{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:51:19Z","timestamp":1787237479782,"version":"build-2736575974"},"reference-count":198,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cDunarea de Jos\u201d University of Galati, Romania"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Atherosclerosis remains the leading cause of mortality and morbidity worldwide characterized by the deposition of lipids and fibrous elements in the form of atheroma plaques in vascular areas which are hemodynamically overloaded. The global burden of atherosclerotic cardiovascular disease is steadily increasing and is considered the largest known non-infectious pandemic. The management of atherosclerotic cardiovascular disease is increasing the cost of health care worldwide, which is a concern for researchers and physicians and has caused them to strive to find effective long-term strategies to improve the efficiency of treatments by managing conventional risk factors. Primary prevention of atherosclerotic cardiovascular disease is the preferred method to reduce cardiovascular risk. Fasting, a Mediterranean diet, and caloric restriction can be considered useful clinical tools. The protective impact of physical exercise over the cardiovascular system has been studied in recent years with the intention of explaining the mechanisms involved; the increase in heat shock proteins, antioxidant enzymes and regulators of cardiac myocyte proliferation concentration seem to be the molecular and biochemical shifts that are involved. Developing new therapeutic strategies such as vagus nerve stimulation, either to prevent or slow the disease\u2019s onset and progression, will surely have a profound effect on the lives of millions of people.<\/jats:p>","DOI":"10.3390\/ijms23169097","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T01:47:21Z","timestamp":1660528041000},"page":"9097","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Impact of Non-Pharmacological Interventions on the Mechanisms of Atherosclerosis"],"prefix":"10.3390","volume":"23","author":[{"given":"Daniela","family":"Matei","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy \u201cGrigore T. 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Suppl."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1161\/ATVBAHA.117.309813","article-title":"Endothelial functions","volume":"37","author":"Godo","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"III-27","DOI":"10.1161\/01.CIR.0000131515.03336.f8","article-title":"Role of endothelial dysfunction in atherosclerosis","volume":"109","author":"Davignon","year":"2004","journal-title":"Circulation"},{"key":"ref_5","first-page":"109","article-title":"Nitric oxide: Physiology, pathophysiology and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0033-0620(96)80003-X","article-title":"Vascular endothelium: Vasoactive mediators","volume":"39","author":"Vanhoutte","year":"1996","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/micc.12035","article-title":"Perivascular innervation: A multiplicity of roles in vasomotor control and myoendothelial signaling","volume":"20","author":"Westcott","year":"2013","journal-title":"Microcirculation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.1038\/sj.bjp.0706458","article-title":"The discovery of nitric oxide and its role in vascular biology","volume":"147","author":"Moncada","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1046\/j.1365-201x.2000.00702.x","article-title":"Large arterioles in the control of blood flow: Role of endothelium-dependent dilation","volume":"168","author":"Pohl","year":"2000","journal-title":"Acta Physiol. Scand."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1042\/CS20110215","article-title":"Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls","volume":"121","author":"Ward","year":"2011","journal-title":"Clin. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1748-1716.2010.02244.x","article-title":"Regulation of blood flow in the microcirculation: Role of conducted vasodilation","volume":"202","author":"Bagher","year":"2011","journal-title":"Acta Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/apha.12646","article-title":"Endothelial dysfunction and vascular disease\u2014A 30th anniversary update","volume":"219","author":"Vanhoutte","year":"2017","journal-title":"Acta Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Sousa, J.B., Vieira-Rocha, M.S., Arribas, S.M., Gonz\u00e1lez, M.C., Fresco, P., and Diniz, C. (2015). Endothelial and neuronal nitric oxide activate distinct pathways on sympathetic neurotransmission in rat tail and mesenteric arteries. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129224"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/01.RES.77.4.841","article-title":"Endogenous and exogenous nitric oxide inhibits norepinephrine release from rat heart sympathetic nerves","volume":"77","author":"Schwarz","year":"1995","journal-title":"Circ. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1113\/JP270710","article-title":"Depressed perivascular sensory innervation of mouse mesenteric arteries with advanced age","volume":"594","author":"Boerman","year":"2016","journal-title":"J. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1152\/japplphysiol.00247.2002","article-title":"Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries","volume":"93","author":"Yu","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.2337\/diabetes.49.11.1939","article-title":"High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C\u2014Dependent activation of NAD(P)H oxidase in cultured vascular cells","volume":"49","author":"Inoguchi","year":"2000","journal-title":"Diabetes"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"H875","DOI":"10.1152\/ajpheart.00008.2003","article-title":"Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects","volume":"285","author":"Ihlemann","year":"2003","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_19","first-page":"99","article-title":"The relationship of stress and blood pressure effectors","volume":"19","author":"Ayada","year":"2015","journal-title":"Hippokratia"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1161\/HYPERTENSIONAHA.110.152629","article-title":"Endothelin activation of reactive oxygen species mediates stress-induced pressor response in Dahl salt-sensitive prehypertensive rats","volume":"56","author":"Loria","year":"2010","journal-title":"Hypertension"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1038\/sj.jhh.1001338","article-title":"Role of endothelin in stress-induced hypertension","volume":"16","author":"Garrido","year":"2002","journal-title":"J. Hum. Hypertens."