{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:47:58Z","timestamp":1788914878895,"version":"build-2803163510"},"reference-count":52,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003375"],"award-info":[{"award-number":["82003375"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["3150120042"],"award-info":[{"award-number":["3150120042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020M671659"],"award-info":[{"award-number":["2020M671659"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020Z153"],"award-info":[{"award-number":["2020Z153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"High-Level Talents Start-up Funding of China Pharmaceutical University","award":["82003375"],"award-info":[{"award-number":["82003375"]}]},{"name":"High-Level Talents Start-up Funding of China Pharmaceutical University","award":["3150120042"],"award-info":[{"award-number":["3150120042"]}]},{"name":"High-Level Talents Start-up Funding of China Pharmaceutical University","award":["2020M671659"],"award-info":[{"award-number":["2020M671659"]}]},{"name":"High-Level Talents Start-up Funding of China Pharmaceutical University","award":["2020Z153"],"award-info":[{"award-number":["2020Z153"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["82003375"],"award-info":[{"award-number":["82003375"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["3150120042"],"award-info":[{"award-number":["3150120042"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M671659"],"award-info":[{"award-number":["2020M671659"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020Z153"],"award-info":[{"award-number":["2020Z153"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Postdoctoral Foundation of Jiangsu Province","award":["82003375"],"award-info":[{"award-number":["82003375"]}]},{"name":"Postdoctoral Foundation of Jiangsu Province","award":["3150120042"],"award-info":[{"award-number":["3150120042"]}]},{"name":"Postdoctoral Foundation of Jiangsu Province","award":["2020M671659"],"award-info":[{"award-number":["2020M671659"]}]},{"name":"Postdoctoral Foundation of Jiangsu Province","award":["2020Z153"],"award-info":[{"award-number":["2020Z153"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ectodysplasin A (EDA) signaling is initially identified as morphogenic signaling regulating the formation of skin appendages including teeth, hair follicles, exocrine glands in mammals, feathers in birds and scales in fish. Gene mutation in EDA signaling causes hypohidrotic ectodermal dysplasia (HED), a congenital hereditary disease with malformation of skin appendages. Interestingly, emerging evidence suggests that EDA and its receptors can modulate the proliferation, apoptosis, differentiation and migration of cancer cells, and thus may regulate tumorigenesis and cancer progression. More recently, as a newly discovered hepatocyte factor, EDA pathway has been demonstrated to be involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and type II diabetes by regulating glucose and lipid metabolism. In this review, we summarize the function of EDA signaling from skin appendage development to multiple other diseases, and discuss the clinical application of recombinant EDA protein as well as other potential targets for disease intervention.<\/jats:p>","DOI":"10.3390\/ijms23168911","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T09:42:56Z","timestamp":1660124576000},"page":"8911","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Ectodysplasin A (EDA) Signaling: From Skin Appendage to Multiple Diseases"],"prefix":"10.3390","volume":"23","author":[{"given":"Ruihan","family":"Yang","sequence":"first","affiliation":[{"name":"Laboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilan","family":"Mei","sequence":"additional","affiliation":[{"name":"Laboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Laboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7206-4191","authenticated-orcid":false,"given":"Ruixi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Laboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Sima","sequence":"additional","affiliation":[{"name":"Laboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3824-8645","authenticated-orcid":false,"given":"Yuyuan","family":"Yao","sequence":"additional","affiliation":[{"name":"Laboratory of Aging Neuroscience and Neuropharmacology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cytogfr.2014.01.004","article-title":"Ectodysplasin A (EDA)\u2014EDA receptor signalling and its pharmacological modulation","volume":"25","author":"Schneider","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"788411","DOI":"10.3389\/fphys.2021.788411","article-title":"Ectodysplasin A\/Ectodysplasin A Receptor System and Their Roles in Multiple Diseases","volume":"12","author":"Cai","year":"2021","journal-title":"Front. 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