{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:10:31Z","timestamp":1788293431979,"version":"build-2803163510"},"reference-count":173,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001823","name":"ERDF-Project","doi-asserted-by":"publisher","award":["CZ.02.1.01\/0.0\/0.0\/17_048\/0007421"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/17_048\/0007421"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Charles University, Faculty of Medicine in Hradec Kralove, Czech Republic","award":["CZ.02.1.01\/0.0\/0.0\/17_048\/0007421"],"award-info":[{"award-number":["CZ.02.1.01\/0.0\/0.0\/17_048\/0007421"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In the field of science, technology and medicine, carbon-based nanomaterials and nanoparticles (CNMs) are becoming attractive nanomaterials that are increasingly used. However, it is important to acknowledge the risk of nanotoxicity that comes with the widespread use of CNMs. CNMs can enter the body via inhalation, ingestion, intravenously or by any other route, spread through the bloodstream and penetrate tissues where (in both compartments) they interact with components of the immune system. Like invading pathogens, CNMs can be recognized by large numbers of receptors that are present on the surface of innate immune cells, notably monocytes and macrophages. Depending on the physicochemical properties of CNMs, i.e., shape, size, or adsorbed contamination, phagocytes try to engulf and process CNMs, which might induce pro\/anti-inflammatory response or lead to modulation and disruption of basic immune activity. This review focuses on existing data on the immunotoxic potential of CNMs, particularly in professional phagocytes, as they play a central role in processing and eliminating foreign particles. The results of immunotoxic studies are also described in the context of the entry routes, impacts of contamination and means of possible elimination. Mechanisms of proinflammatory effect depending on endocytosis and intracellular distribution of CNMs are highlighted as well.<\/jats:p>","DOI":"10.3390\/ijms23168889","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T09:42:56Z","timestamp":1660124576000},"page":"8889","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Immunotoxicity of Carbon-Based Nanomaterials, Starring Phagocytes"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1581-5531","authenticated-orcid":false,"given":"Tereza","family":"Svadlakova","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Allergology, University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University, 50005 Hradec Kralove, Czech Republic"},{"name":"Department of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 50003 Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9865-9991","authenticated-orcid":false,"given":"Drahomira","family":"Holmannova","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 50003 Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Kolackova","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergology, University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University, 50005 Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9444-8065","authenticated-orcid":false,"given":"Andrea","family":"Malkova","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 50003 Hradec Kralove, Czech Republic"},{"name":"Department of Pathological Physiology, Faculty of Medicine in Hradec Kralove, Charles University, 50003 Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Krejsek","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergology, University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University, 50005 Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenek","family":"Fiala","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, 50003 Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/0019-5278.64607","article-title":"Understanding the mechanism of toxicity of carbon nanoparticles in humans in the new millennium: A systemic review","volume":"14","author":"Sharma","year":"2010","journal-title":"Indian J. Occup. Environ. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s41061-019-0278-8","article-title":"Carbon Nanotubes in Biomedicine","volume":"378","author":"Negri","year":"2020","journal-title":"Top. Curr. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.matpr.2020.10.593","article-title":"Carbon-based nanomaterials: Synthesis and prospective applications","volume":"44","author":"Rao","year":"2021","journal-title":"Mater. Today Proc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1126\/science.1102896","article-title":"Electric field effect in atomically thin carbon films","volume":"306","author":"Novoselov","year":"2004","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nmat1849","article-title":"The rise of graphene","volume":"6","author":"Geim","year":"2007","journal-title":"Nat. Mater."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6156","DOI":"10.1021\/cr3000412","article-title":"Functionalization of Graphene: Covalent and Non-Covalent Approaches, Derivatives and Applications","volume":"112","author":"Georgakilas","year":"2012","journal-title":"Chem. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/smll.201001522","article-title":"Enhanced Chemotherapy Efficacy by Sequential Delivery of siRNA and Anticancer Drugs Using PEI-Grafted Graphene Oxide","volume":"7","author":"Zhang","year":"2011","journal-title":"Small"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1002\/adma.201104964","article-title":"Multimodal Imaging Guided Photothermal Therapy using Functionalized Graphene Nanosheets Anchored with Magnetic Nanoparticles","volume":"24","author":"Yang","year":"2012","journal-title":"Adv. Mater."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1038\/s41598-020-59755-0","article-title":"Interactions of graphene oxide and graphene nanoplatelets with the in vitro Caco-2\/HT29 model of intestinal barrier","volume":"10","author":"Domenech","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nnano.2009.58","article-title":"Chemical methods for the production of graphenes","volume":"4","author":"Park","year":"2009","journal-title":"Nat. Nanotechnol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.1171245","article-title":"Large-Area Synthesis of High-Quality and Uniform Graphene Films on Copper Foils","volume":"324","author":"Li","year":"2009","journal-title":"Science"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3389\/fchem.2020.00424","article-title":"Recent Advances on Graphene Quantum Dots for Bioimaging Applications","volume":"8","author":"Younis","year":"2020","journal-title":"Front. