{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:56:51Z","timestamp":1791928611825,"version":"4.3.4"},"reference-count":317,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["FZSR-2020-0006"],"award-info":[{"award-number":["FZSR-2020-0006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The development and pathogenesis of atherosclerosis are significantly influenced by lifestyle, particularly nutrition. The modern level of science and technology development promote personalized nutrition as an efficient preventive measure against atherosclerosis. In this survey, the factors were revealed that contribute to the formation of an individual approach to nutrition: genetic characteristics, the state of the microbiota of the gastrointestinal tract (GIT) and environmental factors (diets, bioactive components, cardioprotectors, etc.). In the course of the work, it was found that in order to analyze the predisposition to atherosclerosis associated with nutrition, genetic features affecting the metabolism of nutrients are significant. The genetic features include the presence of single nucleotide polymorphisms (SNP) of genes and epigenetic factors. The influence of telomere length on the pathogenesis of atherosclerosis and circadian rhythms was also considered. Relatively new is the study of the relationship between chrono-nutrition and the development of metabolic diseases. That is, to obtain the relationship between nutrition and atherosclerosis, a large number of genetic markers should be considered. In this relation, the question arises: \u201cHow many genetic features need to be analyzed in order to form a personalized diet for the consumer?\u201d Basically, companies engaged in nutrigenetic research and choosing a diet for the prevention of a number of metabolic diseases use SNP analysis of genes that accounts for lipid metabolism, vitamins, the body\u2019s antioxidant defense system, taste characteristics, etc. There is no set number of genetic markers. The main diets effective against the development of atherosclerosis were considered, and the most popular were the ketogenic, Mediterranean, and DASH-diets. The advantage of these diets is the content of foods with a low amount of carbohydrates, a high amount of vegetables, fruits and berries, as well as foods rich in antioxidants. However, due to the restrictions associated with climatic, geographical, material features, these diets are not available for a number of consumers. The way out is the use of functional products, dietary supplements. In this approach, the promising biologically active substances (BAS) that exhibit anti-atherosclerotic potential are: baicalin, resveratrol, curcumin, quercetin and other plant metabolites. Among the substances, those of animal origin are popular: squalene, coenzyme Q10, omega-3. For the prevention of atherosclerosis through personalized nutrition, it is necessary to analyze the genetic characteristics (SNP) associated with the metabolism of nutrients, to assess the state of the microbiota of the GIT. Based on the data obtained and food preferences, as well as the individual capabilities of the consumer, the optimal diet can be selected. It is topical to exclude nutrients of which their excess consumption stimulates the occurrence and pathogenesis of atherosclerosis and to enrich the diet with functional foods (FF), BAS containing the necessary anti-atherosclerotic, and stimulating microbiota of the GIT nutrients. Personalized nutrition is a topical preventive measure and there are a number of problems hindering the active use of this approach among consumers. The key factors include weak evidence of the influence of a number of genetic features, the high cost of the approach, and difficulties in the interpretation of the results. Eliminating these deficiencies will contribute to the maintenance of a healthy state of the population through nutrition.<\/jats:p>","DOI":"10.3390\/ijms23158233","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T04:59:16Z","timestamp":1658897956000},"page":"8233","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Tackling Atherosclerosis via Selected Nutrition"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4552-7418","authenticated-orcid":false,"given":"Anna","family":"Vesnina","sequence":"first","affiliation":[{"name":"Laboratory of Natural Nutraceuticals Biotesting, Research Department, Kemerovo State University, 650043 Kemerovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5630-3196","authenticated-orcid":false,"given":"Alexander","family":"Prosekov","sequence":"additional","affiliation":[{"name":"Laboratory of Biocatalysis, Kemerovo State University, 650043 Kemerovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7424-5604","authenticated-orcid":false,"given":"Victor","family":"Atuchin","sequence":"additional","affiliation":[{"name":"Laboratory of Optical Materials and Structures, Institute of Semiconductor Physics, 630090 Novosibirsk, Russia"},{"name":"Research and Development Department, Kemerovo State University, 650000 Kemerovo, Russia"},{"name":"Laboratory of Applied Physics, Novosibirsk State University, 630090 Novosibirsk, Russia"},{"name":"Department of Industrial Machinery Design, Novosibirsk State Technical University, 630073 Novosibirsk, Russia"},{"name":"R&D Center \u201cAdvanced Electronic Technologies\u201d, Tomsk State University, 634034 Tomsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-9123","authenticated-orcid":false,"given":"Varvara","family":"Minina","sequence":"additional","affiliation":[{"name":"Department of Genetic and Fundamental Medicine, Kemerovo State University, 650000 Kemerovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3002-2863","authenticated-orcid":false,"given":"Anastasia","family":"Ponasenko","sequence":"additional","affiliation":[{"name":"Laboratory of Genome Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 650002 Kemerovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.21037\/atm-21-706","article-title":"Association of heart rate with cardiovascular events and mortality in hypertensive and normotensive population: A nationwide prospective cohort study","volume":"9","author":"Wang","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_2","unstructured":"WHO CVD Risk Chart Working Group (2019). World Health Organization cardiovascular disease risk charts: Revised models to estimate risk in 21 global regions. Lancet Glob. Health, 7, e1332\u2013e1345."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Marchio, P., Guerra-Ojeda, S., Vila, J.M., Aldasoro, M., Victor, V.M., and Mauricio, M.D. (2019). Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation. Oxidative Med. Cell. Longev., 2019.","DOI":"10.1155\/2019\/8563845"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1161\/01.ATV.20.5.1177","article-title":"Natural history and histological classification of atherosclerotic lesions: An update","volume":"20","author":"Stary","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Xian, X., Wang, Z., Bi, Y., Chen, Q., Han, X., Tang, D., and Chen, R. (2018). Research Progress on the Relationship between Atherosclerosis and Inflammation. Biomolecules, 8.","DOI":"10.3390\/biom8030080"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1161\/01.ATV.15.9.1512","article-title":"A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association","volume":"15","author":"Stary","year":"1995","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Yeh, C.F., Chen, Y.H., Liu, S.F., Kao, H.L., Wu, M.S., Yang, K.C., and Wu, W.K. (2020). Mutual Interplay of Host Immune System and Gut Microbiota in the Immunopathology of Atherosclerosis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228729"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3389\/fphar.2019.00306","article-title":"Macrophage Death as a Pharmacological Target in Atherosclerosis","volume":"10","author":"Martinet","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.cell.2022.04.004","article-title":"Atherosclerosis: Recent developments","volume":"185","author":"Lusis","year":"2022","journal-title":"Cell"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S0955-2863(03)00032-9","article-title":"Common gene polymorphisms and nutrition: Emerging links with pathogenesis of multifactorial chronic diseases (review)","volume":"14","author":"Loktionov","year":"2003","journal-title":"J. Nutr. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Bays, H.E., Taub, P.R., Epstein, E., Michos, E.D., Ferraro, R.A., Bailey, A.L., Kelli, H.M., Ferdinand, K.C., Echols, M.R., and Weintraub, H. (2021). Ten things to know about ten cardiovascular disease risk factors. Am. J. Prev. Cardiol., 5.","DOI":"10.1016\/j.ajpc.2021.100149"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.yamp.2021.06.003","article-title":"The Role of the Human Gutome on Chronic Disease: A Review of the Microbiome and Nutrigenomics","volume":"4","author":"Hoefer","year":"2021","journal-title":"Adv. Mol. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1136\/gutjnl-2019-320438","article-title":"Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake","volume":"69","author":"Meslier","year":"2020","journal-title":"Gut"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Olas, B. (2020). Probiotics, Prebiotics and Synbiotics-A Promising Strategy in Prevention and Treatment of Cardiovascular Diseases?. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249737"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.arcmed.2015.05.010","article-title":"Nutrition and Atherosclerosis","volume":"46","author":"Torres","year":"2015","journal-title":"Arch. Med. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nrcardio.2017.169","article-title":"Atherosclerosis: Association between the gut microbiome and atherosclerosis","volume":"14","author":"Barrington","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40168-020-00821-0","article-title":"Gut microbiota and cardiovascular disease: Opportunities and challenges","volume":"8","author":"Kazemian","year":"2020","journal-title":"Microbiome"},{"key":"ref_18","first-page":"114","article-title":"The role of optimal nutrition in the prevention of cardiovascular diseases","volume":"89","author":"Smetneva","year":"2020","journal-title":"Vopr. Pitan."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41367-020-0014-4","article-title":"Obesity Programs of Nutrition, Education, Research and Assessment (OPERA) Group. Nutrigenetics-personalized nutrition in obesity and cardiovascular diseases","volume":"10","author":"Barrea","year":"2020","journal-title":"Int. J. Obes. Suppl."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Tuttolomondo, A., Simonetta, I., Daidone, M., Mogavero, A., Ortello, A., and Pinto, A. (2019). Metabolic and Vascular Effect of the Mediterranean Diet. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194716"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12263-017-0584-0","article-title":"Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice","volume":"12","author":"Grimaldi","year":"2017","journal-title":"Genes Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"de Toro-Mart\u00edn, J., Arsenault, B.J., Despr\u00e9s, J.P., and Vohl, M.C. (2017). Precision Nutrition: A Review of Personalized Nutritional Approaches for the Prevention and Management of Metabolic Syndrome. Nutrients, 9.","DOI":"10.3390\/nu9080913"},{"key":"ref_23","first-page":"12","article-title":"Guide and Position of the International Society of Nutrigenetics\/Nutrigenomics on Personalised Nutrition: Part 1\u2014Fields of Precision Nutrition","volume":"9","author":"Ferguson","year":"2016","journal-title":"J. Nutr. Nutr."