{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:18:32Z","timestamp":1791091112958,"version":"4.1.0"},"reference-count":303,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sepsis is a critical condition characterized by increased levels of pro-inflammatory cytokines and proliferating cells such as neutrophils and macrophages in response to microbial pathogens. Such processes lead to an abnormal inflammatory response and multi-organ failure. MicroRNAs (miRNA) are single-stranded non-coding RNAs with the function of gene regulation. This means that miRNAs are involved in multiple intracellular pathways and thus contribute to or inhibit inflammation. As a result, their variable expression in different tissues and organs may play a key role in regulating the pathophysiological events of sepsis. Thanks to this property, miRNAs may serve as potential diagnostic and prognostic biomarkers in such life-threatening events. In this narrative review, we collect the results of recent studies on the expression of miRNAs in heart, blood, lung, liver, brain, and kidney during sepsis and the molecular processes in which they are involved. In reviewing the literature, we find at least 122 miRNAs and signaling pathways involved in sepsis-related organ dysfunction. This may help clinicians to detect, prevent, and treat sepsis-related organ failures early, although further studies are needed to deepen the knowledge of their potential contribution.<\/jats:p>","DOI":"10.3390\/ijms23169354","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T22:23:13Z","timestamp":1661120593000},"page":"9354","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review"],"prefix":"10.3390","volume":"23","author":[{"given":"Aniello","family":"Maiese","sequence":"first","affiliation":[{"name":"Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8727-9769","authenticated-orcid":false,"given":"Andrea","family":"Scatena","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3377-7997","authenticated-orcid":false,"given":"Andrea","family":"Costantino","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1053-5661","authenticated-orcid":false,"given":"Enrica","family":"Chiti","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0476-7394","authenticated-orcid":false,"given":"Carla","family":"Occhipinti","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-7122","authenticated-orcid":false,"given":"Raffaele","family":"La Russa","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Di Paolo","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Turillazzi","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Medical, Molecular and Critical Area, Institute of Legal Medicine, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0358-7965","authenticated-orcid":false,"given":"Paola","family":"Frati","sequence":"additional","affiliation":[{"name":"Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-3236","authenticated-orcid":false,"given":"Vittorio","family":"Fineschi","sequence":"additional","affiliation":[{"name":"Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: International guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensiv. Care Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1007\/s00134-020-06151-x","article-title":"Incidence and mortality of hospital- and ICU-treated sepsis: Results from an updated and expanded systematic review and meta-analysis","volume":"46","author":"Mellhammar","year":"2020","journal-title":"Intensiv. Care Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1097\/CCM.0000000000003342","article-title":"Epidemiology and Costs of Sepsis in the United States\u2014An Analysis Based on Timing of Diagnosis and Severity Level","volume":"46","author":"Paoli","year":"2018","journal-title":"Crit. Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"i1585","DOI":"10.1136\/bmj.i1585","article-title":"Sepsis: Pathophysiology and clinical management","volume":"353","author":"Gotts","year":"2016","journal-title":"BMJ"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ccc.2017.08.003","article-title":"Mechanisms of Organ Dysfunction in Sepsis","volume":"34","author":"Pool","year":"2018","journal-title":"Crit. Care Clin."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri3552","article-title":"Sepsis-induced immunosuppression: From cellular dysfunctions to immunotherapy","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nrc.2017.99","article-title":"Non-coding RNA networks in cancer","volume":"18","author":"Anastasiadou","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrd.2016.117","article-title":"Non-coding RNAs as drug targets","volume":"16","author":"Matsui","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nrc3932","article-title":"MicroRNA biogenesis pathways in cancer","volume":"15","author":"Lin","year":"2015","journal-title":"Nat. Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, Biogenesis, Mechanism, and Function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"ref_13","first-page":"161","article-title":"The Role of MicroRNAs in Human Diseases","volume":"2","author":"Ardekani","year":"2010","journal-title":"Avicenna J. Med. Biotechnol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Healthcare Interventions: Explanation and Elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ (Clin. Res. Ed.)"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1097\/CCM.0000000000003981","article-title":"Acquired Brain Injury Following Sepsis","volume":"47","author":"Hopkins","year":"2019","journal-title":"Crit. Care Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.neuron.2013.10.062","article-title":"Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain","volume":"81","author":"Boudreau","year":"2014","journal-title":"Neuron"},{"key":"ref_17","first-page":"2971","article-title":"MicroRNA-494-3p alleviates inflammatory response in sepsis by targeting TLR6","volume":"23","author":"Wang","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1080\/21655979.2020.1851476","article-title":"Upregulation of the microRNA rno-miR-146b-5p may be involved in the development of intestinal injury through inhibition of Kruppel-like factor 4 in intestinal sepsis","volume":"11","author":"Tong","year":"2020","journal-title":"Bioengineered"},{"key":"ref_19","first-page":"857","article-title":"Protective effects of microRNA-181b on aged rats with sepsis-induced hippocampus injury in vivo","volume":"31","author":"Dong","year":"2019","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.21037\/atm-20-7024","article-title":"JAK\/STAT signaling pathway-mediated microRNA-181b promoted blood-brain barrier impairment by targeting sphingosine-1-phosphate receptor 1 in septic rats","volume":"8","author":"Chen","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_21","first-page":"1811","article-title":"Overexpression of miR-200a-3p promoted inflammation in sepsis-induced brain injury through ROS-induced NLRP3","volume":"44","author":"Yu","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/SHK.0000000000001473","article-title":"Plasma miR-370-3P as a Biomarker of Sepsis-Associated Encephalopathy, the Transcriptomic Profiling Analysis of Microrna-Arrays from Mouse Brains","volume":"54","author":"Visitchanakun","year":"2020","journal-title":"Shock"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1007\/s10753-021-01427-w","article-title":"Characterization of a Murine Model System to Study MicroRNA-147 During Inflammatory Organ Injury","volume":"44","author":"Kim","year":"2021","journal-title":"Inflammation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1080\/21655979.2021.1937905","article-title":"MicroRNA miR-126 attenuates brain injury in septic rats via NF-\u03baB signaling pathway","volume":"12","author":"Nong","year":"2021","journal-title":"Bioengineered"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"728","DOI":"10.18632\/aging.203868","article-title":"Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis","volume":"14","author":"Rani","year":"2022","journal-title":"Aging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbi.2021.11.007","article-title":"Brain innate immune response via miRNA-TLR7 sensing in polymicrobial sepsis","volume":"100","author":"Zou","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.yjmcc.2014.06.003","article-title":"High-mobility group box 1 (HMGB1) impaired cardiac excitation\u2013contraction coupling by enhancing the sarcoplasmic reticulum (SR) Ca2+ leak through TLR4\u2013ROS signaling in cardiomyocytes","volume":"74","author":"Zhang","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e840","DOI":"10.1097\/CCM.0000000000002448","article-title":"Improved Survival in a Long-Term Rat Model of Sepsis Is Associated with Reduced Mitochondrial Calcium Uptake Despite Increased Energetic Demand","volume":"45","author":"Pinto","year":"2017","journal-title":"Crit. Care Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/SHK.0000000000000473","article-title":"The Endothelium in Sepsis","volume":"45","author":"Ince","year":"2016","journal-title":"Shock"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/CCM.0000000000000553","article-title":"International Study on Microcirculatory Shock Occurrence in Acutely Ill Patients*","volume":"43","author":"Vellinga","year":"2015","journal-title":"Crit. Care Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"R969","DOI":"10.1152\/ajpregu.1997.272.3.R969","article-title":"Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to endothelin-1 in septic rats","volume":"272","author":"Hollenberg","year":"1997","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nri1943","article-title":"Apoptosis and caspases regulate death and inflammation in sepsis","volume":"6","author":"Hotchkiss","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(02)09459-X","article-title":"Association between mitochondrial dysfunction and severity and outcome of septic shock","volume":"360","author":"Brealey","year":"2002","journal-title":"Lancet"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.mito.2004.07.023","article-title":"Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome","volume":"4","author":"Crouser","year":"2004","journal-title":"Mitochondrion"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.bbadis.2018.10.011","article-title":"The role of mitochondria in sepsis-induced cardiomyopathy","volume":"1865","author":"Stanzani","year":"2019","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Mol. Basis Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41569-020-00492-2","article-title":"Pathophysiology of sepsis-induced cardiomyopathy","volume":"18","author":"Hollenberg","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ccc.2017.08.002","article-title":"Immune Activation in Sepsis","volume":"34","author":"Wilson","year":"2018","journal-title":"Crit. Care Clin."