{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:49:26Z","timestamp":1790765366473,"version":"4.1.0"},"reference-count":316,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/01122"],"award-info":[{"award-number":["PI20\/01122"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["ERDF\/ESF"],"award-info":[{"award-number":["ERDF\/ESF"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union","award":["PI20\/01122"],"award-info":[{"award-number":["PI20\/01122"]}]},{"name":"European Union","award":["ERDF\/ESF"],"award-info":[{"award-number":["ERDF\/ESF"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Inflammatory bowel diseases (IBD) are an example of chronic diseases affecting 40% of the population, which involved tissue damage and an inflammatory process not satisfactorily controlled with current therapies. Data suggest that mesenchymal stem cells (MSC) may be a therapeutic option for these processes, and especially for IBD, due to their multifactorial approaches such as anti-inflammatory, anti-oxidative stress, anti-apoptotic, anti-fibrotic, regenerative, angiogenic, anti-tumor, or anti-microbial. However, MSC therapy is associated with important limitations as safety issues, handling difficulties for therapeutic purposes, and high economic cost. MSC-derived secretome products (conditioned medium or extracellular vesicles) are therefore a therapeutic option in IBD as they exhibit similar effects to their parent cells and avoid the issues of cell therapy. In this review, we proposed further studies to choose the ideal tissue source of MSC to treat IBD, the implementation of new standardized production strategies, quality controls and the integration of other technologies, such as hydrogels, which may improve the therapeutic effects of derived-MSC secretome products in IBD.<\/jats:p>","DOI":"10.3390\/ijms23168905","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T09:42:56Z","timestamp":1660124576000},"page":"8905","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Mesenchymal (Stem) Stromal Cells Based as New Therapeutic Alternative in Inflammatory Bowel Disease: Basic Mechanisms, Experimental and Clinical Evidence, and Challenges"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5840-4807","authenticated-orcid":false,"given":"Noemi","family":"Eiro","sequence":"first","affiliation":[{"name":"Research Unit, Fundaci\u00f3n Hospital de Jove, Av. de Eduardo Castro, 161, 33290 Gij\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0092-7805","authenticated-orcid":false,"given":"Maria","family":"Fraile","sequence":"additional","affiliation":[{"name":"Research Unit, Fundaci\u00f3n Hospital de Jove, Av. de Eduardo Castro, 161, 33290 Gij\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Gonz\u00e1lez-Jubete","sequence":"additional","affiliation":[{"name":"Research Unit, Fundaci\u00f3n Hospital de Jove, Av. de Eduardo Castro, 161, 33290 Gij\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis O.","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Fundaci\u00f3n Hospital de Jove, Av. de Eduardo Castro, 161, 33290 Gij\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2827-5511","authenticated-orcid":false,"given":"Francisco J.","family":"Vizoso","sequence":"additional","affiliation":[{"name":"Research Unit, Fundaci\u00f3n Hospital de Jove, Av. de Eduardo Castro, 161, 33290 Gij\u00f3n, Spain"},{"name":"Department of Surgery, Fundaci\u00f3n Hospital de Jove, Av. de Eduardo Castro, 161, 33290 Gij\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1053\/j.gastro.2011.01.055","article-title":"Epidemiology and natural history of inflammatory bowel diseases","volume":"140","author":"Cosnes","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/gutjnl-2013-304636","article-title":"East-West gradient in the incidence of inflammatory bowel disease in Europe: The ECCO-EpiCom inception cohort","volume":"63","author":"Burisch","year":"2014","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.3748\/wjg.v21.i40.11282","article-title":"Current stage in inflammatory bowel disease: What is next?","volume":"21","author":"Masedo","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1111\/apt.15523","article-title":"Review article: Fungal alterations in inflammatory bowel diseases","volume":"50","author":"Lam","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.intimp.2014.07.030","article-title":"Potential therapeutic utility of mesenchymal stem cells in inflammatory bowel disease in mice","volume":"22","author":"Ata","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1827901","DOI":"10.1155\/2018\/1827901","article-title":"IL-33 Protects Mice against DSS-Induced Chronic Colitis by Increasing Both Regulatory B Cell and Regulatory T Cell Responses as Well as Decreasing Th17 Cell Response","volume":"2018","author":"Zhu","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1056\/NEJMra0804647","article-title":"Inflammatory bowel disease","volume":"361","author":"Abraham","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7089137","DOI":"10.1155\/2016\/7089137","article-title":"The Th17\/Treg Immune Imbalance in Ulcerative Colitis Disease in a Chinese Han Population","volume":"2016","author":"Gong","year":"2016","journal-title":"Mediat. Inflamm"},{"key":"ref_9","first-page":"928461","article-title":"Role of Th17 Cells in the Pathogenesis of Human IBD","volume":"2014","year":"2014","journal-title":"ISRN Inflamm"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.jcyt.2018.02.372","article-title":"Mesenchymal stromal cell exosome-enhanced regulatory T-cell production through an antigen-presenting cell-mediated pathway","volume":"20","author":"Zhang","year":"2018","journal-title":"Cytotherapy"},{"key":"ref_11","first-page":"G59","article-title":"Colonic macrophage polarization in homeostasis, inflammation, and cancer","volume":"311","author":"Isidro","year":"2016","journal-title":"Am. J. Physiol. Liver Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3122\/jabfm.2014.03.130224","article-title":"Advanced therapy for inflammatory bowel disease: A guide for the primary care physician","volume":"27","author":"Thomas","year":"2014","journal-title":"J. Am. Board Fam. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jacc.2012.06.004","article-title":"2012 ACCF\/AHA focused update of the guideline for the management of patients with unstable angina\/non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): A report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"60","author":"Jneid","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1053\/j.gastro.2008.09.012","article-title":"Direct health care costs of Crohn\u2019s disease and ulcerative colitis in US children and adults","volume":"135","author":"Kappelman","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1517\/14712598.2014.885945","article-title":"New biologic therapeutics for ulcerative colitis and Crohn\u2019s disease","volume":"14","author":"Mozaffari","year":"2014","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/ajg.2014.357","article-title":"Treatment of IBD: Where we are and where we are going","volume":"110","author":"Bernstein","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_17","first-page":"306","article-title":"5-Aminosalyclic Acid (5-ASA): A Unique Anti-Inflammatory Salicylate","volume":"6","year":"2016","journal-title":"Med. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Vizoso, F.J., Eiro, N., Costa, L., Esparza, P., Landin, M., Diaz-Rodriguez, P., Schneider, J., and Perez-Fernandez, R. (2019). Mesenchymal Stem Cells in Homeostasis and Systemic Diseases: Hypothesis, Evidences, and Therapeutic Opportunities. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153738"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMra052638","article-title":"Hematopoietic stem-cell transplantation","volume":"354","author":"Copelan","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev.med.51.1.115","article-title":"New horizons in the treatment of autoimmune diseases: Immunoablation and stem cell transplantation","volume":"51","author":"Marmont","year":"2000","journal-title":"Annu Rev. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1182\/bloodadvances.2017010041","article-title":"Evolution, trends, outcomes, and economics of hematopoietic stem cell transplantation in severe autoimmune diseases","volume":"1","author":"Snowden","year":"2017","journal-title":"Blood Adv."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.12968\/hmed.2019.80.1.33","article-title":"Haematopoietic stem cell transplants: Principles and indications","volume":"80","author":"Balassa","year":"2019","journal-title":"Br. J. Hosp. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1046\/j.1365-2141.1998.01059.x","article-title":"Autologous bone marrow transplantation for non-Hodgkin\u2019s lymphoma resulting in long-term remission of coincidental Crohn\u2019s disease","volume":"103","author":"Kashyap","year":"1998","journal-title":"Br. J. Haematol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/sj.bmt.1702621","article-title":"Crohn\u2019s disease complicated by relapsed extranodal Hodgkin\u2019s lymphoma: Prolonged complete remission after unmanipulated PBPC autotransplant","volume":"26","author":"Musso","year":"2000","journal-title":"Bone Marrow Transplant."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/00365520252903198","article-title":"Long-term endoscopic remission of crohn disease after autologous stem cell transplantation for acute myeloid leukaemia","volume":"37","author":"Malm","year":"2002","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1001\/jama.2015.16700","article-title":"Autologous Hematopoetic Stem Cell Transplantation for Refractory Crohn Disease: A Randomized Clinical Trial","volume":"314","author":"Hawkey","year":"2015","journal-title":"Jama"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/ecco-jcc\/jjx054","article-title":"Autologous Haematopoietic Stem Cell Transplantation for Refractory Crohn\u2019s Disease: Efficacy in a Single-Centre Cohort","volume":"11","author":"Rovira","year":"2017","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S2468-1253(17)30076-6","article-title":"Stem-cell transplantation for Crohn\u2019s disease: Same authors, different conclusions?","volume":"2","author":"Burt","year":"2017","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.dld.2011.07.021","article-title":"Immunomodulatory effects of unselected haematopoietic stem cells autotransplantation in refractory Crohn\u2019s disease","volume":"43","author":"Clerici","year":"2011","journal-title":"Dig. Liver Dis."