},{"key":"ref_24","unstructured":"Naureen, Z., Miggiano, G., Aquilanti, B., Velluti, V., Matera, G., Gagliardi, L., Zulian, A., Romanelli, R., and Bertelli, M. (2020). Genetic test for the prescription of diets in support of physical activity. Acta Bio-Med. Atenei Parm., 91."},{"key":"ref_25","first-page":"153","article-title":"Prescribing personalized nutrition for cardiovascular health: Are we ready?","volume":"7","author":"Juma","year":"2014","journal-title":"J. Nutr. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Di Renzo, L., Gualtieri, P., Romano, L., Marrone, G., Noce, A., Pujia, A., Perrone, M.A., Aiello, V., Colica, C., and De Lorenzo, A. (2019). Role of Personalized Nutrition in Chronic-Degenerative Diseases. Nutrients, 11.","DOI":"10.3390\/nu11081707"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmhg.2011.02.001","article-title":"Nutritional genomics and personalized diet","volume":"12","author":"Gaboon","year":"2011","journal-title":"Egypt. J. Med. Hum. Genet."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.18565\/pharmateca.2018.2.27-35","article-title":"Medicine of the new era: Personalized approach in nutritiology","volume":"2","author":"Kostyuchenko","year":"2018","journal-title":"Pharmateca"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Floris, M., Cano, A., Porru, L., Addis, R., Cambedda, A., Idda, M.L., Steri, M., Ventura, C., and Maioli, M. (2020). Direct-to-Consumer Nutrigenetics Testing: An Overview. Nutrients, 12.","DOI":"10.3390\/nu12020566"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/j.jand.2017.08.008","article-title":"From Neighborhood to Genome: Three Decades of Nutrition-Related Research from the Atherosclerosis Risk in Communities Study","volume":"117","author":"Savoca","year":"2017","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.numecd.2014.10.010","article-title":"Functional foods and cardiometabolic diseases* International Task Force for Prevention of Cardiometabolic Diseases","volume":"24","author":"Assmann","year":"2014","journal-title":"Nutr. Metab. Cardiovasc. Dis. NMCD"},{"key":"ref_32","first-page":"1","article-title":"Nutrigenomics and nutrigenetics","volume":"39","author":"Farhud","year":"2010","journal-title":"Iran. J. Public Health"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.hlc.2018.09.006","article-title":"Markers of Atherosclerosis: Part 2\u2014Genetic and Imaging Markers","volume":"28","author":"Tibaut","year":"2019","journal-title":"Heart Lung Circ."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s00439-009-0654-5","article-title":"Molecular genetics of atherosclerosis","volume":"125","author":"Roy","year":"2009","journal-title":"Hum. Genet."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/nutrit\/nuv016","article-title":"Nutrigenetics of cholesterol metabolism: Observational and dietary intervention studies in the postgenomic era","volume":"73","author":"Abdullah","year":"2015","journal-title":"Nutr. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41435-019-0090-z","article-title":"Analysis of the genetic variants associated with circulating levels of sgp130. Results from the IMPROVE study","volume":"21","author":"Bonomi","year":"2020","journal-title":"Genes Immun."},{"key":"ref_37","first-page":"5","article-title":"Polymorphism of inflammatory regulator protein genes in atherosclerosis complicated by the development of acute myocardial infarction","volume":"7","author":"Konenkov","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref_38","first-page":"91","article-title":"Cholesterol metabolism in macrophages","volume":"9","author":"Khotina","year":"2020","journal-title":"Complex Probl. Cardiovasc. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1172\/JCI122064","article-title":"Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation","volume":"129","author":"Zhong","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_40","unstructured":"Nikiforov, N.G., Orekhov, A.N., Sobenin, I.A., and Karagodin, V.P. (2018). Method for Detection of Predisposition to Atherosclerosis Based on Determination of Expression of Genes Involved in Cholesterol Accumulation. (2698092), Patent, Patent holder FGBNU \u201cResearch Institute of General Pathology and Pathophysiology\u201d."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/joim.12655","article-title":"Integrative studies implicate matrix metalloproteinase-12 as a culprit gene for large-artery atherosclerotic stroke","volume":"282","author":"Mahdessian","year":"2017","journal-title":"J. Intern. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"228","DOI":"10.17816\/KMJ1594","article-title":"The role of antioxidant system genes in the formation of clinical phenotypes of ischemic heart disease","volume":"94","author":"Podolskaya","year":"2013","journal-title":"Kazan Med. J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.15829\/1560-4071-2014-10-53-57","article-title":"Possibilities of lipid metabolism gene polymorphism analysis for detection of atherosclerosis risk factors","volume":"10","author":"Koch","year":"2014","journal-title":"Russ. J. Cardiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"9096","DOI":"10.3390\/nu7115455","article-title":"Oral Fat Sensing and CD36 Gene Polymorphism in Algerian Lean and Obese Teenagers","volume":"7","author":"Daoudi","year":"2015","journal-title":"Nutrients"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/s11306-013-0602-1","article-title":"Salivary markers of taste sensitivity to oleic acid: A combined proteomics and metabolomics approach","volume":"10","author":"Mounayar","year":"2014","journal-title":"Metabolomics"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/s41366-021-00766-w","article-title":"Common variants in the CD36 gene are associated with dietary fat intake, high-fat food consumption and serum triglycerides in a cohort of Quebec adults","volume":"45","author":"Meng","year":"2021","journal-title":"Int. J. Obes."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1093\/hmg\/ddn060","article-title":"Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol","volume":"17","author":"Sherva","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.cardiores.2007.03.010","article-title":"CD36 and macrophages in atherosclerosis","volume":"75","author":"Martin","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.3945\/jn.116.235119","article-title":"Nutrigenomics at the Interface of Aging, Lifespan, and Cancer Prevention","volume":"146","author":"Riscuta","year":"2016","journal-title":"J. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.3945\/jn.111.143826","article-title":"A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI","volume":"141","author":"Corella","year":"2011","journal-title":"J. Nutr."},{"key":"ref_51","first-page":"4","article-title":"FTO gene as a genetic risk factor for the development of obesity","volume":"2","author":"Grechukhina","year":"2019","journal-title":"Med. Pharmacol. Electron. Sci. J."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Danaher, J., Stathis, C.G., and Cooke, M.B. (2019). Similarities in Metabolic Flexibility and Hunger Hormone Ghrelin Exist between FTO Gene Variants in Response to an Acute Dietary Challenge. Nutrients, 11.","DOI":"10.3390\/nu11102518"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ygcen.2017.05.017","article-title":"Ghrelin enhances food intake and carbohydrate oxidation in a nitric oxide dependent manner","volume":"250","author":"Abtahi","year":"2017","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_54","first-page":"41","article-title":"Bioinformatic analysis of the Arg51Gln missense mutation of the ghrelin gene (GHRL)","volume":"4","author":"Mukhiyarova","year":"2017","journal-title":"Bull. M. Akmulla Bashkir State Pedagog. Univ."},{"key":"ref_55","first-page":"80","article-title":"Polymorphisms of LEPR (Arg223Gln), FTO (a23525t), ADRB3 (Trp64Arg) and PPARG (Pro12Ala) genes in norm and in excess body weight","volume":"4","author":"Skarbievich","year":"2016","journal-title":"Q. Peer-Rev. Refereed Sci. J. Bull. ASU"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Khodarahmi, M., Kahroba, H., Jafarabadi, M.A., Mesgari-Abbasi, M., and Farhangi, M.A. (2020). Dietary quality indices modifies the effects of melanocortin-4 receptor (MC4R) rs17782313 polymorphism on cardio-metabolic risk factors and hypothalamic hormones in obese adults. BMC Cardiovasc. Disord., 20.","DOI":"10.1186\/s12872-020-01366-8"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"56","DOI":"10.5001\/omj.2019.09","article-title":"Evaluation of FTO rs9939609 and MC4R rs17782313 Polymorphisms as Prognostic Biomarkers of Obesity: A Population-based Cross-sectional Study","volume":"34","author":"Mozafarizadeh","year":"2019","journal-title":"Oman Med. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/advances\/nmy024","article-title":"Associations between Single Nucleotide Polymorphisms and Total Energy, Carbohydrate, and Fat Intakes: A Systematic Review","volume":"9","author":"Drabsch","year":"2018","journal-title":"Adv. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"68381","DOI":"10.18632\/oncotarget.20266","article-title":"SLC2A2 (GLUT2) as a novel prognostic factor for hepatocellular carcinoma","volume":"8","author":"Kim","year":"2017","journal-title":"Oncotarget"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/ajcn\/nqz043","article-title":"New insight into human sweet taste: A genome-wide association study of the perception and intake of sweet substances","volume":"109","author":"Hwang","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1152\/physiolgenomics.00148.2007","article-title":"Genetic variant in the glucose transporter type 2 is associated with higher intakes of sugars in two distinct populations","volume":"33","author":"Eny","year":"2008","journal-title":"Physiol. Genom."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Borglykke, A., Grarup, N., Spars\u00f8, T., Linneberg, A., and Fenger, M. (2013). Correction: Genetic Variant SCL2A2 Is Associated with Risk of Cardiovascular Disease\u2014Assessing the Individual and Cumulative Effect of 46 Type 2 Diabetes Related Genetic Variants. PLoS ONE, 8.","DOI":"10.1371\/annotation\/77e1d9b0-2b94-4a1b-95d5-4336258cecef"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Carrai, M., Campa, D., Vodicka, P., Flamini, R., Martelli, I., Slyskova, J., Jiraskova, K., Rejhova, A., Vodenkova, S., and Canzian, F. (2017). Association between taste receptor (TAS) genes and the perception of wine characteristics. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-08946-3"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Caradonna, F., Consiglio, O., Luparello, C., and Gentile, C. (2020). Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet. Nutrients, 12.","DOI":"10.3390\/nu12061748"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1097\/HJH.0b013e3282f5315f","article-title":"Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension","volume":"26","author":"Manunta","year":"2008","journal-title":"J. Hypertens."