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Manetti, A.C., Maiese, A., Di Paolo, M., De Matteis, A., La Russa, R., Turillazzi, E., Frati, P., and Fineschi, V. (2020). MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22010321"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1084\/jem.183.3.949","article-title":"Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum","volume":"183","author":"Kumar","year":"1996","journal-title":"J. Exp. Med."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Vasilescu, C., Rossi, S., Shimizu, M., Tudor, S., Veronese, A., Ferracin, M., Nicoloso, M., Barbarotto, E., Popa, M., and Stanciulea, O. (2009). MicroRNA Fingerprints Identify miR-150 as a Plasma Prognostic Marker in Patients with Sepsis. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0007405"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Roderburg, C., Luedde, M., Cardenas, D.V., Vucur, M., Scholten, D., Frey, N., Koch, A., Trautwein, C., Tacke, F., and Luedde, T. (2013). Circulating MicroRNA-150 Serum Levels Predict Survival in Patients with Critical Illness and Sepsis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0054612"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbrc.2010.02.145","article-title":"Serum miR-146a and miR-223 as potential new biomarkers for sepsis","volume":"394","author":"Wang","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/SHK.0b013e318241baf8","article-title":"Serum miR-574-5p","volume":"37","author":"Wang","year":"2012","journal-title":"Shock"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Ma, Y., Vilanova, D., Atalar, K., Delfour, O., Edgeworth, J., Ostermann, M., Hern\u00e1ndez-Fuentes, M., Razafimahatratra, S., Michot, B., and Persing, D.H. (2013). Genome-Wide Sequencing of Cellular microRNAs Identifies a Combinatorial Expression Signature Diagnostic of Sepsis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075918"},{"key":"ref_45","first-page":"1973","article-title":"MicroRNA-181b regulates NF-\u03baB\u2013mediated vascular inflammation","volume":"122","author":"Sun","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.immuni.2013.10.011","article-title":"Plasticity of Leukocytic Exudates in Resolving Acute Inflammation Is Regulated by MicroRNA and Proresolving Mediators","volume":"39","author":"Li","year":"2013","journal-title":"Immunity"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1097\/CCM.0000000000000131","article-title":"Levels of Circulating miR-133a Are Elevated in Sepsis and Predict Mortality in Critically Ill Patients","volume":"42","author":"Tacke","year":"2014","journal-title":"Crit. Care Med."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Benz, F., Roy, S., Trautwein, C., Roderburg, C., and Luedde, T. (2016). Circulating MicroRNAs as Biomarkers for Sepsis. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17010078"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1586\/14737159.2014.899151","article-title":"How might a diagnostic microRNA signature be used to speed up the diagnosis of sepsis?","volume":"14","author":"Lord","year":"2014","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrcardio.2016.185","article-title":"Inflammatory processes in cardiovascular disease: A route to targeted therapies","volume":"14","author":"Ruparelia","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1164\/rccm.201307-1321OC","article-title":"Risk of Cardiovascular Events in Survivors of Severe Sepsis","volume":"189","author":"Yende","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nrcardio.2015.2","article-title":"Inflammation and the pathogenesis of atrial fibrillation","volume":"12","author":"Hu","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pcad.2021.07.005","article-title":"Role of non-coding RNAs as biomarkers of deleterious cardiovascular effects in sepsis","volume":"68","author":"Carbonell","year":"2021","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.bbadis.2014.01.012","article-title":"Loss of duplexmiR-223 (5p and 3p) aggravates myocardial depression and mortality in polymicrobial sepsis","volume":"1842","author":"Wang","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Mol. Basis Dis."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Wang, H., Zhang, P., Chen, W., Feng, D., Jia, Y., and Xie, L. (2012). Serum MicroRNA Signatures Identified by Solexa Sequencing Predict Sepsis Patients\u2019 Mortality: A Prospective Observational Study. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038885"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"17691","DOI":"10.1038\/s41598-020-74965-2","article-title":"The protective role of miR-223 in sepsis-induced mortality","volume":"10","author":"Liu","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1016\/j.bbadis.2018.05.010","article-title":"A multi-omics analysis of the regulatory changes induced by miR-223 in a monocyte\/macrophage cell line","volume":"1864","author":"Louvet","year":"2018","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Mol. Basis Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.bbrc.2015.07.051","article-title":"rhTNFR:Fc increases Nrf2 expression via miR-27a mediation to protect myocardium against sepsis injury","volume":"464","author":"Xue","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","article-title":"Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway","volume":"47","author":"Kensler","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"672","DOI":"10.4049\/jimmunol.1403155","article-title":"Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression","volume":"195","author":"Gao","year":"2015","journal-title":"J. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7163057","DOI":"10.1155\/2018\/7163057","article-title":"miR-146a Attenuates Sepsis-Induced Myocardial Dysfunction by Suppressing IRAK1 and TRAF6 via Targeting ErbB4 Expression","volume":"2018","author":"An","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_62","first-page":"779","article-title":"MicroRNA-146a improves sepsis-induced cardiomyopathy by regulating the TLR-4\/NF-\u03baB signaling pathway","volume":"18","author":"Xie","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s10735-018-9781-4","article-title":"MiR-146b protect against sepsis induced mice myocardial injury through inhibition of Notch1","volume":"49","author":"Wang","year":"2018","journal-title":"Histochem. J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1093\/infdis\/jiw449","article-title":"MicroRNA-125b Prevents Cardiac Dysfunction in Polymicrobial Sepsis by Targeting TRAF6-Mediated Nuclear Factor \u03baB Activation and p53-Mediated Apoptotic Signaling","volume":"214","author":"Ma","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_65","first-page":"3311","article-title":"Long noncoding RNA MALAT1 modulates sepsis-induced cardiac inflammation through the miR-150-5p\/NF-\u03baB axis","volume":"12","author":"Wei","year":"2019","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3023186","DOI":"10.1155\/2020\/3023186","article-title":"Overexpression of miR-150-5p Alleviates Apoptosis in Sepsis-Induced Myocardial Depression","volume":"2020","author":"Zhu","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.yjmcc.2016.03.014","article-title":"miR-21-3p controls sepsis-associated cardiac dysfunction via regulating SORBS2","volume":"94","author":"Wang","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1038\/mtna.2016.80","article-title":"Inhibition of miR-155 Protects Against LPS-induced Cardiac Dysfunction and Apoptosis in Mice","volume":"5","author":"Wang","year":"2016","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s10529-017-2368-4","article-title":"PMicroRNA-124a regulates LPS-induced septic cardiac dysfunction by targeting STX2","volume":"39","author":"Diao","year":"2017","journal-title":"Biotechnol. Lett."