},{"key":"ref_30","first-page":"337","article-title":"Immunoablation followed or not by hematopoietic stem cells as an intense therapy for severe autoimmune diseases. New perspectives, new problems","volume":"86","author":"Marmont","year":"2001","journal-title":"Haematologica"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"105247","DOI":"10.1016\/j.phrs.2020.105247","article-title":"CELL THERAPY IN INFLAMMATORY BOWEL DISEASE","volume":"163","author":"Cassinotti","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa1004383","article-title":"Reduced mortality after allogeneic hematopoietic-cell transplantation","volume":"363","author":"Gooley","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1200\/JCO.2012.46.6193","article-title":"Significant improvement in survival after allogeneic hematopoietic cell transplantation during a period of significantly increased use, older recipient age, and use of unrelated donors","volume":"31","author":"Hahn","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"6825","DOI":"10.1038\/s41598-018-24060-4","article-title":"In-patient outcomes of Hematopoietic Stem Cell Transplantation in Patients with Immune Mediated Inflammatory Diseases: A Nationwide Study","volume":"8","author":"Mehta","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1084\/jem.20090623","article-title":"NOD2 regulates hematopoietic cell function during graft-versus-host disease","volume":"206","author":"Penack","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1097\/MIB.0000000000001135","article-title":"Complementary Roles of Nod2 in Hematopoietic and Nonhematopoietic Cells in Preventing Gut Barrier Dysfunction Dependent on MLCK Activity","volume":"23","author":"Montcuquet","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Lee, C., Choi, C., Kang, H.S., Shin, S.W., Kim, S.Y., Park, H.C., and Hong, S.N. (2019). NOD2 Supports Crypt Survival and Epithelial Regeneration after Radiation-Induced Injury. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20174297"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41385-022-00527-6","article-title":"Challenges and opportunities targeting mechanisms of epithelial injury and recovery in acute intestinal graft-versus-host disease","volume":"15","author":"Jansen","year":"2022","journal-title":"Mucosal Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/01.TP.0000045055.63901.A9","article-title":"Suppression of allogeneic T-cell proliferation by human marrow stromal cells: Implications in transplantation","volume":"75","author":"Tse","year":"2003","journal-title":"Transplantation"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4120","DOI":"10.1182\/blood-2004-02-0586","article-title":"Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells","volume":"105","author":"Jiang","year":"2005","journal-title":"Blood"},{"key":"ref_41","first-page":"5","article-title":"Immunomodulatory nature and site specific affinity of mesenchymal stem cells: A hope in cell therapy","volume":"4","author":"Lotfinegad","year":"2014","journal-title":"Adv. Pharm. Bull."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nbt.2816","article-title":"Mesenchymal stem cells: Immune evasive, not immune privileged","volume":"32","author":"Ankrum","year":"2014","journal-title":"Nat. Biotechnol"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2184.1970.tb00347.x","article-title":"The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells","volume":"3","author":"Friedenstein","year":"1970","journal-title":"Cell Prolif."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Vizoso, F.J., Eiro, N., Cid, S., Schneider, J., and Perez-Fernandez, R. (2017). Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18091852"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/sctm.17-0129","article-title":"Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine","volume":"6","author":"Samsonraj","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Francos, S., Eiro, N., Costa, L.A., Escudero-Cernuda, S., Fern\u00e1ndez-S\u00e1nchez, M.L., and Vizoso, F.J. (2021). Mesenchymal Stem Cells as a Cornerstone in a Galaxy of Intercellular Signals: Basis for a New Era of Medicine. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073576"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13075-015-0634-1","article-title":"Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys?","volume":"17","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3389\/fcell.2019.00285","article-title":"Mesenchymal Stem Cells: Allogeneic MSC May Be Immunosuppressive but Autologous MSC Are Dysfunctional in Lupus Patients","volume":"7","author":"Cheng","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/scrt468","article-title":"Diabetes impairs the angiogenic potential of adipose-derived stem cells by selectively depleting cellular subpopulations","volume":"5","author":"Rennert","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/exd.12446","article-title":"Biological characteristics and gene expression pattern of bone marrow mesenchymal stem cells in patients with psoriasis","volume":"23","author":"Hou","year":"2014","journal-title":"Exp. Dermatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s13287-018-0970-6","article-title":"Senescence of bone marrow-derived mesenchymal stem cells from patients with idiopathic pulmonary fibrosis","volume":"9","author":"Peng","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3389\/fcell.2020.00364","article-title":"Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges","volume":"8","author":"Zhou","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41586-018-0190-3","article-title":"GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells","volume":"558","author":"Degirmenci","year":"2018","journal-title":"Nature"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.cell.2016.11.040","article-title":"The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier","volume":"168","author":"Nowarski","year":"2017","journal-title":"Cell"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.4049\/jimmunol.1203441","article-title":"TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells","volume":"193","author":"Beswick","year":"2014","journal-title":"J. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/imm.13191","article-title":"Immunological roles of intestinal mesenchymal cells","volume":"160","author":"Thomson","year":"2020","journal-title":"Immunology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00441-012-1390-z","article-title":"Proteases and the gut barrier","volume":"351","author":"Biancheri","year":"2013","journal-title":"Cell Tissue Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e13699","DOI":"10.1111\/apha.13699","article-title":"Intestinal mesenchymal cells regulate immune responses and promote epithelial regeneration in vitro and in dextran sulfate sodium-induced experimental colitis in mice","volume":"233","author":"Vezza","year":"2021","journal-title":"Acta Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem. J."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Lacroix, V., Cassard, A., Mas, E., and Barreau, F. (2021). Multi-Omics Analysis of Gut Microbiota in Inflammatory Bowel Diseases: What Benefits for Diagnostic, Prognostic and Therapeutic Tools?. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011255"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40169-019-0251-8","article-title":"Mesenchymal stem cell-gut microbiota interaction in the repair of inflammatory bowel disease: An enhanced therapeutic effect","volume":"8","author":"Ocansey","year":"2019","journal-title":"Clin. Transl. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"642948","DOI":"10.3389\/fcell.2021.642948","article-title":"Cancer-Preventive Role of Bone Marrow-Derived Mesenchymal Stem Cells on Colitis-Associated Colorectal Cancer: Roles of Gut Microbiota Involved","volume":"9","author":"He","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s13287-017-0670-7","article-title":"Microbiota regulates bone marrow mesenchymal stem cell lineage differentiation and immunomodulation","volume":"8","author":"Xiao","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.copbio.2016.02.028","article-title":"The effect of NOD2 on the microbiota in Crohn\u2019s disease","volume":"40","author":"Lauro","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3389\/fimmu.2016.00367","article-title":"Nod2: A Critical Regulator of Ileal Microbiota and Crohn\u2019s Disease","volume":"7","author":"Sidiq","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"660614","DOI":"10.3389\/fmed.2021.660614","article-title":"Exosomal MicroRNA-181a Derived From Mesenchymal Stem Cells Improves Gut Microbiota Composition, Barrier Function, and Inflammatory Status in an Experimental Colitis Model","volume":"8","author":"Gu","year":"2021","journal-title":"Front. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.lfs.2008.09.016","article-title":"Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats","volume":"83","author":"Tanaka","year":"2008","journal-title":"Life Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"30696","DOI":"10.1038\/srep30696","article-title":"Intraperitoneal injection (IP), Intravenous injection (IV) or anal injection (AI)? Best way for mesenchymal stem cells transplantation for colitis","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"412","DOI":"10.5009\/gnl15229","article-title":"Long-Term Effects of Bone Marrow-Derived Mesenchymal Stem Cells in Dextran Sulfate Sodium-Induced Murine Chronic Colitis","volume":"10","author":"Lee","year":"2016","journal-title":"Gut Liver"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13287-016-0376-2","article-title":"Human umbilical cord-derived mesenchymal stem cells protect against experimental colitis via CD5(+) B regulatory cells","volume":"7","author":"Chao","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"9412","DOI":"10.1038\/s41598-017-09827-5","article-title":"Umbilical cord-derived mesenchymal stem cell extracts reduce colitis in mice by re-polarizing intestinal macrophages","volume":"7","author":"Song","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Yu, Y., Song, E.M., Lee, K.E., Joo, Y.H., Kim, S.E., Moon, C.M., Kim, H.Y., Jung, S.A., and Jo, I. (2017). Therapeutic potential of tonsil-derived mesenchymal stem cells in dextran sulfate sodium-induced experimental murine colitis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0183141"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1538\/expanim.16-0094","article-title":"Cotransfer of regulatory T cells improve the therapeutic effectiveness of mesenchymal stem cells in treating a colitis mouse model","volume":"66","author":"Yu","year":"2017","journal-title":"Exp. Anim."