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11906-010-0167-6","article-title":"Genetics of salt-sensitive hypertension","volume":"13","author":"Sanada","year":"2011","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ihj.2017.10.006","article-title":"Salt sensitivity and its implication in clinical practice","volume":"70","author":"Mishra","year":"2018","journal-title":"Indian Heart J."},{"key":"ref_68","first-page":"341","article-title":"Pharmacogenomics and Hypertension: Current Insights","volume":"12","author":"Pereira","year":"2019","journal-title":"Pharm. Pers. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1467-789X.2012.01031.x","article-title":"Obesity and addiction: Neurobiological overlaps","volume":"14","author":"Volkow","year":"2013","journal-title":"Obes. Rev. Off. J. Int. Assoc. Study Obes."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Gluskin, B.S., and Mickey, B.J. (2016). Genetic variation and dopamine D2 receptor availability: A systematic review and meta-analysis of human in vivo molecular imaging studies\/B.S. Gluskin. Transl. Psychiatry, 6.","DOI":"10.1038\/tp.2016.22"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fncir.2013.00152","article-title":"Dopamine signaling in reward-related behaviors","volume":"7","author":"Baik","year":"2013","journal-title":"Front. Neural Circuits"},{"key":"ref_72","first-page":"106","article-title":"Moving towards Specific Nutrigenetic Recommendation Algorithms: Caffeine, Genetic Variation and Cardiovascular Risk","volume":"9","year":"2016","journal-title":"J. Nutr. Nutr."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Vesnina, A., Prosekov, A., Kozlova, O., and Atuchin, V. (2020). Genes and Eating Preferences, Their Roles in Personalized Nutrition. Genes, 11.","DOI":"10.3390\/genes11040357"},{"key":"ref_74","unstructured":"(2022, June 02). Genetic Testing for Personalized Nutrition. Available online: https:\/\/nutrigenomix.com\/."},{"key":"ref_75","unstructured":"(2022, June 02). The Future of Health Will Be Personalized and Genetic Testing Is the Tool That Will Make It Possible. Available online: https:\/\/www.3x4genetics.com\/about-us\/."},{"key":"ref_76","unstructured":"(2022, June 02). Unlock the Power of DNA, Unleash the Best Version of YOU. Available online: https:\/\/mapmygenome.in\/."},{"key":"ref_77","unstructured":"(2022, June 02). Stop Guessing. Live Healthier. Live Happier. Available online: https:\/\/www.genopalate.com\/."},{"key":"ref_78","unstructured":"(2022, June 02). Nutrigenetics Max Panel. Available online: https:\/\/helix.ru\/kb\/item\/42-060."},{"key":"ref_79","unstructured":"(2022, June 02). Center for New Medical Technologies. Available online: https:\/\/www.cnmt.ru\/."},{"key":"ref_80","unstructured":"(2022, June 02). National Center for Genetic Research. Available online: https:\/\/mygenetics.ru\/."},{"key":"ref_81","unstructured":"(2022, June 02). Genotek. Available online: https:\/\/www.genotek.ru\/."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ajcn\/nqy364","article-title":"From nutrigenomics to personalizing diets: Are we ready for precision medicine?","volume":"109","author":"Loos","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-2362.2009.02125.x","article-title":"Strengthening the Reporting of Genetic Association studies (STREGA)\u2014An extension of the STROBE statement","volume":"39","author":"Little","year":"2009","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s12263-013-0331-0","article-title":"Consumers on the Internet: Ethical and legal aspects of commercialization of personalized nutrition","volume":"8","author":"Ahlgren","year":"2013","journal-title":"Genes Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s13353-021-00670-z","article-title":"Genetic testing-whether to allow complete freedom? Direct to consumer tests versus genetic tests for medical purposes","volume":"63","author":"Malgorzata","year":"2022","journal-title":"J. Appl. Genet."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.jand.2019.02.010","article-title":"Academy of Nutrition and Dietetics: Revised 2019 Standards of Practice and Standards of Professional Performance for Registered Dietitian Nutritionists (Competent, Proficient, and Expert) in Nutrition in Integrative and Functional Medicine","volume":"119","author":"Noland","year":"2019","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Yegorov, Y.E., Poznyak, A.V., Nikiforov, N.G., Starodubova, A.V., and Orekhov, A.N. (2021). Role of Telomeres Shortening in Atherogenesis: An Overview. Cells, 10.","DOI":"10.3390\/cells10020395"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1016\/j.clnu.2019.11.003","article-title":"Association between diet quality indexes and the risk of short telomeres in an elderly population of the SUN project","volume":"39","author":"Zazpe","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.bbagen.2009.02.008","article-title":"Epigenetics and atherosclerosis","volume":"1790","author":"Turunen","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pharmthera.2018.11.003","article-title":"Targeting epigenetics and non-coding RNAs in atherosclerosis: From mechanisms to therapeutics","volume":"196","author":"Xu","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.tem.2018.04.007","article-title":"Atherosclerosis Is an Epigenetic Disease","volume":"29","author":"Xu","year":"2018","journal-title":"Trends Endocrinol. Metab. TEM"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.molmed.2017.02.004","article-title":"Epigenetics of Atherosclerosis: Emerging Mechanisms and Methods","volume":"23","author":"Khyzha","year":"2017","journal-title":"Trends Mol. Med."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Kim, M., Long, T.I., Arakawa, K., Wang, R., Yu, M.C., and Laird, P.W. (2010). DNA methylation as a biomarker for cardiovascular disease risk. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009692"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1161\/CIRCGENETICS.110.958744","article-title":"Cardiovascular epigenetics: Basic concepts and results from animal and human studies. Circulation","volume":"3","author":"Baccarelli","year":"2010","journal-title":"Cardiovasc. Genet."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0008-6363(99)00153-4","article-title":"Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system","volume":"43","author":"Post","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1097\/EDE.0b013e3181f20457","article-title":"Ischemic heart disease and stroke in relation to blood DNA methylation","volume":"21","author":"Baccarelli","year":"2010","journal-title":"Epidemiology"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Fishbein, A.B., Knutson, K.L., and Zee, P.C. (2021). Circadian disruption and human health. J. Clin. Investig., 131.","DOI":"10.1172\/JCI148286"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1113\/JP273094","article-title":"Time-restricted feeding for prevention and treatment of cardiometabolic disorders","volume":"595","author":"Melkani","year":"2017","journal-title":"J. Physiol."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Mic\u00f3, V., D\u00edez-Ricote, L., and Daimiel, L. (2016). Nutrigenetics and Nutrimiromics of the Circadian System: The Time for Human Health. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17030299"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41569-019-0167-4","article-title":"Circadian rhythms and the molecular clock in cardiovascular biology and disease","volume":"16","author":"Crnko","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3389\/fphys.2013.00409","article-title":"Possible contribution of chronobiology to cardiovascular health","volume":"4","author":"Sato","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1017\/S0029665116000628","article-title":"Circadian rhythms, food timing and obesity","volume":"75","author":"Garaulet","year":"2016","journal-title":"Proc. Nutr. Soc."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1001\/jamainternmed.2020.2176","article-title":"Association Between Healthy Eating Patterns and Risk of Cardiovascular Disease","volume":"180","author":"Shan","year":"2020","journal-title":"JAMA Intern. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.atherosclerosis.2012.05.024","article-title":"Low carbohydrate, high protein diet promotes atherosclerosis in apolipoprotein E\/low-density lipoprotein receptor double knockout mice (apoE\/LDLR\u2212\/\u2212)","volume":"223","author":"Kostogrys","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Chareonrungrueangchai, K., Wongkawinwoot, K., Anothaisintawee, T., and Reutrakul, S. (2020). Dietary Factors and Risks of Cardiovascular Diseases: An Umbrella Review. Nutrients, 12.","DOI":"10.3390\/nu12041088"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"d\u2019Almeida, K.S.M., Ronchi Spillere, S., Zuchinali, P., and Corr\u00eaa Souza, G. (2018). Mediterranean Diet and Other Dietary Patterns in Primary Prevention of Heart Failure and Changes in Cardiac Function Markers: A Systematic Review. Nutrients, 10.","DOI":"10.3390\/nu10010058"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"739","DOI":"10.2147\/VHRM.S328096","article-title":"Promising Nutritional Fruits Against Cardiovascular Diseases: An Overview of Experimental Evidence and Understanding Their Mechanisms of Action","volume":"17","author":"Zuraini","year":"2021","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Zhao, C.N., Meng, X., Li, Y., Li, S., Liu, Q., Tang, G.Y., and Li, H.B. (2017). Fruits for Prevention and Treatment of Cardiovascular Diseases. Nutrients, 9.","DOI":"10.3390\/nu9060598"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJMoa0708681","article-title":"Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet","volume":"359","author":"Shai","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1017\/S0007114507252687","article-title":"Long-term weight maintenance and cardiovascular risk factors are not different following weight loss on carbohydrate-restricted diets high in either monounsaturated fat or protein in obese hyperinsulinaemic men and women","volume":"97","author":"Keogh","year":"2007","journal-title":"Br. J. Nutr."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Dowis, K., and Banga, S. (2021). The Potential Health Benefits of the Ketogenic Diet: A Narrative Review. Nutrients, 13.","DOI":"10.3390\/nu13051654"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Naude, C.E., Brand, A., Schoonees, A., Nguyen, K.A., Chaplin, M., and Volmink, J. (2022). Low-carbohydrate versus balanced-carbohydrate diets for reducing weight and cardiovascular risk. Cochrane Database Syst. Rev., 1.","DOI":"10.1002\/14651858.CD013334.pub2"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/S0140-6736(17)32252-3","article-title":"Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): A prospective cohort study","volume":"390","author":"Dehghan","year":"2017","journal-title":"Lancet"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1067\/mpd.2003.4","article-title":"Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents","volume":"142","author":"Sondike","year":"2003","journal-title":"J. Pediatr."