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.intimp.2017.01.029","article-title":"MicroRNA-135a is up-regulated and aggravates myocardial depression in sepsis via regulating p38 MAPK\/NF-\u03baB pathway","volume":"45","author":"Zheng","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"47317","DOI":"10.18632\/oncotarget.17636","article-title":"MicroRNA-155 attenuates late sepsis-induced cardiac dysfunction through JNK and \u03b2-arrestin 2","volume":"8","author":"Zhou","year":"2017","journal-title":"Oncotarget"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/SHK.0000000000000978","article-title":"miRNA-214 Protects Sepsis-Induced Myocardial Injury","volume":"50","author":"Ge","year":"2018","journal-title":"Shock"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1409038","DOI":"10.1155\/2020\/1409038","article-title":"miR-214-3p Attenuates Sepsis-Induced Myocardial Dysfunction in Mice by Inhibiting Autophagy through PTEN\/AKT\/mTOR Pathway","volume":"2020","author":"Sang","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.biopha.2018.06.007","article-title":"LncRNA H19 functions as an Aquaporin 1 competitive endogenous RNA to regulate microRNA-874 expression in LPS sepsis","volume":"105","author":"Fang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1096\/fj.14-260828","article-title":"Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling","volume":"29","author":"Wang","year":"2015","journal-title":"FASEB J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.intimp.2016.09.010","article-title":"Protective effects of puerarin on acute lung and cerebrum injury induced by hypobaric hypoxia via the regulation of aquaporin (AQP) via NF-\u03baB signaling pathway","volume":"40","author":"Wang","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Tomita, Y., Dorward, H., Yool, A.J., Smith, E., Townsend, A.R., Price, T.J., and Hardingham, J.E. (2017). Role of Aquaporin 1 Signalling in Cancer Development and Progression. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18020299"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.prp.2018.08.024","article-title":"miR-93-3p alleviates lipopolysaccharide-induced inflammation and apoptosis in H9c2 cardiomyocytes by inhibiting toll-like receptor 4","volume":"214","author":"Tang","year":"2018","journal-title":"Pathol. Res. Pract."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"BSR20171511","DOI":"10.1042\/BSR20171511","article-title":"miR-25 inhibits sepsis-induced cardiomyocyte apoptosis by targetting PTEN","volume":"38","author":"Yao","year":"2018","journal-title":"Biosci. Rep."},{"key":"ref_80","first-page":"1706","article-title":"MicroRNA-494-3p protects rat cardiomyocytes against septic shock via PTEN","volume":"17","author":"Wu","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.biopha.2018.04.092","article-title":"Inhibition of microRNA-23b prevents polymicrobial sepsis-induced cardiac dysfunction by modulating TGIF1 and PTEN","volume":"103","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.intimp.2016.01.026","article-title":"Molecular validation of the precision-cut kidney slice (PCKS) model of renal fibrosis through assessment of TGF-\u03b21-induced Smad and p38\/ERK signaling","volume":"34","author":"Zhang","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/1535370213489441","article-title":"Molecular basis of organ fibrosis: Potential therapeutic approaches","volume":"238","author":"Ghosh","year":"2013","journal-title":"Exp. Biol. Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s10753-019-00958-7","article-title":"Attenuation of Sepsis-Induced Cardiomyopathy by Regulation of MicroRNA-23b Is Mediated Through Targeting of MyD88-Mediated NF-\u03baB Activation","volume":"42","author":"Cao","year":"2019","journal-title":"Inflammation"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40001-019-0396-3","article-title":"MicroRNA-495 serves as a diagnostic biomarker in patients with sepsis and regulates sepsis-induced inflammation and cardiac dysfunction","volume":"24","author":"Guo","year":"2019","journal-title":"Eur. J. Med. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1080\/15384101.2019.1635869","article-title":"microRNA-98 protects sepsis mice from cardiac dysfunction, liver and lung injury by negatively regulating HMGA2 through inhibiting NF-\u03baB signaling pathway","volume":"18","author":"Zhu","year":"2019","journal-title":"Cell Cycle"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"106204","DOI":"10.1016\/j.intimp.2020.106204","article-title":"MicroRNA-208-5p regulates myocardial injury of sepsis mice via targeting SOCS2-mediated NF-\u03baB\/HIF-1\u03b1 pathway","volume":"81","author":"Ouyang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"e9501","DOI":"10.1590\/1414-431x20209501","article-title":"Low expression of microRNA-328 can predict sepsis and alleviate sepsis-induced cardiac dysfunction and inflammatory response","volume":"53","author":"Sun","year":"2020","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1007\/s10753-019-01060-8","article-title":"Characterization of Circular RNA and microRNA Profiles in Septic Myocardial Depression: A Lipopolysaccharide-Induced Rat Septic Shock Model","volume":"42","author":"Zhang","year":"2019","journal-title":"Inflammation"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"117849","DOI":"10.1016\/j.lfs.2020.117849","article-title":"RETRACTED: Protective role of long noncoding RNA CRNDE in myocardial tissues from injury caused by sepsis through the microRNA-29a\/SIRT1 axis","volume":"255","author":"Zhu","year":"2020","journal-title":"Life Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.bbrc.2019.11.129","article-title":"Gracillin inhibits apoptosis and inflammation induced by lipopolysaccharide (LPS) to alleviate cardiac injury in mice via improving miR-29a","volume":"523","author":"Song","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/cbf.3524","article-title":"LncRNA CYTOR attenuates sepsis-induced myocardial injury via regulating miR-24\/XIAP","volume":"38","author":"Chen","year":"2020","journal-title":"Cell Biochem. Funct."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1177\/1535370220908041","article-title":"LncRNA KCNQ1OT1 attenuates sepsis-induced myocardial injury via regulating miR-192-5p\/XIAP axis","volume":"245","author":"Sun","year":"2020","journal-title":"Exp. Biol. Med."},{"key":"ref_95","first-page":"851","article-title":"LncRNA NEAT1 promotes the progression of sepsis-induced myocardial cell injury by sponging miR-144-3p","volume":"24","author":"Wei","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s10528-020-09976-9","article-title":"LncRNA MIAT Promotes Inflammation and Oxidative Stress in Sepsis-Induced Cardiac Injury by Targeting miR-330-5p\/TRAF6\/NF-\u03baB Axis","volume":"58","author":"Xing","year":"2020","journal-title":"Biochem. Genet."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s10753-019-01141-8","article-title":"lncRNA RMRP Prevents Mitochondrial Dysfunction and Cardiomyocyte Apoptosis via the miR-1-5p\/hsp70 Axis in LPS-Induced Sepsis Mice","volume":"43","author":"Han","year":"2020","journal-title":"Inflammation"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"109716","DOI":"10.1016\/j.cellsig.2020.109716","article-title":"miR-29b-3p protects cardiomyocytes against endotoxin-induced apoptosis and inflammatory response through targeting FOXO3A","volume":"74","author":"Li","year":"2020","journal-title":"Cell. Signal."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3892\/ijmm.2021.4853","article-title":"Inhibition of miR-101-3p protects against sepsis-induced myocardial injury by inhibiting MAPK and NF-\u03baB pathway activation via the upregulation of DUSP1","volume":"47","author":"Xin","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"111112","DOI":"10.1016\/j.biopha.2020.111112","article-title":"Protective role of matrine in sepsis-associated cardiac dysfunction through regulating the lncRNA PTENP1\/miR-106b-5p axis","volume":"134","author":"Liu","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s40001-021-00566-y","article-title":"Clinical value and role of microRNA-29c-3p in sepsis-induced inflammation and cardiac dysfunction","volume":"26","author":"Zhang","year":"2021","journal-title":"Eur. J. Med. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s13019-021-01679-5","article-title":"Predictive value and regulatory mechanism of serum miR-499a-5p on myocardial dysfunction in sepsis","volume":"16","author":"Yang","year":"2021","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_103","first-page":"547818","article-title":"Biomarkers for Sepsis","volume":"2014","author":"Losa","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jinf.2010.03.016","article-title":"The diagnostic role of Procalcitonin and other biomarkers in discriminating infectious from non-infectious fever","volume":"60","author":"Limper","year":"2010","journal-title":"J. Infect."},{"key":"ref_105","first-page":"205","article-title":"Recent advances in biosensors for diagnosis and detection of sepsis: A comprehensive review","volume":"124\u2013125","author":"Kumar","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/s41551-018-0288-9","article-title":"Point-of-care sensors for the management of sepsis","volume":"2","author":"Reddy","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"ref_107","first-page":"5620","article-title":"MicroRNA-218 alleviates sepsis inflammation by negatively regulating VOPP1 via JAK\/STAT pathway","volume":"22","author":"Li","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_108","first-page":"105","article-title":"Study of MicroRNA-122 as a Diagnostic Biomarker of Sepsis","volume":"26","author":"Zaki","year":"2019","journal-title":"Egypt. J. Immunol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41419-019-1713-z","article-title":"miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock","volume":"10","author":"Xue","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e703","DOI":"10.1097\/CCM.0000000000002363","article-title":"MicroRNA-21 Is Required for Local and Remote Ischemic Preconditioning in Multiple Organ Protection Against Sepsis*","volume":"45","author":"Jia","year":"2017","journal-title":"Crit. Care Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"118658","DOI":"10.1016\/j.lfs.2020.118658","article-title":"Exosomal miR-21 secreted by IL-1\u03b2-primed-mesenchymal stem cells induces macrophage M2 polarization and ameliorates sepsis","volume":"264","author":"Yao","year":"2021","journal-title":"Life Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"11963","DOI":"10.7150\/thno.50093","article-title":"Discovery and validation of miR-452 as an effective biomarker for acute kidney injury in sepsis","volume":"10","author":"Liu","year":"2020","journal-title":"Theranostics"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Rocchi, A., Chiti, E., Maiese, A., Turillazzi, E., and Spinetti, I. (2020). MicroRNAs: An Update of Applications in Forensic Science. Diagnostics, 11.","DOI":"10.3390\/diagnostics11010032"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Maiese, A., Manetti, A.C., Iacoponi, N., Mezzetti, E., Turillazzi, E., Di Paolo, M., La Russa, R., Frati, P., and Fineschi, V. (2022). State-of-the-Art on Wound Vitality Evaluation: A Systematic Review. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23136881"},{"key":"ref_115","first-page":"8438","article-title":"MicroRNA-218 prevents lung injury in sepsis by inhibiting RUNX2","volume":"22","author":"Zhou","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Rahmel, T., Sch\u00e4fer, S.T., Frey, U., Adamzik, M., and Peters, J. (2018). Increased circulating microRNA-122 is a biomarker for discrimination and risk stratification in patients defined by sepsis-3 criteria. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0197637"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"912492","DOI":"10.3389\/fcimb.2022.912492","article-title":"Identification and Validation of Immune-Related Biomarker Gene and Construction of ceRNA Networks in Septic Cardiomyopathy","volume":"12","author":"Li","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e23103","DOI":"10.1002\/jcla.23103","article-title":"The predictive value of microRNA-21 for sepsis risk and its correlation with disease severity, systemic inflammation, and 28-day mortality in sepsis patients","volume":"34","author":"Na","year":"2020","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e23408","DOI":"10.1002\/jcla.23408","article-title":"The potential of microRNA-126 in predicting disease risk, mortality of sepsis, and its correlation with inflammation and sepsis severity","volume":"34","author":"Lin","year":"2020","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e23036","DOI":"10.1002\/jcla.23036","article-title":"Plasma miR-125a and miR-125b in sepsis: Correlation with disease risk, inflammation, severity, and prognosis","volume":"34","author":"Zhao","year":"2020","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/stem.2564","article-title":"Exosomal miR-146a Contributes to the Enhanced Therapeutic Efficacy of Interleukin-1\u03b2-Primed Mesenchymal Stem Cells Against Sepsis","volume":"35","author":"Song","year":"2017","journal-title":"Stem Cells"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"e19754","DOI":"10.1097\/MD.0000000000019754","article-title":"Correlation of microRNA-146a\/b with disease risk, biochemical indices, inflammatory cytokines, overall disease severity, and prognosis of sepsis","volume":"99","author":"Chen","year":"2020","journal-title":"Medicine"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.intimp.2018.07.040","article-title":"MicroRNA-146a protects against LPS-induced organ damage by inhibiting Notch1 in macrophage","volume":"63","author":"Bai","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/icb.2013.37","article-title":"MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes","volume":"91","author":"Brudecki","year":"2013","journal-title":"Immunol. Cell Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1038\/srep01977","article-title":"Morphine induced exacerbation of sepsis is mediated by tempering endotoxin tolerance through modulation of miR-146a","volume":"3","author":"Banerjee","year":"2013","journal-title":"Sci. Rep."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/eji.201444667","article-title":"MicroRNA-146a controls Th1-cell differentiation of human CD4+ T lymphocytes by targeting PRKC\u03b5","volume":"45","author":"Luchting","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1038\/s41598-019-40690-8","article-title":"Rg6, a rare ginsenoside, inhibits systemic inflammation through the induction of interleukin-10 and microRNA-146a","volume":"9","author":"Paik","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"117637","DOI":"10.1016\/j.lfs.2020.117637","article-title":"Berberine attenuates A\u03b242-induced neuronal damage through regulating circHDAC9\/miR-142-5p axis in human neuronal cells","volume":"252","author":"Zhang","year":"2020","journal-title":"Life Sci."},{"key":"ref_129","first-page":"700","article-title":"MicroRNA-146 regulates the inflammatory cytokines expression in vascular endothelial cells during sepsis","volume":"72","author":"Gao","year":"2017","journal-title":"Die Pharm. Int. J. Pharm. Sci."},{"key":"ref_130","first-page":"938","article-title":"Correlation analysis of microRNA-126 expression in peripheral blood lymphocytes with apoptosis and prognosis in patients with sepsis","volume":"32","author":"Zou","year":"2020","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Dang, C.P., and Leelahavanichkul, A. (2020). Over-expression of miR-223 induces M2 macrophage through glycolysis alteration and attenuates LPS-induced sepsis mouse model, the cell-based therapy in sepsis. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0236038"},{"key":"ref_132","first-page":"7675","article-title":"Clinical evaluation of circulating microRNA-25 level change in sepsis and its potential relationship with oxidative stress","volume":"8","author":"Yao","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Manetti, A.C., Maiese, A., Baronti, A., Mezzetti, E., Frati, P., Fineschi, V., and Turillazzi, E. (2021). MiRNAs as New Tools in Lesion Vitality Evaluation: A Systematic Review and Their Forensic Applications. Biomedicines, 9.","DOI":"10.3390\/biomedicines9111731"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"384208","DOI":"10.1155\/2015\/384208","article-title":"Circulating MicroRNA-223 Serum Levels Do Not Predict Sepsis or Survival in Patients with Critical Illness","volume":"2015","author":"Benz","year":"2015","journal-title":"Dis. Markers"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"e11352","DOI":"10.1097\/MD.0000000000011352","article-title":"Plasma miRNA-223 correlates with risk, inflammatory markers as well as prognosis in sepsis patients","volume":"97","author":"Wu","year":"2018","journal-title":"Medicine"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3892\/ijmm.2016.2613","article-title":"MicroRNA-205-5b inhibits HMGB1 expression in LPS-induced sepsis","volume":"38","author":"Zhou","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/infdis\/jiaa184","article-title":"miR-145a Regulation of Pericyte Dysfunction in a Murine Model of Sepsis","volume":"222","author":"Wu","year":"2020","journal-title":"J. Infect. Dis."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"108626","DOI":"10.1016\/j.biopha.2019.108626","article-title":"A TGFBR2\/SMAD2\/DNMT1\/miR-145 negative regulatory loop is responsible for LPS-induced sepsis","volume":"112","author":"Ma","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.biopha.2018.12.138","article-title":"MiR-145 negatively regulates TGFBR2 signaling responsible for sepsis-induced acute lung injury","volume":"111","author":"Cao","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.3389\/fimmu.2018.02272","article-title":"GSKJ4 Protects Mice Against Early Sepsis via Reducing Proinflammatory Factors and Up-Regulating MiR-146a","volume":"9","author":"Pan","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"eaai9085","DOI":"10.1126\/scisignal.aai9085","article-title":"Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis","volume":"11","author":"Sisti","year":"2018","journal-title":"Sci. Signal."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e23094","DOI":"10.1002\/jcla.23094","article-title":"MiR-125b but not miR-125a is upregulated and exhibits a trend to correlate with enhanced disease severity, inflammation, and increased mortality in sepsis patients","volume":"34","author":"Zhu","year":"2020","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13287-020-02068-w","article-title":"microRNA-27b shuttled by mesenchymal stem cell-derived exosomes prevents sepsis by targeting JMJD3 and downregulating NF-\u03baB signaling pathway","volume":"12","author":"Sun","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"4370983","DOI":"10.1155\/2020\/4370983","article-title":"miR-10a in Peripheral Blood Mononuclear Cells Is a Biomarker for Sepsis and Has Anti-Inflammatory Function","volume":"2020","author":"Zheng","year":"2020","journal-title":"Mediat. Inflamm."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ijid.2015.09.016","article-title":"Elevated miR-155 expression induces immunosuppression via CD39+ regulatory T-cells in sepsis patient","volume":"40","author":"Liu","year":"2015","journal-title":"Int. J. Infect. Dis."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Zhang, W., Jia, J., Liu, Z., Si, D., Ma, L., and Zhang, G. (2019). Circulating microRNAs as biomarkers for Sepsis secondary to pneumonia diagnosed via Sepsis 3.0. BMC Pulm. Med., 19.","DOI":"10.1186\/s12890-019-0836-4"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.12659\/MSM.894321","article-title":"MicroRNA-19a and CD22 Comprise a Feedback Loop for B Cell Response in Sepsis","volume":"21","author":"Cai","year":"2015","journal-title":"Med. Sci. Monit."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40001-020-00408-3","article-title":"Clinical significance of miR-19b-3p in patients with sepsis and its regulatory role in the LPS-induced inflammatory response","volume":"25","author":"Xu","year":"2020","journal-title":"Eur. J. Med. Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"119626","DOI":"10.1016\/j.lfs.2021.119626","article-title":"MicroRNA-150 inhibits myeloid-derived suppressor cells proliferation and function through negative regulation of ARG-1 in sepsis","volume":"278","author":"Liu","year":"2021","journal-title":"Life Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.biopha.2016.11.147","article-title":"miR-375 ameliorates sepsis by downregulating miR-21 level via inhibiting JAK2-STAT3 signaling","volume":"86","author":"Sheng","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1128\/IAI.01495-14","article-title":"MicroRNA 21 (miR-21) and miR-181b Couple with NFI-A to Generate Myeloid-Derived Suppressor Cells and Promote Immunosuppression in Late Sepsis","volume":"82","author":"McClure","year":"2014","journal-title":"Infect. Immun."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/icb.2016.63","article-title":"Stat3 and C\/EBP\u03b2 synergize to induce miR-21 and miR-181b expression during sepsis","volume":"95","author":"McClure","year":"2017","journal-title":"Immunol. Cell Biol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1177\/0300060516645003","article-title":"Diagnostic value of elevated serum miRNA-143 levels in sepsis","volume":"44","author":"Han","year":"2016","journal-title":"J. Int. Med. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1111\/jcmm.15324","article-title":"Down-regulation of circDMNT3B is conducive to intestinal mucosal permeability dysfunction of rats with sepsis via sponging miR-20b-5p","volume":"24","author":"Liu","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s10753-018-0931-3","article-title":"Schisandrin B Attenuates Inflammation in LPS-Induced Sepsis Through miR-17-5p Downregulating TLR4","volume":"42","author":"Ji","year":"2019","journal-title":"Inflammation"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Szil\u00e1gyi, B., Fejes, Z., P\u00f3liska, S., P\u00f3csi, M., Czimmerer, Z., Patsalos, A., Fenyvesi, F., Ruszny\u00e1k, \u00c1., Nagy, G., and Kerekes, G. (2020). Reduced miR-26b Expression in Megakaryocytes and Platelets Contributes to Elevated Level of Platelet Activation Status in Sepsis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030866"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"BSR20201267","DOI":"10.1042\/BSR20201267","article-title":"MiR-96-5p alleviates inflammatory responses by targeting NAMPT and regulating the NF-\u03baB pathway in neonatal sepsis","volume":"40","author":"Chen","year":"2020","journal-title":"Biosci. Rep."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cellimm.2014.06.006","article-title":"miR-27a is up regulated and promotes inflammatory response in sepsis","volume":"290","author":"Wang","year":"2014","journal-title":"Cell. Immunol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.biopha.2017.11.003","article-title":"Paclitaxel alleviated liver injury of septic mice by alleviating inflammatory response via microRNA-27a\/TAB3\/NF-\u03baB signaling pathway","volume":"97","author":"Yang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"101444","DOI":"10.1016\/j.mcp.2019.101444","article-title":"Hsa-miR-346 plays a role in the development of sepsis by downregulating SMAD3 expression and is negatively regulated by lncRNA MALAT1","volume":"47","author":"Yang","year":"2019","journal-title":"Mol. Cell. Probes"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.3389\/fimmu.2020.01391","article-title":"Extracellular Vesicles from Adipose Tissue-Derived Stem Cells Affect Notch-miR148a-3p Axis to Regulate Polarization of Macrophages and Alleviate Sepsis in Mice","volume":"11","author":"Bai","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s11658-019-0142-4","article-title":"Honokiol alleviates sepsis-induced acute kidney injury in mice by targeting the miR-218-5p\/heme oxygenase-1 signaling pathway","volume":"24","author":"Zhang","year":"2019","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1007\/s11010-021-04170-w","article-title":"Inhibition of miR-1298-5p attenuates sepsis lung injury by targeting SOCS6","volume":"476","author":"Ma","year":"2021","journal-title":"Mol. Cell. Biochem."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10875-019-00702-8","article-title":"MiR-608 Exerts Anti-inflammatory Effects by Targeting ELANE in Monocytes","volume":"40","author":"Gu","year":"2020","journal-title":"J. Clin. Immunol."},{"key":"ref_165","first-page":"4604","article-title":"Urinary miR-26b as a potential biomarker for patients with sepsis-associated acute kidney injury: A Chinese population-based study","volume":"22","author":"Zhang","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_166","first-page":"646","article-title":"Predictive value of miRNA-29a and miRNA-10a-5p for 28-day mortality in patients with sepsis-induced acute kidney injury","volume":"37","author":"Huo","year":"2017","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"107218","DOI":"10.1016\/j.intimp.2020.107218","article-title":"Inhibition of miR-155 alleviates sepsis-induced inflammation and intestinal barrier dysfunction by inactivating NF-\u03baB signaling","volume":"90","author":"Cao","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1080\/13880209.2017.1297838","article-title":"Anti-inflammatory effects of curcumin are associated with down regulating microRNA-155 in LPS-treated macrophages and mice","volume":"55","author":"Ma","year":"2017","journal-title":"Pharm. Biol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1007\/s10753-014-9922-1","article-title":"STAT1 Regulates MD-2 Expression in Monocytes of Sepsis via miR-30a","volume":"37","author":"Wang","year":"2014","journal-title":"Inflammation"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"19370","DOI":"10.1038\/s41598-019-55980-4","article-title":"Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p","volume":"9","author":"Mei","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"31687","DOI":"10.1038\/srep31687","article-title":"Spherical nucleic acid targeting microRNA-99b enhances intestinal MFG-E8 gene expression and restores enterocyte migration in lipopolysaccharide-induced septic mice","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"106000","DOI":"10.1016\/j.intimp.2019.106000","article-title":"MiR-215-5p inhibits the inflammation injury in septic H9c2 by regulating ILF3 and LRRFIP1","volume":"78","author":"Yao","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1515\/cclm-2011-0826","article-title":"Evidence for serum miR-15a and miR-16 levels as biomarkers that distinguish sepsis from systemic inflammatory response syndrome in human subjects","volume":"50","author":"Wang","year":"2012","journal-title":"Clin. Chem. Lab. Med. (CCLM)"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.21037\/apm-20-1391","article-title":"The correlations between the serum expression of miR-206 and the severity and prognosis of sepsis","volume":"9","author":"Liang","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Wang, Y., Wang, H., Zhang, C., Zhang, C., Yang, H., Gao, R., and Tong, Z. (2020). Plasma Hsa-miR-92a-3p in correlation with lipocalin-2 is associated with sepsis-induced coagulopathy. BMC Infect. Dis., 20.","DOI":"10.1186\/s12879-020-4853-y"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41572-019-0069-0","article-title":"Acute respiratory distress syndrome","volume":"5","author":"Matthay","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1056\/NEJMra1608077","article-title":"Acute Respiratory Distress Syndrome","volume":"377","author":"Thompson","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.2017.21907","article-title":"Acute Respiratory Distress Syndrome","volume":"319","author":"Fan","year":"2018","journal-title":"JAMA"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1056\/NEJMoa1212722","article-title":"A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients","volume":"368","author":"Heyland","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1378\/chest.112.1.164","article-title":"A Trial of Antioxidants N-acetylcysteine and Procysteine in ARDS","volume":"112","author":"Bernard","year":"1997","journal-title":"Chest"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1097\/00003246-199207000-00004","article-title":"Antioxidant treatment with N-acetylcysteine during adult respiratory distress syndrome","volume":"20","author":"Jepsen","year":"1992","journal-title":"Crit. Care Med."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"ARDS Clinical Trials Network, and National Institutes of Health (2002). Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome. Crit. Care Med., 30, 1\u20136.","DOI":"10.1097\/00003246-200201000-00001"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1097\/00003246-199908000-00013","article-title":"Liposomal prostaglandin E1 (TLC C-53) in acute respiratory distress syndrome","volume":"27","author":"Abraham","year":"1999","journal-title":"Crit. Care Med."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1378\/chest.96.1.114","article-title":"Randomized Double-Blind, Multicenter Study of Prostaglandin E1 in Patients with the Adult Respiratory Distress Syndrome","volume":"96","author":"Bone","year":"1989","journal-title":"Chest"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1097\/01.CCM.0000133332.48386.85","article-title":"Neutrophil elastase inhibition in acute lung injury: Results of the STRIVE study","volume":"32","author":"Zeiher","year":"2004","journal-title":"Crit. Care Med."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1164\/rccm.200803-419OC","article-title":"Randomized Clinical Trial of Activated Protein C for the Treatment of Acute Lung Injury","volume":"178","author":"Liu","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network, Truwit, J.D., Bernard, G.R., Steingrub, J., Matthay, M.A., Liu, K.D., Albertson, T.E., Brower, R.G., Shanholtz, C., and Rock, P. (2014). Rosuvastatin for Sepsis-Associated Acute Respiratory Distress Syndrome. N. Engl. J. Med., 370, 2191\u20132200.","DOI":"10.1056\/NEJMoa1401520"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1403285","article-title":"Simvastatin in the Acute Respiratory Distress Syndrome","volume":"371","author":"McAuley","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S2213-2600(17)30171-6","article-title":"Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): A randomised, double-blind, placebo-controlled phase 2 trial","volume":"5","author":"McAuley","year":"2017","journal-title":"Lancet Respir. Med."