{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:43:07Z","timestamp":1778798587148,"version":"3.51.4"},"reference-count":28,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>We investigated the relationship between pachydrusen and choroidal thickness and age in eyes with polypoidal choroidal vasculopathy (PCV) and fellow eyes, compared to eyes with central serous chorioretinopathy (CSC). This retrospective study included 89 eyes with PCV and 146 eyes with CSC. The number, location, and shape of the pachydrusen and their association with choroidal thickness and age were analyzed. PCV eyes showed pachydrusen more frequently than eyes with CSC (52% vs. 20%, p &lt; 0.001). Large solitary type and clustered type were more frequent in PCV eyes compared to CSC eyes (p = 0.003 and p = 0.001, respectively). Subfoveal choroidal thickness was associated with pachydrusen in eyes with PCV (odds ratio [OR] 1.006, 95% confidence interval [CI] 1.001\u20131.011, p = 0.027), while age was associated with pachydrusen in CSC eyes (OR 1.137, 95% CI, 1.073\u20131.205; p &lt; 0.001). Pachydrusen were localized directly over the pachyvessel on optical coherence tomographic findings in approximately two thirds of PCV eyes and fellow eyes (62% and 67%, respectively). Risk factors for pachydrusen differ according to diseases. The presence of pachydrusen was associated with choroidal thickness in PCV, while the association with age was more prominent in CSC.<\/jats:p>","DOI":"10.3390\/ijms23158353","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T20:49:28Z","timestamp":1659041368000},"page":"8353","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Association of Pachydrusen Characteristics with Choroidal Thickness and Patient\u2019s Age in Polypoidal Choroidal Vasculopathy versus Central Serous Chorioretinopathy"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5281-1185","authenticated-orcid":false,"given":"Young Ho","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Korea University College of Medicine, Seoul 02841, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoo-Ri","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chungwoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kihwang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ajou University School of Medicine, Suwon 16499, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-1762","authenticated-orcid":false,"given":"Won Ki","family":"Lee","sequence":"additional","affiliation":[{"name":"Retina Center, Nune Eye Hospital, Seoul 06198, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41433-018-0158-4","article-title":"Pachychoroid disease","volume":"33","author":"Cheung","year":"2019","journal-title":"Eye"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/IAE.0000000000001689","article-title":"Disease expression in nonexudative age-related macular degeneration varies with choroidal thickness","volume":"38","author":"Spaide","year":"2018","journal-title":"Retina"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1097\/IAE.0000000000002019","article-title":"Prevalence and clinical characteristics of pachydrusen in polypoidal choroidal vasculopathy: Multimodal image study","volume":"39","author":"Lee","year":"2019","journal-title":"Retina"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00417-019-04284-4","article-title":"Clinical characteristics of pachydrusen in central serous chorioretinopathy","volume":"257","author":"Matsumoto","year":"2019","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/ijo.IJO_528_19","article-title":"Low incidence of pachydrusen in central serous chorioretinopathy in an Indian cohort","volume":"68","author":"Singh","year":"2020","journal-title":"Indian J. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.4103\/ijo.IJO_1757_18","article-title":"Pachydrusen in polypoidal choroidal vasculopathy in an Indian cohort","volume":"67","author":"Singh","year":"2019","journal-title":"Indian J. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"11906","DOI":"10.1038\/s41598-019-48494-6","article-title":"Clinical and genetic characteristics of pachydrusen in patients with exudative age-related macular degeneration","volume":"9","author":"Fukuda","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1097\/IAE.0b013e3182680a66","article-title":"Type 1 (sub-retinal pigment epithelial) neovascularization in central serous chorioretinopathy masquerading as neovascular age-related macular degeneration","volume":"32","author":"Fung","year":"2012","journal-title":"Retina"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1007\/s00417-018-4143-1","article-title":"Morphologic features of large choroidal vessel layer: Age-related macular degeneration, polypoidal choroidal vasculopathy, and central serous chorioretinopathy","volume":"256","author":"Baek","year":"2018","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.oret.2018.06.014","article-title":"Association between choroidal thickness and drusen subtypes in age-related macular degeneration","volume":"2","author":"Cheung","year":"2018","journal-title":"Ophthalmol. Retin."