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1001\/archinternmed.2009.115","article-title":"The effect of a plant-based low-carbohydrate (\u201cEco-Atkins\u201d) diet on body weight and blood lipid concentrations in hyperlipidemic subjects","volume":"169","author":"Jenkins","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3945\/jn.108.099440","article-title":"A moderate-protein diet produces sustained weight loss and long-term changes in body composition and blood lipids in obese adults","volume":"139","author":"Layman","year":"2009","journal-title":"J. Nutr."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1001\/archinte.164.19.2141","article-title":"The national cholesterol education program diet vs a diet lower in carbohydrates and higher in protein and monounsaturated fat: A randomized trial","volume":"164","author":"Aude","year":"2004","journal-title":"Arch. Intern. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.clnu.2020.05.017","article-title":"The impact of type of dietary protein, animal versus vegetable, in modifying cardiometabolic risk factors: A position paper from the International Lipid Expert Panel (ILEP)","volume":"40","author":"Bajraktari","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.nut.2012.12.018","article-title":"Effects of Dietary Approaches to Stop Hypertension (DASH)-style diet on fatal or nonfatal cardiovascular diseases\u2014Incidence: A systematic review and meta-analysis on observational prospective studies","volume":"29","author":"Maghsoudi","year":"2013","journal-title":"Nutrition"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Trautwein, E.A., and McKay, S. (2020). The Role of Specific Components of a Plant-Based Diet in Management of Dyslipidemia and the Impact on Cardiovascular Risk. Nutrients, 12.","DOI":"10.3390\/nu12092671"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Casas, R., Castro-Barquero, S., Estruch, R., and Sacanella, E. (2018). Nutrition and Cardiovascular Health. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19123988"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1001\/archinte.168.7.713","article-title":"Adherence to a DASH-style diet and risk of coronary heart disease and stroke in women","volume":"168","author":"Fung","year":"2008","journal-title":"Arch. Intern. Med."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Rees, K., Takeda, A., Martin, N., Ellis, L., Wijesekara, D., Vepa, A., Das, A., Hartley, L., and Stranges, S. (2019). Mediterranean-style diet for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst. Rev., 3.","DOI":"10.1002\/14651858.CD009825.pub3"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pcad.2015.04.003","article-title":"Benefits of the Mediterranean Diet: Insights from the PREDIMED Study","volume":"58","author":"Estruch","year":"2015","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCGENETICS.114.000635","article-title":"Pro12Ala polymorphism of the PPAR\u03b32 gene interacts with a mediterranean diet to prevent telomere shortening in the PREDIMED-NAVARRA randomized trial","volume":"8","author":"Razquin","year":"2015","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Crous-Bou, M., Fung, T.T., Prescott, J., Julin, B., Du, M., Sun, Q., Rexrode, K.M., Hu, F.B., and De Vivo, I. (2014). Mediterranean diet and telomere length in Nurses\u2019 Health Study: Population based cohort study. BMJ Clin. Res. Ed., 349.","DOI":"10.1136\/bmj.g6674"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.clnu.2016.03.013","article-title":"Mediterranean diet and telomere length in high cardiovascular risk subjects from the PREDIMED-NAVARRA study","volume":"35","author":"Razquin","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1093\/eurheartj\/ehaa209","article-title":"The Mediterranean diet, plasma metabolome, and cardiovascular disease risk","volume":"41","author":"Li","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Ros, E., Mart\u00ednez-Gonz\u00e1lez, M.A., Estruch, R., Salas-Salvad\u00f3, J., Fit\u00f3, M., Mart\u00ednez, J.A., and Corella, D. (2014). Mediterranean diet and cardiovascular health: Teachings of the PREDIMED study. Adv. Nutr., 5.","DOI":"10.3945\/an.113.005389"},{"key":"ref_130","first-page":"11","article-title":"The role of nutrition in the prevention of cardiovascular disease","volume":"10","author":"Barbarash","year":"2019","journal-title":"Neurology"},{"key":"ref_131","first-page":"32","article-title":"Mechanisms of cardioprotective effects of the Mediterranean diet","volume":"14","author":"Tsygankova","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/nutrit\/nuy056","article-title":"Yogurt and other fermented foods as sources of health-promoting bacteria","volume":"76","author":"Kok","year":"2018","journal-title":"Nutr. Rev."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Ravera, A., Carubelli, V., Sciatti, E., Bonadei, I., Gorga, E., Cani, D., Vizzardi, E., Metra, M., and Lombardi, C. (2016). Nutrition and Cardiovascular Disease: Finding the Perfect Recipe for Cardiovascular Health. Nutrients, 8.","DOI":"10.3390\/nu8060363"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Kanauchi, M., and Kanauchi, K. (2019). Proposal for an Empirical Japanese Diet Score and the Japanese Diet Pyramid. Nutrients, 11.","DOI":"10.3390\/nu11112741"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Lo, K., Glenn, A.J., Yeung, S., Kendall, C., Sievenpiper, J.L., Jenkins, D., and Woo, J. (2021). Prospective Association of the Portfolio Diet with All-Cause and Cause-Specific Mortality Risk in the Mr. OS and Ms. OS Study. Nutrients, 13.","DOI":"10.3390\/nu13124360"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.ijcard.2014.07.080","article-title":"Vegetarian diet, Seventh Day Adventists and risk of cardiovascular mortality: A systematic review and meta-analysis","volume":"176","author":"Kwok","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Rees, K., Al-Khudairy, L., Takeda, A., and Stranges, S. (2021). Vegan dietary pattern for the primary and secondary prevention of cardiovascular diseases. Cochrane Database Syst. Rev., 2021.","DOI":"10.1002\/14651858.CD013501.pub2"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/ajcn\/nqaa157","article-title":"Glycemic index, glycemic load, and risk of coronary heart disease: A pan-European cohort study","volume":"112","author":"Sieri","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1017\/S0007114507778674","article-title":"Beneficial effects of a 5-week low-glycaemic index regimen on weight control and cardiovascular risk factors in overweight non-diabetic subjects","volume":"98","author":"Normand","year":"2007","journal-title":"Br. J. Nutr."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1001\/archinte.166.14.1466","article-title":"Comparison of 4 diets of varying glycemic load on weight loss and cardiovascular risk reduction in overweight and obese young adults: A randomized controlled trial","volume":"166","author":"Petocz","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Schmucker, C., Eisele-Metzger, A., Meerpohl, J.J., Lehane, C., de Gaudry, D.K., Lohner, S., and Schwingshackl, L. (2022). Effects of a gluten-reduced or gluten-free diet for the primary prevention of cardiovascular disease. Cochrane Database Syst. Rev., 2.","DOI":"10.1002\/14651858.CD013556.pub2"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Allaf, M., Elghazaly, H., Mohamed, O.G., Fareen, M., Zaman, S., Salmasi, A.M., Tsilidis, K., and Dehghan, A. (2021). Intermittent fasting for the prevention of cardiovascular disease. Cochrane Database Syst. Rev., 2021.","DOI":"10.1002\/14651858.CD013496.pub2"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Lou-Bonafonte, J.M., Gab\u00e1s-Rivera, C., Navarro, M.A., and Osada, J. (2017). The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18020416"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.biopha.2016.06.046","article-title":"Anti-atherosclerotic potential of baicalin mediated by promoting cholesterol efflux from macrophages via the PPAR\u03b3-LXR\u03b1-ABCA1\/ABCG1 pathway","volume":"83","author":"He","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Xin, L., Gao, J., Lin, H., Qu, Y., Shang, C., Wang, Y., Lu, Y., and Cui, X. (2020). Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.583200"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.bbrc.2006.07.155","article-title":"Resveratrol regulates the expression of LXR-alpha in human macrophages","volume":"348","author":"Sevov","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"837","DOI":"10.3389\/fimmu.2019.00837","article-title":"Clinical Advances in Immunonutrition and Atherosclerosis: A Review","volume":"10","author":"Lapuente","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41698-017-0038-6","article-title":"The therapeutic potential of resveratrol: A review of clinical trials","volume":"1","author":"Berman","year":"2017","journal-title":"NPJ Precis. Oncol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"e02210","DOI":"10.1128\/mBio.02210-15","article-title":"Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota","volume":"7","author":"Chen","year":"2016","journal-title":"mBio"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Bonnefont-Rousselot, D. (2016). Resveratrol and Cardiovascular Diseases. Nutrients, 8.","DOI":"10.3390\/nu8050250"},{"key":"ref_151","first-page":"7","article-title":"Resveratrol, wine, and atherosclerosis","volume":"21","author":"Prasad","year":"2012","journal-title":"Int. J. Angiol. Off. Publ. Int. Coll. Angiol. Inc."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Wici\u0144ski, M., Socha, M., Walczak, M., W\u00f3dkiewicz, E., Malinowski, B., Rewerski, S., G\u00f3rski, K., and Pawlak-Osi\u0144ska, K. (2018). Beneficial Effects of Resveratrol Administration-Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions. Nutrients, 10.","DOI":"10.3390\/nu10111813"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Malhotra, A., Bath, S., and Elbarbry, F. (2015). An Organ System Approach to Explore the Antioxidative, Anti-Inflammatory, and Cytoprotective Actions of Resveratrol. Oxidative Med. Cell. Longev., 2015.","DOI":"10.1155\/2015\/803971"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12986-020-00461-z","article-title":"Resveratrol ameliorates atherosclerosis induced by high-fat diet and LPS in ApoE\u2212\/\u2212 mice and inhibits the activation of CD4+ T cells","volume":"17","author":"Zhou","year":"2020","journal-title":"Nutr. Metab."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1089\/jmf.2009.0232","article-title":"The effect of grape seed extracts on serum paraoxonase activities in streptozotocin-induced diabetic rats","volume":"13","author":"Kiyici","year":"2010","journal-title":"J. Med. Food"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.jnutbio.2008.06.002","article-title":"Effects of red wine polyphenolic compounds on paraoxonase-1 and lectin-like oxidized low-density lipoprotein receptor-1 in hyperhomocysteinemic mice","volume":"20","author":"Noll","year":"2009","journal-title":"J. Nutr. Biochem."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1017\/S0007114510004356","article-title":"Curcumin induces paraoxonase 1 in cultured hepatocytes in vitro but not in mouse liver in vivo","volume":"105","author":"Schrader","year":"2011","journal-title":"Br. J. Nutr."