{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:32:54Z","timestamp":1790839974590,"version":"4.1.0"},"reference-count":148,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870044"],"award-info":[{"award-number":["81870044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31171129"],"award-info":[{"award-number":["31171129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>As the global aging process continues to lengthen, aging-related diseases (e.g., chronic obstructive pulmonary disease (COPD), heart failure) continue to plague the elderly population. Aging is a complex biological process involving multiple tissues and organs and is involved in the development and progression of multiple aging-related diseases. At the same time, some of these aging-related diseases are often accompanied by hypoxia, chronic inflammation, oxidative stress, and the increased secretion of the senescence-associated secretory phenotype (SASP). Hypoxia seems to play an important role in the process of inflammation and aging, but is often neglected in advanced clinical research studies. Therefore, we have attempted to elucidate the role played by different degrees and types of hypoxia in aging and aging-related diseases and their possible pathways, and propose rational treatment options based on such mechanisms for reference.<\/jats:p>","DOI":"10.3390\/ijms23158165","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T21:20:59Z","timestamp":1658784059000},"page":"8165","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Hypoxia in Aging and Aging-Related Diseases: Mechanism and Therapeutic Strategies"],"prefix":"10.3390","volume":"23","author":[{"given":"Yaqin","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Geriatrics, Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Giunta","sequence":"additional","affiliation":[{"name":"Casa di Cura Prof. Nobili\u2013GHC Garofalo Health Care, 40035 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijin","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai 200000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/20459","article-title":"The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis","volume":"399","author":"Maxwell","year":"1999","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/resp.13722","article-title":"Hypoxia-inducible factor and bacterial infections in chronic obstructive pulmonary disease","volume":"25","author":"Shukla","year":"2020","journal-title":"Respirology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e63003","DOI":"10.7554\/eLife.63003","article-title":"Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary disease","volume":"10","author":"Wu","year":"2021","journal-title":"eLife"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2002258","DOI":"10.1183\/13993003.02258-2020","article-title":"Sleep-related breathing disorders and pulmonary hypertension","volume":"57","author":"Adir","year":"2021","journal-title":"Eur. Respir. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1159\/000515602","article-title":"Sleep-Disordered Breathing and Nocturnal Hypoxemia in Precapillary Pulmonary Hypertension: Prevalence, Pathophysiological Determinants, and Clinical Consequences","volume":"100","author":"Spiesshoefer","year":"2021","journal-title":"Respiration"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Adler, D., Bailly, S., Benmerad, M., Joyeux-Faure, M., Jullian-Desayes, I., Soccal, P.M., Janssens, J.P., Sap\u00e8ne, M., Grillet, Y., and Stach, B. (2020). Clinical presentation and comorbidities of obstructive sleep apnea-COPD overlap syndrome. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0235331"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.chest.2016.09.001","article-title":"Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine","volume":"151","author":"Wu","year":"2017","journal-title":"Chest"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1161\/CIRCRESAHA.118.312563","article-title":"Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease","volume":"123","author":"Donato","year":"2018","journal-title":"Circ. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.arr.2016.09.006","article-title":"Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: An aging effect","volume":"34","author":"Cai","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.jacc.2017.01.064","article-title":"The Aging Cardiovascular System: Understanding It at the Cellular and Clinical Levels","volume":"69","author":"Paneni","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","first-page":"937","article-title":"Systematic Review of Pulmonary Function and Cognition in Aging","volume":"75","author":"Duggan","year":"2020","journal-title":"J. Gerontol. Ser. B Psychol. Sci. Soc. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Gupta, R., Ruppel, G.L., and Espiritu, J.R.D. (2020). Exercise-Induced Oxygen Desaturation during the 6-Minute Walk Test. Med. Sci., 8.","DOI":"10.3390\/medsci8010008"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1183\/13993003.00975-2015","article-title":"Oxygen desaturation in 6-min walk test is a risk factor for adverse outcomes in COPD","volume":"48","author":"Waatevik","year":"2016","journal-title":"Eur. Respir. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1590\/S1806-37132014000300004","article-title":"Oxygen desaturation during the six-minute walk test in COPD patients","volume":"40","author":"Moreira","year":"2014","journal-title":"J. Bras. Pneumol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"106393","DOI":"10.1016\/j.rmed.2021.106393","article-title":"Predicting long-term mortality with two different criteria of exercise-induced desaturation in COPD","volume":"182","author":"Kim","year":"2021","journal-title":"Respir. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"106542","DOI":"10.1016\/j.rmed.2021.106542","article-title":"CT-defined emphysema in COPD patients and risk for change in desaturation status in 6-min walk test","volume":"187","author":"Waatevik","year":"2021","journal-title":"Respir. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"111423","DOI":"10.1016\/j.exger.2021.111423","article-title":"Do inflammaging and coagul-aging play a role as conditions contributing to the co-occurrence of the severe hyper-inflammatory state and deadly coagulopathy during COVID-19 in older people?","volume":"151","author":"Xu","year":"2021","journal-title":"Exp. Gerontol."},{"key":"ref_19","unstructured":"Giunta, S., Wei, Y., Xu, K., and Xia, S. Cold-inflammaging: When a state of homeostatic-imbalance associated with aging precedes the low-grade pro-inflammatory-state (inflammaging): Meaning, evolution, inflammaging phenotypes, Clin. Exp. Pharmacol. Physiol., in press."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/geronj\/11.3.298","article-title":"Aging: A theory based on free radical and radiation chemistry","volume":"11","author":"Harman","year":"1956","journal-title":"J. Gerontol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1532-5415.1972.tb00787.x","article-title":"The biologic clock: The mitochondria?","volume":"20","author":"Harman","year":"1972","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00709-013-0515-x","article-title":"Do we age because we have mitochondria?","volume":"251","year":"2014","journal-title":"Protoplasma"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1172\/JCI120842","article-title":"The role of mitochondria in aging","volume":"128","author":"Jang","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pneurobio.2016.06.006","article-title":"Mitochondrial function in hypoxic ischemic injury and influence of aging","volume":"157","author":"Ham","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.freeradbiomed.2018.06.016","article-title":"Adaptive homeostasis and the free radical theory of ageing","volume":"124","author":"Pomatto","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"L103","DOI":"10.1152\/ajplung.00320.2015","article-title":"Rejuvenating cellular respiration for optimizing respiratory function: Targeting mitochondria","volume":"310","author":"Agrawal","year":"2016","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12931-020-1292-7","article-title":"Oxidative stress and Nrf2 expression in peripheral blood mononuclear cells derived from COPD patients: An observational longitudinal study","volume":"21","author":"Stranieri","year":"2020","journal-title":"Respir. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1080\/15548627.2021.1911016","article-title":"Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells","volume":"17","author":"Qin","year":"2021","journal-title":"Autophagy"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.1416","article-title":"The role of iron and reactive oxygen species in cell death","volume":"10","author":"Dixon","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Magall\u00f3n, M., Navarro-Garc\u00eda, M.M., and Das\u00ed, F. (2019). Oxidative Stress in COPD. J. Clin. Med., 8.","DOI":"10.3390\/jcm8111953"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1073\/pnas.90.6.2423","article-title":"Inducible operation of the erythropoietin 3\u2032 enhancer in multiple cell lines: Evidence for a widespread oxygen-sensing mechanism","volume":"90","author":"Maxwell","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1073\/pnas.91.14.6496","article-title":"Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3\u2032 enhancer","volume":"91","author":"Firth","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/cvr\/cvx076","article-title":"Role of phosphatase and tensin homolog in hypoxic pulmonary vasoconstriction","volume":"113","author":"Krauszman","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/s41590-022-01216-z","article-title":"Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation","volume":"23","author":"Mirchandani","year":"2022","journal-title":"Nat. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"101000","DOI":"10.1016\/j.mam.2021.101000","article-title":"Interplay between hypoxia and inflammation contributes to the progression and severity of respiratory viral diseases","volume":"81","author":"Bhattacharya","year":"2021","journal-title":"Mol. Asp. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"719009","DOI":"10.3389\/fimmu.2021.719009","article-title":"Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis","volume":"12","author":"Jeny","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s11658-021-00283-8","article-title":"HIF-1\u03b1\/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury","volume":"26","author":"Zhao","year":"2021","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1038\/s41467-020-17873-3","article-title":"HIF-1\u03b1 and HIF-2\u03b1 differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice","volume":"11","author":"Hoefflin","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5591582","DOI":"10.1155\/2021\/5591582","article-title":"EZH2 Mediates miR-146a-5p\/HIF-1\u03b1 to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury","volume":"2021","author":"Ni","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"Kishton","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1002\/hep.29681","article-title":"Hypoxia-inducible factor-1\u03b1\/interleukin-1\u03b2 signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment","volume":"67","author":"Zhang","year":"2018","journal-title":"Hepatology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"630318","DOI":"10.3389\/fimmu.2021.630318","article-title":"Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1\u03b1 and AMPK in Macrophages","volume":"12","author":"Chin","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1002\/jcp.24666","article-title":"Short-term hypoxia enhances the migratory capability of dendritic cell through HIF-1\u03b1 and PI3K\/Akt pathway","volume":"229","author":"Filippi","year":"2014","journal-title":"J. Cell. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"7554","DOI":"10.1002\/jcp.29659","article-title":"Glucose regulates hypoxia-induced NLRP3 inflammasome activation in macrophages","volume":"235","author":"Watanabe","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ha, J.S., Choi, H.R., Kim, I.S., Kim, E.A., Cho, S.W., and Yang, S.J. (2021). Hypoxia-Induced S100A8 Expression Activates Microglial Inflammation and Promotes Neuronal Apoptosis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031205"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/s41598-020-57677-5","article-title":"Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK\/p65 signaling pathway","volume":"10","author":"Delprat","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in healthy aging and disease","volume":"1","author":"Aman","year":"2021","journal-title":"Nat. Aging"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41586-022-04786-y","article-title":"Clonal dynamics of haematopoiesis across the human lifespan","volume":"606","author":"Mitchell","year":"2022","journal-title":"Nature"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1101\/gad.235184.113","article-title":"Cellular senescence and its effector programs","volume":"28","author":"Salama","year":"2014","journal-title":"Genes Dev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10522-018-9762-8","article-title":"Myeloid-derived suppressor cells (MDSC): An important partner in cellular\/tissue senescence","volume":"19","author":"Salminen","year":"2018","journal-title":"Biogerontology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1101\/gad.290635.116","article-title":"The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration","volume":"31","author":"Ritschka","year":"2017","journal-title":"Genes Dev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"362ra144","DOI":"10.1126\/scitranslmed.aaf9440","article-title":"Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy","volume":"8","author":"Oubaha","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1152\/physrev.00020.2018","article-title":"Cellular Senescence: Aging, Cancer, and Injury","volume":"99","author":"Calcinotto","year":"2019","journal-title":"Physiol. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.stem.2016.11.020","article-title":"Injury-Induced Senescence Enables In Vivo Reprogramming in Skeletal Muscle","volume":"20","author":"Chiche","year":"2017","journal-title":"Cell Stem Cell"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"108779","DOI":"10.1016\/j.celrep.2021.108779","article-title":"Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination","volume":"34","author":"Yasuda","year":"2021","journal-title":"Cell Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.molmed.2010.03.003","article-title":"Inflammatory networks during cellular senescence: Causes and consequences","volume":"16","author":"Freund","year":"2010","journal-title":"Trends Mol. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/ncb3195","article-title":"MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation","volume":"17","author":"Laberge","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/emboj.2011.69","article-title":"p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype","volume":"30","author":"Freund","year":"2011","journal-title":"EMBO J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.bbamcr.2010.08.006","article-title":"Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning","volume":"1813","author":"Semenza","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e21407","DOI":"10.7554\/eLife.21407","article-title":"Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I\/R heart injury","volume":"5","author":"Zhang","year":"2016","journal-title":"eLife"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"101671","DOI":"10.1016\/j.redox.2020.101671","article-title":"HIF-1alpha-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia\/reperfusion injury","volume":"36","author":"Fu","year":"2020","journal-title":"Redox Biol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"8668","DOI":"10.1002\/jcp.27527","article-title":"PINK1\/Parkin-mediated mitophagy promotes apelin-13-induced vascular smooth muscle cell proliferation by AMPKalpha and exacerbates atherosclerotic lesions","volume":"234","author":"He","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1172\/JCI126655","article-title":"Roles of HIFs and VEGF in angiogenesis in the retina and brain","volume":"129","author":"Rattner","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e12473","DOI":"10.1111\/jpi.12473","article-title":"Melatonin attenuated retinal neovascularization and neuroglial dysfunction by inhibition of HIF-1\u03b1-VEGF pathway in oxygen-induced retinopathy mice","volume":"64","author":"Xu","year":"2018","journal-title":"J. Pineal Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"101109","DOI":"10.1016\/j.redox.2019.101109","article-title":"HIF-1\u03b1 protects against oxidative stress by directly targeting mitochondria","volume":"25","author":"Li","year":"2019","journal-title":"Redox Biol."},{"key":"ref_67","first-page":"L256","article-title":"Endothelial HIF-2\u03b1 contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition","volume":"314","author":"Tang","year":"2018","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e011628","DOI":"10.1161\/JAHA.118.011628","article-title":"Influence of 2-Methoxyestradiol and Sex on Hypoxia-Induced Pulmonary Hypertension and Hypoxia-Inducible Factor-1-\u03b1","volume":"8","author":"Docherty","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.molcel.2010.05.023","article-title":"Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha","volume":"38","author":"Lim","year":"2010","journal-title":"Mol. Cell"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.bbrc.2015.04.119","article-title":"SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) via direct interactions during hypoxia","volume":"462","author":"Joo","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Laemmle, A., Lechleiter, A., Roh, V., Schwarz, C., Portmann, S., Furer, C., Keogh, A., Tschan, M.P., Candinas, D., and Vorburger, S.A. (2012). Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1\u03b1 protein under hypoxic conditions. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033433"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.cmet.2020.11.019","article-title":"Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis","volume":"33","author":"Chen","year":"2021","journal-title":"Cell Metab."},{"key":"ref_73","first-page":"1","article-title":"Hypoxia and aging","volume":"51","author":"Yeo","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.2147\/COPD.S177034","article-title":"Correlation of serum levels of HIF-1\u03b1 and IL-19 with the disease progression of COPD: A retrospective study","volume":"13","author":"Rong","year":"2018","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"ref_75","first-page":"6077","article-title":"HIF-1\u03b1 promotes inflammatory response of chronic obstructive pulmonary disease by activating EGFR\/PI3K\/AKT pathway","volume":"22","author":"Zhang","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"7695","DOI":"10.1002\/jcp.27767","article-title":"Roles of Nrf2\/HO-1 and HIF-1\u03b1\/VEGF in lung tissue injury and repair following cerebral ischemia\/reperfusion injury","volume":"234","author":"Fan","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/resp.12709","article-title":"Platelet-activating factor receptor (PAFr) is upregulated in small airways and alveoli of smokers and COPD patients","volume":"21","author":"Shukla","year":"2016","journal-title":"Respirology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0090-6980(02)00058-8","article-title":"Platelet-activating factor receptor","volume":"68\u201369","author":"Ishii","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.2147\/COPD.S151142","article-title":"Upregulated pneumococcal adhesion molecule (platelet-activating factor receptor) may predispose COPD patients to community-acquired pneumonia","volume":"12","author":"Shukla","year":"2017","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1378\/chest.09-2764","article-title":"The effects of hypoxia on markers of coagulation and systemic inflammation in patients with COPD","volume":"138","author":"Sabit","year":"2010","journal-title":"Chest"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.pulmoe.2018.04.007","article-title":"Clinical characteristics of COPD patients with early-onset desaturation in the 6-minute walk test","volume":"24","author":"Gurbani","year":"2018","journal-title":"Pulmonology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"661","DOI":"10.7150\/ijbs.65861","article-title":"Regulation of lung epithelial cell senescence in smoking-induced COPD\/emphysema by microR-125a-5p via Sp1 mediation of SIRT1\/HIF-1a","volume":"18","author":"Wu","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S2213-2600(15)00543-3","article-title":"A global view of pulmonary hypertension","volume":"4","author":"Hoeper","year":"2016","journal-title":"Lancet Respir. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"200321","DOI":"10.1183\/16000617.0321-2020","article-title":"Effect of pulmonary hypertension on exercise tolerance in patients with COPD: A prognostic systematic review and meta-analysis","volume":"30","author":"Orizaga","year":"2021","journal-title":"Eur. Respir. Rev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"R800","DOI":"10.1152\/ajpregu.00282.2020","article-title":"Pulmonary hypertension is attenuated and ventilation-perfusion matching is maintained during chronic hypoxia in deer mice native to high altitude","volume":"320","author":"West","year":"2021","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1902474","DOI":"10.1183\/13993003.02474-2019","article-title":"Cardiac function and pulmonary hypertension in Central Asian highlanders at 3250 m","volume":"56","author":"Lichtblau","year":"2020","journal-title":"Eur. Respir. J."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"3668422","DOI":"10.1155\/2021\/3668422","article-title":"MicroRNA-146-5p Promotes Pulmonary Artery Endothelial Cell Proliferation under Hypoxic Conditions through Regulating USP3","volume":"2021","author":"Zhang","year":"2021","journal-title":"Dis. Markers"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12931-022-01927-9","article-title":"Notch4 mediates vascular remodeling via ERK\/JNK\/P38 MAPK signaling pathways in hypoxic pulmonary hypertension","volume":"23","author":"Guo","year":"2022","journal-title":"Respir. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/j.biopha.2018.11.058","article-title":"MicroRNA-150 relieves vascular remodeling and fibrosis in hypoxia-induced pulmonary hypertension","volume":"109","author":"Li","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e21212","DOI":"10.1096\/fj.202000533RR","article-title":"Intermittent short-duration reoxygenation protects against simulated high altitude-induced pulmonary hypertension in rats","volume":"35","author":"Lyu","year":"2021","journal-title":"FASEB J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"690341","DOI":"10.3389\/fphys.2021.690341","article-title":"Oxidative Stress, Kinase Activation, and Inflammatory Pathways Involved in Effects on Smooth Muscle Cells During Pulmonary Artery Hypertension Under Hypobaric Hypoxia Exposure","volume":"12","author":"Siques","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1601530","DOI":"10.1183\/13993003.01530-2016","article-title":"Association between sleep apnoea and pulmonary hypertension in Kyrgyz highlanders","volume":"49","author":"Latshang","year":"2017","journal-title":"Eur. Respir. J."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"R785","DOI":"10.1152\/ajpregu.00363.2011","article-title":"Chronic intermittent hypoxia alters glutamatergic control of sympathetic and respiratory activities in the commissural NTS of rats","volume":"302","author":"Zoccal","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.smrv.2014.06.003","article-title":"Does obstructive sleep apnea cause endothelial dysfunction? A critical review of the literature","volume":"20","author":"Hoyos","year":"2015","journal-title":"Sleep Med. Rev."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1074\/jbc.M115.686709","article-title":"Hypoxia Potentiates Palmitate-induced Pro-inflammatory Activation of Primary Human Macrophages","volume":"291","author":"Snodgrass","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1161\/HYPERTENSIONAHA.115.05886","article-title":"Endothelial Hypoxia-Inducible Factor-1\u03b1 Promotes Atherosclerosis and Monocyte Recruitment by Upregulating MicroRNA-19a","volume":"66","author":"Akhtar","year":"2015","journal-title":"Hypertension"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1161\/CIRCRESAHA.120.317348","article-title":"Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway","volume":"128","author":"Chen","year":"2021","journal-title":"Circ. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1161\/CIRCULATIONAHA.121.054204","article-title":"Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging","volume":"144","author":"Czibik","year":"2021","journal-title":"Circulation"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.jacc.2019.06.053","article-title":"Cardiovascular Aging and Heart Failure: JACC Review Topic of the Week","volume":"74","author":"Triposkiadis","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/gerona\/glu127","article-title":"Aging and the burden of multimorbidity: Associations with inflammatory and anabolic hormonal biomarkers","volume":"70","author":"Fabbri","year":"2015","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/ncb0808-887","article-title":"Cytokine loops driving senescence","volume":"10","author":"Bartek","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1080\/10715760802244768","article-title":"Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: A culture study","volume":"42","author":"Sasaki","year":"2008","journal-title":"Free Radic. Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1093\/eurheartj\/ehz961","article-title":"Inflamm-ageing: The role of inflammation in age-dependent cardiovascular disease","volume":"41","author":"Liberale","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1056\/NEJMra065985","article-title":"Time to treatment in primary percutaneous coronary intervention","volume":"357","author":"Nallamothu","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_106","first-page":"15","article-title":"Targeting the Hypoxia-Adenosine Link for Controlling Excessive Inflammation","volume":"135","author":"Czopik","year":"2021","journal-title":"Anesthesiology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2500\/ajra.2015.29.4155","article-title":"Superoxide dismutase reduces the inflammatory response to Aspergillus and Alternaria in human sinonasal epithelial cells derived from patients with chronic rhinosinusitis","volume":"29","author":"Lawrence","year":"2015","journal-title":"Am. J. Rhinol. Allergy"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1083\/jcb.201708007","article-title":"Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling","volume":"217","author":"Wang","year":"2018","journal-title":"J. Cell Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1016\/j.bbagen.2012.11.020","article-title":"Glutathione peroxidases","volume":"1830","author":"Maiorino","year":"2013","journal-title":"Biochim. Biophys. Acta (BBA)-Gen. Subj."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2006.09.024","article-title":"Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators","volume":"127","author":"Drori","year":"2006","journal-title":"Cell"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41598-019-57147-7","article-title":"Extracellular Superoxide Dismutase Regulates Early Vascular Hyaluronan Remodeling in Hypoxic Pulmonary Hypertension","volume":"10","author":"Tseng","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3389\/fmed.2020.00509","article-title":"Alteration of Extracellular Superoxide Dismutase in Idiopathic Pulmonary Arterial Hypertension","volume":"7","author":"Zhang","year":"2020","journal-title":"Front. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1007\/s00394-020-02338-6","article-title":"Antistress and anti-aging activities of Caenorhabditis elegans were enhanced by Momordica saponin extract","volume":"60","author":"Lin","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.cell.2020.04.049","article-title":"Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut","volume":"181","author":"Vaccaro","year":"2020","journal-title":"Cell"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD(+) metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.abe9985","article-title":"Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women","volume":"372","author":"Yoshino","year":"2021","journal-title":"Science"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cmet.2016.09.013","article-title":"Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice","volume":"24","author":"Mills","year":"2016","journal-title":"Cell Metab."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12970-021-00442-4","article-title":"Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: A randomized, double-blind study","volume":"18","author":"Liao","year":"2021","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41573-020-0067-7","article-title":"The quest to slow ageing through drug discovery","volume":"19","author":"Partridge","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cmet.2020.05.020","article-title":"Niacin Cures Systemic NAD(+) Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy","volume":"32","author":"Pirinen","year":"2020","journal-title":"Cell Metab."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1517\/14740338.3.2.101","article-title":"The effect of fibrates and other lipid-lowering drugs on plasma homocysteine levels","volume":"3","author":"Dierkes","year":"2004","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ahj.2013.12.025","article-title":"Cardiovascular drugs that increase the risk of new-onset diabetes","volume":"167","author":"Ong","year":"2014","journal-title":"Am. Heart J."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.cmet.2018.03.018","article-title":"Quantitative Analysis of NAD Synthesis-Breakdown Fluxes","volume":"27","author":"Liu","year":"2018","journal-title":"Cell Metab."