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.intimp.2017.11.001","article-title":"Study the effects of mesenchymal stem cell conditioned medium injection in mouse model of acute colitis","volume":"54","author":"Pouya","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"8754","DOI":"10.1002\/jcp.26765","article-title":"The immunomodulatory effects of adipose-derived mesenchymal stem cells and mesenchymal stem cells-conditioned medium in chronic colitis","volume":"233","author":"Heidari","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1136\/gut.2008.168534","article-title":"Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis","volume":"58","author":"Anderson","year":"2009","journal-title":"Gut"},{"key":"ref_78","first-page":"54","article-title":"Mesenteric injection of adipose-derived mesenchymal stem cells relieves experimentally-induced colitis in rats by regulating Th17\/Treg cell balance","volume":"10","author":"Fu","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.3389\/fimmu.2018.01078","article-title":"MIS416 Enhances Therapeutic Functions of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Experimental Colitis by Modulating Systemic Immune Milieu","volume":"9","author":"Lee","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/sctm.17-0305","article-title":"Mesenchymal Stem Cells (MSC) Derived from Induced Pluripotent Stem Cells (iPSC) Equivalent to Adipose-Derived MSC in Promoting Intestinal Healing and Microbiome Normalization in Mouse Inflammatory Bowel Disease Model","volume":"7","author":"Soontararak","year":"2018","journal-title":"Stem Cells Transl. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13287-018-0837-x","article-title":"Endoscopic submucosal injection of adipose-derived mesenchymal stem cells ameliorates TNBS-induced colitis in rats and prevents stenosis","volume":"9","author":"Robredo","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_82","first-page":"4149","article-title":"Interleukin-25 primed mesenchymal stem cells achieve better therapeutic effects on dextran sulfate sodium-induced colitis via inhibiting Th17 immune response and inducing T regulatory cell phenotype","volume":"9","author":"Cheng","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1007\/s12015-016-9677-1","article-title":"Therapeutic Potential of Secreted Molecules Derived from Human Amniotic Fluid Mesenchymal Stem\/Stroma Cells in a Mice Model of Colitis","volume":"12","author":"Legaki","year":"2016","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10787-017-0404-6","article-title":"Mesenchymal stromal cells modulate gut inflammation in experimental colitis","volume":"26","author":"Castoldi","year":"2018","journal-title":"Inflammopharmacology"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13287-018-0841-1","article-title":"TSG-6 released from intraperitoneally injected canine adipose tissue-derived mesenchymal stem cells ameliorate inflammatory bowel disease by inducing M2 macrophage switch in mice","volume":"9","author":"Song","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s13287-018-0874-5","article-title":"Treatment of experimental colitis by endometrial regenerative cells through regulation of B lymphocytes in mice","volume":"9","author":"Xu","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_87","first-page":"940","article-title":"Therapeutic effects of human amnion-derived mesenchymal stem cell transplantation and conditioned medium enema in rats with trinitrobenzene sulfonic acid-induced colitis","volume":"9","author":"Miyamoto","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"11314","DOI":"10.1038\/s41598-018-29617-x","article-title":"Endoscopic Transplantation of Mesenchymal Stem Cell Sheets in Experimental Colitis in Rats","volume":"8","author":"Pak","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.bbrc.2018.03.096","article-title":"Adipose-derived stem cells ameliorate colitis by suppression of inflammasome formation and regulation of M1-macrophage population through prostaglandin E2","volume":"498","author":"Park","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"39","DOI":"10.15283\/ijsc17074","article-title":"Local Mesenchymal Stem Cell Therapy in Experimentally Induced Colitis in the Rat","volume":"11","author":"Yuste","year":"2018","journal-title":"Int. J. Stem Cells"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1093\/ibd\/izy130","article-title":"Endoscopic Administration of Mesenchymal Stromal Cells Reduces Inflammation in Experimental Colitis","volume":"24","author":"Barnhoorn","year":"2018","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"17646","DOI":"10.1038\/s41598-019-54194-y","article-title":"Mechanism and therapeutic effect of umbilical cord mesenchymal stem cells in inflammatory bowel disease","volume":"9","author":"Pan","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/mt.2010.54","article-title":"Targeting improves MSC treatment of inflammatory bowel disease","volume":"18","author":"Ko","year":"2010","journal-title":"Mol. Ther."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.tvjl.2015.08.003","article-title":"Safety and efficacy of allogeneic adipose tissue-derived mesenchymal stem cells for treatment of dogs with inflammatory bowel disease: Clinical and laboratory outcomes","volume":"206","author":"Gualtieri","year":"2015","journal-title":"Vet. J."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Cristobal, J.I., Duque, F.J., Uson-Casaus, J.M., Ruiz, P., Nieto, E.L., and Perez-Merino, E.M. (2021). Effects of Allogeneic Mesenchymal Stem Cell Transplantation in Dogs with Inflammatory Bowel Disease Treated with and without Corticosteroids. Animals, 11.","DOI":"10.3390\/ani11072061"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1186\/s13287-021-02533-0","article-title":"Stem cell therapy for Crohn\u2019s disease: Systematic review and meta-analysis of preclinical and clinical studies","volume":"12","author":"Wang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/ecco-jcc\/jjz116","article-title":"Long-term Evaluation of Allogeneic Bone Marrow-derived Mesenchymal Stromal Cell Therapy for Crohn\u2019s Disease Perianal Fistulas","volume":"14","author":"Barnhoorn","year":"2020","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00384-012-1581-9","article-title":"Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn\u2019s disease: Results from a multicenter phase I\/IIa clinical trial","volume":"28","author":"Alba","year":"2013","journal-title":"Int. J. Color. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.dld.2018.08.015","article-title":"Allogeneic mesenchymal stromal cells for refractory luminal Crohn\u2019s disease: A phase I-II study","volume":"50","author":"Gregoire","year":"2018","journal-title":"Dig. Liver. Dis."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"5906","DOI":"10.1002\/jcp.30275","article-title":"Adipose-derived mesenchymal stem cell-secreted exosome alleviates dextran sulfate sodium-induced acute colitis by Treg cell induction and inflammatory cytokine reduction","volume":"236","author":"Heidari","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.3892\/etm.2016.3724","article-title":"Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis","volume":"12","author":"Hu","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"5356760","DOI":"10.1155\/2017\/5356760","article-title":"Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Relieve Inflammatory Bowel Disease in Mice","volume":"2017","author":"Mao","year":"2017","journal-title":"Biomed Res. Int."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.procbio.2016.04.017","article-title":"Revisiting MSC expansion from critical quality attributes to critical culture process parameters","volume":"59","author":"Martin","year":"2017","journal-title":"Process Biochem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1053\/j.gastro.2015.06.014","article-title":"Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn\u2019s Disease","volume":"149","author":"Molendijk","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0140-6736(16)31203-X","article-title":"Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn\u2019s disease: A phase 3 randomised, double-blind controlled trial","volume":"388","author":"Colombel","year":"2016","journal-title":"Lancet"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1053\/j.gastro.2017.12.020","article-title":"Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn\u2019s Disease","volume":"154","author":"Colombel","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ymthe.2017.09.023","article-title":"Stem Cell Secretome and Its Effect on Cellular Mechanisms Relevant to Wound Healing","volume":"26","author":"Park","year":"2018","journal-title":"Mol. Ther."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/aps.2015.51","article-title":"IL-37b gene transfer enhances the therapeutic efficacy of mesenchumal stromal cells in DSS-induced colitis mice","volume":"36","author":"Wang","year":"2015","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_109","first-page":"2026","article-title":"Exosomes derived from human umbilical cord mesenchymal stem cells alleviate inflammatory bowel disease in mice through ubiquitination","volume":"10","author":"Wu","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","article-title":"Transforming growth factor-beta regulation of immune responses","volume":"24","author":"Li","year":"2006","journal-title":"Annu. Rev. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1182\/blood.V99.10.3838","article-title":"Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli","volume":"99","author":"Magni","year":"2002","journal-title":"Blood"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1182\/blood-2004-04-1559","article-title":"Human mesenchymal stem cells modulate allogeneic immune cell responses","volume":"105","author":"Aggarwal","year":"2005","journal-title":"Blood"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1182\/blood-2006-02-002246","article-title":"Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells","volume":"109","author":"Sato","year":"2007","journal-title":"Blood"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1182\/blood-2003-11-3909","article-title":"Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation","volume":"103","author":"Meisel","year":"2004","journal-title":"Blood"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.3748\/wjg.v19.i25.3931","article-title":"Why interleukin-10 supplementation does not work in Crohn\u2019s disease patients","volume":"19","author":"Marlow","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.3748\/wjg.v19.i29.4702","article-title":"Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses","volume":"19","author":"Chen","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/cei.13262","article-title":"A single administration of human adipose tissue-derived mesenchymal stromal cells (MSC) induces durable and sustained long-term regulation of inflammatory response in experimental colitis","volume":"196","author":"Alves","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1053\/j.gastro.2013.08.033","article-title":"Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2","volume":"145","author":"Kim","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/cbf.2950","article-title":"Novel aspects of parenchymal-mesenchymal interactions: From cell types to molecules and beyond","volume":"31","author":"Bluguermann","year":"2013","journal-title":"Cell Biochem. Funct."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Ahangar, P., Mills, S.J., and Cowin, A.J. (2020). Mesenchymal Stem Cell Secretome as an Emerging Cell-Free Alternative for Improving Wound Repair. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197038"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s13287-019-1336-4","article-title":"Mesenchymal stem cells for the treatment of ulcerative colitis: A systematic review and meta-analysis of experimental and clinical studies","volume":"10","author":"Shi","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Sendon-Lago, J., Rio, L.G., Eiro, N., Diaz-Rodriguez, P., Avila, L., Gonzalez, L.O., Vizoso, F.J., Perez-Fernandez, R., and Landin, M. (2021). Tailored Hydrogels as Delivery Platforms for Conditioned Medium from Mesenchymal Stem Cells in a Model of Acute Colitis in Mice. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13081127"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Pardali, E., Sanchez-Duffhues, G., Gomez-Puerto, M.C., and Ten Dijke, P. (2017). TGF-\u03b2-Induced Endothelial-Mesenchymal Transition in Fibrotic Diseases. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18102157"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Choi, A., Park, S.E., Jeong, J.B., Choi, S.J., Oh, S.Y., Ryu, G.H., Lee, J., Jeon, H.B., and Chang, J.W. (2020). Anti-Fibrotic Effect of Human Wharton\u2019s Jelly-Derived Mesenchymal Stem Cells on Skeletal Muscle Cells, Mediated by Secretion of MMP-1. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176269"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13287-020-01642-6","article-title":"Hypoxia-preconditioned mesenchymal stem cells prevent renal fibrosis and inflammation in ischemia-reperfusion rats","volume":"11","author":"Ishiuchi","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1186\/s13287-020-01891-5","article-title":"The anti-fibrotic effect of human fetal skin-derived stem cell secretome on the liver fibrosis","volume":"11","author":"Yao","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbi.2018.07.008","article-title":"New insights into TGF-\u03b2\/Smad signaling in tissue fibrosis","volume":"292","author":"Hu","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fphar.2017.00461","article-title":"Targeting TGF-\u03b2 Mediated SMAD Signaling for the Prevention of Fibrosis","volume":"8","author":"Walton","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00535-019-01599-1","article-title":"The mesenchymal stem cell secretome as an acellular regenerative therapy for liver disease","volume":"54","author":"Driscoll","year":"2019","journal-title":"J. Gastroenterol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jhep.2018.01.030","article-title":"Mesenchymal stromal cell therapy for liver diseases","volume":"68","author":"Alfaifi","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"58","DOI":"10.5483\/BMBRep.2017.50.2.012","article-title":"Identification of MFGE8 in mesenchymal stem cell secretome as an anti-fibrotic factor in liver fibrosis","volume":"50","author":"Jang","year":"2017","journal-title":"BMB Rep."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13287-019-1204-2","article-title":"Human bone marrow mesenchymal stem cells-derived exosomes alleviate liver fibrosis through the Wnt\/\u03b2-catenin pathway","volume":"10","author":"Rong","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"104468","DOI":"10.1016\/j.yexmp.2020.104468","article-title":"Human umbilical cord mesenchymal stem cell-derived exosomes suppress dermal fibroblasts-myofibroblats transition via inhibiting the TGF-\u03b21\/Smad 2\/3 signaling pathway","volume":"115","author":"Hu","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1186\/s13287-020-01803-7","article-title":"Human amnion mesenchymal stem cells restore spermatogenesis in mice with busulfan-induced testis toxicity by inhibiting apoptosis and oxidative stress","volume":"11","author":"Qian","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.2147\/DDDT.S255828","article-title":"Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization","volume":"14","author":"Duan","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Yang, J., Liu, X.X., Fan, H., Tang, Q., Shou, Z.X., Zuo, D.M., Zou, Z., Xu, M., Chen, Q.Y., and Peng, Y. (2015). Extracellular Vesicles Derived from Bone Marrow Mesenchymal Stem Cells Protect against Experimental Colitis via Attenuating Colon Inflammation, Oxidative Stress and Apoptosis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0140551"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/sctm.19-0446","article-title":"The emerging antioxidant paradigm of mesenchymal stem cell therapy","volume":"9","author":"Stavely","year":"2020","journal-title":"Stem Cells Transl. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: A concept in Redox Biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/WOX.0b013e3182439613","article-title":"Oxidative stress and antioxidant defense","volume":"5","author":"Birben","year":"2012","journal-title":"World Allergy Organ. J."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"4535194","DOI":"10.1155\/2017\/4535194","article-title":"Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies","volume":"2017","author":"Tian","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00109-013-1007-3","article-title":"Inflammation and oxidative stress in angiogenesis and vascular disease","volume":"91","author":"Kim","year":"2013","journal-title":"J. Mol. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"46116","DOI":"10.1074\/jbc.M209124200","article-title":"Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation","volume":"277","author":"Zhang","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.2174\/092986706778773095","article-title":"Reactions of myeloperoxidase-derived oxidants with biological substrates: Gaining chemical insight into human inflammatory diseases","volume":"13","author":"Pattison","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1089\/scd.2010.0093","article-title":"Human mesenchymal stem cells efficiently manage oxidative stress","volume":"19","author":"Conget","year":"2010","journal-title":"Stem Cells Dev."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"186795","DOI":"10.1155\/2013\/186795","article-title":"Adaptive redox response of mesenchymal stromal cells to stimulation with lipopolysaccharide inflammagen: Mechanisms of remodeling of tissue barriers in sepsis","volume":"2013","author":"Gorbunov","year":"2013","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3389\/fphys.2018.00661","article-title":"Paracrine Anti-inflammatory Effects of Adipose Tissue-Derived Mesenchymal Stem Cells in Human Monocytes","volume":"9","author":"Platas","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/stem.1608","article-title":"Mesenchymal stem\/stromal cells inhibit the NLRP3 inflammasome by decreasing mitochondrial reactive oxygen species","volume":"32","author":"Oh","year":"2014","journal-title":"Stem Cells"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cell.2017.11.018","article-title":"Intrinsic Immunity Shapes Viral Resistance of Stem Cells","volume":"172","author":"Wu","year":"2018","journal-title":"Cell"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-virology-031413-085537","article-title":"IFITM-Family Proteins: The Cell\u2019s First Line of Antiviral Defense","volume":"1","author":"Bailey","year":"2014","journal-title":"Annu. Rev. Virol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1016\/j.cub.2015.11.017","article-title":"Antimicrobial peptides","volume":"26","author":"Zhang","year":"2016","journal-title":"Curr. Biol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s13287-020-01807-3","article-title":"Antimicrobial activity of mesenchymal stem cells against Staphylococcus aureus","volume":"11","author":"Yagi","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nrmicro1098","article-title":"Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria?","volume":"3","author":"Brogden","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_154","first-page":"339","article-title":"Antimicrobial Activity of Mesenchymal Stem Cells: Current Status and New Perspectives of Antimicrobial Peptide-Based Therapies","volume":"8","author":"Cuenca","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00109-019-01752-6","article-title":"Exploring the roles of MSCs in infections: Focus on bacterial diseases","volume":"97","author":"Marrazzo","year":"2019","journal-title":"J. Mol. Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1182\/blood.V96.9.3086","article-title":"The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations","volume":"96","author":"Agerberth","year":"2000","journal-title":"Blood"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-981-13-3588-4_12","article-title":"Design of Antimicrobial Peptides: Progress Made with Human Cathelicidin LL-37","volume":"1117","author":"Wang","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.bbamem.2015.11.003","article-title":"The human cathelicidin LL-37--A pore-forming antibacterial peptide and host-cell modulator","volume":"1858","author":"Xhindoli","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s10529-005-0936-5","article-title":"Human antimicrobial peptides: Defensins, cathelicidins and histatins","volume":"27","author":"Contreras","year":"2005","journal-title":"Biotechnol. Lett."