{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:30:17Z","timestamp":1769729417796,"version":"3.49.0"},"reference-count":21,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF)","award":["2020R1G1A1004280"],"award-info":[{"award-number":["2020R1G1A1004280"]}]},{"name":"Korean government (Ministry of Science, ICT, &amp; Future Planning)","award":["2020R1G1A1004280"],"award-info":[{"award-number":["2020R1G1A1004280"]}]},{"name":"Catholic University of Korea","award":["2020R1G1A1004280"],"award-info":[{"award-number":["2020R1G1A1004280"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Background: Atrophy of the vocal folds and the accompanying glottic insufficiency affect the quality of life. Although growth factors have been used to treat muscle atrophy, their effectiveness is limited by their short half-life. Methods: In total, 15 rabbits and 24 rats were used for the study. The right recurrent laryngeal nerves of all animals were transected. One month following nerve transection, PBS (PBS group), rHGF (HGF group), or a c-Met agonistic antibody (c-Met group) was injected into the paralyzed vocal folds. The larynges of the rabbits were harvested from each group for histologic examination and subjected to PCR analysis. Results: Cross-sectional areas (CSAs) of thyroarytenoid muscles were evaluated. The c-Met group had increased CSAs compared to the PBS and HGF groups, but there were no significant differences compared to normal controls. The expression levels of myogenesis-related genes were evaluated three weeks after the injection. The expression levels of myosin heavy chain IIa were significantly increased in the PBS group, while the expression levels of MyoD were increased in the c-Met group. Conclusions: The c-Met agonistic antibody showed promise for promoting muscle regeneration in a vocal fold palsy model.<\/jats:p>","DOI":"10.3390\/ijms23147818","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T22:57:06Z","timestamp":1658098626000},"page":"7818","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Regenerative Effects of c-Met Agonistic Antibodies in Vocal Fold Atrophy"],"prefix":"10.3390","volume":"23","author":[{"given":"Hyunsu","family":"Choi","sequence":"first","affiliation":[{"name":"Clinical Research Institute, Daejeon St. Mary\u2019s Hospital, Daejeon 34943, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Shin","family":"Yu","sequence":"additional","affiliation":[{"name":"R&D Center for Innovative Medicines, Helixmith Co., Ltd., Seoul 07794, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiwon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9551-9571","authenticated-orcid":false,"given":"Choung-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"key":"ref_1","unstructured":"Onwordi, L.N., and Al Yaghchi, C. 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