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1093\/nar\/gkw116","article-title":"Distribution of miRNA expression across human tissues","volume":"44","author":"Ludwig","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/SHK.0000000000000839","article-title":"MiR-155 Alleviates Septic Lung Injury by Inducing Autophagy Via Inhibition of Transforming Growth Factor-\u03b2-Activated Binding Protein 2","volume":"48","author":"Liu","year":"2017","journal-title":"Shock"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.ymthe.2019.07.003","article-title":"Peripheral Circulating Exosome-Mediated Delivery of miR-155 as a Novel Mechanism for Acute Lung Inflammation","volume":"27","author":"Jiang","year":"2019","journal-title":"Mol. Ther."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"L426","DOI":"10.1152\/ajplung.00195.2015","article-title":"TREM-1-accentuated lung injury via miR-155 is inhibited by LP17 nanomedicine","volume":"310","author":"Yuan","year":"2016","journal-title":"Am. J. Physiol. Cell. Mol. Physiol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/s41467-018-04013-1","article-title":"The molecular basis of JAK\/STAT inhibition by SOCS1","volume":"9","author":"Liau","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"C1070","DOI":"10.1152\/ajpcell.00116.2020","article-title":"Inhibition of miR-155 potentially protects against lipopolysaccharide-induced acute lung injury through the IRF2BP2-NFAT1 pathway","volume":"319","author":"Li","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.7754\/Clin.Lab.2016.160511","article-title":"The Prognostic Value of Plasma MicroRNA-155 and MicroRNA-146a Level in Severe Sepsis and Sepsis-Induced Acute Lung Injury Patients","volume":"62","author":"Han","year":"2016","journal-title":"Clin. Lab."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"394","DOI":"10.4049\/jimmunol.1300959","article-title":"Akt2 Deficiency Protects from Acute Lung Injury via Alternative Macrophage Activation and miR-146a Induction in Mice","volume":"192","author":"Vergadi","year":"2014","journal-title":"J. Immunol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3109\/01902148.2013.808285","article-title":"Upregulation of miR-146a contributes to the suppression of inflammatory responses in LPS-induced acute lung injury","volume":"39","author":"Zeng","year":"2013","journal-title":"Exp. Lung Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.imlet.2020.12.015","article-title":"MicroRNA-144-3p enhances LPS induced septic acute lung injury in mice through downregulating Caveolin-2","volume":"231","author":"Xu","year":"2021","journal-title":"Immunol. Lett."},{"key":"ref_200","first-page":"201","article-title":"miR-19a-3p inhibition alleviates sepsis-induced lung injury via enhancing USP13 expression","volume":"68","author":"Ren","year":"2021","journal-title":"Acta Biochim. Pol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"C449","DOI":"10.1152\/ajpcell.00173.2017","article-title":"Acute downregulation of miR-199a attenuates sepsis-induced acute lung injury by targeting SIRT1","volume":"314","author":"Liu","year":"2018","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.3389\/fimmu.2020.01829","article-title":"MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_203","first-page":"1042","article-title":"Effect of miR-132 on lung injury in sepsis rats via regulating Sirt1 expression","volume":"25","author":"Zhu","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s13054-021-03775-3","article-title":"Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury","volume":"25","author":"Jiao","year":"2021","journal-title":"Crit. Care"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/08923973.2021.2001497","article-title":"The function and mechanism of microRNA-92a-3p in lipopolysaccharide-induced acute lung injury","volume":"44","author":"Wang","year":"2022","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.biopha.2018.07.097","article-title":"miRNA-23a has effects to improve lung injury induced by sepsis in vitro and vivo study","volume":"107","author":"Yang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"168","DOI":"10.5603\/FHC.a2019.0019","article-title":"MiR-539-5p alleviates sepsis-induced acute lung injury by targeting ROCK1","volume":"57","author":"Meng","year":"2020","journal-title":"Folia Histochem. Cytobiol."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"105835","DOI":"10.1016\/j.intimp.2019.105835","article-title":"MicroRNA-124 alleviates the lung injury in mice with septic shock through inhibiting the activation of the MAPK signaling pathway by downregulating MAPK14","volume":"76","author":"Pan","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2131\/jts.45.77","article-title":"High expression of miR-483-5p aggravates sepsis-induced acute lung injury","volume":"45","author":"Leng","year":"2020","journal-title":"J. Toxicol. Sci."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"6624702","DOI":"10.1155\/2021\/6624702","article-title":"Downregulation of miR-497-5p Improves Sepsis-Induced Acute Lung Injury by Targeting IL2RB","volume":"2021","author":"Lou","year":"2021","journal-title":"BioMed Res. Int."},{"key":"ref_211","first-page":"75","article-title":"MiR-802 alleviates lipopolysaccharide-induced acute lung injury by targeting Peli2","volume":"69","author":"You","year":"2020","journal-title":"Agents Actions"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/10715762.2020.1781847","article-title":"MicroRNA-326 prevents sepsis-induced acute lung injury via targeting TLR4","volume":"54","author":"Wang","year":"2020","journal-title":"Free Radic. Res."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jss.2020.05.101","article-title":"Overexpression of miR-129-5p Mitigates Sepsis-Induced Acute Lung Injury by Targeting High Mobility Group Box 1","volume":"256","author":"Yang","year":"2020","journal-title":"J. Surg. Res."},{"key":"ref_214","first-page":"151","article-title":"MiR-490 alleviates sepsis-induced acute lung injury by targeting MRP4 in new-born mice","volume":"68","author":"Lin","year":"2021","journal-title":"Acta Biochim. Pol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3892\/ijmm.2021.4972","article-title":"MicroRNA-129 plays a protective role in sepsis-induced acute lung injury through the suppression of pulmonary inflammation via the modulation of the TAK1\/NF-\u03baB pathway","volume":"48","author":"Yao","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.4049\/jimmunol.1101070","article-title":"MicroRNA-127 Inhibits Lung Inflammation by Targeting IgG Fc\u03b3 Receptor I","volume":"188","author":"Xie","year":"2012","journal-title":"J. Immunol."},{"key":"ref_217","first-page":"205","article-title":"Upregulation of endothelial cell-derived exosomal microRNA-125b-5p protects from sepsis-induced acute lung injury by inhibiting topoisomerase II alpha","volume":"70","author":"Jiang","year":"2021","journal-title":"Agents Actions"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s11671-021-03534-x","article-title":"Restoring microRNA-499-5p Protects Sepsis-Induced Lung Injury Mice Via Targeting Sox6","volume":"16","author":"Zhang","year":"2021","journal-title":"Nanoscale Res. Lett."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/iep.12413","article-title":"miR-942-5p prevents sepsis-induced acute lung injury via targeting TRIM37","volume":"102","author":"Lu","year":"2021","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"107691","DOI":"10.1016\/j.intimp.2021.107691","article-title":"LncRNA NEAT1 inhibition upregulates miR-16-5p to restrain the progression of sepsis-induced lung injury via suppressing BRD4 in a mouse model","volume":"97","author":"Yin","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"ref_221","doi-asserted-by":"crossref","unstructured":"Qiu, N., Xu, X., and He, Y. (2020). LncRNA TUG1 alleviates sepsis-induced acute lung injury by targeting miR-34b-5p\/GAB1. BMC Pulm. Med., 20.","DOI":"10.1186\/s12890-020-1084-3"},{"key":"ref_222","first-page":"559","article-title":"Down-regulation of lncRNA CASC9 aggravates sepsis-induced acute lung injury by regulating miR-195-5p\/PDK4 axis","volume":"69","author":"Wang","year":"2020","journal-title":"Agents Actions"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1080\/08820139.2021.1928693","article-title":"LncRNA CASC2 Alleviates Sepsis-induced Acute Lung Injury by Regulating the miR-152-3p\/PDK4 Axis","volume":"51","author":"Zhu","year":"2022","journal-title":"Immunol. Investig."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"9723","DOI":"10.1080\/21655979.2021.1987132","article-title":"Overexpressing long non-coding RNA OIP5-AS1 ameliorates sepsis-induced lung injury in a rat model via regulating the miR-128-3p\/Sirtuin-1 pathway","volume":"12","author":"Xie","year":"2021","journal-title":"Bioengineered"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.molimm.2020.07.021","article-title":"LncRNA THRIL aggravates sepsis-induced acute lung injury by regulating miR-424\/ROCK2 axis","volume":"126","author":"Chen","year":"2020","journal-title":"Mol. Immunol."},{"key":"ref_226","first-page":"9493710","article-title":"MicroRNA-1224-5p Aggravates Sepsis-Related Acute Lung Injury in Mice","volume":"2022","author":"Liu","year":"2022","journal-title":"Oxid Med Cell Longev."