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/rheumatology\/kel294","article-title":"Theroleofendothelin in connective tissue diseases","volume":"45","author":"Sticherling","year":"2006","journal-title":"Rheumatology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00005-014-0310-1","article-title":"The role of endothelin-1 and endothelin receptor antagonists in inflammatory response and sepsis","volume":"63","author":"Kowalczyk","year":"2015","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1073\/pnas.93.19.10417","article-title":"Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: Cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress","volume":"93","author":"Topper","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.carpath.2012.06.006","article-title":"Vascular endothelium, hemodynamics, and the pathobiology of atherosclerosis","volume":"22","author":"Gimbrone","year":"2013","journal-title":"Cardiovasc. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1084\/jem.20031132","article-title":"KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation","volume":"199","author":"SenBanerjee","year":"2004","journal-title":"J. Exp. Med."},{"key":"ref_27","first-page":"21","article-title":"Pathogenesis of atherosclerosis in the tunica intima, media, and adventitia of coronary arteries: An updated review","volume":"20","year":"2020","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"707529","DOI":"10.3389\/fcvm.2021.707529","article-title":"Role of Lipid Accumulation and Inflammation in Atherosclerosis: Focus on Molecular and Cellular Mechanisms","volume":"6","author":"Malekmohammad","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Xian, X., Wang, Z., Bi, Y., Chen, Q., Han, X., Tang, D., and Chen, R. (2018). Research Progress on the Relationship between Atherosclerosis and Inflammation. Biomolecules, 8.","DOI":"10.3390\/biom8030080"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"175291","DOI":"10.1155\/2015\/175291","article-title":"Ox-LDL induces dysfunction of endothelial progenitor cells via activation of NF-B","volume":"2015","author":"Ji","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cell.2011.04.005","article-title":"Macrophages in the pathogenesis of atherosclerosis","volume":"145","author":"Moore","year":"2011","journal-title":"Cell"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0026-0495(03)00157-4","article-title":"Mechanisms of high-density lipoprotein cholesterol effects on the endothelial function in hyperlipemia","volume":"52","author":"Lupattelli","year":"2003","journal-title":"Metabolism"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1161\/01.ATV.0000243941.72375.15","article-title":"Increased ratio of CD31+\/CD42\u2212 microparticles to endothelial progenitors as a novel marker of atherosclerosis in hypercholesterolemia","volume":"26","author":"Pirro","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/MOL.0b013e3282efd0d4","article-title":"Immunomodulation of the inflammatory response in atherosclerosis","volume":"18","author":"Kuiper","year":"2007","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1126\/science.3513311","article-title":"A receptor-mediated pathway for cholesterol homeostasis","volume":"232","author":"Brown","year":"1986","journal-title":"Science"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.cellbio.22.010305.104656","article-title":"Cholesterol sensing, trafficking, and esterification","volume":"22","author":"Chang","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","article-title":"SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver","volume":"109","author":"Horton","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cell.2005.12.022","article-title":"Protein sensors for membrane sterols","volume":"124","author":"Goldstein","year":"2006","journal-title":"Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm3312","article-title":"Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR","volume":"13","author":"Calkin","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1038\/s41467-021-26787-7","article-title":"MMAB promotes negative feedback control of cholesterol homeostasis","volume":"12","author":"Goedeke","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1016\/j.celrep.2017.05.093","article-title":"Lanosterol modulates TLR4-mediated innate immune responses in macrophages","volume":"19","author":"Araldi","year":"2017","journal-title":"Cell Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coi.2018.08.001","article-title":"Loss of sterol metabolic homeostasis triggers inflammasomes\u2014How and why","volume":"56","author":"Dang","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.cell.2017.09.029","article-title":"Oxysterol restraint of cholesterol synthesis prevents AIM2 inflammasome activation","volume":"171","author":"Dang","year":"2017","journal-title":"Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e2107682118","DOI":"10.1073\/pnas.2107682118","article-title":"Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis","volume":"118","author":"Zhang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1161\/ATVBAHA.112.250571","article-title":"Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis","volume":"32","author":"Zhang","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1161\/CIRCRESAHA.118.314415","article-title":"Specific Disruption of Abca1 Targeting Largely Mimics the Effects of miR-33 Knockout on Macrophage Cholesterol Efflux and Atherosclerotic Plaque Development","volume":"124","author":"Price","year":"2019","journal-title":"Circ. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0022-2275(20)39245-2","article-title":"Role of plasma lecithin: Cholesterol acyltransferase in the metabolism of high density lipoproteins","volume":"7","author":"Glomset","year":"1966","journal-title":"J. Lipid Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/cvr\/cvy022","article-title":"Smooth muscle cell fate and plasticity in atherosclerosis","volume":"114","author":"Allahverdian","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1161\/CIRCRESAHA.119.312617","article-title":"HDL and Reverse Cholesterol Transport. Basic Mechanisms and Their Roles in Vascular Health and Disease","volume":"124","author":"Ouimet","year":"2019","journal-title":"Circ. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1161\/CIRCRESAHA.114.300760","article-title":"High-density lipoprotein and atherosclerosis regression: Evidence from preclinical and clinical studies","volume":"114","author":"Feig","year":"2014","journal-title":"Circ. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-09665-0_1","article-title":"Structure of HDL: Particle subclasses and molecular components","volume":"224","author":"Kontush","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nri3520","article-title":"Macrophages in atherosclerosis: A dynamic balance","volume":"13","author":"Moore","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.tem.2012.02.001","article-title":"Crosstalk between reverse cholesterol transport and innate immunity","volume":"23","author":"Azzam","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1161\/CIRCRESAHA.114.301137","article-title":"Artery tertiary lymphoid organs contribute to innate and adaptive immune responses in advanced mouse atherosclerosis","volume":"114","author":"Mohanta","year":"2014","journal-title":"Circ. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1161\/ATVBAHA.109.191395","article-title":"Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1\/lymphotoxin \u03b2-receptor NF-\u03baB signaling","volume":"30","author":"Connert","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20080752","article-title":"Lymphotoxin \u03b2 receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE\u2212\/\u2212 mice","volume":"206","author":"Hildner","year":"2009","journal-title":"J. Exp. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3389\/fimmu.2016.00387","article-title":"Artery Tertiary Lymphoid Organs: Powerhouses of Atherosclerosis Immunity","volume":"7","author":"Yin","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1172\/JCI63685","article-title":"Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice","volume":"123","author":"Martel","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1161\/ATVBAHA.114.302528","article-title":"Lymphatic vessel insufficiency in hypercholesterolemic mice alters lipoprotein levels and promotes atherogenesis","volume":"34","author":"Vuorio","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000119095","article-title":"Sympathetic innervation of human mesenteric artery and vein","volume":"45","author":"Birch","year":"2008","journal-title":"J. Vasc. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1023\/A:1009894007055","article-title":"Angiotensin II\u2014Nitric oxide interactions in the control of sympathetic outflow in heart failure","volume":"5","author":"Zucker","year":"2000","journal-title":"Heart Fail. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fphys.2012.00284","article-title":"Sympathetic regulation of vascular function in health and disease","volume":"3","author":"Bruno","year":"2012","journal-title":"Front. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: Regulation and function","volume":"33","author":"Sessa","year":"2012","journal-title":"Eur. Heart J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41586-022-04673-6","article-title":"Neuroimmune cardiovascular interfaces control atherosclerosis","volume":"605","author":"Mohanta","year":"2022","journal-title":"Nature"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.immuni.2018.05.004","article-title":"Sympathetic neuronal activation triggers myeloid progenitor proliferation and differentiation","volume":"49","author":"Vasamsetti","year":"2018","journal-title":"Immunity"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/cphy.c130051","article-title":"Autonomic nervous system and immune system interactions","volume":"4","author":"Kenney","year":"2014","journal-title":"Compr. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1186\/s13075-014-0504-2","article-title":"The sympathetic nervous response in inflammation","volume":"16","author":"Pongratz","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nri2566","article-title":"Reflex control of immunity","volume":"9","author":"Tracey","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev-immunol-020711-075015","article-title":"Reflex principles of immunological homeostasis","volume":"30","author":"Andersson","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"11008","DOI":"10.1073\/pnas.0803237105","article-title":"Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia","volume":"105","author":"Ochani","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1209985","article-title":"Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit","volume":"334","author":"Olofsson","year":"2011","journal-title":"Science"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/nbt.3663","article-title":"Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase","volume":"34","author":"Olofsson","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1161\/ATVBAHA.114.303892","article-title":"\u03b17 Nicotinic acetylcholine receptor is expressed in human atherosclerosis and inhibits disease in mice\u2014Brief report","volume":"34","author":"Johansson","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1097\/ALN.0000000000001083","article-title":"Neural control of inflammation: Implications for perioperative and critical care","volume":"124","author":"Steinberg","year":"2016","journal-title":"Anesthesiology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e93340","DOI":"10.1172\/jci.insight.93340","article-title":"Galantamine alleviates inflammation and insulin resistance in patients with metabolic syndrome in a randomized trial","volume":"2","author":"Sangaleti","year":"2017","journal-title":"JCI Insight"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1084\/jem.20040463","article-title":"Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation","volume":"201","author":"Saeed","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1161\/CIRCRESAHA.115.306361","article-title":"Vascular smooth muscle cells in atherosclerosis","volume":"118","author":"Bennett","year":"2016","journal-title":"Circ. