{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T16:35:06Z","timestamp":1775579706924,"version":"3.50.1"},"reference-count":20,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology","doi-asserted-by":"publisher","award":["NRF-2018R1A6A1A03025523"],"award-info":[{"award-number":["NRF-2018R1A6A1A03025523"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Intermittent hypoxia (IH) has been an issue of considerable research in recent years and triggers a bewildering array of both detrimental and beneficial effects in several physiological systems. However, the mechanisms leading to the effect are not yet clear. Consequently, we investigated the effects of IH on allergen-induced allergic asthma via the mitogen-activated protein kinase (MAPK) signaling pathway. Forty BALB\/c mice were dived into four groups. We evaluated the influence of IH on the cell signaling system of the airway during the allergen-induced challenge in an animal model, especially through the MAPK (mitogen-activated protein kinase) pathway. The protein concentrations of p-ERK\/ERK, p-JNK\/JNK, p-p38\/p38, and pMEK\/MEK were significantly reduced in the allergen-induced+IH group, compared to the allergen-induced group (p-value &lt; 0.05 as considered statistically significant). The number of eosinophils, neutrophils, macrophages, and lymphocytes in the bronchoalveolar lavage fluid and Dp (Dermatophagoides pteronyssinus)-specific IgG2a and interleukins 4, 5, 13, and 17 were significantly reduced in the Dp+IH group, compared to the Dp group. These findings suggest that the MAPK pathway might be associated with the beneficial effect of IH on the attenuation of allergic response in an allergen-induced mouse model.<\/jats:p>","DOI":"10.3390\/ijms23169235","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T21:23:56Z","timestamp":1660771436000},"page":"9235","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Intermittent Hypoxia on the Attenuation of Induced Nasal Allergy and Allergic Asthma by MAPK Signaling Pathway Downregulation in a Mice Animal Model"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-4450","authenticated-orcid":false,"given":"Doston","family":"Sultonov","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head & Neck Surgery, Inha University Hospital, Incheon 22332, Korea"},{"name":"Inha Research Institute for Aerospace Medicine, Inha University College of Medicine, Incheon 22332, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Hyo","family":"Kim","sequence":"additional","affiliation":[{"name":"Kimyounghyo ENT Clinic, 161 Shin-song-ro, Yeonsu-gu, Incheon 22002, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1420-7526","authenticated-orcid":false,"given":"Hyelim","family":"Park","sequence":"additional","affiliation":[{"name":"Inha Research Institute for Aerospace Medicine, Inha University College of Medicine, Incheon 22332, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5650-3526","authenticated-orcid":false,"given":"Kyu-Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head & Neck Surgery, Inha University Hospital, Incheon 22332, Korea"},{"name":"Inha Research Institute for Aerospace Medicine, Inha University College of Medicine, Incheon 22332, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41392-019-0079-0","article-title":"Targeting cell signaling in allergic asthma","volume":"4","author":"Athari","year":"2019","journal-title":"Signal Transduct. 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