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2147\/IJN.S189819","article-title":"Synergistic effects of liposomes encapsulating atorvastatin calcium and curcumin and targeting dysfunctional endothelial cells in reducing atherosclerosis","volume":"14","author":"Li","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.atherosclerosis.2010.02.027","article-title":"Impact of apolipoprotein E genotype and dietary quercetin on paraoxonase 1 status in apoE3 and apoE4 transgenic mice","volume":"211","author":"Niering","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Cao, H., Jia, Q., Yan, L., Chen, C., Xing, S., and Shen, D. (2019). Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20236093"},{"key":"ref_161","first-page":"893","article-title":"Quercetin protects against atherosclerosis by regulating the expression of PCSK9, CD36, PPAR\u03b3, LXR\u03b1 and ABCA1","volume":"44","author":"Jia","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"545","DOI":"10.21037\/cdt.2019.12.04","article-title":"Microbiome and metabonomics study of quercetin for the treatment of atherosclerosis","volume":"9","author":"Wu","year":"2019","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1002\/jsfa.6620","article-title":"Onion extract (Allium cepa L.), quercetin and catechin up-regulate paraoxonase 1 activity with concomitant protection against low-density lipoprotein oxidation in male Wistar rats subjected to oxidative stress","volume":"94","author":"Jaiswal","year":"2014","journal-title":"J. Sci. Food Agric."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Jeong, Y.Y., Ryu, J.H., Shin, J.H., Kang, M.J., Kang, J.R., Han, J., and Kang, D. (2016). Comparison of Anti-Oxidant and Anti-Inflammatory Effects between Fresh and Aged Black Garlic Extracts. Molecules, 21.","DOI":"10.3390\/molecules21040430"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"460S","DOI":"10.3945\/jn.114.206953","article-title":"Aged Garlic Extract Suppresses the Development of Atherosclerosis in Apolipoprotein E-Knockout Mice","volume":"146","author":"Morihara","year":"2016","journal-title":"J. Nutr."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/FJC.0b013e31815a9575","article-title":"A preparation of herbal medicine Salvia miltiorrhiza reduces expression of intercellular adhesion molecule-1 and development of atherosclerosis in apolipoprotein E-deficient mice","volume":"51","author":"Ling","year":"2008","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jep.2013.07.036","article-title":"Extracts from Astragalus membranaceus limit myocardial cell death and improve cardiac function in a rat model of myocardial ischemia","volume":"149","author":"Ma","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.numecd.2010.04.011","article-title":"Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice","volume":"22","author":"Mauray","year":"2012","journal-title":"Nutr. Metab. Cardiovasc. Dis. NMCD"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/ajcn\/87.2.323","article-title":"Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol","volume":"87","author":"Erlund","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/mnfr.201500738","article-title":"Lingonberries reduce atherosclerosis in Apoe\u2212\/\u2212 mice in association with altered gut microbiota composition and improved lipid profile","volume":"60","author":"Matziouridou","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/jn\/133.3.744","article-title":"Supplementation of diets with the black rice pigment fraction attenuates atherosclerotic plaque formation in apolipoprotein e deficient mice","volume":"133","author":"Xia","year":"2003","journal-title":"J. Nutr."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.atherosclerosis.2010.05.018","article-title":"Dietary rice protein isolate attenuates atherosclerosis in apoE-deficient mice by upregulating antioxidant enzymes","volume":"212","author":"Burris","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Chao, P.Y., Lin, K.H., Chiu, C.C., Yang, Y.Y., Huang, M.Y., and Yang, C.M. (2013). Inhibitive effects of mulberry leaf-related extracts on cell adhesion and inflammatory response in human aortic endothelial cells. Evid.-Based Complement. Altern. Med. ECAM, 2013.","DOI":"10.1155\/2013\/267217"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s12013-011-9216-2","article-title":"Inhibitory effect of delphinidin on monocyte-endothelial cell adhesion induced by oxidized low-density lipoprotein via ROS\/p38MAPK\/NF-\u03baB pathway","volume":"61","author":"Chen","year":"2011","journal-title":"Cell Biochem. Biophys."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1017\/BJN20061913","article-title":"Inulin attenuates atherosclerosis in apolipoprotein E-deficient mice","volume":"96","author":"Gueux","year":"2006","journal-title":"Br. J. Nutr."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Lai, S., Mazzaferro, S., Muscaritoli, M., Mastroluca, D., Testorio, M., Perrotta, A., Esposito, Y., Carta, M., Campagna, L., and Di Grado, M. (2020). Prebiotic Therapy with Inulin Associated with Low Protein Diet in Chronic Kidney Disease Patients: Evaluation of Nutritional, Cardiovascular and Psychocognitive Parameters. Toxins, 12.","DOI":"10.3390\/toxins12060381"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1093\/jn\/128.11.1937","article-title":"Dietary inulin lowers plasma cholesterol and triacylglycerol and alters biliary bile acid profile in hamsters","volume":"128","author":"Trautwein","year":"1998","journal-title":"J. Nutr."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/ajcn\/77.3.559","article-title":"Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans","volume":"77","author":"Letexier","year":"2003","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"507","DOI":"10.15171\/apb.2015.069","article-title":"A Combination of Prebiotic Inulin and Oligofructose Improve Some of Cardiovascular Disease Risk Factors in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial","volume":"5","author":"Aliasgharzadeh","year":"2015","journal-title":"Adv. Pharm. Bull."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1017\/S0007114516003627","article-title":"Inulin oligofructose attenuates metabolic syndrome in high-carbohydrate, high-fat diet-fed rats","volume":"116","author":"Kumar","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Hoving, L.R., Katiraei, S., Heijink, M., Pronk, A., van der Wee-Pals, L., Streefland, T., Giera, M., Willems van Dijk, K., and van Harmelen, V. (2018). Dietary Mannan Oligosaccharides Modulate Gut Microbiota, Increase Fecal Bile Acid Excretion, and Decrease Plasma Cholesterol and Atherosclerosis Development. Mol. Nutr. Food Res., 62.","DOI":"10.1002\/mnfr.201700942"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Relevy, N.Z., Harats, D., Harari, A., Ben-Amotz, A., Bitzur, R., R\u00fchl, R., and Shaish, A. (2015). Vitamin A-deficient diet accelerated atherogenesis in apolipoprotein E\u2212\/\u2212 mice and dietary \u03b2-carotene prevents this consequence. BioMed Res. Int., 2015.","DOI":"10.1155\/2015\/758723"},{"key":"ref_183","first-page":"161","article-title":"Evaluation of Antioxidant, Hypolipidemic, and Antiatherogenic Property of Lycopene and Astaxanthin in Atherosclerosis-induced Rats","volume":"9","author":"Kumar","year":"2017","journal-title":"Pharmacogn. Res."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1161\/01.CIR.0000012142.69612.25","article-title":"Vulnerable atherosclerotic plaque morphology in apolipoprotein E-deficient mice unable to make ascorbic Acid","volume":"105","author":"Nakata","year":"2002","journal-title":"Circulation"},{"key":"ref_185","first-page":"4081","article-title":"Niacin Suppresses Progression of Atherosclerosis by Inhibiting Vascular Inflammation and Apoptosis of Vascular Smooth Muscle Cells","volume":"21","author":"Su","year":"2015","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"e1126","DOI":"10.1212\/WNL.0000000000008932","article-title":"Interaction of serum vitamin B12 and folate with MTHFR genotypes on risk of ischemic stroke","volume":"94","author":"Qin","year":"2020","journal-title":"Neurology"},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Harari, A., Abecassis, R., Relevi, N., Levi, Z., Ben-Amotz, A., Kamari, Y., Harats, D., and Shaish, A. (2013). Prevention of atherosclerosis progression by 9-cis-\u03b2-carotene rich alga Dunaliella in apoE-deficient mice. BioMed Res. Int., 2013.","DOI":"10.1155\/2013\/169517"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1017\/S0007114509991565","article-title":"Lupin protein isolate and cysteine-supplemented casein reduce calcification of atherosclerotic lesions in apoE-deficient mice","volume":"103","author":"Weisse","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1093\/jn\/130.5.1124","article-title":"Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice","volume":"130","author":"Fuhrman","year":"2000","journal-title":"J. Nutr."},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Wu, C., Luan, H., Zhang, X., Wang, S., Zhang, X., Sun, X., and Guo, P. (2014). Chlorogenic acid protects against atherosclerosis in ApoE-\/- mice and promotes cholesterol efflux from RAW264.7 macrophages. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0095452"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s11745-016-4188-z","article-title":"Perilla Oil Reduces Fatty Streak Formation at Aortic Sinus via Attenuation of Plasma Lipids and Regulation of Nitric Oxide Synthase in ApoE KO Mice","volume":"51","author":"Hong","year":"2016","journal-title":"Lipids"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1476-511X-12-123","article-title":"Ethanolic extract of propolis inhibits atherosclerosis in ApoE-knockout mice","volume":"12","author":"Fang","year":"2013","journal-title":"Lipids Health Dis."},{"key":"ref_193","doi-asserted-by":"crossref","unstructured":"Li, F., Zhang, T., He, Y., Gu, W., Yang, X., Zhao, R., and Yu, J. (2020). Inflammation inhibition and gut microbiota regulation by TSG to combat atherosclerosis in ApoE\u2212\/\u2212 mice. J. Ethnopharmacol., 247.","DOI":"10.1016\/j.jep.2019.112232"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3389\/fphar.2020.00223","article-title":"Effect of Berberine on Atherosclerosis and Gut Microbiota Modulation and Their Correlation in High-Fat Diet-Fed ApoE\u2212\/\u2212 Mice","volume":"11","author":"Wu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Kou, J.Y., Li, Y., Zhong, Z.Y., Jiang, Y.Q., Li, X.S., Han, X.B., Liu, Z.N., Tian, Y., and Yang, L.M. (2017). Berberine-sonodynamic therapy induces autophagy and lipid unloading in macrophage. Cell Death Dis., 8.","DOI":"10.1038\/cddis.2016.354"},{"key":"ref_196","doi-asserted-by":"crossref","unstructured":"Parolini, C., Vik, R., Busnelli, M., Bj\u00f8rndal, B., Holm, S., Brattelid, T., Manzini, S., Ganzetti, G.S., Dellera, F., and Halvorsen, B. (2014). A salmon protein hydrolysate exerts lipid-independent anti-atherosclerotic activity in ApoE-deficient mice. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0097598"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1017\/S0007114507793893","article-title":"Functional effects of eggs, naturally enriched with conjugated linoleic acid, on the blood lipid profile, development of atherosclerosis and composition of atherosclerotic plaque in apolipoprotein E and low-density lipoprotein receptor double-knockout mice (apoE\/LDLR\u2212\/\u2212)","volume":"99","author":"Kostogrys","year":"2008","journal-title":"Br. J. Nutr."