{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:44:54Z","timestamp":1787237094139,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"grant-in-aid for scientific research from the Japan Society for the Promotion of Science to Hidenori Suzuki","doi-asserted-by":"publisher","award":["JP20K09346"],"award-info":[{"award-number":["JP20K09346"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The relationships between repeated non-fasting triglyceride (TG) measurements and carotid stenosis progression during follow-ups have never been investigated. In 111 consecutive carotid arteries of 88 patients with \u226550% atherosclerotic stenosis on at least one side, who had \u22653 blood samples taken during \u2265one-year follow-ups, clinical variables were compared between carotid arteries with and without subsequent stenosis progression. To evaluate non-fasting TG burden, a new parameter area [TG \u2265 175] was calculated by integrating non-fasting TG values \u2265 175 mg\/dL (i.e., TG values minus 175) with the measurement intervals (year). Carotid stenosis progression occurred in 22 arteries (19.8%) during the mean follow-up period of 1185 days. Younger age, symptomatic stenosis, higher mean values of TG during follow-ups, the area [TG \u2265 175], mean TG values \u2265 175 mg\/dL and maximum TG values \u2265175 mg\/dL were significant factors related to the progression on univariate analyses. The cut-off value of the area [TG \u2265 175] to discriminate carotid stenosis progression was 6.35 year-mg\/dL. Multivariate analyses demonstrated that symptomatic stenosis and the area [TG \u2265 175] \u2265 6.35 year-mg\/dL were independently related to carotid stenosis progression. In conclusion, the area [TG \u2265 175] was an independent risk factor for carotid stenosis progression, and this study suggests the importance to continuously control non-fasting TG levels &lt; 175 mg\/dL during follow-ups to prevent carotid stenosis progression.<\/jats:p>","DOI":"10.3390\/ijms23169197","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T23:44:25Z","timestamp":1660693465000},"page":"9197","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Non-Fasting Hypertriglyceridemia Burden as a Residual Risk of the Progression of Carotid Artery Stenosis"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4451-5204","authenticated-orcid":false,"given":"Yoichi","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2144-0297","authenticated-orcid":false,"given":"Ryuta","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8174-3428","authenticated-orcid":false,"given":"Naoki","family":"Toma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8555-5448","authenticated-orcid":false,"given":"Hidenori","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu 514-8507, Mie, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/aje\/153.5.490","article-title":"Serum Triglycerides and Risk of Coronary Heart Disease among Japanese Men and Women","volume":"153","author":"Iso","year":"2001","journal-title":"Am. J. Epidemiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jacc.2013.09.038","article-title":"Elevated Lipoprotein(a) and Risk of Aortic Valve Stenosis in the General Population","volume":"63","author":"Kamstrup","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2188\/jea.JE20200399","article-title":"Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90","volume":"32","author":"Hirata","year":"2022","journal-title":"J. Epidemiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1373\/clinchem.2015.241752","article-title":"Identifying an Optimal Cutpoint for the Diagnosis of Hypertriglyceridemia in the Nonfasting State","volume":"61","author":"White","year":"2015","journal-title":"Clin. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.2174\/138945009787846434","article-title":"Nonfasting hyperlipidemia and cardiovascular disease","volume":"10","author":"Nordestgaard","year":"2009","journal-title":"Curr. Drug Targets"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"422","DOI":"10.2176\/nmc.oa.2020-0430","article-title":"Higher Non-fasting Serum Triglyceride Preceding the Carotid Stenosis Progression","volume":"61","author":"Miura","year":"2021","journal-title":"Neurol. Med. Chir."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"8601762","DOI":"10.1155\/2020\/8601762","article-title":"Carotid Disease and Ageing: A Literature Review on the Pathogenesis of Vascular Senescence in Older Subjects","volume":"2020","author":"Sertedaki","year":"2020","journal-title":"Curr. Gerontol. Geriatr. Res."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Rink\u016bnien\u0117, E., D\u017eenkevi\u010di\u016bt\u0117, V., Petrulionien\u0117, \u017d., Majauskien\u0117, E., Ryli\u0161kyt\u0117, L., Puronait\u0117, R., Badarien\u0117, J., Navickas, R., and Laucevi\u010dius, A. (2021). Hypertriglyceridemia impact on arterial parameters in patients with metabolic syndrome. BMC Cardiovasc. Disord., 21.","DOI":"10.1186\/s12872-021-02202-3"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.atherosclerosis.2019.09.025","article-title":"Lifestyle factors modulate postprandial hypertriglyceridemia: From the CORDIOPREV study","volume":"290","author":"Tinahones","year":"2019","journal-title":"Atherosclerosis"},{"key":"ref_10","first-page":"e22","article-title":"Interleukin-6 Predicts Carotid Plaque Severity, Vulnerability, and Progression","volume":"131","author":"Saba","year":"2022","journal-title":"Circ. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1373\/clinchem.2016.258897","article-title":"Fasting Is Not Routinely Required for Determination of a Lipid Profile: Clinical and Laboratory Implications Including Flagging at Desirable Concentration Cutpoints\u2014A Joint Consensus Statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine","volume":"62","author":"Nordestgaard","year":"2016","journal-title":"Clin. Chem."