{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:02:45Z","timestamp":1790542965125,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institute of Health Carlos III","award":["CD19\/00154"],"award-info":[{"award-number":["CD19\/00154"]}]},{"name":"Institute of Health Carlos III","award":["PI19\/01355"],"award-info":[{"award-number":["PI19\/01355"]}]},{"name":"Institute of Health Carlos III","award":["DTS20\/00179"],"award-info":[{"award-number":["DTS20\/00179"]}]},{"name":"Institute of Health Carlos III and the European Regional Development Fund","award":["CD19\/00154"],"award-info":[{"award-number":["CD19\/00154"]}]},{"name":"Institute of Health Carlos III and the European Regional Development Fund","award":["PI19\/01355"],"award-info":[{"award-number":["PI19\/01355"]}]},{"name":"Institute of Health Carlos III and the European Regional Development Fund","award":["DTS20\/00179"],"award-info":[{"award-number":["DTS20\/00179"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>We present a case report on an older woman with unspecific symptoms and predominant long-term gastrointestinal disturbances, acute overall health deterioration with loss of autonomy for daily activities, and cognitive impairment. Autopsy revealed the presence of alpha-synuclein deposits spread into intestinal mucosa lesions, enteric plexuses, pelvic and retroperitoneal nerves and ganglia, and other organs as well as Lewy pathology in the central nervous system (CNS). Moreover, we isolated norovirus from the patient, indicating active infection in the colon and detected colocalization of norovirus and alpha-synuclein in different regions of the patient\u2019s brain. In view of this, we report a concomitant norovirus infection with synthesis of alpha-synuclein in the gastrointestinal mucosa and Lewy pathology in the CNS, which might support Braak\u2019s hypothesis about the pathogenic mechanisms underlying synucleinopathies.<\/jats:p>","DOI":"10.3390\/ijms23158376","type":"journal-article","created":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T23:37:29Z","timestamp":1659310649000},"page":"8376","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Norovirus Intestinal Infection and Lewy Body Disease in an Older Patient with Acute Cognitive Impairment"],"prefix":"10.3390","volume":"23","author":[{"given":"Manuel","family":"Moreno-Valladares","sequence":"first","affiliation":[{"name":"Pathology Department, Donostia University Hospital, Osakidetza Basque Health Service, 20014 San Sebastian, Spain"},{"name":"Group of Cellular Oncology, Biodonostia Health Research Institute, 20014 San Sebastian, Spain"},{"name":"CIBER on Frailty and Healthy Aging (CIBERfes), Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7914-6683","authenticated-orcid":false,"given":"Veronica","family":"Moncho-Amor","sequence":"additional","affiliation":[{"name":"Group of Cellular Oncology, Biodonostia Health Research Institute, 20014 San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iraide","family":"Bernal-Simon","sequence":"additional","affiliation":[{"name":"Pathology Department, Donostia University Hospital, Osakidetza Basque Health Service, 20014 San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4756-9598","authenticated-orcid":false,"given":"E\u00f1aut","family":"Agirre-Iturrioz","sequence":"additional","affiliation":[{"name":"Pathology Department, Donostia University Hospital, Osakidetza Basque Health Service, 20014 San Sebastian, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-5357","authenticated-orcid":false,"given":"Mar\u00eda","family":"\u00c1lvarez-Satta","sequence":"additional","affiliation":[{"name":"Group of Cellular Oncology, Biodonostia Health Research Institute, 20014 San Sebastian, Spain"},{"name":"CIBER on Frailty and Healthy Aging (CIBERfes), Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ander","family":"Matheu","sequence":"additional","affiliation":[{"name":"Group of Cellular Oncology, Biodonostia Health Research Institute, 20014 San Sebastian, Spain"},{"name":"CIBER on Frailty and Healthy Aging (CIBERfes), Institute of Health Carlos III, 28029 Madrid, Spain"},{"name":"IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1111\/j.1471-4159.1992.tb10991.x","article-title":"Cloning and characterization of the cDNA encoding a novel brain-specific 14-kDa protein","volume":"59","author":"Tobe","year":"1992","journal-title":"J. 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