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.0022-202X.2005.23713.x","article-title":"Anti-fungal activity of cathelicidins and their potential role in Candida albicans skin infection","volume":"125","author":"Lee","year":"2005","journal-title":"J. Investig. Dermatol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"410","DOI":"10.2174\/157016207781023947","article-title":"The antimicrobial peptide LL-37 inhibits HIV-1 replication","volume":"5","author":"Bergman","year":"2007","journal-title":"Curr. HIV Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1128\/IAI.01218-07","article-title":"Expression of cathelicidin LL-37 during Mycobacterium tuberculosis infection in human alveolar macrophages, monocytes, neutrophils, and epithelial cells","volume":"76","author":"Carranza","year":"2008","journal-title":"Infect. Immun."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s13287-015-0192-0","article-title":"Combination therapy of menstrual derived mesenchymal stem cells and antibiotics ameliorates survival in sepsis","volume":"6","author":"Cuenca","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/leu.2010.310","article-title":"Human but not murine multipotent mesenchymal stromal cells exhibit broad-spectrum antimicrobial effector function mediated by indoleamine 2,3-dioxygenase","volume":"25","author":"Meisel","year":"2011","journal-title":"Leukemia"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/cr.2012.179","article-title":"A subset of IL-17(+) mesenchymal stem cells possesses anti-Candida albicans effect","volume":"23","author":"Yang","year":"2013","journal-title":"Cell Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1167\/iovs.14-15859","article-title":"Corneal epithelial wound healing and bactericidal effect of conditioned medium from human uterine cervical stem cells","volume":"56","author":"Bermudez","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.2147\/IDR.S244990","article-title":"Evaluation of the Antimicrobial and Antibiofilm Effect of Chitosan Nanoparticles as Carrier for Supernatant of Mesenchymal Stem Cells on Multidrug-Resistant Vibrio cholerae","volume":"13","author":"Saberpour","year":"2020","journal-title":"Infect. Drug Resist."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"L1003","DOI":"10.1152\/ajplung.00180.2011","article-title":"Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes","volume":"302","author":"Krasnodembskaya","year":"2012","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jctube.2016.05.003","article-title":"Effectiveness of a novel cellular therapy to treat multidrug-resistant tuberculosis","volume":"4","author":"Skrahin","year":"2016","journal-title":"J. Clin. Tuberc. Other Mycobact. Dis."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s13287-017-0610-6","article-title":"Antimicrobial peptides secreted by equine mesenchymal stromal cells inhibit the growth of bacteria commonly found in skin wounds","volume":"8","author":"Harman","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.3389\/fmicb.2018.02818","article-title":"Antifungal Activity of the Human Uterine Cervical Stem Cells Conditioned Medium (hUCESC-CM) Against Candida albicans and Other Medically Relevant Species of Candida","volume":"9","author":"Schneider","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/sctm.19-0092","article-title":"Antibacterial activity of human mesenchymal stem cells mediated directly by constitutively secreted factors and indirectly by activation of innate immune effector cells","volume":"9","author":"Chow","year":"2020","journal-title":"Stem Cells Transl. Med."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/sctm.19-0333","article-title":"The mesenchymal stromal cell secretome impairs methicillin-resistant Staphylococcus aureus biofilms via cysteine protease activity in the equine model","volume":"9","author":"Marx","year":"2020","journal-title":"Stem Cells Transl. Med."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"30015","DOI":"10.3390\/ijms161226215","article-title":"Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression","volume":"16","author":"Rhee","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"2820853","DOI":"10.1155\/2019\/2820853","article-title":"Mesenchymal Stem Cells and Cancer: Clinical Challenges and Opportunities","volume":"2019","author":"Lin","year":"2019","journal-title":"Biomed Res. Int."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00018-020-03600-0","article-title":"Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: Implications for further clinical uses","volume":"78","author":"Costa","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/jcp.22344","article-title":"Mesenchymal stem cells inhibit both endogenous and exogenous MMPs via secreted TIMPs","volume":"226","author":"Lozito","year":"2011","journal-title":"J. Cell. Physiol"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"5162","DOI":"10.1016\/j.biomaterials.2014.03.014","article-title":"Molecular imaging for assessment of mesenchymal stem cells mediated breast cancer therapy","volume":"35","author":"Leng","year":"2014","journal-title":"Biomaterials"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1634\/stemcells.2008-0084","article-title":"Therapeutic potential of mesenchymal stem cells producing interferon-alpha in a mouse melanoma lung metastasis model","volume":"26","author":"Ren","year":"2008","journal-title":"Stem Cells"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"10692","DOI":"10.18632\/oncotarget.2530","article-title":"Potential therapeutic effect of the secretome from human uterine cervical stem cells against both cancer and stromal cells compared with adipose tissue stem cells","volume":"5","author":"Seoane","year":"2014","journal-title":"Oncotarget"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0090-8258(89)90019-X","article-title":"An immunohistochemical study of colon-ovarian tumor antigen and colon-specific antigen in gynecologic tumors","volume":"35","author":"Ueda","year":"1989","journal-title":"Gynecol. Oncol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"241.e1","DOI":"10.1016\/j.urology.2016.01.028","article-title":"PLK-1 Silencing in Bladder Cancer by siRNA Delivered with Exosomes","volume":"91","author":"Greco","year":"2016","journal-title":"Urology"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1016\/j.bbamem.2014.07.026","article-title":"Examination of the specificity of tumor cell derived exosomes with tumor cells in vitro","volume":"1838","author":"Smyth","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Wu, S., Ju, G.Q., Du, T., Zhu, Y.J., and Liu, G.H. (2013). Microvesicles derived from human umbilical cord Wharton\u2019s jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061366"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"38498","DOI":"10.1038\/srep38498","article-title":"Human adipose mesenchymal stem cell-derived exosomal-miRNAs are critical factors for inducing anti-proliferation signalling to A2780 and SKOV-3 ovarian cancer cells","volume":"6","author":"Reza","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.2174\/138161212802083707","article-title":"Molecular link mechanisms between inflammation and cancer","volume":"18","author":"Carvalho","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-med-112211-154330","article-title":"The role of anti-inflammatory drugs in colorectal cancer","volume":"64","author":"Wang","year":"2013","journal-title":"Annu. Rev. Med."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.bbrc.2014.07.002","article-title":"Bone marrow mesenchymal stem cells ameliorate colitis-associated tumorigenesis in mice","volume":"450","author":"Chen","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/stem.1594","article-title":"Mesenchymal stem cells cancel azoxymethane-induced tumor initiation","volume":"32","author":"Nasuno","year":"2014","journal-title":"Stem Cells"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13287-015-0055-8","article-title":"Mesenchymal stem cells-regulated Treg cells suppress colitis-associated colorectal cancer","volume":"6","author":"Tang","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/1477-3163.78279","article-title":"The AOM\/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies","volume":"10","author":"Massi","year":"2011","journal-title":"J. Carcinog."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1002\/ijc.31559","article-title":"Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice","volume":"143","author":"Koh","year":"2018","journal-title":"Int. J. Cancer"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.micres.2017.08.006","article-title":"Apoptosis induced by Staphylococcus aureus toxins","volume":"205","author":"Zhang","year":"2017","journal-title":"Microbiol. Res."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"eaao4502","DOI":"10.1126\/sciadv.aao4502","article-title":"A commensal strain of Staphylococcus epidermidis protects against skin neoplasia","volume":"4","author":"Nakatsuji","year":"2018","journal-title":"Sci. Adv."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"Jostins","year":"2012","journal-title":"Nature"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1002\/sctm.21-0021","article-title":"Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell-free products and human pluripotent stem cell-derived mesenchymal stem cells","volume":"10","author":"Wang","year":"2021","journal-title":"Stem Cells Transl. Med."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/DCR.0b013e3182099d9e","article-title":"Quality of life in perianal Crohn\u2019s disease: What do patients consider important?","volume":"54","author":"Mahadev","year":"2011","journal-title":"Dis. Colon Rectum"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nrgastro.2017.104","article-title":"Perianal fistulizing Crohn\u2019s disease: Pathogenesis, diagnosis and therapy","volume":"14","author":"Rimola","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00384-003-0490-3","article-title":"Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal Crohn\u2019s disease: A new cell-based therapy","volume":"18","author":"Cuellar","year":"2003","journal-title":"Int. J. Color. Dis."