},{"key":"ref_12","unstructured":"Koeppen, B.M., and Stanton, B.A. (2008). Hormonal regulation of energy metabolism. Berne and Levy Physiology, Mosby\/Elsevier. [6th ed.]."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1016\/j.jacc.2014.09.042","article-title":"Genetics and Causality of Triglyceride-Rich Lipoproteins in Atherosclerotic Cardiovascular Disease","volume":"64","author":"Rosenson","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1161\/CIR.0b013e3182160726","article-title":"American Heart association Clinical Lipidology, Thrombosis, and Prevention Committee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular Nursing; Council on the Kidney in Cardiovascular Disease. Triglycerides and Cardiovascular Disease: A scientific statement from the American Heart Association","volume":"123","author":"Miller","year":"2011","journal-title":"Circulation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"258","DOI":"10.2174\/157016111795495549","article-title":"Assessment and Clinical Relevance of Non-Fasting and Postprandial Triglycerides: An Expert Panel Statement","volume":"9","author":"Kolovou","year":"2011","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1385\/ENDO:28:2:157","article-title":"Association Between Postprandial Remnant-like Particle Triglyceride (RLP-TG) Levels and Carotid Intima-Media Thickness (IMT) in Japanese Patients with Type 2 Diabetes: Assessment by Meal Tolerance Tests (MTT)","volume":"28","author":"Mori","year":"2005","journal-title":"Endocrine"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.2337\/diacare.23.9.1401","article-title":"Association of postprandial hypertriglyceridemia and carotid intima-media thickness in patients with type 2 diabetes","volume":"23","author":"Teno","year":"2000","journal-title":"Diabetes Care"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cca.2013.12.022","article-title":"Mean postprandial triglyceride concentration is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes","volume":"430","author":"Idei","year":"2014","journal-title":"Clin. Chim. Acta"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1365-2796.1999.00548.x","article-title":"Postprandial lipoprotein metabolism and atherosclerosis","volume":"246","author":"Karpe","year":"1991","journal-title":"J. Intern. Med."},{"key":"ref_20","first-page":"1","article-title":"Dyslipidemia and atherosclerotic carotid artery stenosis","volume":"3","author":"Miura","year":"2019","journal-title":"Vessel Plus"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12933-019-0864-7","article-title":"The selective peroxisome proliferator-activated receptor alpha modulator (SPPARM\u03b1) paradigm: Conceptual framework and therapeutic potential: A consensus statement from the International Ath-erosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation","volume":"18","author":"Fruchart","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s12944-017-0625-0","article-title":"Hypertriglyceridemia and atherosclerosis","volume":"16","author":"Peng","year":"2017","journal-title":"Lipids Health Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00125-003-1111-y","article-title":"Diabetic dyslipidaemia: From basic research to clinical practice","volume":"46","author":"Taskinen","year":"2003","journal-title":"Diabetologia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0002-9149(01)01831-8","article-title":"Postprandial dyslipidemia: An atherogenic disorder common in patients with diabetes mellitus","volume":"88","author":"Ginsberg","year":"2001","journal-title":"Am. J. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"636947","DOI":"10.3389\/fcvm.2021.636947","article-title":"Mechanisms of Atherosclerosis Induced by Postprandial Lipemia","volume":"8","author":"Zhao","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1161\/STROKEAHA.107.510644","article-title":"Geometry of the Carotid Bifurcation Predicts Its Exposure to Disturbed Flow","volume":"39","author":"Lee","year":"2008","journal-title":"Stroke"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1161\/CIRCIMAGING.110.958504","article-title":"In Vivo Wall Shear Stress Distribution in the Carotid Artery","volume":"3","author":"Markl","year":"2010","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e415","DOI":"10.1016\/j.wneu.2021.09.091","article-title":"Nonfasting Triglyceride as an Independent Predictor of Carotid Restenosis After Carotid Endarterectomy or Carotid Artery Stenting","volume":"156","author":"Miura","year":"2021","journal-title":"World Neurosurg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1161\/STROKEAHA.112.663138","article-title":"High-Risk Plaque for Carotid Artery Stenting Evaluated With 3-Dimensional T1-Weighted Gradient Echo Sequence","volume":"44","author":"Tanemura","year":"2013","journal-title":"Stroke"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.04.010","article-title":"Impact of Hypertriglyceridemia on Carotid Stenosis Progression under Normal Low-Density Lipoprotein Cholesterol Levels","volume":"26","author":"Kitagami","year":"2017","journal-title":"J. Stroke Cerebrovasc. Dis."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/16\/9197\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:10:30Z","timestamp":1760141430000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/16\/9197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":30,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["ijms23169197"],"URL":"https:\/\/doi.org\/10.3390\/ijms23169197","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,16]]}}}