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Among the large number of VDR ligands that have been developed, we have previously shown that BXL-62 and Gemini-72, two C-20-modified vitamin D analogs are highly potent VDR agonists. In this study, we show that both VDR ligands restore the transcriptional activities of VDR variants unresponsive to the natural ligand and identified in patients with rickets. The elucidated mechanisms of action underlying the activities of these C-20-modified analogs emphasize the mutual adaptation of the ligand and the VDR ligand-binding pocket.<\/jats:p>","DOI":"10.3390\/ijms23158445","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T02:06:42Z","timestamp":1659319602000},"page":"8445","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants"],"prefix":"10.3390","volume":"23","author":[{"given":"Anna Y.","family":"Belorusova","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire (IGBMC), F-67400 Illkirch, France"},{"name":"Centre National de la Recherche Scientifique (CNRS), UMR 7104, F-67400 Illkirch, France"},{"name":"Institut National de la Sant\u00e9 et de la 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Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1248\/cpb.c19-00131","article-title":"Discovery of Nuclear Receptor Ligands and Elucidation of Their Mechanisms of Action","volume":"67","author":"Yamamoto","year":"2019","journal-title":"Chem. Pharm. Bull."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10551","DOI":"10.1074\/jbc.270.18.10551","article-title":"Distinct conformational changes induced by 20-epi analogues of 1 alpha,25-dihydroxyvitamin D3 are associated with enhanced activation of the vitamin D receptor","volume":"270","author":"Peleg","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.2174\/156802606777864962","article-title":"C-20 cyclopropyl vitamin D3 analogs","volume":"6","author":"Uskokovic","year":"2006","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.1073\/pnas.091018698","article-title":"Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands","volume":"98","author":"Rochel","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jsbmb.2006.12.003","article-title":"Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: Remodelling the LBP with one side chain rotation","volume":"103","author":"Ciesielski","year":"2007","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1039\/c1md00059d","article-title":"Structure-function study of gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097","volume":"2","author":"Huet","year":"2011","journal-title":"Med. Chem. Comm."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"eabg5982","DOI":"10.1126\/sciadv.abg5982","article-title":"Single-cell analyses unravel cell type-specific responses to a vitamin D analog in prostatic precancerous lesions","volume":"7","author":"Grelet","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1124\/mol.105.022079","article-title":"A novel vitamin D derivative activates bone morphogenetic protein signaling in MCF10 breast epithelial cells","volume":"69","author":"Lee","year":"2006","journal-title":"Mol. Pharm."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jsbmb.2016.09.015","article-title":"Structural analysis and biological activities of BXL0124, a gemini analog of vitamin D","volume":"173","author":"Belorusova","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1021\/jm400032t","article-title":"Diastereotopic and deuterium effects in gemini","volume":"56","author":"Maehr","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.celrep.2014.12.045","article-title":"A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects","volume":"10","author":"Huet","year":"2015","journal-title":"Cell. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1021\/jm801365a","article-title":"Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3","volume":"52","author":"Laverny","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.imlet.2010.03.006","article-title":"Efficacy of a potent and safe vitamin D receptor agonist for the treatment of inflammatory bowel disease","volume":"131","author":"Laverny","year":"2010","journal-title":"Immunol. Lett."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0145-2126(94)90081-7","article-title":"1,25(OH)2-16ene-vitamin D3 is a potent antileukemic agent with low potential to cause hypercalcemia","volume":"18","author":"Jung","year":"1994","journal-title":"Leuk. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0039-128X(00)00142-2","article-title":"Differential activities of 1alpha,25-dihydroxy-16-ene-vitamin D(3) analogs and their 3-epimers on human promyelocytic leukemia (HL-60) cell differentiation and apoptosis","volume":"66","author":"Nakagawa","year":"2001","journal-title":"Steroids"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1021\/jm970761l","article-title":"Conformation-function relationship of vitamin D: Conformational analysis predicts potential side-chain structure","volume":"41","author":"Yamada","year":"1998","journal-title":"J. Med. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1530\/JME-16-0048","article-title":"Transcriptional activation of the wild-type and mutant vitamin D receptors by vitamin D3 analogs","volume":"57","author":"Futawaka","year":"2016","journal-title":"J. Mol. Endocrinol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1359\/JBMR.050410","article-title":"Enhanced coactivator binding and transcriptional activation of mutant vitamin D receptors from patients with hereditary 1,25-dihydroxyvitamin D-resistant rickets by phosphorylation and vitamin D analogs","volume":"20","author":"Liu","year":"2005","journal-title":"J. Bone Min. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jsbmb.2016.11.008","article-title":"Novel screening system for high-affinity ligand of heredity vitamin D-resistant rickets-associated vitamin D receptor mutant R274L using bioluminescent sensor","volume":"167","author":"Mano","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.gene.2012.09.078","article-title":"Enteral calcium infusion used successfully as treatment for a patient with hereditary vitamin D resistant rickets (HVDRR) without alopecia: A novel mutation","volume":"512","author":"Huang","year":"2013","journal-title":"Gene"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1359\/jbmr.2002.17.9.1728","article-title":"Tryptophan missense mutation in the ligand-binding domain of the vitamin D receptor causes severe resistance to 1,25-dihydroxyvitamin D","volume":"17","author":"Nguyen","year":"2002","journal-title":"J. Bone Min. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1021\/jm900780q","article-title":"Calcitriol derivatives with two different side chains at C-20. V. Potent inhibitors of mammary carcinogenesis and inducers of leukemia differentiation","volume":"52","author":"Maehr","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","article-title":"Xds","volume":"66","author":"Kabsch","year":"2010","journal-title":"Acta Cryst. D Biol. Cryst."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1107\/S0907444905036693","article-title":"Scaling and assessment of data quality","volume":"62","author":"Evans","year":"2006","journal-title":"Acta Cryst. D Biol. Cryst."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1107\/S0907444905007894","article-title":"A robust bulk-solvent correction and anisotropic scaling procedure","volume":"61","author":"Afonine","year":"2005","journal-title":"Acta Cryst. D Biol. Cryst."},{"key":"ref_35","unstructured":"Bricogne, G., Blanc, E., Brandl, M., Flensburg, C., Keller, P., Paciorek, W., Roversi, P., Sharff, A., Smart, O.S., and Vonrhein, C. (2011). BUSTER Version 2.11.2, Global Phasing Ltd."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: Model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Cryst. D Biol. Cryst."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/15\/8445\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:59:42Z","timestamp":1760140782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/15\/8445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,30]]},"references-count":36,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["ijms23158445"],"URL":"https:\/\/doi.org\/10.3390\/ijms23158445","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,30]]}}}