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1007\/s10350-005-0052-6","article-title":"A phase I clinical trial of the treatment of Crohn\u2019s fistula by adipose mesenchymal stem cell transplantation","volume":"48","author":"Herreros","year":"2005","journal-title":"Dis. Colon Rectum"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/DCR.0b013e3181973487","article-title":"Expanded adipose-derived stem cells for the treatment of complex perianal fistula: A phase II clinical trial","volume":"52","author":"Herreros","year":"2009","journal-title":"Dis. Colon Rectum"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00384-011-1350-1","article-title":"Long-term follow-up of patients undergoing adipose-derived adult stem cell administration to treat complex perianal fistulas","volume":"27","author":"Guadalajara","year":"2012","journal-title":"Int. J. Color. Dis."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1136\/gut.2010.214841","article-title":"Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn\u2019s disease","volume":"60","author":"Ciccocioppo","year":"2011","journal-title":"Gut"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.mayocp.2015.03.023","article-title":"Long-Term Follow-Up of Crohn Disease Fistulas After Local Injections of Bone Marrow-Derived Mesenchymal Stem Cells","volume":"90","author":"Ciccocioppo","year":"2015","journal-title":"Mayo Clin. Proc."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/codi.13223","article-title":"Allogeneic adipose-derived stem cells for the treatment of perianal fistula in Crohn\u2019s disease: A pilot clinical trial","volume":"18","author":"Park","year":"2016","journal-title":"Color. Dis."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/sctm.19-0271","article-title":"Autologous adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistula: A randomized clinical trial with long-term follow-up","volume":"9","author":"Herreros","year":"2020","journal-title":"Stem Cells Transl. Med."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s10151-019-01994-z","article-title":"The clinical efficacy of stem cell therapy for complex perianal fistulas: A meta-analysis","volume":"23","author":"Choi","year":"2019","journal-title":"Tech. Coloproctol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"8816737","DOI":"10.1155\/2020\/8816737","article-title":"Efficacy and Safety of Mesenchymal Stem Cells in Treatment of Complex Perianal Fistulas: A Meta-Analysis","volume":"2020","author":"Cheng","year":"2020","journal-title":"Stem Cells Int."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1136\/gut.2010.215152","article-title":"Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn\u2019s disease: Results of a phase I study","volume":"59","author":"Duijvestein","year":"2010","journal-title":"Gut"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/apt.13717","article-title":"The safety of autologous and metabolically fit bone marrow mesenchymal stromal cells in medically refractory Crohn\u2019s disease\u2014A phase 1 trial with three doses","volume":"44","author":"Dhere","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1136\/gutjnl-2011-300083","article-title":"Allogeneic mesenchymal stem cell transplantation in seven patients with refractory inflammatory bowel disease","volume":"61","author":"Liang","year":"2012","journal-title":"Gut"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cgh.2013.06.021","article-title":"A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn\u2019s disease refractory to biologic therapy","volume":"12","author":"Forbes","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_213","unstructured":"Onken, J., Gallup, D., Hanson, J., Pandak, M., and Custer, L. (2006, January 20\u201325). Successful outpatient treatment of refractory Crohn\u2019s disease using adult mesenchymal stem cells. Proceedings of the American College of Gastroenterology Conference, Las Vegas, NV, USA."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1097\/MIB.0b013e31827f27df","article-title":"Safety and tolerability of human placenta-derived cells (PDA001) in treatment-resistant crohn\u2019s disease: A phase 1 study","volume":"19","author":"Mayer","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5009\/gnl17035","article-title":"Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn\u2019s Disease: A Randomized Controlled Clinical Trial","volume":"12","author":"Zhang","year":"2018","journal-title":"Gut Liver"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"e000206","DOI":"10.1136\/bmjgast-2018-000206","article-title":"Evaluation of amnion-derived mesenchymal stem cells for treatment-resistant moderate Crohn\u2019s disease: Study protocol for a phase I\/II, dual-centre, open-label, uncontrolled, dose-response trial","volume":"5","author":"Otagiri","year":"2018","journal-title":"BMJ Open Gastroenterol."},{"key":"ref_217","unstructured":"Lazebnik, L.B., Kniazev, O.V., Konopliannikov, A.G., Parfenov, A.I., Ruchkina, I.N., Mikha\u012dlova, Z.F., Tsaregorodtseva, T.M., Khomeriki, S.G., Rogozina, V.A., and Gudkova, R.B. (2010). Allogeneic mesenchymal stromal cells in patients with ulcerative colitis: Two years of observation. Eksp. Klin. Gastroenterol., 3\u201315."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"S313","DOI":"10.1093\/ecco-jcc\/jjx180.540","article-title":"P413 Relative frequency of relapses in patients with ulcerative colitis and Crohn\u2019s disease treated with mesenchymal stromal cells: Five-years of follow-up","volume":"12","author":"Fadeeva","year":"2018","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_219","first-page":"S51","article-title":"Laboratory prediction of the effectiveness of transplantation of allogeneic mesenchymal stromal cells of bone marrow in patients with ulcerative colitis.: P-131","volume":"17","author":"Lazebnik","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2174\/1574889810666150702124059","article-title":"Exosome-based strategies for Diagnosis and Therapy","volume":"10","author":"Urbanelli","year":"2015","journal-title":"Recent Pat. CNS Drug Discov."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1182\/blood-2005-03-1004","article-title":"Allogeneic marrow stromal cells are immune rejected by MHC class I- and class II-mismatched recipient mice","volume":"106","author":"Eliopoulos","year":"2005","journal-title":"Blood"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1097\/TP.0b013e31818bd96f","article-title":"Inhibition of humoral response to allogeneic porcine mesenchymal stem cell with 12 days of tacrolimus","volume":"86","author":"Poncelet","year":"2008","journal-title":"Transplantation"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s12015-017-9789-2","article-title":"Molecular and Cellular Mechanisms Involved in Mesenchymal Stem Cell-Based Therapy of Inflammatory Bowel Diseases","volume":"14","author":"Markovic","year":"2018","journal-title":"Stem Cell Rev."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/apt.13864","article-title":"Review article: Mesenchymal stromal cell therapy for inflammatory bowel diseases","volume":"45","author":"Gregoire","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1002\/hep.23506","article-title":"Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development","volume":"51","author":"Touboul","year":"2010","journal-title":"Hepatology"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3748\/wjg.v20.i5.1211","article-title":"Therapy with stem cells in inflammatory bowel disease","volume":"20","author":"Flores","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"54","DOI":"10.15283\/ijsc.2015.8.1.54","article-title":"New strategies for overcoming limitations of mesenchymal stem cell-based immune modulation","volume":"8","author":"Kim","year":"2015","journal-title":"Int. J. Stem Cells"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.intimp.2012.03.024","article-title":"Comparison of immunomodulatory effects of placenta mesenchymal stem cells with bone marrow and adipose mesenchymal stem cells","volume":"13","author":"Lee","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.molmed.2010.02.005","article-title":"Mesenchymal stem cell therapy: Two steps forward, one step back","volume":"16","author":"Ankrum","year":"2010","journal-title":"Trends Mol. Med."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1002\/med.21659","article-title":"An overview of international regulatory frameworks for mesenchymal stromal cell-based medicinal products: From laboratory to patient","volume":"40","author":"Guadix","year":"2020","journal-title":"Med. Res. Rev."},{"key":"ref_231","unstructured":"(2022, July 02). FDA Rejects Mesoblast Flagship Treatment. Available online: https:\/\/www.pharmamanufacturing.com\/industrynews\/2020\/fda-rejects-mesoblast-flagship-treatment\/."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nbt.3525","article-title":"Quality cell therapy manufacturing by design","volume":"34","author":"Lipsitz","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.stemcr.2017.01.024","article-title":"Lessons Learned from Pioneering Neural Stem Cell Studies","volume":"8","author":"Temple","year":"2017","journal-title":"Stem Cell Rep."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1253\/circj.CJ-11-0246","article-title":"Gene and protein expression analysis of mesenchymal stem cells derived from rat adipose tissue and bone marrow","volume":"75","author":"Nakanishi","year":"2011","journal-title":"Circ. J."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s12015-012-9365-8","article-title":"Human stromal (mesenchymal) stem cells from bone marrow, adipose tissue and skin exhibit differences in molecular phenotype and differentiation potential","volume":"9","author":"Vishnubalaji","year":"2013","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.transproceed.2017.03.078","article-title":"Thromboembolism Induced by Umbilical Cord Mesenchymal Stem Cell Infusion: A Report of Two Cases and Literature Review","volume":"49","author":"Wu","year":"2017","journal-title":"Transplant. Proc."},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Coppin, L., Sokal, E., and Stephenne, X. (2019). Thrombogenic Risk Induced by Intravascular Mesenchymal Stem Cell Therapy: Current Status and Future Perspectives. Cells, 8.","DOI":"10.3390\/cells8101160"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1186\/s13287-021-02609-x","article-title":"The safety of MSC therapy over the past 15 years: A meta-analysis","volume":"12","author":"Wang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1177\/0963689719837897","article-title":"The Pros and Cons of Mesenchymal Stem Cell-Based Therapies","volume":"28","author":"Kot","year":"2019","journal-title":"Cell Transplant."