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We used in silico approaches to identify a specific antigenic peptide (p_ROCV2) in the NS1 protein of the Rocio virus that was theoretically predicted to be stable and exposed on its surface, where it demonstrated key properties allowing it to interact with antibodies. These findings related to the molecular dynamics of this peptide provide important insights for advancing diagnostic platforms and investigating therapeutic alternatives.<\/jats:p>","DOI":"10.3390\/ijms23147681","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T20:52:41Z","timestamp":1657659161000},"page":"7681","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Predicting Antigenic Peptides from Rocio Virus NS1 Protein for Immunodiagnostic Testing Using Immunoinformatics and Molecular Dynamics Simulation"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7627-621X","authenticated-orcid":false,"given":"Marielena Vogel","family":"Saivish","sequence":"first","affiliation":[{"name":"Departamento de Doen\u00e7as Dermatol\u00f3gicas, Infecciosas e Parasit\u00e1rias, Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP), S\u00e3o Jos\u00e9 do Rio Preto 15090-000, SP, Brazil"},{"name":"Laborat\u00f3rio Nacional de Bioci\u00eancias, Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas 13083-100, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8944-8148","authenticated-orcid":false,"given":"Gabriela de Lima","family":"Menezes","sequence":"additional","affiliation":[{"name":"N\u00facleo Colaborativo de Biosistemas, Universidade Federal de Jata\u00ed, Jata\u00ed 75801-615, GO, Brazil"},{"name":"Bioinformatics Multidisciplinary Environment, Programa de P\u00f3s Gradua\u00e7\u00e3o em Bioinform\u00e1tica, Universidade Federal do Rio Grande do Norte, Natal 59078-400, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9359-0198","authenticated-orcid":false,"given":"Vivaldo Gomes da","family":"Costa","sequence":"additional","affiliation":[{"name":"Instituto de Bioci\u00eancias, Letras e Ci\u00eancias Exatas, Universidade Estadual Paulista (UNESP), S\u00e3o Jos\u00e9 do Rio Preto 15054-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gislaine Celestino Dutra da","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Doen\u00e7as Dermatol\u00f3gicas, Infecciosas e Parasit\u00e1rias, Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP), S\u00e3o Jos\u00e9 do Rio Preto 15090-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6949-0947","authenticated-orcid":false,"given":"Rafael Elias","family":"Marques","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Nacional de Bioci\u00eancias, Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas 13083-100, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-2419","authenticated-orcid":false,"given":"Maur\u00edcio Lacerda","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Departamento de Doen\u00e7as Dermatol\u00f3gicas, Infecciosas e Parasit\u00e1rias, Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto (FAMERP), S\u00e3o Jos\u00e9 do Rio Preto 15090-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5624-4790","authenticated-orcid":false,"given":"Roosevelt Alves Da","family":"Silva","sequence":"additional","affiliation":[{"name":"N\u00facleo Colaborativo de Biosistemas, Universidade Federal de Jata\u00ed, Jata\u00ed 75801-615, GO, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"key":"ref_1","first-page":"415","article-title":"Encefalite Humana Prim\u00e1ria Epid\u00eamica Por Arbov\u00edrus Observada No Litoral Sul Do Estado de S\u00e3o Paulo","volume":"22","author":"Tiriba","year":"1976","journal-title":"Rev. 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