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.2147\/IJN.S58783","article-title":"Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug","volume":"9","author":"Xu","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"10708","DOI":"10.1021\/nn303904z","article-title":"Fabrication of Highly-Aligned, Conductive, and Strong Graphene Papers Using Ultralarge Graphene Oxide Sheets","volume":"6","author":"Lin","year":"2012","journal-title":"ACS Nano"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/354056a0","article-title":"Helical microtubules of graphitic carbon","volume":"354","author":"Iijima","year":"1991","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s40898-020-00009-x","article-title":"Carbon nanotubes and their polymeric composites: The applications in tissue engineering","volume":"5","author":"Huang","year":"2020","journal-title":"Biomanuf. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1021\/je900296s","article-title":"Solubility of Light Fullerenes in Organic Solvents","volume":"55","author":"Semenov","year":"2009","journal-title":"J. Chem. Eng. Data"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"110091","DOI":"10.1016\/j.matdes.2021.110091","article-title":"Nanodiamonds: Synthesis, properties, and applications in nanomedicine","volume":"210","author":"Qin","year":"2021","journal-title":"Mater. Des."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"17256","DOI":"10.1021\/jp404311a","article-title":"Understanding the Surfaces of Nanodiamonds","volume":"117","author":"Paci","year":"2013","journal-title":"J. Phys. Chem. C"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7521","DOI":"10.1007\/s00216-015-8849-1","article-title":"Improving surface and defect center chemistry of fluorescent nanodiamonds for imaging purposes\u2014A review","volume":"407","author":"Nagl","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1021\/acscentsci.0c01306","article-title":"Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications","volume":"6","author":"Liu","year":"2020","journal-title":"ACS Central Sci."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Lategan, K., Fowler, J., Bayati, M., de Cortalezzi, M.F., and Pool, E. (2018). The Effects of Carbon Dots on Immune System Biomarkers, Using the Murine Macrophage Cell Line RAW 264.7 and Human Whole Blood Cell Cultures. Nanomaterials, 8.","DOI":"10.3390\/nano8060388"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10753-019-01165-0","article-title":"Differential Immunomodulatory Effect of Carbon Dots Influenced by the Type of Surface Passivation Agent","volume":"43","author":"Ayaz","year":"2020","journal-title":"Inflammation"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Mousavi, S.M., Hashemi, S.A., Kalashgrani, M.Y., Omidifar, N., Bahrani, S., Rao, N.V., Babapoor, A., Gholami, A., and Chiang, W.-H. (2022). Bioactive Graphene Quantum Dots Based Polymer Composite for Biomedical Applications. Polymers, 14.","DOI":"10.3390\/polym14030617"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Gaur, M., Misra, C., Yadav, A.B., Swaroop, S., Maolmhuaidh, F., Bechelany, M., and Barhoum, A. (2021). Biomedical Applications of Carbon Nanomaterials: Fullerenes, Quantum Dots, Nanotubes, Nanofibers, and Graphene. Materials, 14.","DOI":"10.3390\/ma14205978"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1080\/21691401.2020.1817052","article-title":"Development of graphene based nanocomposites towards medical and biological applications","volume":"48","author":"Mousavi","year":"2020","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Mousavi, S.M., Yousefi, K., Hashemi, S.A., Afsa, M., BahranI, S., Gholami, A., Ghahramani, Y., Alizadeh, A., and Chiang, W.-H. (2021). Renewable Carbon Nanomaterials: Novel Resources for Dental Tissue Engineering. Nanomaterials, 11.","DOI":"10.3390\/nano11112800"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Bilal, M., and Iqbal, H.M.N. (2020). New Insights on Unique Features and Role of Nanostructured Materials in Cosmetics. Cosmetics, 7.","DOI":"10.3390\/cosmetics7020024"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Angelopoulou, P., Giaouris, E., and Gardikis, K. (2022). Applications and Prospects of Nanotechnology in Food and Cosmetics Preservation. Nanomaterials, 12.","DOI":"10.3390\/nano12071196"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3389\/fimmu.2017.00673","article-title":"Graphene and the Immune System: A Romance of Many Dimensions","volume":"8","author":"Mukherjee","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12989-020-00378-8","article-title":"Occupational exposure to carbon black nanoparticles increases inflammatory vascular disease risk: An implication of an ex vivo biosensor assay","volume":"17","author":"Tang","year":"2020","journal-title":"Part. Fibre Toxicol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"503405","DOI":"10.1016\/j.mrgentox.2021.503405","article-title":"Pro-inflammatory response and genotoxicity caused by clay and graphene nanomaterials in A549 and THP-1 cells","volume":"872","author":"Vogel","year":"2021","journal-title":"Mutat. Res.