{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T19:58:49Z","timestamp":1793563129575,"version":"4.5.0"},"reference-count":99,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3 Privada Cellex","award":["CP042187"],"award-info":[{"award-number":["CP042187"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The distinguishing pathogenic features of neurodegenerative diseases include mitochondrial dysfunction and derived reactive oxygen species generation. The neural tissue is highly sensitive to oxidative stress and this is a prominent factor in both chronic and acute neurodegeneration. Based on this, therapeutic strategies using antioxidant molecules towards redox equilibrium have been widely used for the treatment of several brain pathologies. Globally, polyphenols, carotenes and vitamins are among the most typical exogenous antioxidant agents that have been tested in neurodegeneration as adjunctive therapies. However, other types of antioxidants, including hormones, such as the widely used melatonin, are also considered neuroprotective agents and have been used in different neurodegenerative contexts. This review highlights the most relevant mitochondrial antioxidant targets in the main neurodegenerative disorders including Alzheimer\u2019s disease, Parkinson\u2019s disease, and Huntington\u2019s disease and also in the less represented amyotrophic lateral sclerosis, as well as traumatic brain injury, while summarizing the latest randomized placebo-controlled trials.<\/jats:p>","DOI":"10.3390\/ijms23169328","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T22:23:13Z","timestamp":1661120593000},"page":"9328","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":119,"title":["Antioxidant Therapeutic Strategies in Neurodegenerative Diseases"],"prefix":"10.3390","volume":"23","author":[{"given":"Constanza","family":"Mor\u00e9n","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Raras (CIBERER), 28029 Madrid, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"},{"name":"Faculty of Medicine, University of Barcelona-Hospital Cl\u00ednic of Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth Mary","family":"deSouza","sequence":"additional","affiliation":[{"name":"Emergency Department, Guy\u2019s and St. Thomas Hospital (NHS Foundation Trust), London SE1 9RT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darly Milena","family":"Giraldo","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Comarcal Sant Jaume de Calella, 08370 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9787-8001","authenticated-orcid":false,"given":"Christopher","family":"Uff","sequence":"additional","affiliation":[{"name":"Neurotrauma and Neurovascular Surgery, Royal London Hospital, London E1 1FR, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Chi, H., Chang, H.Y., and Sang, T.K. 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