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.molimm.2022.06.005","article-title":"WIN55212-2 alleviates acute lung injury by inhibiting macrophage glycolysis through the miR-29b-3p\/FOXO3\/PFKFB3 axis","volume":"149","author":"He","year":"2022","journal-title":"Mol Immunol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.3892\/etm.2016.3476","article-title":"Xuebijing injection alleviates cytokine-induced inflammatory liver injury in CLP-induced septic rats through induction of suppressor of cytokine signaling 1","volume":"12","author":"Li","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.yexmp.2018.09.003","article-title":"MiR-155 aggravated septic liver injury by oxidative stress-mediated ER stress and mitochondrial dysfunction via targeting Nrf-2","volume":"105","author":"Yang","year":"2018","journal-title":"Exp. Mol. Pathol."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.biopha.2018.05.042","article-title":"MicroRNA-30e promotes hepatocyte proliferation and inhibits apoptosis in cecal ligation and puncture-induced sepsis through the JAK\/STAT signaling pathway by binding to FOSL2","volume":"104","author":"Ling","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"17839","DOI":"10.1002\/jcp.28410","article-title":"microRNA-30a inhibits the liver cell proliferation and promotes cell apoptosis through the JAK\/STAT signaling pathway by targeting SOCS-1 in rats with sepsis","volume":"234","author":"Yuan","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1002\/cbin.11372","article-title":"Inhibition of miR-103a-3p suppresses lipopolysaccharide-induced sepsis and liver injury by regulating FBXW7 expression","volume":"44","author":"Zhou","year":"2020","journal-title":"Cell Biol. Int."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1007\/s10753-020-01275-0","article-title":"miR-103a-3p Could Attenuate Sepsis-Induced Liver Injury by Targeting HMGB1","volume":"43","author":"Chen","year":"2020","journal-title":"Inflammation"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"104681","DOI":"10.1016\/j.meegid.2020.104681","article-title":"microRNA-103a-3p confers protection against lipopolysaccharide-induced sepsis and consequent multiple organ dysfunction syndrome by targeting HMGB1","volume":"89","author":"Li","year":"2021","journal-title":"Infect. Genet. Evol."},{"key":"ref_235","first-page":"299","article-title":"miR-425-5p improves inflammation and septic liver damage through negatively regulating the RIP1-mediated necroptosis","volume":"69","author":"Gu","year":"2020","journal-title":"Agents Actions"},{"key":"ref_236","first-page":"862","article-title":"Effect of miR-10a on sepsis-induced liver injury in rats through TGF-\u03b21\/Smad signaling pathway","volume":"24","author":"Zhou","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_237","first-page":"5293","article-title":"Upregulation of miR-142-5p induced by lipopolysaccharide contributes to apoptosis of hepatocytes and hepatic failure","volume":"25","author":"Xu","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s40001-022-00763-3","article-title":"Evidence for the circulating microRNA hsa-let-7d-3p as a potential new biomarker for sepsis in human subjects","volume":"27","author":"Zhang","year":"2022","journal-title":"Eur J Med Res."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"104562","DOI":"10.1016\/j.yexmp.2020.104562","article-title":"Down-regulation of long noncoding RNA LINC00472 alleviates sepsis-induced acute hepatic injury by regulating miR-373-3p\/TRIM8 axis","volume":"117","author":"Li","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/iub.2230","article-title":"Long noncoding RNA colorectal neoplasia differentially expressed alleviates sepsis-induced liver injury via regulating miR-126-5p","volume":"72","author":"Li","year":"2020","journal-title":"IUBMB Life"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"BSR20200740","DOI":"10.1042\/BSR20200740","article-title":"LPS promotes the progression of sepsis by activation of lncRNA HULC\/miR-204-5p\/TRPM7 network in HUVECs","volume":"40","author":"Chen","year":"2020","journal-title":"Biosci. Rep."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"22450","DOI":"10.1002\/jcp.28809","article-title":"MCPIP1 alleviated lipopolysaccharide-induced liver injury by regulating SIRT1 via modulation of microRNA-9","volume":"234","author":"Han","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/10520295.2018.1535138","article-title":"An immunohistochemical study of the diagnostic value of TREM-1 as marker for fatal sepsis cases","volume":"94","author":"Maiese","year":"2019","journal-title":"Biotech Histochem."},{"key":"ref_244","first-page":"8988","article-title":"MiR-640 inhibition alleviates acute liver injury via regulating WNT signaling pathway and LRP1","volume":"24","author":"Wang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/MCC.0000000000000153","article-title":"Sepsis-induced acute kidney injury revisited: Pathophysiology, prevention and future therapies","volume":"20","author":"Zarbock","year":"2014","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrneph.2017.2","article-title":"Acute kidney disease and renal recovery: Consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup","volume":"13","author":"Chawla","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/sdi.12705","article-title":"Acute kidney injury: Epidemiology, outcomes, complications, and therapeutic strategies","volume":"31","author":"Negi","year":"2018","journal-title":"Semin. Dial."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations","volume":"193","author":"Fleischmann","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/MCC.0000000000000356","article-title":"Sepsis-induced acute kidney injury","volume":"22","author":"Kellum","year":"2016","journal-title":"Curr. Opin. Crit. Care"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1097\/01.ASN.0000121781.89599.16","article-title":"Signaling Danger: Toll-Like Receptors and their Potential Roles in Kidney Disease","volume":"15","author":"Anders","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-\u03baB by Toll-like receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol. Med."},{"key":"ref_252","doi-asserted-by":"crossref","unstructured":"Petejova, N., Martinek, A., Zadrazil, J., Kanova, M., Klementa, V., Sigutova, R., Kacirova, I., Hrabovsky, V., Svagera, Z., and Stejskal, D. (2020). Acute Kidney Injury in Septic Patients Treated by Selected Nephrotoxic Antibiotic Agents\u2014Pathophysiology and Biomarkers\u2014A Review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197115"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1681\/ASN.2009070718","article-title":"Targeted Deletion of Dicer from Proximal Tubules Protects against Renal Ischemia-Reperfusion Injury","volume":"21","author":"Wei","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1080\/0886022X.2019.1669460","article-title":"The miR-15a-5p-XIST-CUL3 regulatory axis is important for sepsis-induced acute kidney injury","volume":"41","author":"Xu","year":"2019","journal-title":"Ren. Fail."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.biopha.2017.07.098","article-title":"MiRNA-21 has effects to protect kidney injury induced by sepsis","volume":"94","author":"Fu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"303","DOI":"10.21037\/atm.2020.03.01","article-title":"miR-21 protects against lipopolysaccharide-stimulated acute kidney injury and apoptosis by targeting CDK6","volume":"8","author":"Wei","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"2821731","DOI":"10.1155\/2019\/2821731","article-title":"MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT\/CDK2-FOXO1 Pathway","volume":"2019","author":"Lin","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2020.12.018","article-title":"Circular RNA circ_0068,888 protects against lipopolysaccharide-induced HK-2 cell injury via sponging microRNA-21\u20135p","volume":"540","author":"Wei","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"2370253","DOI":"10.1155\/2020\/2370253","article-title":"Nrp-1 Mediated Plasmatic Ago2 Binding miR-21a-3p Internalization: A Novel Mechanism for miR-21a-3p Accumulation in Renal Tubular Epithelial Cells during Sepsis","volume":"2020","author":"Zou","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"142","DOI":"10.7150\/ijms.21645","article-title":"MiR-22-3p Regulates Cell Proliferation and Inhibits Cell Apoptosis through Targeting the eIF4EBP3 Gene in Human Cervical Squamous Carcinoma Cells","volume":"15","author":"Lv","year":"2018","journal-title":"Int. J. Med. Sci."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.omtn.2019.12.037","article-title":"The Biomarker TCONS_00016233 Drives Septic AKI by Targeting the miR-22-3p\/AIFM1 Signaling Axis","volume":"19","author":"Zhang","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"BSR20200527","DOI":"10.1042\/BSR20200527","article-title":"MiR-22-3p suppresses sepsis-induced acute kidney injury by targeting PTEN","volume":"40","author":"Wang","year":"2020","journal-title":"Biosci. Rep."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"e11571","DOI":"10.1590\/1414-431x2021e11571","article-title":"miR-23a-3p inhibits sepsis-induced kidney epithelial cell injury by suppressing Wnt\/\u03b2-catenin signaling by targeting wnt5a","volume":"55","author":"Ye","year":"2022","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1080\/0886022X.2022.2056486","article-title":"The miR-26a-5p\/IL-6 axis alleviates sepsis-induced acute kidney injury by inhibiting renal inflammation","volume":"44","author":"Chen","year":"2022","journal-title":"Ren. Fail."