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1038\/s41591-019-0512-5","article-title":"Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis","volume":"25","author":"Wirka","year":"2019","journal-title":"Nat. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1160\/th15-09-0765","article-title":"Endothelial erosion of plaques as a substrate for coronary thrombosis","volume":"115","author":"White","year":"2016","journal-title":"Thromb. Haemost."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3724\/SP.J.1263.2012.02132","article-title":"Atherosclerosis: From biology to pharmacological treatment","volume":"9","author":"Riccioni","year":"2012","journal-title":"J. Geriatr. Cardiol. JGC"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1161\/CIR.0b013e31820a55f5","article-title":"Forecasting the future of cardiovascular disease in the United States: A policy statement from the American Heart Association","volume":"123","author":"Heidenreich","year":"2011","journal-title":"Circulation"},{"key":"ref_82","unstructured":"WHO (2019, March 14). WHO\/Fact Sheets\/Detail\/Cardiovascular Diseases (CVDs). Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds)."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1177\/2047487319869400","article-title":"Lifestyle factors and high-risk atherosclerosis: Pathways and mechanisms beyond traditional risk factors","volume":"27","author":"Lechner","year":"2020","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/CIRCULATIONAHA.115.018585","article-title":"Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: A comprehensive review","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.aau2095","article-title":"A time to fast","volume":"362","author":"Bernier","year":"2018","journal-title":"Science"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.1073\/pnas.0308291101","article-title":"Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans","volume":"101","author":"Fontana","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2049-3002-1-10","article-title":"Calorie restriction and cancer prevention: A mechanistic perspective","volume":"1","author":"Hursting","year":"2013","journal-title":"Cancer Metab."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1161\/CIRCRESAHA.107.168369","article-title":"Mechanisms underlying caloric restriction and lifespan regulation: Implications for vascular aging","volume":"102","author":"Ungvari","year":"2008","journal-title":"Circ. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jacc.2005.08.069","article-title":"Long-term caloric restriction ameliorates the decline in diastolic function in humans","volume":"47","author":"Meyer","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S2213-8587(19)30151-2","article-title":"2 years of calorie restriction and cardiometabolic risk (CALERIE): Exploratory outcomes of a multicentre, phase 2, randomised controlled trial","volume":"7","author":"Kraus","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e009112","DOI":"10.1161\/JAHA.118.009112","article-title":"Calorie restriction curbs proinflammation that accompanies arterial aging, preserving a youthful phenotype","volume":"7","author":"Wang","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/gerona\/glq168","article-title":"Design and conduct of the CALERIE study: Comprehensive assessment of the long-term effects of reducing intake of energy","volume":"66","author":"Rochon","year":"2011","journal-title":"J. Gerontol. Ser. A Biomed. Sci. Med. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/gerona\/glv057","article-title":"A 2-year randomized controlled trial of human caloric restriction: Feasibility and effects on predictors of health span and longevity","volume":"70","author":"Ravussin","year":"2015","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"B1007","DOI":"10.1093\/gerona\/59.10.B1007","article-title":"Caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): Metabolic, physiologic, and atherosclerotic measures from a 4-year intervention trial","volume":"59","author":"Cefalu","year":"2004","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1210\/er.2018-00141","article-title":"Insulin resistance and atherosclerosis: Implications for insulin-sensitizing agents","volume":"40","author":"DeFronzo","year":"2019","journal-title":"Endocr. Rev."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.bbrc.2020.01.109","article-title":"Food with calorie restriction reduces the development of atherosclerosis in apoE-deficient mice","volume":"524","author":"Yang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3945\/ajcn.116.131391","article-title":"Effects of matched weight loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: A randomized intervention trial","volume":"104","author":"Weiss","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/oby.21079","article-title":"Importance of substantial weight loss for altering gene expression during cardiovascular lifestyle modification","volume":"23","author":"Ellsworth","year":"2015","journal-title":"Obesity"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1017\/S0007114514002001","article-title":"Effects of an energy-restricted diet rich in plant-derived \u03b1-linolenic acid on systemic inflammation and endothelial function in overweight-to-obese patients with metabolic syndrome traits","volume":"112","author":"Egert","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.atherosclerosis.2014.12.056","article-title":"Weight loss improves fasting flow-mediated vasodilation in adults: A meta-analysis of intervention studies","volume":"239","author":"Joris","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1161\/01.ATV.0000109749.11042.7c","article-title":"Weight reduction with very-low-caloric diet and endothelial function in overweight adults: Role of plasma glucose","volume":"24","author":"Raitakari","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1101\/gad.227439.113","article-title":"Calorie restriction and sirtuins revisited","volume":"27","author":"Guarente","year":"2013","journal-title":"Genes Dev."