},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Barekzai, J., Petry, F., Zitzmann, J., Czermak, P., and Salzig, D. (2020). Bioprocess Development for Human Mesenchymal Stem Cell Therapy Products. New Adv. Ferment. Processes, 1\u201325.","DOI":"10.5772\/intechopen.90029"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1089\/ten.teb.2017.0083","article-title":"Mesenchymal Stem Cell-Based Cartilage Regeneration Approach and Cell Senescence: Can We Manipulate Cell Aging and Function?","volume":"23","author":"Szychlinska","year":"2017","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1089\/ten.tec.2018.0031","article-title":"Isolating Pediatric Mesenchymal Stem Cells with Enhanced Expansion and Differentiation Capabilities","volume":"24","author":"Knuth","year":"2018","journal-title":"Tissue Eng. Part C Methods"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13287-018-0876-3","article-title":"Changes in phenotype and differentiation potential of human mesenchymal stem cells aging in vitro","volume":"9","author":"Yang","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.scr.2013.12.006","article-title":"Combination of immortalization and inducible death strategies to generate a human mesenchymal stromal cell line with controlled survival","volume":"12","author":"Bourgine","year":"2014","journal-title":"Stem Cell Res."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1089\/scd.2013.0599","article-title":"Generation and characterization of an immortalized human mesenchymal stromal cell line","volume":"23","author":"Noordhuis","year":"2014","journal-title":"Stem Cells Dev."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/scrt452","article-title":"Immortalization of human adipose-derived stromal cells: Production of cell lines with high growth rate, mesenchymal marker expression and capability to secrete high levels of angiogenic factors","volume":"5","author":"Balducci","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"ref_247","first-page":"5726947","article-title":"Immortalizing Mesenchymal Stromal Cells from Aged Donors While Keeping Their Essential Features","volume":"2020","year":"2020","journal-title":"Stem Cells Int."},{"key":"ref_248","first-page":"331","article-title":"Human Uterine Cervical Stromal Stem Cells (hUCESCs): Why and How they Exert their Antitumor Activity","volume":"13","author":"Schneider","year":"2016","journal-title":"Cancer Genom. Proteom."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00702-008-0135-3","article-title":"The neuroprotective effect of dental pulp cells in models of Alzheimer\u2019s and Parkinson\u2019s disease","volume":"116","author":"Apel","year":"2009","journal-title":"J. Neural Transm."},{"key":"ref_250","first-page":"3","article-title":"Non-viral and viral vectors for gene therapy","volume":"51","author":"Boulaiz","year":"2005","journal-title":"Cell. Mol. Biol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s12015-019-09897-0","article-title":"Enhancing the Therapeutic Potential of Mesenchymal Stem Cells with the CRISPR-Cas System","volume":"15","author":"Filho","year":"2019","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13036-019-0163-6","article-title":"Transplantation of CRISPRa system engineered IL10-overexpressing bone marrow-derived mesenchymal stem cells for the treatment of myocardial infarction in diabetic mice","volume":"13","author":"Meng","year":"2019","journal-title":"J. Biol. Eng."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4103\/1673-5374.264455","article-title":"Mesenchymal stem cells secretome: Current trends and future challenges","volume":"15","author":"Teixeira","year":"2020","journal-title":"Neural Regen. Res."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1089\/ten.tea.2011.0325","article-title":"Conditioned media from mesenchymal stem cells enhanced bone regeneration in rat calvarial bone defects","volume":"18","author":"Osugi","year":"2012","journal-title":"Tissue Eng. Part A"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"Raposo","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"e346","DOI":"10.1038\/emm.2017.63","article-title":"Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases","volume":"49","author":"Lou","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"ref_257","doi-asserted-by":"crossref","unstructured":"Lasda, E., and Parker, R. (2016). Circular RNAs Co-Precipitate with Extracellular Vesicles: A Possible Mechanism for circRNA Clearance. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0148407"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/s13287-018-1046-3","article-title":"Circular RNAs are abundantly expressed and upregulated during repair of the damaged endometrium by Wharton\u2019s jelly-derived mesenchymal stem cells","volume":"9","author":"Sun","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.omtn.2019.02.005","article-title":"Circular RNAs in Cancer","volume":"16","author":"Bach","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s10620-010-1286-2","article-title":"CD4+CD25+ regulatory T cells suppress Th17-responses in an experimental colitis model","volume":"56","author":"Ogino","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5217\/ir.2018.16.1.26","article-title":"Immunological pathogenesis of inflammatory bowel disease","volume":"16","author":"Lee","year":"2018","journal-title":"Intest. Res."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.immuni.2018.07.015","article-title":"Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution","volume":"49","author":"Proto","year":"2018","journal-title":"Immunity"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/icb.2010.70","article-title":"Phenotypic and functional switch of macrophages induced by regulatory CD4+CD25+ T cells in mice","volume":"89","author":"Liu","year":"2011","journal-title":"Immunol. Cell Biol."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.intimp.2019.04.020","article-title":"Extracellular vesicles derived from bone marrow mesenchymal stem cells attenuate dextran sodium sulfate-induced ulcerative colitis by promoting M2 macrophage polarization","volume":"72","author":"Cao","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"e131273","DOI":"10.1172\/jci.insight.131273","article-title":"Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism","volume":"4","author":"Liu","year":"2019","journal-title":"JCI Insight"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s13287-021-02404-8","article-title":"A novel therapeutic approach for inflammatory bowel disease by exosomes derived from human umbilical cord mesenchymal stem cells to repair intestinal barrier via TSG-6","volume":"12","author":"Yang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s12026-016-8798-6","article-title":"Immunomodulatory effects of mesenchymal stromal cells-derived exosome","volume":"64","author":"Chen","year":"2016","journal-title":"Immunol. Res."},{"key":"ref_268","doi-asserted-by":"crossref","unstructured":"Harrell, C.R., Jovicic, N., Djonov, V., Arsenijevic, N., and Volarevic, V. (2019). Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases. Cells, 8.","DOI":"10.3390\/cells8121605"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/s13287-021-02363-0","article-title":"Mesenchymal stem cell-derived microvesicles improve intestinal barrier function by restoring mitochondrial dynamic balance in sepsis rats","volume":"12","author":"Zheng","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","article-title":"The cell biology of mitochondrial membrane dynamics","volume":"21","author":"Giacomello","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"9529465","DOI":"10.1155\/2020\/9529465","article-title":"Large-Scale Expansion of Human Mesenchymal Stem Cells","volume":"2020","author":"Hassan","year":"2020","journal-title":"Stem Cells Int."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.biotechadv.2013.03.006","article-title":"Application of human mesenchymal and pluripotent stem cell microcarrier cultures in cellular therapy: Achievements and future direction","volume":"31","author":"Chen","year":"2013","journal-title":"Biotechnol. Adv."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.biomaterials.2016.12.017","article-title":"Decellularized adipose tissue microcarriers as a dynamic culture platform for human adipose-derived stem\/stromal cell expansion","volume":"120","author":"Yu","year":"2017","journal-title":"Biomaterials"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"19589","DOI":"10.1038\/s41598-021-98711-4","article-title":"Three-dimensional culture method enhances the therapeutic efficacies of tonsil-derived mesenchymal stem cells in murine chronic colitis model","volume":"11","author":"Song","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/978-1-4939-3584-0_23","article-title":"GMP-Compliant Expansion of Clinical-Grade Human Mesenchymal Stromal\/Stem Cells Using a Closed Hollow Fiber Bioreactor","volume":"1416","author":"Barckhausen","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10439-019-02400-3","article-title":"Effects of Physical, Chemical, and Biological Stimulus on h-MSC Expansion and Their Functional Characteristics","volume":"48","author":"Domenech","year":"2020","journal-title":"Ann. Biomed. Eng."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13287-019-1224-y","article-title":"Priming approaches to improve the efficacy of mesenchymal stromal cell-based therapies","volume":"10","author":"Noronha","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"643","DOI":"10.5966\/sctm.2013-0196","article-title":"Concise review: Optimizing expansion of bone marrow mesenchymal stem\/stromal cells for clinical applications","volume":"3","author":"Hoch","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1016\/j.jcyt.2019.03.470","article-title":"Full-time physioxic culture conditions promote MSC proliferation more than hypoxic preconditioning","volume":"21","author":"Henn","year":"2019","journal-title":"Cytotherapy"},{"key":"ref_280","doi-asserted-by":"crossref","unstructured":"Basciano, L., Nemos, C., Foliguet, B., de Isla, N., de Carvalho, M., Tran, N., and Dalloul, A. (2011). Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status. BMC Cell Biol., 12.","DOI":"10.1186\/1471-2121-12-12"},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"35489","DOI":"10.1038\/srep35489","article-title":"Hypoxia-inducible factor-2 alpha promotes the proliferation of human placenta-derived mesenchymal stem cells through the MAPK\/ERK signaling pathway","volume":"6","author":"Zhu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_282","doi-asserted-by":"crossref","unstructured":"Bader, A.M., Klose, K., Bieback, K., Korinth, D., Schneider, M., Seifert, M., Choi, Y.H., Kurtz, A., Falk, V., and Stamm, C. (2015). Hypoxic Preconditioning Increases Survival and Pro-Angiogenic Capacity of Human Cord Blood Mesenchymal Stromal Cells In Vitro. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0138477"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1524-475X.2009.00499.x","article-title":"Hypoxia-enhanced wound-healing function of adipose-derived stem cells: Increase in stem cell proliferation and up-regulation of VEGF and bFGF","volume":"17","author":"Lee","year":"2009","journal-title":"Wound Repair Regen."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"291","DOI":"10.15283\/ijsc19002","article-title":"Enhanced Anti-Cancer Effects of Conditioned Medium from Hypoxic Human Umbilical Cord-Derived Mesenchymal Stem Cells","volume":"12","author":"Han","year":"2019","journal-title":"Int. J. Stem Cells"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/scrt153","article-title":"High targeted migration of human mesenchymal stem cells grown in hypoxia is associated with enhanced activation of RhoA","volume":"4","author":"Vertelov","year":"2013","journal-title":"Stem Cell Res. Ther."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.rvsc.2021.11.004","article-title":"Hypoxic preconditioning promotes the immunosuppressive effects of mesenchymal stem cells in mice with colitis","volume":"144","author":"Ying","year":"2021","journal-title":"Res. Vet. Sci."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1089\/ten.tea.2013.0500","article-title":"The pH in the microenvironment of human mesenchymal stem cells is a critical factor for optimal osteogenesis in tissue-engineered constructs","volume":"20","author":"Monfoulet","year":"2014","journal-title":"Tissue Eng. Part A"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1634\/stemcells.2005-0008","article-title":"Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells","volume":"24","author":"Krampera","year":"2006","journal-title":"Stem Cells"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.stem.2007.11.014","article-title":"Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide","volume":"2","author":"Ren","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ijpharm.2014.10.066","article-title":"Bioadhesive emulsions for control release of progesterone resistant to vaginal fluids clearance","volume":"477","author":"Peleteiro","year":"2014","journal-title":"Int. J. Pharm."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.intimp.2018.12.043","article-title":"Extracellular vesicles containing miR-146a attenuate experimental colitis by targeting TRAF6 and IRAK1","volume":"68","author":"Wu","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_292","doi-asserted-by":"crossref","unstructured":"Joo, H., Oh, M.K., Kang, J.Y., Park, H.S., Chae, D.H., Kim, J., Lee, J.H., Yoo, H.M., Choi, U., and Kim, D.K. (2021). Extracellular Vesicles from Thapsigargin-Treated Mesenchymal Stem Cells Ameliorated Experimental Colitis via Enhanced Immunomodulatory Properties. Biomedicines, 9.","DOI":"10.3390\/biomedicines9020209"},{"key":"ref_293","doi-asserted-by":"crossref","unstructured":"Kang, J.Y., Oh, M.K., Joo, H., Park, H.S., Chae, D.H., Kim, J., Lee, H.R., Oh, I.H., and Yu, K.R. (2020). Xeno-Free Condition Enhances Therapeutic Functions of Human Wharton\u2019s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis by Upregulated Indoleamine 2,3-Dioxygenase Activity. J. Clin. Med., 9.","DOI":"10.3390\/jcm9092913"},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3389\/fbioe.2020.00586","article-title":"Serum-Free Medium Enhances the Therapeutic Effects of Umbilical Cord Mesenchymal Stromal Cells on a Murine Model for Acute Colitis","volume":"8","author":"Wu","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00204-020-02964-3","article-title":"Nrf2 deficiency aggravates the kidney injury induced by subacute cadmium exposure in mice","volume":"95","author":"Chen","year":"2021","journal-title":"Arch. Toxicol."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"21507","DOI":"10.1038\/srep21507","article-title":"Comprehensive transcriptomic and proteomic characterization of human mesenchymal stem cells reveals source specific cellular markers","volume":"6","author":"Billing","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1089\/scd.2012.0594","article-title":"Clinical-grade mesenchymal stromal cells produced under various good manufacturing practice processes differ in their immunomodulatory properties: Standardization of immune quality controls","volume":"22","author":"Menard","year":"2013","journal-title":"Stem Cells Dev."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ijom.2015.06.022","article-title":"Comparison of human mesenchymal stem cells derived from bone marrow, synovial fluid, adult dental pulp, and exfoliated deciduous tooth pulp","volume":"45","author":"Isobe","year":"2016","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1159\/000447458","article-title":"Mesenchymal Stem\/Stromal Cells in Regenerative Medicine: Can Preconditioning Strategies Improve Therapeutic Efficacy?","volume":"43","author":"Spohn","year":"2016","journal-title":"Transfus. Med. Hemother."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"27791","DOI":"10.1038\/srep27791","article-title":"Modulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bioreactors: Impact on Neuronal Cell Proliferation, Survival and Differentiation","volume":"6","author":"Teixeira","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jbiotec.2017.01.014","article-title":"Bioprocess integration for human mesenchymal stem cells: From up to downstream processing scale-up to cell proteome characterization","volume":"248","author":"Cunha","year":"2017","journal-title":"J. Biotechnol."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.3389\/fimmu.2019.02474","article-title":"Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties","volume":"10","author":"Andrzejewska","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1111\/trf.15252","article-title":"Production and quality testing of multipotent mesenchymal stromal cell therapeutics for clinical use","volume":"59","author":"Bieback","year":"2019","journal-title":"Transfusion"},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1053\/j.gastro.2015.03.013","article-title":"Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine","volume":"149","author":"Sala","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_305","doi-asserted-by":"crossref","unstructured":"Castelo-Branco, M.T., Soares, I.D., Lopes, D.V., Buongusto, F., Martinusso, C.A., do Rosario, A., Souza, S.A., Gutfilen, B., Fonseca, L.M., and Elia, C. (2012). Intraperitoneal but not intravenous cryopreserved mesenchymal stromal cells home to the inflamed colon and ameliorate experimental colitis. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0033360"},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/DCR.0000000000002325","article-title":"Follow-up Study to Evaluate the Long-term Safety and Efficacy of Darvadstrocel (Mesenchymal Stem Cell Treatment) in Patients With Perianal Fistulizing Crohn\u2019s Disease: ADMIRE-CD Phase 3 Randomized Controlled Trial","volume":"65","author":"Gilaberte","year":"2022","journal-title":"Dis. Colon Rectum"},{"key":"ref_307","doi-asserted-by":"crossref","unstructured":"Laroui, H., Ingersoll, S.A., Liu, H.C., Baker, M.T., Ayyadurai, S., Charania, M.A., Laroui, F., Yan, Y., Sitaraman, S.V., and Merlin, D. (2012). Dextran sodium sulfate (DSS) induces colitis in mice by forming nano-lipocomplexes with medium-chain-length fatty acids in the colon. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0032084"},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ejps.2005.11.001","article-title":"Modulation of the rheological and mucoadhesive properties of thermosensitive poloxamer-based hydrogels intended for the rectal administration of quinine","volume":"27","author":"Koffi","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/03639045.2016.1254239","article-title":"Thermosensitive bioadhesive gels for the vaginal delivery of sildenafil citrate: In vitro characterization and clinical evaluation in women using clomiphene citrate for induction of ovulation","volume":"43","author":"Soliman","year":"2017","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jconrel.2006.11.024","article-title":"Controlled delivery of recombinant hirudin based on thermo-sensitive Pluronic F127 hydrogel for subcutaneous administration: In vitro and in vivo characterization","volume":"117","author":"Liu","year":"2007","journal-title":"J. Control. Release"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.exer.2018.12.004","article-title":"Corneal regeneration by conditioned medium of human uterine cervical stem cells is mediated by TIMP-1 and TIMP-2","volume":"180","author":"Seoane","year":"2019","journal-title":"Exp. Eye Res."},{"key":"ref_312","doi-asserted-by":"crossref","unstructured":"Sosnik, A., and Seremeta, K.P. (2017). Polymeric Hydrogels as Technology Platform for Drug Delivery Applications. Gels, 3.","DOI":"10.3390\/gels3030025"},{"key":"ref_313","doi-asserted-by":"crossref","unstructured":"Chatterjee, S., Hui, P.C., and Kan, C.W. (2018). Thermoresponsive Hydrogels and Their Biomedical Applications: Special Insight into Their Applications in Textile Based Transdermal Therapy. Polymers, 10.","DOI":"10.3390\/polym10050480"},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"110252","DOI":"10.1016\/j.msec.2019.110252","article-title":"New tools to design smart thermosensitive hydrogels for protein rectal delivery in IBD","volume":"106","author":"Landin","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejpb.2015.04.019","article-title":"Novel dual-reverse thermosensitive solid lipid nanoparticle-loaded hydrogel for rectal administration of flurbiprofen with improved bioavailability and reduced initial burst effect","volume":"94","author":"Din","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.colsurfb.2015.11.048","article-title":"Budesonide-hydroxypropyl-\u03b2-cyclodextrin inclusion complex in binary poloxamer 407\/403 system for ulcerative colitis treatment: A physico-chemical study from micelles to hydrogels","volume":"138","author":"Keppler","year":"2016","journal-title":"Colloids Surf. 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