{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:19:32Z","timestamp":1791523172306,"version":"4.3.4"},"reference-count":129,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health (Rome, Italy)","award":["NET-2016-02361805 (WP5)"],"award-info":[{"award-number":["NET-2016-02361805 (WP5)"]}]},{"name":"Ministry of Health (Rome, Italy)","award":["PS- neuro ex 56\/05\/15"],"award-info":[{"award-number":["PS- neuro ex 56\/05\/15"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Murine models are fundamental in the study of clinical conditions and the development of new drugs and treatments. Transgenic technology has started to offer advantages in oncology, encompassing all research fields related to the study of painful syndromes. Knockout mice or mice overexpressing genes encoding for proteins linked to pain development and maintenance can be produced and pain models can be applied to transgenic mice to model the most disabling neurological conditions. Due to the association of movement disorders with sensitivity and pain processing, our group focused for the first time on the role of the torsinA gene GAG deletion\u2014responsible for DYT1 dystonia\u2014in baseline sensitivity and neuropathic responses. The aim of the present report are to review the complex network that exists between the chaperonine-like protein torsinA and the baseline sensitivity pattern\u2014which are fundamental in neuropathic pain\u2014and to point at its possible role in neurodegenerative diseases.<\/jats:p>","DOI":"10.3390\/ijms23158580","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T21:41:37Z","timestamp":1659476497000},"page":"8580","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Transgenic Mice for the Translational Study of Neuropathic Pain and Dystonia"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-7058","authenticated-orcid":false,"given":"Damiana","family":"Scuteri","sequence":"first","affiliation":[{"name":"Pharmacotechnology Documentation and Transfer Unit, Preclinical and Translational Pharmacology, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"},{"name":"Regional Center for Serious Brain Injuries, S. Anna Institute, 88900 Crotone, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9146-8554","authenticated-orcid":false,"given":"Kengo","family":"Hamamura","sequence":"additional","affiliation":[{"name":"Center for Clinical Pharmacology and Pharmaceutics, Nihon Pharmaceutical University, Saitama 362-0806, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chizuko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Physiology and Anatomy, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4867-1378","authenticated-orcid":false,"given":"Paolo","family":"Tonin","sequence":"additional","affiliation":[{"name":"Regional Center for Serious Brain Injuries, S. Anna Institute, 88900 Crotone, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8540-6218","authenticated-orcid":false,"given":"Giacinto","family":"Bagetta","sequence":"additional","affiliation":[{"name":"Pharmacotechnology Documentation and Transfer Unit, Preclinical and Translational Pharmacology, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6472-0697","authenticated-orcid":false,"given":"Maria Tiziana","family":"Corasaniti","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University \u201cMagna Graecia\u201d of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"ref_1","unstructured":"Schappert, S.M., and Burt, C.W. (2006). 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