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.advms.2015.09.003","article-title":"The role of sirtuins in aging and age-related diseases","volume":"61","author":"Szukiewicz","year":"2016","journal-title":"Adv. Med. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/oby.20060","article-title":"Effect of weight loss and exercise on angiogenic factors in the circulation and in adipose tissue in obese subjects","volume":"21","author":"Cullberg","year":"2013","journal-title":"Obesity"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/jn\/136.2.343","article-title":"Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue","volume":"136","author":"Higami","year":"2006","journal-title":"J. Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nm0603-653","article-title":"Angiogenesis in health and disease","volume":"9","author":"Carmeliet","year":"2003","journal-title":"Nat. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cccn.2005.04.020","article-title":"Mechanisms of endothelial dysfunction in obesity","volume":"360","author":"Avogaro","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cmet.2013.12.008","article-title":"Fasting: Molecular mechanisms and clinical applications","volume":"19","author":"Longo","year":"2014","journal-title":"Cell Metab."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cell.2015.02.020","article-title":"Promoting health and longevity through diet: From model organisms to humans","volume":"161","author":"Fontana","year":"2015","journal-title":"Cell"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/acel.12338","article-title":"Interventions to slow aging in humans: Are we ready?","volume":"14","author":"Longo","year":"2015","journal-title":"Aging Cell"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"16647","DOI":"10.1073\/pnas.1413965111","article-title":"Meal frequency and timing in health and disease","volume":"111","author":"Mattson","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cmet.2019.07.016","article-title":"Alternate day fasting improves physiological and molecular markers of aging in healthy, non-obese humans","volume":"30","author":"Stekovic","year":"2019","journal-title":"Cell Metab."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.metabol.2012.07.002","article-title":"Alternate day fasting (ADF) with a high-fat diet produces similar weight loss and cardio-protection as ADF with a low-fat diet","volume":"62","author":"Klempel","year":"2013","journal-title":"Metabolism"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2251-6581-12-4","article-title":"The effects of modified alternate-day fasting diet on weight loss and CAD risk factors in overweight and obese women","volume":"12","author":"Eshghinia","year":"2013","journal-title":"J. Diabetes Metab. Disord."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1002\/oby.20909","article-title":"Meal timing during alternate day fasting: Impact on body weight and cardiovascular disease risk in obese adults","volume":"22","author":"Hoddy","year":"2014","journal-title":"Obesity"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/ijo.2010.171","article-title":"The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: A randomized trial in young overweight women","volume":"35","author":"Harvie","year":"2011","journal-title":"Int. J. Obes."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/sj.ejcn.1602378","article-title":"Comparison of three different dietary scores in relation to 10-year mortality in elderly European subjects: The HALE project","volume":"60","author":"Knoops","year":"2006","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1161\/CIRCULATIONAHA.104.503995","article-title":"Effect size estimates of lifestyle and dietary changes on all-cause mortality in coronary artery disease patients: A systematic review","volume":"112","author":"Iestra","year":"2005","journal-title":"Circulation"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1056\/NEJMoa1800389","article-title":"Primary prevention of cardiovascular disease with a Mediterranean diet supplemented with extra-virgin olive oil or nuts","volume":"378","author":"Estruch","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"134","DOI":"10.12688\/f1000research.9845.1","article-title":"Apolipoprotein B-containing lipoproteins and atherosclerotic cardiovascular disease","volume":"6","author":"Shapiro","year":"2017","journal-title":"F1000Research"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/CIRCRESAHA.118.313348","article-title":"The Mediterranean diet and cardiovascular health: A critical review","volume":"124","author":"Gea","year":"2019","journal-title":"Circ. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2147\/ciia.2007.2.1.109","article-title":"Mediterranean diet and prevention of coronary heart disease in the elderly","volume":"2","author":"Dontas","year":"2007","journal-title":"Clin. Interv. Aging"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/oxfordjournals.aje.a114480","article-title":"The diet and 15-year death rate in the seven countries study","volume":"124","author":"Keys","year":"1986","journal-title":"Am. J. Epidemiol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Dontas, A.S. (1994). Recent trends in Cardiovascular disease and risk factors in the Seven Countries Study: Greece. Lessons for Science from the Seven Countries Study, Springer.","DOI":"10.1007\/978-4-431-68269-1_9"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.numecd.2014.03.003","article-title":"Mediterranean dietary pattern, inflammation and endothelial function: A systematic review and meta-analysis of intervention trials","volume":"24","author":"Schwingshackl","year":"2014","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/CIRCHEARTFAILURE.112.966622","article-title":"Phosphoinositide 3-kinase p110\u03b1 is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction","volume":"5","author":"Weeks","year":"2012","journal-title":"Circ. Heart Fail."