\/Genet. Toxicol. Environ. Mutagenesis"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1907609","DOI":"10.1002\/smll.201907609","article-title":"Carbon Nanomaterials Promote M1\/M2 Macrophage Activation","volume":"16","author":"Kinaret","year":"2020","journal-title":"Small"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/jat.3361","article-title":"Pulmonary persistence of graphene nanoplatelets may disturb physiological and immunological homeostasis","volume":"37","author":"Park","year":"2016","journal-title":"J. Appl. Toxicol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3109\/17435390.2015.1133865","article-title":"28-Day inhalation toxicity of graphene nanoplatelets in Sprague-Dawley rats","volume":"10","author":"Kim","year":"2016","journal-title":"Nanotoxicology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"19316","DOI":"10.1039\/C8NR06535G","article-title":"Peroxidase mimicking DNAzymes degrade graphene oxide","volume":"10","author":"Kurapati","year":"2018","journal-title":"Nanoscale"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"10113","DOI":"10.1021\/acsnano.5b03708","article-title":"Carbon Nanotube Degradation in Macrophages: Live Nanoscale Monitoring and Understanding of Biological Pathway","volume":"9","author":"Elgrabli","year":"2015","journal-title":"ACS Nano"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/wnan.166","article-title":"Interactions of nanomaterials with the immune system","volume":"4","author":"Hussain","year":"2011","journal-title":"WIREs Nanomed. Nanobiotechnology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1743-8977-8-22","article-title":"Nanoparticle exposure at nanotechnology workplaces: A review","volume":"8","author":"Kuhlbusch","year":"2011","journal-title":"Part. Fibre Toxicol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1289\/ehp.7339","article-title":"Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles","volume":"113","year":"2005","journal-title":"Env. Health Perspect"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.nano.2015.11.011","article-title":"Biological interactions of carbon-based nanomaterials: From coronation to degradation","volume":"12","author":"Bhattacharya","year":"2016","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.2147\/IJN.S129300","article-title":"Protein corona: A new approach for nanomedicine design","volume":"12","author":"Nguyen","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-3-319-47754-1_8","article-title":"Biological Surface Adsorption Index of Nanomaterials: Modelling Surface Interactions of Nanomaterials with Biomolecules","volume":"947","author":"Chen","year":"2017","journal-title":"Model. Toxic. Nanoparticles"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Graham, U.M., Jacobs, G., Yokel, R.A., Davis, B.H., Dozier, A.K., Birch, M.E., Tseng, M.T., Oberd\u00f6rster, G., Elder, A., and DeLouise, L. (2017). From Dose to Response: In Vivo Nanoparticle Processing and Potential Toxicity. Modelling the Toxicity of Nanoparticles, Springer.","DOI":"10.1007\/978-3-319-47754-1_4"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"9457683","DOI":"10.1155\/2019\/9457683","article-title":"Interactions of Carbon Nanotubes and Carbon Nanohorns with a Model Membrane Layer and Lung Surfactant In Vitro","volume":"2019","author":"Kondej","year":"2019","journal-title":"J. Nanomater."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5413","DOI":"10.1021\/acsnano.5b01181","article-title":"Biophysical Influence of Airborne Carbon Nanomaterials on Natural Pulmonary Surfactant","volume":"9","author":"Valle","year":"2015","journal-title":"ACS Nano"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5715","DOI":"10.1021\/nn500475u","article-title":"Carbon Nanotube Translocation to Distant Organs after Pulmonary Exposure: Insights from in Situ\u00a014C-Radiolabeling and Tissue Radioimaging","volume":"8","author":"Czarny","year":"2014","journal-title":"ACS Nano"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1038\/am.2013.7","article-title":"Biodistribution and pulmonary toxicity of intratracheally instilled graphene oxide in mice","volume":"5","author":"Li","year":"2013","journal-title":"NPG Asia Mater."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Bergamaschi, E., Garzaro, G., Jones, G.W., Buglisi, M., Caniglia, M., Godono, A., Bosio, D., Fenoglio, I., and Canu, I.G. (2021). Occupational Exposure to Carbon Nanotubes and Carbon Nanofibres: More Than a Cobweb. Nanomaterials, 11.","DOI":"10.3390\/nano11030745"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S1470-2045(14)71109-X","article-title":"Carcinogenicity of fluoro-edenite, silicon carbide fibres and whiskers, and carbon nanotubes","volume":"15","author":"Grosse","year":"2014","journal-title":"Lancet Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"012031","DOI":"10.1088\/1757-899X\/98\/1\/012031","article-title":"Workers\u2019 cytokines profiling upon exposure to MWCNT aerosol in occupational settings","volume":"98","author":"Fatkhutdinova","year":"2015","journal-title":"IOP Conf. Ser. Mater. Sci. Eng."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.taap.2016.02.016","article-title":"Fibrosis biomarkers in workers exposed to MWCNTs","volume":"299","author":"Fatkhutdinova","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Shvedova, A.A., Yanamala, N., Kisin, E.R., Khailullin, T.O., Birch, M.E., and Fatkhutdinova, L. (2016). Integrated Analysis of Dysregulated ncRNA and mRNA Expression Profiles in Humans Exposed to Carbon Nanotubes. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150628"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/17435390.2017.1308031","article-title":"A cross-sectional study of changes in markers of immunological effects and lung health due to exposure to multi-walled carbon nanotubes","volume":"11","author":"Vlaanderen","year":"2017","journal-title":"Nanotoxicology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/oemed-2017-104796","article-title":"Cardiovascular effects among workers exposed to multiwalled carbon nanotubes","volume":"75","author":"Kuijpers","year":"2018","journal-title":"Occup. Environ. Med."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Berger, M., De Boer, J.D., Lutter, R., Makkee, M., Sterk, P.J., Kemper, E.M., and Van Der Zee, J.S. (2017). Pulmonary challenge with carbon nanoparticles induces a dose-dependent increase in circulating leukocytes in healthy males. BMC Pulm. Med., 17.","DOI":"10.1186\/s12890-017-0463-x"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Yang, S.-T., Liu, X., and Xie, J. (2016). Biodistribution and Pharmacokinetics of Carbon Nanomaterials In Vivo. Biomedical Applications and Toxicology of Carbon Nanomaterials, Wiley.","DOI":"10.1002\/9783527692866.ch3"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"13997","DOI":"10.1021\/acs.analchem.0c02909","article-title":"Biodistribution of Graphene Oxide Determined through Postadministration Labeling with DNA-Conjugated Gold Nanoparticles and ICPMS","volume":"92","author":"Lin","year":"2020","journal-title":"Anal. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1016\/j.biomaterials.2011.11.064","article-title":"The influence of surface chemistry and size of nanoscale graphene oxide on photothermal therapy of cancer using ultra-low laser power","volume":"33","author":"Yang","year":"2011","journal-title":"Biomaterials"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S1001-0742(12)60252-6","article-title":"The ex vivo and in vivo biological performances of graphene oxide and the impact of surfactant on graphene oxide\u2019s biocompatibility","volume":"25","author":"Qu","year":"2013","journal-title":"J. Environ. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"075101","DOI":"10.1088\/0957-4484\/19\/7\/075101","article-title":"A generally adoptable radiotracing method for tracking carbon nanotubes in animals","volume":"19","author":"Deng","year":"2008","journal-title":"Nanotechnology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1080\/17435390.2021.1919778","article-title":"Comparative assessments of the biodistribution and toxicity of oxidized single-walled carbon nanotubes dispersed with two different reagents after intravenous injection","volume":"15","author":"Zhang","year":"2021","journal-title":"Nanotoxicology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1039\/D0NJ04762G","article-title":"Preparation, biodistribution and dosimetry study of Tc-99m labeled N-doped graphene quantum dot nanoparticles as a multimodular radiolabeling agent","volume":"45","author":"Gharepapagh","year":"2021","journal-title":"N. J. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jconrel.2021.08.028","article-title":"The impact of graphene oxide sheet lateral dimensions on their pharmacokinetic and tissue distribution profiles in mice","volume":"338","author":"Jasim","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.cell.2020.02.041","article-title":"Toll-like Receptors and the Control of Immunity","volume":"180","author":"Fitzgerald","year":"2020","journal-title":"Cell"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"6811","DOI":"10.1016\/j.biomaterials.2005.04.063","article-title":"Endotoxin: The uninvited guest","volume":"26","author":"Gorbet","year":"2005","journal-title":"Biomaterials"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"8829","DOI":"10.1021\/la904589p","article-title":"Binding of Functionalized Paramagnetic Nanoparticles to Bacterial Lipopolysaccharides And DNA","volume":"26","author":"Bromberg","year":"2010","journal-title":"Langmuir"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0142-9612(99)00022-8","article-title":"Functionalized nanoparticles for endotoxin binding in aqueous solutions","volume":"20","author":"Darkow","year":"1999","journal-title":"Biomaterials"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1021\/nl060860z","article-title":"The Importance of an Endotoxin-Free Environment during the Production of Nanoparticles Used in Medical Applications","volume":"6","author":"Vallhov","year":"2006","journal-title":"Nano Lett."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/jat.3477","article-title":"Graphene and carbon nanotubes activate different cell surface receptors on macrophages before and after deactivation of endotoxins","volume":"37","author":"Lahiani","year":"2017","journal-title":"J. Appl. Toxicol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1039\/C4TX00193A","article-title":"Titanium dioxide nanoparticles enhance macrophage activation by LPS through a TLR4-dependent intracellular pathway","volume":"4","author":"Bianchi","year":"2015","journal-title":"Toxicol. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"7135","DOI":"10.1039\/c2nr31355c","article-title":"Enhancement of lipopolysaccharide-induced nitric oxide and interleukin-6 production by PEGylated gold nanoparticles in RAW264.7 cells","volume":"4","author":"Liu","year":"2012","journal-title":"Nanoscale"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1080\/17435390.2017.1401142","article-title":"Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation","volume":"11","author":"Li","year":"2017","journal-title":"Nanotoxicology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature13683","article-title":"Inflammatory caspases are innate immune receptors for intracellular LPS","volume":"514","author":"Shi","year":"2014","journal-title":"Nature"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2147\/JIR.S141220","article-title":"Spotlight on the NLRP3 inflammasome pathway","volume":"11","author":"Groslambert","year":"2018","journal-title":"J. Inflamm. Res."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Svadlakova, T., Hubatka, F., Turanek Knotigova, P., Kulich, P., Masek, J., Kotoucek, J., Macak, J., Motola, M., Kalbac, M., and Kolackova, M. (2020). Proinflammatory Effect of Carbon-Based Nanomaterials: In Vitro Study on Stimulation of Inflammasome NLRP3 via Destabilisation of Lysosomes. Nanomaterials, 10.","DOI":"10.3390\/nano10030418"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/j.cub.2004.10.027","article-title":"Identification of bacterial muramyl dipeptide as activator of the NALP3\/cryopyrin inflammasome","volume":"14","author":"Martinon","year":"2004","journal-title":"Curr. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1743-8977-9-41","article-title":"Contamination of nanoparticles by endotoxin: Evaluation of different test methods","volume":"9","author":"Smulders","year":"2012","journal-title":"Part. Fibre Toxicol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"8450","DOI":"10.1021\/acsami.7b00543","article-title":"Carbon Nanotubes Activate Limulus Amebocyte Lysate Coagulation by Interface Adsorption","volume":"9","author":"Yang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Mukherjee, S.P., Lozano, N., Kucki, M., Del Rio-Castillo, A.E., Newman, L., V\u00e1zquez, E., Kostarelos, K., Wick, P., and Fadeel, B. (2016). Detection of Endotoxin Contamination of Graphene Based Materials Using the TNF-\u03b1 Expression Test and Guidelines for Endotoxin-Free Graphene Oxide Production. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0166816"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Svadlakova, T., Kolackova, M., Vankova, R., Karakale, R., Malkova, A., Kulich, P., Hubatka, F., Turanek-Knotigova, P., Kratochvilova, I., and Raska, M. (2021). Carbon-Based Nanomaterials Increase Reactivity of Primary Monocytes towards Various Bacteria and Modulate Their Differentiation into Macrophages. Nanomaterials, 11.","DOI":"10.3390\/nano11102510"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/s41598-018-19521-9","article-title":"Macrophage sensing of single-walled carbon nanotubes via Toll-like receptors","volume":"8","author":"Mukherjee","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.nantod.2015.06.006","article-title":"Nanoparticle uptake: The phagocyte problem","volume":"10","author":"Gustafson","year":"2015","journal-title":"Nano Today"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","article-title":"Diversity, Mechanisms, and Significance of Macrophage Plasticity","volume":"15","author":"Locati","year":"2020","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/s41598-017-01746-9","article-title":"Length effects on the dynamic process of cellular uptake and exocytosis of single-walled carbon nanotubes in murine macrophage cells","volume":"7","author":"Cui","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Wang, R., Lohray, R., Chow, E., Gangupantula, P., Smith, L., and Draper, R. (2020). Selective Uptake of Carboxylated Multi-Walled Carbon Nanotubes by Class A Type 1 Scavenger Receptors and Impaired Phagocytosis in Alveolar Macrophages. Nanomaterials, 10.","DOI":"10.3390\/nano10122417"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Huynh, M., Mikoryak, C., Pantano, P., and Draper, R. (2021). Scavenger Receptor A1 Mediates the Uptake of Carboxylated and Pristine Multi-Walled Carbon Nanotubes Coated with Bovine Serum Albumin. Nanomaterials, 11.","DOI":"10.3390\/nano11020539"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1477-3155-9-45","article-title":"Single wall carbon nanotubes enter cells by endocytosis and not membrane penetration","volume":"9","author":"Yaron","year":"2011","journal-title":"J. Nanobiotechnol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"12295","DOI":"10.1073\/pnas.1222276110","article-title":"Graphene microsheets enter cells through spontaneous membrane penetration at edge asperities and corner sites","volume":"110","author":"Li","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1021\/acs.molpharmaceut.9b00225","article-title":"Application of Advanced Microscopic Methods to Study the Interaction of Carboxylated Fluorescent Nanodiamonds with Membrane Structures in THP-1 Cells: Activation of Inflammasome NLRP3 as the Result of Lysosome Destabilization","volume":"16","author":"Hubatka","year":"2019","journal-title":"Mol. Pharm."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Li, L., Chen, L., Lu, Y., Li, B., Hu, R., Huang, L., Zhang, T., Wei, X., Yang, Z., and Mao, C. (2022). Aggregated carbon dots-loaded macrophages treat sepsis by eliminating multidrug-resistant bacteria and attenuating inflammation. Aggregate, e200.","DOI":"10.1002\/agt2.200"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1016\/j.carbon.2007.05.011","article-title":"An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammatory mediators and frustrated phagocytosis","volume":"45","author":"Brown","year":"2007","journal-title":"Carbon"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.tiv.2015.06.012","article-title":"Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos","volume":"29","author":"Boyles","year":"2015","journal-title":"Toxicol. Vitr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"324","DOI":"10.5114\/ceji.2017.70978","article-title":"Interaction and cellular uptake of surface-modified carbon dot nanoparticles by J774.1 macrophages","volume":"3","author":"Thoo","year":"2017","journal-title":"Central Eur. J. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"100243","DOI":"10.1016\/j.colcom.2020.100243","article-title":"The effect of surface charge on cellular uptake and inflammatory behavior of carbon dots","volume":"35","author":"Usman","year":"2020","journal-title":"Colloids Interface Sci. Commun."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"15214","DOI":"10.1039\/C5NR01839K","article-title":"Protein corona mitigates the cytotoxicity of graphene oxide by reducing its physical interaction with cell membrane","volume":"7","author":"Duan","year":"2015","journal-title":"Nanoscale"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"7208","DOI":"10.1038\/s41467-021-27406-1","article-title":"Influence of the chirality of carbon nanodots on their interaction with proteins and cells","volume":"12","author":"Yan","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.1021\/nn5066606","article-title":"Reduced Cytotoxicity of Graphene Nanosheets Mediated by Blood-Protein Coating","volume":"9","author":"Chong","year":"2015","journal-title":"ACS Nano"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"16968","DOI":"10.1073\/pnas.1105270108","article-title":"Binding of blood proteins to carbon nanotubes reduces cytotoxicity","volume":"108","author":"Ge","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"3488","DOI":"10.1039\/C3NR05772K","article-title":"Immunotoxicity of nanoparticles: A computational study suggests that CNTs and C60 fullerenes might be recognized as pathogens by Toll-like receptors","volume":"6","author":"Turabekova","year":"2014","journal-title":"Nanoscale"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.2147\/IJN.S254808","article-title":"Protein\u2013Nanoparticle Interaction: Corona Formation and Conformational Changes in Proteins on Nanoparticles","volume":"15","author":"Park","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molimm.2005.02.006","article-title":"Complement activation and protein adsorption by carbon nanotubes","volume":"43","author":"Flahaut","year":"2006","journal-title":"Mol. Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.nano.2018.09.009","article-title":"Recognition protein C1q of innate immunity agglutinates nanodiamonds without activating complement","volume":"18","author":"Belime","year":"2018","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.biomaterials.2015.11.028","article-title":"Soluble and immobilized graphene oxide activates complement system differently dependent on surface oxidation state","volume":"78","author":"Wibroe","year":"2016","journal-title":"Biomaterials"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1021\/am302706g","article-title":"Functionalization of Graphene Oxide Generates a Unique Interface for Selective Serum Protein Interactions","volume":"5","author":"Tan","year":"2013","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"10161","DOI":"10.1021\/acsnano.6b05409","article-title":"Stealth Immune Properties of Graphene Oxide Enabled by Surface-Bound Complement Factor H","volume":"10","author":"Belling","year":"2016","journal-title":"ACS Nano"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"5991","DOI":"10.2147\/IJN.S249717","article-title":"Poly(Ethylene Glycol) Functionalized Graphene Oxide in Tissue Engineering: A Review on Recent Advances","volume":"15","author":"Ghosh","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"13569","DOI":"10.1039\/c3ra40852c","article-title":"PEGylated carbon nanotubes: Preparation, properties and applications","volume":"3","author":"Ravelli","year":"2013","journal-title":"RSC Adv."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"14537","DOI":"10.1038\/ncomms14537","article-title":"PEGylated graphene oxide elicits strong immunological responses despite surface passivation","volume":"8","author":"Luo","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1021\/acsnano.6b00539","article-title":"Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation","volume":"10","author":"Xu","year":"2016","journal-title":"ACS Nano"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Khramtsov, P., Bochkova, M., Timganova, V., Nechaev, A., Uzhviyuk, S., Shardina, K., Maslennikova, I., Rayev, M., and Zamorina, S. (2021). Interaction of Graphene Oxide Modified with Linear and Branched PEG with Monocytes Isolated from Human Blood. Nanomaterials, 12.","DOI":"10.3390\/nano12010126"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejpb.2015.03.007","article-title":"It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system","volume":"95","author":"Farrera","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.carbon.2020.01.003","article-title":"Impact of the surface functionalization on nanodiamond biocompatibility: A comprehensive view on human blood immune cells","volume":"160","author":"Fusco","year":"2020","journal-title":"Carbon"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Malkova, A., Svadlakova, T., Singh, A., Kolackova, M., Vankova, R., Borsky, P., Holmannova, D., Karas, A., Borska, L., and Fiala, Z. (2021). In Vitro Assessment of the Genotoxic Potential of Pristine Graphene Platelets. Nanomaterials, 11.","DOI":"10.3390\/nano11092210"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.carbon.2018.05.012","article-title":"Single exposure to aerosolized graphene oxide and graphene nanoplatelets did not initiate an acute biological response in a 3D human lung model","volume":"137","author":"Drasler","year":"2018","journal-title":"Carbon"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Malanagahalli, S., Murera, D., Mart\u00edn, C., Lin, H., Wadier, N., Dumortier, H., V\u00e1zquez, E., and Bianco, A. (2020). Few Layer Graphene Does Not Affect Cellular Homeostasis of Mouse Macrophages. Nanomaterials, 10.","DOI":"10.3390\/nano10020228"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"10493","DOI":"10.1039\/C9NR00846B","article-title":"Few layer graphene does not affect the function and the autophagic activity of primary lymphocytes","volume":"11","author":"Murera","year":"2019","journal-title":"Nanoscale"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.nano.2011.11.004","article-title":"Double-walled carbon nanotubes trigger IL-1beta release in human monocytes through Nlrp3 inflammasome activation","volume":"8","author":"Meunier","year":"2012","journal-title":"Nanomedicine"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1002\/smll.201402859","article-title":"NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes","volume":"11","author":"Sun","year":"2015","journal-title":"Small"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: Mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/smll.201201962","article-title":"NLRP3 Inflammasome Activation Induced by Engineered Nanomaterials","volume":"9","author":"Sun","year":"2012","journal-title":"Small"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.tibs.2016.09.002","article-title":"Mechanism and Regulation of NLRP3 Inflammasome Activation","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"565924","DOI":"10.3389\/fimmu.2020.565924","article-title":"Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro","volume":"11","author":"Gritsenko","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"6861","DOI":"10.1021\/nn200595c","article-title":"Long, Needle-like Carbon Nanotubes and Asbestos Activate the NLRP3 Inflammasome through a Similar Mechanism","volume":"5","author":"Sund","year":"2011","journal-title":"ACS Nano"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1080\/17435390.2021.1988171","article-title":"Multi-walled carbon nanotubes trigger lysosome-dependent cell death (pyroptosis) in macrophages but not in neutrophils","volume":"15","author":"Keshavan","year":"2021","journal-title":"Nanotoxicology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1080\/17435390.2019.1592258","article-title":"Comparison of the effects of multiwall carbon nanotubes on the epithelial cells and macrophages","volume":"13","author":"Horie","year":"2019","journal-title":"Nanotoxicology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.toxlet.2013.06.208","article-title":"Single-walled carbon nanotubes and graphene oxides induce autophagosome accumulation and lysosome impairment in primarily cultured murine peritoneal macrophages","volume":"221","author":"Wan","year":"2013","journal-title":"Toxicol. Lett."