},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Abbate, J.M., Macr\u00ec, F., Arfuso, F., Iaria, C., Capparucci, F., Anfuso, C., Ieni, A., Cicero, L., Briguglio, G., and Lanteri, G. (2021). Anti-Atherogenic Effect of 10% Supplementation of Anchovy (Engraulis encrasicolus) Waste Protein Hydrolysates in ApoE-Deficient Mice. Nutrients, 13.","DOI":"10.3390\/nu13072137"},{"key":"ref_199","first-page":"3052","article-title":"A chicken protein hydrolysate exerts anti-atherosclerotic effect beyond plasma cholesterol-lowering activity in Apoe\u2212\/\u2212 mice","volume":"8","author":"Aloysius","year":"2019","journal-title":"Food Sci. Nutr."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.atherosclerosis.2007.08.008","article-title":"Squalene in a sex-dependent manner modulates atherosclerotic lesion which correlates with hepatic fat content in apoE-knockout male mice","volume":"197","author":"Navarro","year":"2008","journal-title":"Atherosclerosis"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s12944-018-0928-9","article-title":"Coenzyme Q10 protects against hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice","volume":"17","author":"Zhang","year":"2018","journal-title":"Lipids Health Dis."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.atherosclerosis.2013.10.014","article-title":"Omega-3 PUFAs improved endothelial function and arterial stiffness with a parallel antiinflammatory effect in adults with metabolic syndrome","volume":"232","author":"Tousoulis","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.jnutbio.2012.11.009","article-title":"Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden.CETP mice","volume":"24","author":"Wong","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1161\/ATVBAHA.116.307841","article-title":"Resveratrol Inhibits Aortic Root Dilatation in the Fbn1C1039G\/+ Marfan Mouse Model","volume":"36","author":"Hibender","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1161\/01.ATV.0000146530.24736.ce","article-title":"Induction of the paraoxonase-1 gene expression by resveratrol","volume":"24","author":"Barouki","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.freeradbiomed.2013.08.185","article-title":"Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: A critical role for heme oxygenase-1","volume":"65","author":"Shen","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s11010-005-9070-x","article-title":"Effect of ascorbic acid on prevention of hypercholesterolemia induced atherosclerosis","volume":"285","author":"Das","year":"2006","journal-title":"Mol. Cell. Biochem."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.ijbiomac.2017.02.025","article-title":"Vitamin C down-regulate apo(a) expression via Tet2-dependent DNA demethylation in HepG2 cells","volume":"98","author":"Qu","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.atherosclerosis.2003.08.009","article-title":"Vitamins C and E downregulate vascular VEGF and VEGFR-2 expression in apolipoprotein-E-deficient mice","volume":"171","author":"Nespereira","year":"2003","journal-title":"Atherosclerosis"},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Ghosh, S.S., Bie, J., Wang, J., and Ghosh, S. (2014). Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet-induced atherosclerosis and glucose intolerance in LDLR\u2212\/\u2212 mice\u2014Role of intestinal permeability and macrophage activation. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108577"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1021\/acs.jafc.7b04260","article-title":"Curcumin Protects against Atherosclerosis in Apolipoprotein E-Knockout Mice by Inhibiting Toll-like Receptor 4 Expression","volume":"66","author":"Zhang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_212","first-page":"5896","article-title":"Curcumin modulates covalent histone modification and TIMP1 gene activation to protect against vascular injury in a hypertension rat model","volume":"14","author":"Hu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1016\/j.apsb.2021.12.014","article-title":"Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB-P300-BRD4 axis","volume":"12","author":"Li","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.clnu.2003.10.002","article-title":"Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation","volume":"23","author":"Aviram","year":"2004","journal-title":"Clin. Nutr."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1093\/ajcn\/71.5.1062","article-title":"Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: Studies in humans and in atherosclerotic apolipoprotein E-deficient mice","volume":"71","author":"Aviram","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"D\u00edez-Ricote, L., Ruiz-Valderrey, P., Mic\u00f3, V., Blanco-Rojo, R., Tom\u00e9-Carneiro, J., D\u00e1valos, A., Ordov\u00e1s, J.M., and Daimiel, L. (2021). Trimethylamine n-Oxide (TMAO) Modulates the Expression of Cardiovascular Disease-Related microRNAs and Their Targets. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011145"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4143\/crt.2014.46.1.2","article-title":"Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: The golden pigment from golden Spice","volume":"46","author":"Prasad","year":"2014","journal-title":"Cancer Res. Treat."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Thiruvengadam, M., Venkidasamy, B., Subramanian, U., Samynathan, R., Ali Shariati, M., Rebezov, M., Girish, S., Thangavel, S., Dhanapal, A.R., and Fedoseeva, N. (2021). Bioactive Compounds in Oxidative Stress-Mediated Diseases: Targeting the NRF2\/ARE Signaling Pathway and Epigenetic Regulation. Antioxidants, 10.","DOI":"10.3390\/antiox10121859"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gene.2015.02.045","article-title":"The role dietary of bioactive compounds on the regulation of histone acetylases and deacetylases: A review","volume":"562","author":"Vahid","year":"2015","journal-title":"Gene"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.biotechadv.2014.04.004","article-title":"Curcumin, a component of golden spice: From bedside to bench and back","volume":"32","author":"Prasad","year":"2014","journal-title":"Biotechnol. Adv."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/sj.bjc.6605039","article-title":"Activation of ATM\/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells","volume":"100","author":"Sahu","year":"2009","journal-title":"Br. J. Cancer"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/sj.pcan.4500399","article-title":"Therapeutic potential of curcumin in human prostate cancer\u2014I. curcumin induces apoptosis in both androgen-dependent and androgen-independent prostate cancer cells","volume":"3","author":"Dorai","year":"2000","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"34405","DOI":"10.18632\/oncotarget.14907","article-title":"Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line","volume":"8","author":"Masuelli","year":"2017","journal-title":"Oncotarget"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1055\/s-0028-1088302","article-title":"Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals","volume":"74","author":"Surh","year":"2008","journal-title":"Planta Med."},{"key":"ref_225","first-page":"57","article-title":"Water-soluble antioxidants improve the antioxidant and anticancer activity of low concentrations of curcumin in human leukemia cells","volume":"60","author":"Chen","year":"2005","journal-title":"Pharmazie"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejphar.2009.03.060","article-title":"Curcumin mediates time and concentration dependent regulation of redox homeostasis leading to cytotoxicity in macrophage cells","volume":"611","author":"Kunwar","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Maiti, P., Plemmons, A., and Dunbar, G.L. (2019). Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K\/Akt\/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0225660"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"3469840","DOI":"10.1155\/2020\/3469840","article-title":"Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells","volume":"2020","author":"Li","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3892\/ol.2021.12737","article-title":"Curcumin induces apoptosis and inhibits the growth of adrenocortical carcinoma: Identification of potential candidate genes and pathways by transcriptome analysis","volume":"21","author":"Huang","year":"2021","journal-title":"Oncol. Lett."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"20","DOI":"10.21603\/2308-4057-2020-1-20-29","article-title":"Specialized Hypocholesterolemic foods: Ingredients, technology, effects","volume":"8","author":"Vorobyeva","year":"2020","journal-title":"Foods Raw Mater."},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Kuhl, G.C., and De Dea Lindner, J. (2016). Biohydrogenation of Linoleic Acid by Lactic Acid Bacteria for the Production of Functional Cultured Dairy Products: A Review. Foods, 5.","DOI":"10.3390\/foods5010013"},{"key":"ref_232","unstructured":"Lobach, E.Y., Tohirien, B., Guryanov, Y.G., and Poznyakovsky, V.M. (2018). Specialized Food Product for the Prevention of Atherosclerosis, Cardiovascular Diseases and Correction of Metabolic Disorders, and the Method of Its Preparation. (No. 2018106412), Patent 2692651 RF, IPC A23L 33\/10, A23L 33\/125, A23L 33\/15."},{"key":"ref_233","unstructured":"Shi, D., Liu, J., Chai, H., Cui, Y., Liang, X., Feng, J., and Liu, Y. (2020). Medicine for Treating Atherosclerosis and Protecting Blood Vessels, Preparation Method and Application. (No. 202010798705.8), Patent CN111759830, IPC A61K31\/12, A61P9\/10, Applicant Xiyuan Hospital of China Acad of Chinese Medical Sciences."},{"key":"ref_234","unstructured":"Cao, S. (2020). Traditional Chinese Medicine Composition and Traditional Chinese Medicine Preparation for Resisting Atherosclerosis. (No 202010814755.0), Patent CN111714589, IPC A61K35\/62, A61K36\/8988, A61P7\/10, Applicant Henan University of Chinese Medicine."},{"key":"ref_235","unstructured":"Luo, Z., Wang, W., Zhang, L., Bao, Y., and Wang, J. (2020). Pharmaceutical Composition for Preventing and Treating Atherosclerosis as Well as Preparation Method and Application Method thereof. (No 202010552685.6), Patent CN111671797, IPC A61K35\/62, A61K36\/8988, A61P7\/10, Applicant Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory."},{"key":"ref_236","unstructured":"Yuan, K., Luo, Y., and Fang, J. (2019). Natural Medicine Preparation for Preventing and Treating Atherosclerosis by Regulating Intestinal Flora Balance. (No 201910150700.1), Patent CN110496192, IPC A61K36\/899, A61K36\/48, A61P9\/10, A61K31\/353, A61K31\/12, Applicant Jiyang College of Zhejiang A&F University."},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Amato, A., Caldara, G.F., Nuzzo, D., Baldassano, S., Picone, P., Rizzo, M., Mul\u00e8, F., and Di Carlo, M. (2017). NAFLD and Atherosclerosis Are Prevented by a Natural Dietary Supplement Containing Curcumin, Silymarin, Guggul, Chlorogenic Acid and Inulin in Mice Fed a High-Fat Diet. Nutrients, 9.","DOI":"10.3390\/nu9050492"},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Xu, J., Xia, Z., Rong, S., Gao, H., Yang, W., Li, J., Ma, C., Deng, Q., Huang, Q., and Xiao, L. (2018). Yirui Capsules Alleviate Atherosclerosis by Improving the Lipid Profile and Reducing Inflammation in Apolipoprotein E-Deficient Mice. Nutrients, 10.","DOI":"10.3390\/nu10020142"},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Song, M.Y., Cho, H., Lee, S., Lee, K.H., and Kim, W. (2022). Daeshiho-tang Attenuates Atherosclerosis by Regulating Cholesterol Metabolism and Inducing M2 Macrophage Polarization. Life, 12.","DOI":"10.3390\/life12020197"},{"key":"ref_240","unstructured":"Zhou, Q., Zhao, W., Han, X., Bai, B., Yan, C., and Dong, X. (2017). Application of Rhodiola rosea oligomer procyanidine in Preparing Medicine for Treating Atherosclerosis Disease. (No 201710684812.6), Patent CN107441080, IPC A61K31\/353, A61P1\/16, A61P3\/06, A61P9\/08, A61P9\/10, Applicant Agricultural University of Hebei."