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2165\/00007256-200838120-00005","article-title":"Exercise, vascular wall and cardiovascular diseases","volume":"38","author":"Leung","year":"2008","journal-title":"Sports Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"H1378","DOI":"10.1152\/ajpheart.00190.2002","article-title":"Exercise training regulates SOD-1 and oxidative stress in porcine aortic endothelium","volume":"284","author":"Rush","year":"2003","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_129","first-page":"79","article-title":"Short-term exercise training improves vascular function in hypercholesterolemic rabbit femoral artery","volume":"48","author":"Jen","year":"2005","journal-title":"Chin. J. Physiol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1161\/01.RES.74.2.349","article-title":"Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression","volume":"74","author":"Sessa","year":"1994","journal-title":"Circ. Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"789607","DOI":"10.1155\/2013\/789607","article-title":"Exercise and the aging endothelium","volume":"2013","author":"Golbidi","year":"2013","journal-title":"J. Diabetes Res."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4330\/wjc.v3.i1.18","article-title":"Effects of interventions on oxidative stress and inflammation of cardiovascular diseases","volume":"3","author":"Lee","year":"2011","journal-title":"World J. Cardiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/eurheartj\/ehp078","article-title":"From bone marrow to the arterial wall: The ongoing tale of endothelial progenitor cells","volume":"30","author":"Leone","year":"2009","journal-title":"Eur. Heart J."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00392-012-0517-2","article-title":"Acute and chronic effects of exercise on circulating endothelial progenitor cells in healthy and diseased patients","volume":"102","author":"Volaklis","year":"2013","journal-title":"Clin. Res. Cardiol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"17880","DOI":"10.1038\/s41598-017-18156-6","article-title":"Effects of resistance exercise on endothelial progenitor cell mobilization in women","volume":"7","author":"Ribeiro","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00421-021-04876-1","article-title":"The impact of different forms of exercise on circulating endothelial progenitor cells in cardiovascular and metabolic disease","volume":"122","author":"Ferentinos","year":"2022","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"3583956","DOI":"10.1155\/2016\/3583956","article-title":"Vascular ageing and exercise: Focus on cellular reparative processes","volume":"2016","author":"Ross","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.exger.2014.02.014","article-title":"Chronic aerobic exercise training attenuates aortic stiffening and endothelial dysfunction through preserving aortic mitochondrial function in aged rats","volume":"56","author":"Gu","year":"2014","journal-title":"Exp. Gerontol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ejphar.2014.08.017","article-title":"Contribution of receptor for advanced glycation end products to vasculature-protecting effects of exercise training in aged rats","volume":"741","author":"Gu","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_140","first-page":"767025","article-title":"Exercise and Carotid Properties in the Young\u2014The KiGGS-2 Study","volume":"8","author":"Sarganas","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3233\/JAD-201456","article-title":"One-year aerobic exercise reduced carotid arterial stiffness and increased cerebral blood flow in amnestic mild cognitive impairment","volume":"80","author":"Tomoto","year":"2021","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Long, T.M., Rath, S.R., Wallman, K.E., Howie, E.K., Straker, L.M., Bullock, A., Walwyn, T.S., Gottardo, N., Cole, C.H., and Choong, C.S. (2018). Exercise training improves vascular function and secondary health measures in survivors of pediatric oncology related cerebral insult. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0201449"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Ambrosino, P., Parrella, P., Formisano, R., Perrotta, G., D\u2019anna, S.E., Mosella, M., Papa, A., and Maniscalco, M. (2022). Cardiopulmonary Exercise Performance and Endothelial Function in Convalescent COVID-19 Patients. J. Clin. Med., 11.","DOI":"10.3390\/jcm11051452"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Matei, D., Luca, C., Onu, I., Matei, P., Iordan, D.A., and Buculei, I. (2022). Effects of Exercise Training on the Autonomic Nervous System with a Focus on Anti-Inflammatory and Antioxidants Effects. Antioxidants, 11.","DOI":"10.3390\/antiox11020350"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/cvr\/cvm092","article-title":"Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction","volume":"77","author":"Tsutsumi","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"13687","DOI":"10.1038\/s41598-017-14021-8","article-title":"Cholinergic stimulation improves oxidative stress and inflammation in experimental myocardial infarction","volume":"7","author":"Bezerra","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"a016360","DOI":"10.1101\/cshperspect.a016360","article-title":"Approaching the next revolution? Revolutionary integration of neural and immune pathogen sensing and response","volume":"7","author":"Tracey","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"e12745","DOI":"10.1111\/sji.12745","article-title":"Towards improved control of inflammatory bowel disease","volume":"89","author":"Eberhardson","year":"2019","journal-title":"Scand. J. Immunol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"8284","DOI":"10.1073\/pnas.1605635113","article-title":"Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis","volume":"113","author":"Koopman","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/joim.12611","article-title":"Vagus nerve stimulation: A new promising therapeutic tool in inflammatory bowel disease","volume":"282","author":"Bonaz","year":"2017","journal-title":"J. Intern. Med."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Levine, Y.A., Koopman, F.A., Faltys, M., Caravaca, A., Bendele, A., Zitnik, R., Vervoordeldonk, M.J., and Tak, P.P. (2014). Neurostimulation of the cholinergic anti-inflammatory pathway ameliorates disease in rat collagen-induced arthritis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104530"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"e12136","DOI":"10.14814\/phy2.12136","article-title":"Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity","volume":"2","author":"Saku","year":"2014","journal-title":"Physiol. Rep."