{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T10:05:06Z","timestamp":1766829906959,"version":"build-2065373602"},"reference-count":55,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Centre Poland (NCN)","award":["2020\/04\/X\/ST4\/00446","POPW.01.03.00-20-004\/11"],"award-info":[{"award-number":["2020\/04\/X\/ST4\/00446","POPW.01.03.00-20-004\/11"]}]},{"name":"University of Lodz, Poland, Faculty of Chemistry and by EFRD in Operational Programme Development of Eastern Poland","award":["2020\/04\/X\/ST4\/00446","POPW.01.03.00-20-004\/11"],"award-info":[{"award-number":["2020\/04\/X\/ST4\/00446","POPW.01.03.00-20-004\/11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The quest to find new inhibitors of biologically relevant targets is considered an important strategy to introduce new drug candidates for the treatment of neurodegenerative diseases. A series of (aminomethyl)benzylphosphonates 8a\u2013c and their metallocarbonyl iron 9a\u2013c and ruthenium 10a\u2013c complexes were designed, synthesized, and evaluated for their inhibitory potentials against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) by determination of IC50. Metallocarbonyl derivatives, in general, did not show significant inhibition activity against these enzymes, the most potent inhibitor was the (aminomethyl)benzylphosphonate 8a (IC50 = 1.215 \u00b5M against AChE). Molecular docking analysis of AChE and (aminomethyl)benzylphosphonates 8a\u2013c showed the strongest interactions of 8a and AChE compared to isomers 8b and 8c. Cytotoxicity studies of synthesized compounds towards the V79 cell line were also performed and discussed.<\/jats:p>","DOI":"10.3390\/ijms23158091","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T12:53:45Z","timestamp":1658494425000},"page":"8091","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis and Biological Studies of Novel Aminophosphonates and Their Metal Carbonyl Complexes (Fe, Ru)"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3999-6514","authenticated-orcid":false,"given":"Aneta","family":"Kosi\u0144ska","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, Poland"},{"name":"ICGM, Univ. Montpellier, CNRS, ENSCM, 34090 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Virieux","sequence":"additional","affiliation":[{"name":"ICGM, Univ. Montpellier, CNRS, ENSCM, 34090 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Luc","family":"Pirat","sequence":"additional","affiliation":[{"name":"ICGM, Univ. Montpellier, CNRS, ENSCM, 34090 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamila","family":"Czarnecka","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Girek","sequence":"additional","affiliation":[{"name":"Animal House, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3438-7509","authenticated-orcid":false,"given":"Pawe\u0142","family":"Szyma\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland"},{"name":"Department of Radiobiology and Radiation Protection, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u0142awomir","family":"Wojtulewski","sequence":"additional","affiliation":[{"name":"Department of Structural Chemistry, Faculty of Chemistry, University of Bialystok, Cio\u0142kowskiego 1K, 15-245 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6024-1381","authenticated-orcid":false,"given":"Saranya","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9924-0503","authenticated-orcid":false,"given":"Arkadiusz","family":"Chworos","sequence":"additional","affiliation":[{"name":"Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0319-0535","authenticated-orcid":false,"given":"Bogna","family":"Rudolf","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cbi.2009.12.018","article-title":"Kinetics and mechanism of inhibition of serine esterases by fluorinated aminophosphonates","volume":"187","author":"Makhaeva","year":"2010","journal-title":"Chem. 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