},{"key":"ref_241","unstructured":"Heye, L.H. (2004). Composition, Pharmaceutical Preparation and Method for the Prevention and\/or Treatment and\/or Attenuation of Cardiovascular Diseases. (No. 2001117226\/13), Patent 2235483, Patent Holder of Nutripharma ASA."},{"key":"ref_242","unstructured":"Timofeevna, S.N., Mukhsen, A.A., Alekseevna, S.T., Igorevna, V.A., Zakharievna, T.A., and Hovhannesovna, T.L. (2020). A Method for the Production of Flour Confectionery Products for Special Purposes. (RU2728336), RU Patent."},{"key":"ref_243","unstructured":"Timofeevna, S.N., Mukhsen, A.A., Alekseevna, S.T., Igorevna, V.A., Vladimirovna, D.A., Zakharievna, T.A., and Ovanesovna, T.L. (2020). A Method of Production of Bakery Products for Special Purposes. (RU0002728392), RU Patent."},{"key":"ref_244","unstructured":"Romanchuk, N.P., Romanchuk, P.I., and Malyshev, V.K. (2013). A Product of Dietary, Preventive and Functional Nutrition for Chronic Ischemia of the Human Brain. (Application No. 2012122914\/13), Patent 2489038, Patent Holder Romanchuk, N.P."},{"key":"ref_245","unstructured":"Chong, P.V., Hafner, T., and Let, I. (2015). A Composition to Reduce the Absorption of Fat Included in the Diet. (Patent 2566050), Patent Holder Omega Pharma Innovation & Development NV."},{"key":"ref_246","unstructured":"Marco, R., Angles, B., Maria, L., Reguant, N., Jordi, M., Alberich, S., Godas, R., and Gemma, B. (2009). Functional Food Having Positive Effects in the Prevention of Cardiovascular Diseases. (US20090297687), US Patent, Agents LADAS & PARRY LLP."},{"key":"ref_247","unstructured":"Zaitseva, L.V., Zinchenko, V.Z., Yeltsova, T.S., and Baranov, V.A. (2018). A Functional Food Product for the Prevention of Cardiovascular Diseases. (RU2651275), RU Patent, Patent Holder of Soyuz Corporation LLC."},{"key":"ref_248","unstructured":"Chen, J., Hu, L., Zheng, C., Duan, L., Huang, X., Ji, Y., and Cai, C. (2020). Fermented Milk, and Preparation Method and Application Thereof. (No 202010172930.0), Patent CN111418653, IPC A23C9\/13, Applicant Sungen Bioscience Co., Ltd."},{"key":"ref_249","unstructured":"Polyanskaya, I.S., and Topal, O.I. (2013). Method of Producing Kefir with Functional Properties. (Patent 2482689. Application 2011149047\/10), Patent holder Vologda State Dairy Academy named after N.V. Vereshchagin."},{"key":"ref_250","unstructured":"Hu, Z., Wu, H., Wang, X., Liu, H., and Wang, A. (2020). Vascular Maintenance Composition Containing Kefir Fermented Milk Powder and Preparation Method of Vascular Maintenance Composition. (No 202010307023.2), Patent CN111671078, IPC A23L11\/00, A23L19\/00, A23L33\/00, A23L33\/10, A23L33\/105, A23L33\/15, A23L33\/16\/, Applicant Shandong Hawei Pharmaceutical Co., Ltd."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.3945\/an.115.011403","article-title":"Systematic Review of the Association between Dairy Product Consumption and Risk of Cardiovascular-Related Clinical Outcomes","volume":"7","author":"Brassard","year":"2016","journal-title":"Adv. Nutr."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1093\/advances\/nmaa030","article-title":"Fermented Dairy Products, Probiotic Supplementation, and Cardiometabolic Diseases: A Systematic Review and Meta-analysis","volume":"11","author":"Companys","year":"2020","journal-title":"Adv. Nutr."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"110426","DOI":"10.1016\/j.biopha.2020.110426","article-title":"Small rodent models of atherosclerosis","volume":"129","author":"Zhao","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"e9557","DOI":"10.1590\/1414-431x20209557","article-title":"Animal models of human atherosclerosis: Current progress","volume":"53","author":"Poznyak","year":"2020","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-394596-9.00001-9","article-title":"Animal models of atherosclerosis","volume":"105","author":"Fuster","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_256","first-page":"4614","article-title":"Modelling of atherosclerosis in genetically modified animals","volume":"11","author":"Mushenkova","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejphar.2017.05.010","article-title":"Animal models of atherosclerosis","volume":"816","author":"Perrotta","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1161\/ATVBAHA.111.237693","article-title":"Animal models of atherosclerosis","volume":"32","author":"Getz","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_259","first-page":"497841","article-title":"Animal models of cardiovascular diseases","volume":"2011","author":"Zaragoza","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3892\/br.2017.843","article-title":"Animal models of atherosclerosis","volume":"6","author":"Lee","year":"2017","journal-title":"Biomed. Rep."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.freeradbiomed.2012.08.004","article-title":"Emerging applications for zebrafish as a model organism to study oxidative mechanisms and their roles in inflammation and vascular accumulation of oxidized lipids","volume":"53","author":"Fang","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1089\/zeb.2019.1742","article-title":"Influence of Commercial and Laboratory Diets on Growth, Body Composition, and Reproduction in the Zebrafish Danio rerio","volume":"16","author":"Fowler","year":"2019","journal-title":"Zebrafish"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"9995401","DOI":"10.1155\/2021\/9995401","article-title":"Zebrafish Model for Screening Antiatherosclerosis Drugs","volume":"2021","author":"Han","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1161\/CIRCRESAHA.108.189803","article-title":"Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish","volume":"104","author":"Stoletov","year":"2009","journal-title":"Circ. Res."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"643697","DOI":"10.3389\/fcell.2021.643697","article-title":"Recent Application of Zebrafish Models in Atherosclerosis Research","volume":"9","author":"Tang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/B978-0-12-387036-0.00005-0","article-title":"Zebrafish lipid metabolism: From mediating early patterning to the metabolism of dietary fat and cholesterol","volume":"101","author":"Anderson","year":"2011","journal-title":"Methods Cell Biol."},{"key":"ref_267","doi-asserted-by":"crossref","unstructured":"Landgraf, K., Schuster, S., Meusel, A., Garten, A., Riemer, T., Schleinitz, D., Kiess, W., and K\u00f6rner, A. (2017). Short-term overfeeding of zebrafish with normal or high-fat diet as a model for the development of metabolically healthy versus unhealthy obesity. BMC Physiol., 17.","DOI":"10.1186\/s12899-017-0031-x"},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"155138","DOI":"10.1016\/j.metabol.2022.155138","article-title":"The zebrafish model system for dyslipidemia and atherosclerosis research: Focus on environmental\/exposome factors and genetic mechanisms","volume":"129","author":"Vasyutina","year":"2022","journal-title":"Metab. Clin. Exp."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.phymed.2016.01.003","article-title":"Cellular models of atherosclerosis and their implication for testing natural substances with anti-atherosclerotic potential","volume":"23","author":"Orekhov","year":"2016","journal-title":"Phytomedicine"},{"key":"ref_270","doi-asserted-by":"crossref","unstructured":"Rossmann, C., Nusshold, C., Paar, M., Ledinski, G., Tafeit, E., Koestenberger, M., Bernhart, E.M., Sattler, W., Cvirn, G., and Hallstr\u00f6m, S. (2018). Ethyl pyruvate inhibits oxidation of LDL in vitro and attenuates oxLDL toxicity in EA.hy926 cells. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0191477"},{"key":"ref_271","doi-asserted-by":"crossref","unstructured":"Aboufarrag, H.T., Needs, P.W., Rimbach, G., and Kroon, P.A. (2019). The Effects of Anthocyanins and Their Microbial Metabolites on the Expression and Enzyme Activities of Paraoxonase 1, an Important Marker of HDL Function. Nutrients, 11.","DOI":"10.3390\/nu11122872"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1017\/S0029665113003911","article-title":"\u2018The way to a man\u2019s heart is through his gut microbiota\u2019--dietary pro- and prebiotics for the management of cardiovascular risk","volume":"73","author":"Tuohy","year":"2014","journal-title":"Proc. Nutr. Soc."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3389\/fphar.2018.01082","article-title":"The Role of Gut Microbiota in Atherosclerosis and Hypertension","volume":"9","author":"Ma","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_274","doi-asserted-by":"crossref","unstructured":"Mills, S., Stanton, C., Lane, J.A., Smith, G.J., and Ross, R.P. (2019). Precision Nutrition and the Microbiome, Part I: Current State of the Science. Nutrients, 11.","DOI":"10.3390\/nu11040923"},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.cmet.2014.10.006","article-title":"\u03b3-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO","volume":"20","author":"Koeth","year":"2014","journal-title":"Cell Metab."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/joim.12328","article-title":"Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure","volume":"277","author":"Ueland","year":"2015","journal-title":"J. Intern. Med."},{"key":"ref_277","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Montero, C., Fraile-Mart\u00ednez, O., G\u00f3mez-Lahoz, A.M., Pekarek, L., Castellanos, A.J., Noguerales-Fraguas, F., Coca, S., Guijarro, L.G., Garc\u00eda-Honduvilla, N., and As\u00fansolo, A. (2021). Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota-Immune System Interplay. Implications for Health and Disease. Nutrients, 13.","DOI":"10.3390\/nu13020699"},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"1600804","DOI":"10.1002\/mnfr.201600804","article-title":"Dietary \u03b1-cyclodextrin reduces atherosclerosis and modifies gut flora in apolipoprotein E-deficient mice","volume":"61","author":"Sakurai","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_279","doi-asserted-by":"crossref","unstructured":"De Filippis, A., Ullah, H., Baldi, A., Dacrema, M., Esposito, C., Garzarella, E.U., Santarcangelo, C., Tantipongpiradet, A., and Daglia, M. (2020). Gastrointestinal Disorders and Metabolic Syndrome: Dysbiosis as a Key Link and Common Bioactive Dietary Components Useful for their Treatment. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21144929"},{"key":"ref_280","doi-asserted-by":"crossref","unstructured":"Markowiak, P., and \u015ali\u017cewska, K. (2017). Effects of Probiotics, Prebiotics, and Synbiotics on Human Health. Nutrients, 9.","DOI":"10.3390\/nu9091021"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1161\/CIRCULATIONAHA.115.019645","article-title":"Akkermansia muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe\u2212\/\u2212 Mice","volume":"133","author":"Li","year":"2016","journal-title":"Circulation"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"e1900732","DOI":"10.1002\/mnfr.201900732","article-title":"Akkermansia muciniphila Exerts Lipid-Lowering and Immunomodulatory Effects without Affecting Neointima Formation in Hyperlipidemic APOE*3-Leiden.CETP Mice","volume":"64","author":"Katiraei","year":"2020","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.3168\/jds.2010-3311","article-title":"Lactobacillus acidophilus CHO-220 and inulin reduced plasma total cholesterol and low-density lipoprotein cholesterol via alteration of lipid transporters","volume":"93","author":"Ooi","year":"2010","journal-title":"J. Dairy Sci."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"7496","DOI":"10.1128\/AEM.02926-14","article-title":"Lactobacillus acidophilus ATCC 4356 prevents atherosclerosis via inhibition of intestinal cholesterol absorption in apolipoprotein E-knockout mice","volume":"80","author":"Huang","year":"2014","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1017\/S000711451200373X","article-title":"Cholesterol-lowering efficacy of Lactobacillus plantarum CECT 7527, 7528 and 7529 in hypercholesterolaemic adults","volume":"109","author":"Fuentes","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_286","doi-asserted-by":"crossref","unstructured":"Costabile, A., Buttarazzi, I., Kolida, S., Quercia, S., Baldini, J., Swann, J.R., Brigidi, P., and Gibson, G.R. (2017). An in vivo assessment of the cholesterol-lowering efficacy of Lactobacillus plantarum ECGC 13110402 in normal to mildly hypercholesterolaemic adults. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187964"},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.3168\/jds.2012-6123","article-title":"Lactobacillus plantarum strains as potential probiotic cultures with cholesterol-lowering activity","volume":"96","author":"Huang","year":"2013","journal-title":"J. Dairy Sci."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1161\/CIRCRESAHA.118.313565","article-title":"Lactobacillus plantarum 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men with Stable Coronary Artery Disease","volume":"123","author":"Malik","year":"2018","journal-title":"Circ. Res."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s12602-011-9086-3","article-title":"Lactobacillus rhamnosus BFE 5264 and Lactobacillus plantarum NR74 Promote Cholesterol Excretion Through the Up-Regulation of ABCG5\/8 in Caco-2 Cells","volume":"3","author":"Yoon","year":"2011","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_290","doi-asserted-by":"crossref","unstructured":"Chan, Y.K., Brar, M.S., Kirjavainen, P.V., Chen, Y., Peng, J., Li, D., Leung, F.C., and El-Nezami, H. (2016). High fat diet induced atherosclerosis is accompanied with low colonic bacterial diversity and altered abundances that correlates with plaque size, plasma A-FABP and cholesterol: A pilot study of high fat diet and its intervention with Lactobacillus rhamnosus GG (LGG) or telmisartan in ApoE-\/- mice. BMC Microbiol., 16.","DOI":"10.1186\/s12866-016-0883-4"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12937-021-00703-7","article-title":"Effect of probiotic supplementation along with calorie restriction on metabolic endotoxemia, and inflammation markers in coronary artery disease patients: A double blind placebo controlled randomized clinical trial","volume":"20","author":"Moludi","year":"2021","journal-title":"Nutr. J."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/ejcn.2012.126","article-title":"Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: A randomized controlled trial","volume":"66","author":"Jones","year":"2012","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"e1800298","DOI":"10.1002\/mnfr.201800298","article-title":"The Probiotic Lactobacillus fermentum Prevents Dysbiosis and Vascular Oxidative Stress in Rats with Hypertension Induced by Chronic Nitric Oxide Blockade","volume":"62","author":"Toral","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/jsfa.4214","article-title":"Characterisation of Lactobacillus fermentum SM-7 isolated from koumiss, a potential probiotic bacterium with cholesterol-lowering effects","volume":"91","author":"Pan","year":"2011","journal-title":"J. Sci. Food Agric."},{"key":"ref_295","unstructured":"Dimitrov, J., and Mikhailova, M. (2018). Lactobacillus Gasseri Strain and Bacterial Preparation with Hypocholesterolemic and Anti-Inflammatory Immunomodulatory Activity. (No. 2017126392), Patent 2672571 RF, MPC A61K 35\/747, A61P 3\/00, A61P 37\/02, patent holder LB BUL-GARICUM plc."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"110941","DOI":"10.1016\/j.nut.2020.110941","article-title":"Reduction of intestinal trimethylamine by probiotics ameliorated lipid metabolic disorders associated with atherosclerosis","volume":"79\u201380","author":"Liang","year":"2020","journal-title":"Nutrition"},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jff.2017.06.032","article-title":"Bifidobacterium animalis subsp. lactis LKM512 reduces levels of intestinal trimethylamine produced by intestinal microbiota in healthy volunteers: A double-blind, placebo-controlled study","volume":"36","author":"Matsumoto","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-511X-8-1","article-title":"Effects of probiotic bacteria, isoflavones and simvastatin on lipid profile and atherosclerosis in cholesterol-fed rabbits: A randomized double-blind study","volume":"8","author":"Cavallini","year":"2009","journal-title":"Lipids Health Dis."},{"key":"ref_299","doi-asserted-by":"crossref","unstructured":"Yang, L., Xie, X., Li, Y., Wu, L., Fan, C., Liang, T., Xi, Y., Yang, S., Li, H., and Zhang, J. (2021). Evaluation of the Cholesterol-Lowering Mechanism of Enterococcus faecium Strain 132 and Lactobacillus paracasei Strain 201 in Hypercholesterolemia Rats. Nutrients, 13.","DOI":"10.3390\/nu13061982"},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"103424","DOI":"10.1016\/j.jff.2019.103424","article-title":"Pediococcus acidilactici AS185 attenuates early atherosclerosis development through inhibition of lipid regulation and inflammation in rats","volume":"60","author":"Wang","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/jsfa.5880","article-title":"The effect of probiotic-fermented soy milk on enhancing the NO-mediated vascular relaxation factors","volume":"93","author":"Cheng","year":"2013","journal-title":"J. Sci. Food Agric."},{"key":"ref_302","first-page":"21","article-title":"A Randomized Controlled Clinical Trial Investigating the Effect of Synbiotic Administration on Markers of Insulin Metabolism and Lipid Profiles in Overweight Type 2 Diabetic Patients with Coronary Heart Disease","volume":"125","author":"Sharifi","year":"2017","journal-title":"Exp. Clin. Endocrinol. Diabetes Off. J. Ger. Soc. Endocrinol. Ger. Diabetes Assoc."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13098-018-0353-2","article-title":"The effects of probiotic supplementation on metabolic status in type 2 diabetic patients with coronary heart disease","volume":"10","author":"Raygan","year":"2018","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_304","unstructured":"Dimitrov, J., and Mikhailova, M. (2017). A Polybacterial Preparation with Health Benefits: With Antioxidant Effect, Lowering Cholesterol Concentration, Anti-Inflammatory Immunomodulatory Effect and Release of Bioactive Peptides Inhibiting Angiotensin-Converting Enzyme. (No. 2013153578), Patent 2627651 RF, IPC A61K 35\/747, C07K14\/47, C12N1\/20, A61P37\/02, A61P39\/06, A61P9\/12, A61P9\/02, A61P1\/14, patent holder LB BULGARIKUM PLC."},{"key":"ref_305","doi-asserted-by":"crossref","unstructured":"Nabi, X.H., Ma, C.Y., Manaer, T., Heizati, M., Wulazibieke, B., and Aierken, L. (2016). Anti-atherosclerotic effect of traditional fermented cheese whey in atherosclerotic rabbits and identification of probiotics. BMC Complement. Altern. Med., 16.","DOI":"10.1186\/s12906-016-1285-8"},{"key":"ref_306","doi-asserted-by":"crossref","unstructured":"Li, H.Y., Zhou, D.D., Gan, R.Y., Huang, S.Y., Zhao, C.N., Shang, A., Xu, X.Y., and Li, H.B. (2021). Effects and Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics on Metabolic Diseases Targeting Gut Microbiota: A Narrative Review. Nutrients, 13.","DOI":"10.3390\/nu13093211"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"846","DOI":"10.5551\/jat.GL2017","article-title":"Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017","volume":"25","author":"Kinoshita","year":"2018","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_308","first-page":"7","article-title":"Diagnosis and correction of lipid metabolism disorders for the prevention and treatment of atherosclerosis Russian recommendations, VII revision","volume":"1","author":"Kukharchuk","year":"2020","journal-title":"Atheroscler. Dyslipidemia"},{"key":"ref_309","unstructured":"(2018). Cardiovascular prevention 2017. National guidelines. Russ. J. Cardiol., 7\u2013122."},{"key":"ref_310","first-page":"787","article-title":"Updated Cardiovascular Prevention Guideline of the Brazilian Society of Cardiology\u20142019","volume":"113","author":"Oliveira","year":"2019","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_311","first-page":"e563","article-title":"2019 ACC\/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"140","author":"Arnett","year":"2019","journal-title":"Circulation"},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0828-282X(09)70715-9","article-title":"Canadian Cardiovascular Society\/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult\u20142009 recommendations","volume":"25","author":"Genest","year":"2009","journal-title":"Can. J. Cardiol."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.atherosclerosis.2016.08.018","article-title":"2016 ESC\/EAS Guidelines for the Management of Dyslipidaemias: The Task Force for the Management of Dyslipidaemias of the European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) Developed with the special contribution of the European Assocciation for Cardiovascular Prevention & Rehabilitation (EACPR)","volume":"253","author":"Catapano","year":"2016","journal-title":"Atherosclerosis"},{"key":"ref_314","unstructured":"Article, E.E. (2017). 2016 European Guidelines on Cardiovascular Disease Prevention in Clinical Practice. The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by Representatives of 10 Societies and by Invited Experts). Russ. J. Cardiol., 7\u201385. (In Russian)."},{"key":"ref_315","doi-asserted-by":"crossref","unstructured":"Biesiekierski, J.R., Livingstone, K.M., and Moschonis, G. (2019). Personalised Nutrition: Updates, Gaps and Next Steps. Nutrients, 11.","DOI":"10.3390\/nu11081793"},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"160110","DOI":"10.1183\/16000617.0110-2016","article-title":"Diet and exercise in the management of obstructive sleep apnoea and cardiovascular disease risk","volume":"26","author":"Dobrosielski","year":"2017","journal-title":"Eur. Respir. Rev. Off. J. Eur. Respir. Soc."},{"key":"ref_317","first-page":"194","article-title":"Utilization of nutrition-focused physical assessment in identifying micronutrient deficiencies","volume":"30","author":"Esper","year":"2015","journal-title":"Nutr. Clin. Pract. Off. Publ. Am. Soc. Parenter. Enter. 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