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"602901","DOI":"10.3389\/fcell.2020.602901","article-title":"Autophagy in the Regulation of Tissue Differentiation and Homeostasis","volume":"8","author":"Perrotta","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/aps.2012.184","article-title":"Why should autophagic flux be assessed?","volume":"34","author":"Zhang","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1080\/15548627.2018.1474993","article-title":"Carbon nanotubes, but not spherical nanoparticles, block autophagy by a shape-related targeting of lysosomes in murine macrophages","volume":"14","author":"Cohignac","year":"2018","journal-title":"Autophagy"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.1016\/j.biomaterials.2012.05.064","article-title":"Simultaneous induction of autophagy and toll-like receptor signaling pathways by graphene oxide","volume":"33","author":"Chen","year":"2012","journal-title":"Biomaterials"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"5732","DOI":"10.1021\/nn402330b","article-title":"Graphene Oxide Induces Toll-like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages","volume":"7","author":"Qu","year":"2013","journal-title":"ACS Nano"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1700815","DOI":"10.1002\/adhm.201700815","article-title":"Cytokine Profiling of Primary Human Macrophages Exposed to Endotoxin-Free Graphene Oxide: Size-Independent NLRP3 Inflammasome Activation","volume":"7","author":"Mukherjee","year":"2017","journal-title":"Adv. Health Mater."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"14098","DOI":"10.1021\/acs.langmuir.9b02536","article-title":"Understanding the Synergic Mechanism of Weak Interactions between Graphene Oxide and Lipid Membrane Leading to the Extraction of Lipids","volume":"35","author":"Zhang","year":"2019","journal-title":"Langmuir"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.chempr.2017.12.017","article-title":"Graphene Oxide Elicits Membrane Lipid Changes and Neutrophil Extracellular Trap Formation","volume":"4","author":"Mukherjee","year":"2018","journal-title":"Chem"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2102439","DOI":"10.1002\/adhm.202102439","article-title":"Encountering and Wrestling: Neutrophils Recognize and Defensively Degrade Graphene Oxide","volume":"11","author":"Huang","year":"2021","journal-title":"Adv. Health Mater."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"11192","DOI":"10.1039\/C9NR09661B","article-title":"Pristine graphene induces innate immune training","volume":"12","author":"Lebre","year":"2020","journal-title":"Nanoscale"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1250684","DOI":"10.1126\/science.1250684","article-title":"mTOR- and HIF-1\u03b1\u2013mediated aerobic glycolysis as metabolic basis for trained immunity","volume":"345","author":"Cheng","year":"2014","journal-title":"Science"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2100882","DOI":"10.1002\/adbi.202100882","article-title":"Graphene Particles Interfere with Pro-Inflammatory Polarization of Human Macrophages: Functional and Electrophysiological Evidence","volume":"5","author":"Mojena","year":"2021","journal-title":"Adv. Biol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1080\/17435390.2021.1905098","article-title":"Carbon nanotubes promote alveolar macrophages toward M2 polarization mediated epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation","volume":"15","author":"Zhang","year":"2021","journal-title":"Nanotoxicology"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1182\/blood-2011-08-372383","article-title":"Induction of autophagy is essential for monocyte-macrophage differentiation","volume":"119","author":"Zhang","year":"2012","journal-title":"Blood"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41577-018-0095-2","article-title":"Autophagy in the renewal, differentiation and homeostasis of immune cells","volume":"19","author":"Clarke","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.tibs.2019.11.003","article-title":"The Cytoskeleton as Regulator of Cell Signaling Pathways","volume":"45","author":"Moujaber","year":"2020","journal-title":"Trends Biochem. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Hohmann, T., and Dehghani, F. (2019). The Cytoskeleton-A Complex Interacting Meshwork. Cells, 8.","DOI":"10.3390\/cells8040362"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1602133","DOI":"10.1002\/smll.201602133","article-title":"Graphene Oxide Nanosheets Retard Cellular Migration via Disruption of Actin Cytoskeleton","volume":"13","author":"Tian","year":"2016","journal-title":"Small"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"17625","DOI":"10.18632\/aging.103821","article-title":"Graphene oxide inhibits cell migration and invasion by destroying actin cytoskeleton in cervical cancer cells","volume":"12","author":"Wang","year":"2020","journal-title":"Aging"},{"key":"ref_147","unstructured":"Krejsek, J., Andr\u00fds, C., and Kr\u010dmov\u00e1, I. (2016). Imunologie \u010clov\u011bka, Garamon s.r.o."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.3389\/fphar.2020.01206","article-title":"Cytotoxicity and Immune Dysfunction of Dendritic Cells Caused by Graphene Oxide","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2102528","DOI":"10.1002\/adma.202102528","article-title":"Large-Sized Graphene Oxide Nanosheets Increase DC\u2013T-Cell Synaptic Contact and the Efficacy of DC Vaccines against SARS-CoV-2","volume":"33","author":"Zhou","year":"2021","journal-title":"Adv. Mater."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2107652","DOI":"10.1002\/smll.202107652","article-title":"2D Materials and Primary Human Dendritic Cells: A Comparative Cytotoxicity Study","volume":"18","author":"Lin","year":"2022","journal-title":"Small"},{"key":"ref_151","first-page":"664","article-title":"The interaction of human dendritic cells with graphene oxide nanoparticles in vitro","volume":"172","author":"Uzhviyuk","year":"2021","journal-title":"Cell Technol. Biol. Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tox.2009.02.009","article-title":"Pro-inflammatory and potential allergic responses resulting from B cell activation in mice treated with multi-walled carbon nanotubes by intratracheal instillation","volume":"259","author":"Park","year":"2009","journal-title":"Toxicology"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.taap.2009.04.003","article-title":"Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model","volume":"237","author":"Inoue","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/toxsci\/kfp057","article-title":"Single-Walled and Multi-Walled Carbon Nanotubes Promote Allergic Immune Responses in Mice","volume":"109","author":"Nygaard","year":"2009","journal-title":"Toxicol. Sci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1021\/nn406454u","article-title":"Graphene Oxide Attenuates Th2-Type Immune Responses, but Augments Airway Remodeling and Hyperresponsiveness in a Murine Model of Asthma","volume":"8","author":"Shurin","year":"2014","journal-title":"ACS Nano"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/17435390.2019.1663954","article-title":"Multi-walled carbon nanotubes activate and shift polarization of pulmonary macrophages and dendritic cells in an in vivo model of chronic obstructive lung disease","volume":"14","author":"Beyeler","year":"2019","journal-title":"Nanotoxicology"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"152598","DOI":"10.1016\/j.tox.2020.152598","article-title":"Impaired mitochondrial function of alveolar macrophages in carbon nanotube-induced chronic pulmonary granulomatous disease","volume":"445","author":"Soliman","year":"2020","journal-title":"Toxicology"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Dellinger, A.L., Cunin, P., Lee, D., Kung, A., Brooks, D.B., Zhou, Z., Nigrovic, P.A., and Kepley, C.L. (2015). Inhibition of Inflammatory Arthritis Using Fullerene Nanomaterials. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0126290"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.imlet.2020.05.006","article-title":"Poly dispersed acid-functionalized single walled carbon nanotubes target activated T and B cells to suppress acute and chronic GVHD in mouse model","volume":"224","author":"Mia","year":"2020","journal-title":"Immunol. Lett."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuropharm.2018.11.030","article-title":"Graphene quantum dots inhibit T cell-mediated neuroinflammation in rats","volume":"146","author":"Tasic","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"41088","DOI":"10.1021\/acsami.0c11735","article-title":"Carbon Dots Derived from Citric Acid and Glutathione as a Highly Efficient Intracellular Reactive Oxygen Species Scavenger for Alleviating the Lipopolysaccharide-Induced Inflammation in Macrophages","volume":"12","author":"Wang","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00339-019-3189-1","article-title":"Effects of endogenous molasses carbon dots on macrophages and their potential utilization as anti-inflammatory agents","volume":"126","author":"Yavuz","year":"2019","journal-title":"Appl. Phys. A"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1002\/smll.201202792","article-title":"Broad-Spectrum Antibacterial Activity of Carbon Nanotubes to Human Gut Bacteria","volume":"9","author":"Chen","year":"2013","journal-title":"Small"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"154789","DOI":"10.1016\/j.scitotenv.2022.154789","article-title":"Gut microbiome interactions with graphene based nanomaterials: Challenges and opportunities","volume":"830","author":"Bantun","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"25708","DOI":"10.1021\/acsami.9b07635","article-title":"Impact of Pristine Graphene on Intestinal Microbiota Assessed Using a Bioreactor-Rotary Cell Culture System","volume":"11","author":"Lahiani","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1021\/nn103265h","article-title":"The Enzymatic Oxidation of Graphene Oxide","volume":"5","author":"Kotchey","year":"2011","journal-title":"ACS Nano"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1002\/smll.201500038","article-title":"Dispersibility-Dependent Biodegradation of Graphene Oxide by Myeloperoxidase","volume":"11","author":"Kurapati","year":"2015","journal-title":"Small"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.taap.2012.07.027","article-title":"PEGylated single-walled carbon nanotubes activate neutrophils to increase production of hypochlorous acid, the oxidant capable of degrading nanotubes","volume":"264","author":"Vlasova","year":"2012","journal-title":"Toxicol. Appl. Pharm."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Shvedova, A.A., Kapralov, O., Feng, W.H., Kisin, E.R., Murray, A.R., Mercer, R.R., Croix, C.M.S., Lang, M.A., Watkins, S., and Konduru, N.V. (2012). Impaired Clearance and Enhanced Pulmonary Inflammatory\/Fibrotic Response to Carbon Nanotubes in Myeloperoxidase-Deficient Mice. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030923"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1039\/C9FD00094A","article-title":"Biodegradation of graphene materials catalyzed by human eosinophil peroxidase","volume":"227","author":"Kurapati","year":"2020","journal-title":"Faraday Discuss."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1002\/smll.201202508","article-title":"Biodegradation of single-walled carbon nanotubes by eosinophil peroxidase","volume":"9","author":"Kapralov","year":"2013","journal-title":"Small"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"5610","DOI":"10.1021\/nn406484b","article-title":"Lung Macrophages \u201cDigest\u201d Carbon Nanotubes Using a Superoxide\/Peroxynitrite Oxidative Pathway","volume":"8","author":"Kagan","year":"2014","journal-title":"ACS Nano"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Hou, J., Wan, B., Yang, Y., Ren, X.-M., Guo, L.-H., and Liu, J.-F. (2016). Biodegradation of Single-Walled Carbon Nanotubes in Macrophages through Respiratory Burst Modulation. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17030409"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/16\/8889\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:06:39Z","timestamp":1760141199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/16\/8889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,10]]},"references-count":173,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["ijms23168889"],"URL":"https:\/\/doi.org\/10.3390\/ijms23168889","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,10]]}}}