{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:49:22Z","timestamp":1790192962309,"version":"4.1.0"},"reference-count":108,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Paulo Foundation, Glaukoomatukis\u00e4\u00e4ti\u00f6 Lux, Elsemay Bj\u00f6rn Fund"},{"name":"Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Tear fluid forms the outermost layer of the ocular surface and its characteristics and composition have been connected to various ocular surface diseases. As tear proteomics enables the non-invasive investigation of protein levels in the tear fluid, it has become an increasingly popular approach in ocular surface and systemic disease studies. Glaucoma, which is a set of multifactorial diseases affecting mainly the optic nerve and retinal ganglion cells, has also been studied using tear proteomics. In this condition, the complete set of pathophysiological changes occurring in the eye is not yet fully understood, and biomarkers for early diagnosis and accurate treatment selection are needed. More in-depth analyses of glaucoma tear proteomics have started to emerge only more recently with the implementation of LC-MS\/MS and other modern technologies. The aim of this review was to examine the published data of the tear protein changes occurring during glaucoma, its topical treatment, and surgical interventions.<\/jats:p>","DOI":"10.3390\/ijms23158136","type":"journal-article","created":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T22:49:02Z","timestamp":1658702942000},"page":"8136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Clinical Tear Fluid Proteomics\u2014A Novel Tool in Glaucoma Research"],"prefix":"10.3390","volume":"23","author":[{"given":"Janika","family":"N\u00e4ttinen","sequence":"first","affiliation":[{"name":"Eye and Vision Research, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland"},{"name":"Tays Eye Centre, Tampere University Hospital, 33520 Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7691-3170","authenticated-orcid":false,"given":"Ulla","family":"Aapola","sequence":"additional","affiliation":[{"name":"Eye and Vision Research, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland"},{"name":"Tays Eye Centre, Tampere University Hospital, 33520 Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveena","family":"Nukareddy","sequence":"additional","affiliation":[{"name":"Eye and Vision Research, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Uusitalo","sequence":"additional","affiliation":[{"name":"Eye and Vision Research, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland"},{"name":"Tays Eye Centre, Tampere University Hospital, 33520 Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3892\/ijmm.2021.4916","article-title":"Critical Role of Mass Spectrometry Proteomics in Tear Biomarker Discovery for Multifactorial Ocular Diseases (Review)","volume":"47","author":"Ma","year":"2021","journal-title":"Int. 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