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/kjm2.12431","article-title":"Downregulation of miR -29b-3p aggravates podocyte injury by targeting HDAC4 in LPS-induced acute kidney injury","volume":"37","author":"Ha","year":"2021","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"10288","DOI":"10.1080\/21655979.2022.2062195","article-title":"MicroRNA-103a-3p enhances sepsis-induced acute kidney injury via targeting CXCL12","volume":"13","author":"Ding","year":"2022","journal-title":"Bioengineered"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"e201900602","DOI":"10.1590\/s0102-865020190060000002","article-title":"MiR-106a aggravates sepsis-induced acute kidney injury by targeting THBS2 in mice model","volume":"34","author":"Shen","year":"2019","journal-title":"Acta Cir. Bras."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bbrc.2017.01.013","article-title":"MiR-107 induces TNF-\u03b1 secretion in endothelial cells causing tubular cell injury in patients with septic acute kidney injury","volume":"483","author":"Wang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bbrc.2022.03.009","article-title":"The regulation of LPCAT3 by miR-124-3p.1 in acute kidney injury suppresses cell proliferation by disrupting phospholipid metabolism","volume":"604","author":"Zhang","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"110101","DOI":"10.1016\/j.cellsig.2021.110101","article-title":"MiR-150-5p protects against septic acute kidney injury via repressing the MEKK3\/JNK pathway","volume":"86","author":"Shi","year":"2021","journal-title":"Cell. Signal."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.canlet.2016.11.027","article-title":"NF-kB-regulated exosomal miR-155 promotes the inflammation associated with arsenite carcinogenesis","volume":"388","author":"Chen","year":"2017","journal-title":"Cancer Lett."},{"key":"ref_272","first-page":"9362","article-title":"Inhibition of microRNA-155 alleviates lipopolysaccharide-induced kidney injury in mice","volume":"10","author":"Ren","year":"2017","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_273","first-page":"249","article-title":"Expression patterns and prognostic value of miR-210, miR-494, and miR-205 in middle-aged and old patients with sepsis-induced acute kidney injury","volume":"19","author":"Lin","year":"2019","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3892\/mmr.2021.12322","article-title":"miR-214 ameliorates sepsis-induced acute kidney injury via PTEN\/AKT\/mTOR-regulated autophagy","volume":"24","author":"Sang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/ddr.21863","article-title":"MicroRNA -214-5p aggravates sepsis-related acute kidney injury in mice","volume":"83","author":"Guo","year":"2022","journal-title":"Drug Dev. Res."},{"key":"ref_276","doi-asserted-by":"crossref","unstructured":"Zhang, J., Chen, Q., Dai, Z., and Pan, H. (2022). miR-22 alleviates sepsis-induced acute kidney injury via targeting the HMGB1\/TLR4\/NF-\u03baB signaling pathway. Int Urol Nephrol.","DOI":"10.1007\/s11255-022-03321-2"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"2961187","DOI":"10.1155\/2022\/2961187","article-title":"Inhibition of microRNA-665 Alleviates Septic Acute Kidney Injury by Targeting Bcl-2","volume":"2022","author":"Qi","year":"2022","journal-title":"J. Healthc. Eng."},{"key":"ref_278","doi-asserted-by":"crossref","unstructured":"Ge, Q.-M., Huang, C.-M., Zhu, X.-Y., Bian, F., and Pan, S.-M. (2017). Differentially expressed miRNAs in sepsis-induced acute kidney injury target oxidative stress and mitochondrial dysfunction pathways. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0173292"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"28006","DOI":"10.1038\/srep28006","article-title":"Circulating Plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS)","volume":"6","author":"Caserta","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1177\/1535370216685005","article-title":"Urinary MicroRNA-30c-5p and MicroRNA-192-5p as potential biomarkers of ischemia\u2013reperfusion-induced kidney injury","volume":"242","author":"Zou","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg2843","article-title":"The widespread regulation of microRNA biogenesis, function and decay","volume":"11","author":"Krol","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"ref_282","doi-asserted-by":"crossref","unstructured":"Agrawal, S., Tapmeier, T.T., Rahmioglu, N., Kirtley, S., Zondervan, K.T., and Becker, C.M. (2018). The miRNA Mirage: How Close Are We to Finding a Non-Invasive Diagnostic Biomarker in Endometriosis? A Systematic Review. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020599"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/jop.13134","article-title":"miRNA for the assessment of lymph node metastasis in patients with oral squamous cell carcinoma: Systematic review and metanalysis","volume":"50","author":"Jadhav","year":"2021","journal-title":"J. Oral Pathol. Med."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.2217\/epi-2021-0237","article-title":"MiRNA expression profiling in HIV pathogenesis, disease progression and response to treatment: A systematic review","volume":"13","author":"Leo","year":"2021","journal-title":"Epigenomics"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"6156","DOI":"10.1007\/s12035-019-1500-y","article-title":"Systematic Review of miRNA as Biomarkers in Alzheimer\u2019s Disease","volume":"56","author":"Swarbrick","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.trsl.2020.11.012","article-title":"miRNAs in lung cancer. A systematic review identifies predictive and prognostic miRNA candidates for precision medicine in lung cancer","volume":"230","author":"Zhong","year":"2021","journal-title":"Transl. Res."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1096\/fj.14-260323","article-title":"Noncoding RNAs, cytokines, and inflammation-related diseases","volume":"29","author":"Milagro","year":"2015","journal-title":"FASEB J."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3389\/fimmu.2018.01377","article-title":"Anti-Inflammatory MicroRNAs and Their Potential for Inflammatory Diseases Treatment","volume":"9","author":"Tahamtan","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12943-018-0766-4","article-title":"New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications","volume":"17","author":"Wang","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/imr.12601","article-title":"High-mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair","volume":"280","author":"Bianchi","year":"2017","journal-title":"Immunol. Rev."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-\u03baB: A key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fimmu.2012.00020","article-title":"SOCS, Inflammation, and Autoimmunity","volume":"3","author":"Yoshimura","year":"2012","journal-title":"Front. Immunol."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/ni.2565","article-title":"A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation","volume":"14","author":"Chen","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0960-9822(01)00225-1","article-title":"Tumor suppressor and anti-inflammatory actions of PPAR\u03b3 agonists are mediated via upregulation of PTEN","volume":"11","author":"Patel","year":"2001","journal-title":"Curr. Biol."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fnmol.2011.00051","article-title":"PI3K\/AKT\/mTOR Pathway in Angiogenesis","volume":"4","author":"Karar","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"ref_296","doi-asserted-by":"crossref","unstructured":"Seminerio, I., Descamps, G., Dupont, S., de Marrez, L., Laigle, J.-A., Lechien, J.R., Kindt, N., Journe, F., and Saussez, S. (2019). Infiltration of FoxP3+ Regulatory T Cells is a Strong and Independent Prognostic Factor in Head and Neck Squamous Cell Carcinoma. Cancers, 11.","DOI":"10.3390\/cancers11020227"},{"key":"ref_297","doi-asserted-by":"crossref","unstructured":"de Moraes, G.N., Carneiro, L.D.T., Maia, R.C., Lam, E.W.-F., and Sharrocks, A.D. (2019). FOXK2 Transcription Factor and Its Emerging Roles in Cancer. Cancers, 11.","DOI":"10.3390\/cancers11030393"},{"key":"ref_298","doi-asserted-by":"crossref","unstructured":"Gurnari, C., Falconi, G., De Bellis, E., Voso, M.T., and Fabiani, E. (2019). The Role of Forkhead Box Proteins in Acute Myeloid Leukemia. Cancers, 11.","DOI":"10.3390\/cancers11060865"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/scientificamerican0306-48","article-title":"Unlocking the Secrets of Longevity Genes","volume":"294","author":"Sinclair","year":"2006","journal-title":"Sci. Am."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1172\/JCI0215650","article-title":"What does Stat3 do?","volume":"109","author":"Levy","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_301","doi-asserted-by":"crossref","unstructured":"Condrat, C.E., Thompson, D.C., Barbu, M.G., Bugnar, O.L., Boboc, A., Cretoiu, D., Suciu, N., Cretoiu, S.M., and Voinea, S.C. (2020). miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis. Cells, 9.","DOI":"10.3390\/cells9020276"},{"key":"ref_302","doi-asserted-by":"crossref","unstructured":"Giordano, M., Trotta, M.C., Ciarambino, T., D\u2019Amico, M., Schettini, F., Di Sisto, A., D\u2019Auria, V., Voza, A., Malatino, L.S., and Biolo, G. (2022). Circulating miRNA-195-5p and -451a in Patients with Acute Hemorrhagic Stroke in Emergency Department. Life, 12.","DOI":"10.3390\/life12050763"},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.3389\/fmicb.2020.01197","article-title":"MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing","volume":"11","author":"Tribolet","year":"2020","journal-title":"Front. Microbiol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/16\/9354\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:12:30Z","timestamp":1760141550000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/16\/9354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,19]]},"references-count":303,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["ijms23169354"],"URL":"https:\/\/doi.org\/10.3390\/ijms23169354","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,19]]}}}