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0008-6363(98)00122-9","article-title":"Vagal nerve stimulation releases vasoactive intestinal peptide which significantly increases coronary artery blood flow","volume":"40","author":"Feliciano","year":"1998","journal-title":"Cardiovasc. Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2018.03.042","article-title":"Hypoxia, oxidative stress and inflammation","volume":"125","author":"McGarry","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neubiorev.2021.04.018","article-title":"Vagus nerve stimulation in brain diseases: Therapeutic applications and biological mechanisms","volume":"127","author":"Wang","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/nmo.12792","article-title":"Chronic vagus nerve stimulation in Crohn\u2019s disease: A 6-month follow-up pilot study","volume":"28","author":"Bonaz","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.1113\/JP271539","article-title":"Anti-inflammatory properties of the vagus nerve: Potential therapeutic implications of vagus nerve stimulation","volume":"594","author":"Bonaz","year":"2016","journal-title":"J. Physiol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s13075-015-0667-5","article-title":"Transvenous vagus nerve stimulation does not modulate the innate immune response during experimental human endotoxemia: A randomized controlled study","volume":"17","author":"Kox","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"ref_160","first-page":"51","article-title":"Lot-to-lot variation","volume":"39","author":"Thompson","year":"2018","journal-title":"Clin. Biochem. Rev."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"37","DOI":"10.15424\/bioelectronmed.2015.00006","article-title":"Single-pulse and unidirectional electrical activation of the cervical vagus nerve reduces TNF in endotoxemia","volume":"2","author":"Olofsson","year":"2015","journal-title":"Bioelectron. Med."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"066005","DOI":"10.1088\/1741-2552\/aa7a42","article-title":"A novel flexible cuff-like microelectrode for dual purpose, acute and chronic electrical interfacing with the mouse cervical vagus nerve","volume":"14","author":"Caravaca","year":"2017","journal-title":"J. Neural Eng."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"10135","DOI":"10.1039\/C4CP05899B","article-title":"Materials analyses and electrochemical impedance of implantable metal electrodes","volume":"17","author":"Howlader","year":"2015","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1540-8159.1991.tb04052.x","article-title":"The implantable neurocybernetic prosthesis system","volume":"14","author":"Terry","year":"1991","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10741-010-9216-0","article-title":"Vagus nerve stimulation: From pre-clinical to clinical application: Challenges and future directions","volume":"16","author":"Schwartz","year":"2011","journal-title":"Heart Fail. Rev."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/eurheartj\/ehq391","article-title":"Chronic vagus nerve stimulation: A new and promising therapeutic approach for chronic heart failure","volume":"32","author":"Crijns","year":"2011","journal-title":"Eur. Heart J."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.yebeh.2013.08.014","article-title":"Preliminary experience with a new system for vagus nerve stimulation for the treatment of refractory focal onset seizures","volume":"29","author":"Rydenhag","year":"2013","journal-title":"Epilepsy Behav."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.brs.2019.01.008","article-title":"Inter-ictal assay of peripheral circulating inflammatory mediators in migraine patients under adjunctive cervical non-invasive vagus nerve stimulation (nVNS): A proof-of-concept study","volume":"12","author":"Chaudhry","year":"2019","journal-title":"Brain Stimul."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/ner.12398","article-title":"Noninvasive transcutaneous vagus nerve stimulation decreases whole blood culture-derived cytokines and chemokines: A randomized, blinded, healthy control pilot trial","volume":"19","author":"Lerman","year":"2016","journal-title":"Neuromodulation"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/s00702-007-0755-z","article-title":"BOLD fMRI deactivation of limbic and temporal brain structures and mood enhancing effect by transcutaneous vagus nerve stimulation","volume":"114","author":"Kraus","year":"2007","journal-title":"J. Neural Transm."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.brs.2017.12.009","article-title":"Neurophysiologic effects of transcutaneous auricular vagus nerve stimulation (taVNS) via electrical stimulation of the tragus: A concurrent taVNS\/fMRI study and review","volume":"11","author":"Badran","year":"2018","journal-title":"Brain Stimul."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/14768320701212099","article-title":"Executive function moderates the intention-behavior link for physical activity and dietary behavior","volume":"23","author":"Hall","year":"2008","journal-title":"Psychol. Health"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.brs.2013.01.011","article-title":"CNS BOLD fMRI effects of sham-controlled transcutaneous electrical nerve stimulation in the left outer auditory canal\u2014A pilot study","volume":"6","author":"Kraus","year":"2013","journal-title":"Brain Stimul."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"a034173","DOI":"10.1101\/cshperspect.a034173","article-title":"Vagus nerve stimulation and the cardiovascular system","volume":"10","author":"Capilupi","year":"2020","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"685872","DOI":"10.3389\/fnins.2021.685872","article-title":"Selective neuromodulation of the vagus nerve","volume":"15","author":"Fitchett","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_176","first-page":"103","article-title":"Hatha yoga program determinants on cardiovascular health in physically active adult women","volume":"1","year":"2011","journal-title":"J. Yoga Phys. Ther."