aim of the study was to determine the effect of a parturient\u2019s age, umbilical cord blood pH and length of pregnancy on the quality of stem cells derived from Wharton\u2019s jelly (WJSC) by looking at birth weight and using SOX2 gene expression as a marker. Using qPCR the authors, evaluated the expression of SOX2 in WJSC acquired from the umbilical cords of 30 women right after the delivery. The results showed a significant correlation between the birth weight and the expression of SOX2 in WJSC in relation to maternal age, umbilical cord blood pH, and the length of pregnancy. The authors observed that the younger the woman and the lower the umbilical cord blood pH, the earlier the delivery occurs, the lower the birth weight and the higher SOX2 gene expression in WJSC. In research studies and clinical applications of regenerative medicine utilizing mesenchymal stem cells derived from Wharton\u2019s Jelly of the umbilical cord, assessment of maternal and embryonic factors influencing the quality of cells is critical.<\/jats:p>","DOI":"10.3390\/ijms23147630","type":"journal-article","created":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T20:48:00Z","timestamp":1657486080000},"page":"7630","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of the Impact of Pregnancy-Associated Factors on the Quality of Wharton\u2019s Jelly-Derived Stem Cells Using SOX2 Gene Expression as a Marker"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3119-981X","authenticated-orcid":false,"given":"Paulina","family":"Gil-Kulik","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9366-3556","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"\u015awistowska","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1147-3359","authenticated-orcid":false,"given":"Arkadiusz","family":"Krzy\u017canowski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 11 Staszica Str., 20-081 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9926-0870","authenticated-orcid":false,"given":"Alicja","family":"Petniak","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2553-8635","authenticated-orcid":false,"given":"Anna","family":"Kwa\u015bniewska","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 11 Staszica Str., 20-081 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5579-5101","authenticated-orcid":false,"given":"Bartosz J.","family":"P\u0142achno","sequence":"additional","affiliation":[{"name":"Department of Plant Cytology and Embryology, Institute of Botany, Faculty of Biology, Jagiellonian University in Krak\u00f3w, 9 Gronostajowa St., 30-387 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Galkowski","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-7429","authenticated-orcid":false,"given":"Anna","family":"Bogucka-Kocka","sequence":"additional","affiliation":[{"name":"Chair and Department of Biology and Genetics, Medical University of Lublin, 4a Chod\u017aki St., 20\u2013093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9541-6353","authenticated-orcid":false,"given":"Janusz","family":"Kocki","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2022,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jcyt.2014.08.009","article-title":"Discarded Wharton jelly of the human umbilical cord: A viable source for mesenchymal stromal cells","volume":"17","author":"Watson","year":"2015","journal-title":"Cytotherapy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/sctm.16-0492","article-title":"Concise Review: Wharton\u2019s Jelly: The Rich, but Enigmatic, Source of Mesenchymal Stromal Cells","volume":"6","author":"Davies","year":"2017","journal-title":"Stem Cells Transl. 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