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ajo.2018.07.004","article-title":"Optical coherence tomography angiography quantitative assessment of choriocapillaris blood flow in central serous chorioretinopathy","volume":"19","author":"Rochepeau","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1007\/s00417-021-05180-6","article-title":"Pachydrusen, choroidal vascular hyperpermeability, and punctate hyperfluorescent spots","volume":"259","author":"Kang","year":"2021","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ajo.2016.07.023","article-title":"Choriocapillaris Flow Features Follow a Power Law Distribution: Implications for Characterization and Mechanisms of Disease Progression","volume":"170","author":"Spaide","year":"2016","journal-title":"Am. J. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/IAE.0000000000000742","article-title":"En Face imaging of pachychoroid spectrum disorders with swept-source optical coherence tomography","volume":"36","author":"Dansingani","year":"2016","journal-title":"Retina"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/IAE.0000000000002419","article-title":"Drusen subtypes and choroidal characteristics in Asian eyes with typical neovascular age-related macular degeneration","volume":"40","author":"Lee","year":"2020","journal-title":"Retina"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1097\/IAE.0000000000000998","article-title":"Choroidal thickness in patients with central serous chorioretinopathy: Assessment of Haller and Sattler Layers","volume":"36","author":"Chung","year":"2016","journal-title":"Retina"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/IAE.0b013e318263d11f","article-title":"Choroidal thickness in central serous chorioretinopathy","volume":"33","author":"Kuroda","year":"2013","journal-title":"Retina"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1097\/IAE.0b013e3181be0a83","article-title":"Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy","volume":"29","author":"Imamura","year":"2009","journal-title":"Retina"},{"key":"ref_19","first-page":"e222","article-title":"Altered plasma cytokine levels in acute and chronic central serous chorioretinopathy","volume":"99","author":"Sanak","year":"2021","journal-title":"Acta Ophthalmol."},{"key":"ref_20","first-page":"235","article-title":"Differences in anti-endothelial and anti-retinal antibody titers: Implications for the pathohysiology of acute and chronic central serous chorioretinopathy","volume":"71","author":"Chrzaszcz","year":"2020","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5565","DOI":"10.1038\/s41598-019-42052-w","article-title":"Choriocapillaris flow impairments in association with pachyvessel in early stages of pachychoroid","volume":"9","author":"Baek","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1097\/IAE.0000000000002966","article-title":"Polypoidal choroidal vasculopathy features vary according to subfoveal choroidal thickness","volume":"41","author":"Teo","year":"2021","journal-title":"Retina"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1097\/IAE.0000000000001346","article-title":"Choroidal morphology in eyes with polypoidal choroidal vasculopathy and normal or subnormal subfoveal choroidal thickness","volume":"36","author":"Lee","year":"2016","journal-title":"Retina"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"100973","DOI":"10.1016\/j.preteyeres.2021.100973","article-title":"Venous overload choroidopathy: A hypothetical framework for central serous chorioretinopathy and allied disorders","volume":"86","author":"Spaide","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/ceo.13438","article-title":"Choroidal morphology under pachydrusen","volume":"47","author":"Baek","year":"2019","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4093\/dmj.2020.0254","article-title":"Diabetes Fact Sheets in Korea, 2020: An appraisal of current status","volume":"45","author":"Jung","year":"2021","journal-title":"Diabetes Metab. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"495","DOI":"10.4070\/kcj.2021.0097","article-title":"Korea Heart Disease Fact Sheet 2020: Analysis of nationwide data","volume":"51","author":"Lee","year":"2021","journal-title":"Korean Circ. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/tvst.7.5.16","article-title":"Measurable range of subfoveal choroidal thickness with conventional spectral domain optical coherence tomography","volume":"7","author":"Kong","year":"2018","journal-title":"Transl. Vis. Sci. 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