},{"key":"ref_177","first-page":"142","article-title":"Effect of yoga on anxiety score and resting heart rate in young healthy individuals","volume":"3","author":"Mehrotra","year":"2012","journal-title":"Natl. J. Integr. Res. Med. (NJIRM)"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1200\/JCO.2013.51.8860","article-title":"Yoga\u2019s impact on inflammation, mood, and fatigue in breast cancer survivors: A randomized controlled trial","volume":"32","author":"Bennett","year":"2014","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.psyneuen.2014.01.019","article-title":"Yoga reduces inflammatory signaling in fatigued breast cancer survivors: A randomized controlled trial","volume":"43","author":"Bower","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1089\/acm.2012.0086","article-title":"Adiponectin, interleukin-6, and cardiovascular disease risk factors are modified by a short-term yoga-based lifestyle intervention in overweight and obese men","volume":"19","author":"Sarvottam","year":"2013","journal-title":"J. Altern. Complement. Med."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3389\/fpsyg.2014.00756","article-title":"Heart rate variability biofeedback: How and why does it work?","volume":"5","author":"Lehrer","year":"2014","journal-title":"Front. Psychol."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10484-017-9364-2","article-title":"Effect of heart rate variability biofeedback on sport performance, a systematic review","volume":"42","year":"2017","journal-title":"Appl. Psychophysiol. Biofeedback"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12529-017-9707-7","article-title":"One-year cardiovascular prognosis of the randomized, controlled, shortterm heart rate variability biofeedback among patients with coronary artery disease","volume":"25","author":"Yu","year":"2018","journal-title":"Int. J. Behav. Med."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10484-020-09466-z","article-title":"Heart rate variability biofeedback improves emotional and physical health and performance: A systematic review and meta analysis","volume":"45","author":"Lehrer","year":"2020","journal-title":"Appl. Psychophysiol. Biofeedback"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10484-010-9139-5","article-title":"Voluntarily produced increases in heart rate variability modulate autonomic effects of endotoxin induced systemic inflammation: An exploratory study","volume":"35","author":"Lehrer","year":"2010","journal-title":"Appl. Psychophysiol. Biofeedback"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10484-017-9382-0","article-title":"Heart rate variability biofeedback does not substitute for asthma steroid controller medication","volume":"43","author":"Lehrer","year":"2018","journal-title":"Appl. Psychophysiol. Biofeedback"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1089\/acm.2010.0607","article-title":"Heart rate variability biofeedback decreases blood pressure in prehypertensive subjects by improving autonomic function and baroreflex","volume":"18","author":"Lin","year":"2012","journal-title":"J. Altern. Complement. Med."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"673","DOI":"10.33549\/physiolres.932950","article-title":"Slow breathing training reduces resting blood pressure and the pressure responses to exercise","volume":"64","author":"Jones","year":"2015","journal-title":"Physiol. Res."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1161\/01.CIR.102.20.2473","article-title":"Mental stress induces transient endothelial dysfunction in humans","volume":"102","author":"Ghiadoni","year":"2000","journal-title":"Circulation"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000366231","article-title":"Hemodynamic changes and baroreflex sensitivity associated with carotid endarterectomy and carotid artery stenting","volume":"3","author":"Cao","year":"2015","journal-title":"Interv. Neurol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuint.2014.11.001","article-title":"Endothelial dysfunction impairs vascular neurotransmission in tail arteries","volume":"80","author":"Sousa","year":"2015","journal-title":"Neurochem. Int."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nm.3589","article-title":"Chronic variable stress activates hematopoietic stem cells","volume":"20","author":"Heidt","year":"2014","journal-title":"Nat. Med."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bbi.2008.09.009","article-title":"Determinants of the NF-\u03baB response to acute psychosocial stress in humans","volume":"23","author":"Wolf","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bbi.2021.08.217","article-title":"Parasympathetic neural activity and the reciprocal regulation of innate antiviral and inflammatory genes in the human immune system","volume":"98","author":"Sloan","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bbi.2017.01.011","article-title":"The effects of acute psychological stress on circulating and stimulated inflammatory markers: A systematic review and meta-analysis","volume":"64","author":"Marsland","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"104745","DOI":"10.1016\/j.psyneuen.2020.104745","article-title":"Autonomic nervous system activity predicts increasing serum cytokines in children","volume":"119","author":"Alen","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"100273","DOI":"10.1016\/j.bbih.2021.100273","article-title":"Heart rate variability and circulating inflammatory markers in midlife","volume":"15","author":"Alen","year":"2021","journal-title":"Brain Behav. Immun. Health"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/nyas.13728","article-title":"Stress and the psyche-brain\u2014Immune network in psychiatric diseases based on Psychoneuroendocrineimmunology","volume":"1437","author":"Bottaccioli","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/16\/9097\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:08:26Z","timestamp":1760141306000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/16\/9097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,13]]},"references-count":198,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["ijms23169097"],"URL":"https:\/\/doi.org\/10.3390\/ijms23169097","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,13]]}}}