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1111\/bph.13403","article-title":"Crosstalk of mitochondria with NADPH oxidase via reactive oxygen and nitrogen species signalling and its role for vascular function","volume":"174","author":"Daiber","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"17017","DOI":"10.3390\/ijms140817017","article-title":"Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis","volume":"14","author":"Kinkade","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1007\/s10753-019-01084-0","article-title":"Inhibition of NADPH Oxidase-Derived Reactive Oxygen Species Decreases Expression of Inflammatory Cytokines in A549 Cells","volume":"42","author":"Wieczfinska","year":"2019","journal-title":"Inflammation"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1007\/s00125-013-2858-4","article-title":"NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents","volume":"56","author":"Koulajian","year":"2013","journal-title":"Diabetologia"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.bbi.2019.12.006","article-title":"NADPH oxidase 2 as a potential therapeutic target for protection against cognitive deficits following systemic inflammation in mice","volume":"84","author":"Huang","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"101638","DOI":"10.1016\/j.redox.2020.101638","article-title":"Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII\/ERK1\/2\/MLCK and endothelial cell barrier dysfunction","volume":"36","author":"Jiang","year":"2020","journal-title":"Redox Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1146\/annurev.bi.52.070183.003431","article-title":"Glutathione","volume":"52","author":"Meister","year":"1983","journal-title":"Annu. Rev. Biochem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1586\/17476348.2016.1121105","article-title":"Oxidation pathway and exacerbations in COPD: The role of NAC","volume":"10","author":"Matera","year":"2016","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1183\/16000617.00002215","article-title":"Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: A meta-analysis","volume":"24","author":"Cazzola","year":"2015","journal-title":"Eur. Respir. Rev."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1038\/s41467-021-24634-3","article-title":"Dietary thiols accelerate aging of C. elegans","volume":"12","author":"Gusarov","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1126\/science.abb5916","article-title":"Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders","volume":"371","author":"Johmura","year":"2021","journal-title":"Science"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.freeradbiomed.2020.11.026","article-title":"Methionine transsulfuration pathway is upregulated in long-lived humans","volume":"162","author":"Obis","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"650250","DOI":"10.3389\/fcell.2021.650250","article-title":"Inhibition of JAK-STAT Signaling Pathway Alleviates Age-Related Phenotypes in Tendon Stem\/Progenitor Cells","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"E6301","DOI":"10.1073\/pnas.1515386112","article-title":"JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age","volume":"112","author":"Xu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1530\/JOE-19-0518","article-title":"JAK2\/STAT3 regulates estrogen-related senescence of bone marrow stem cells","volume":"245","author":"Wu","year":"2020","journal-title":"J. Endocrinol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13045-017-0417-z","article-title":"Long-term treatment with ruxolitinib for patients with myelofibrosis: 5-year update from the randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial","volume":"10","author":"Verstovsek","year":"2017","journal-title":"J. Hematol. Oncol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1056\/NEJMoa1409002","article-title":"Ruxolitinib versus standard therapy for the treatment of polycythemia vera","volume":"372","author":"Vannucchi","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e13122","DOI":"10.1111\/acel.13122","article-title":"The JAK1\/2 inhibitor ruxolitinib delays premature aging phenotypes","volume":"19","author":"Griveau","year":"2020","journal-title":"Aging Cell"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"194","DOI":"10.7150\/ijbs.39024","article-title":"Ruxolitinib Alleviates Renal Interstitial Fibrosis in UUO Mice","volume":"16","author":"Bai","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1038\/s41467-019-11174-0","article-title":"A novel rapamycin analog is highly selective for mTORC1 in vivo","volume":"10","author":"Schreiber","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/acel.12344","article-title":"The Achilles\u2019 heel of senescent cells: From transcriptome to senolytic drugs","volume":"14","author":"Zhu","year":"2015","journal-title":"Aging Cell"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ebiom.2018.12.052","article-title":"Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study","volume":"40","author":"Justice","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1093\/gerona\/glab002","article-title":"Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice","volume":"76","author":"Saccon","year":"2021","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.medj.2021.04.014","article-title":"Invariant Natural Killer T cells coordinate removal of senescent cells","volume":"2","author":"Arora","year":"2021","journal-title":"Med"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/15\/8165\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:55:54Z","timestamp":1760140554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/15\/8165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,25]]},"references-count":148,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["ijms23158165"],"URL":"https:\/\/doi.org\/10.3390\/ijms23158165","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,25]]}}}