{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:23:09Z","timestamp":1793380989248,"version":"4.5.0"},"reference-count":141,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Program of the National Natural Science Foundation of China","award":["81730039"],"award-info":[{"award-number":["81730039"]}]},{"name":"Key Program of the National Natural Science Foundation of China","award":["82071653"],"award-info":[{"award-number":["82071653"]}]},{"name":"Key Program of the National Natural Science Foundation of China","award":["2017ZZ02015"],"award-info":[{"award-number":["2017ZZ02015"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730039"],"award-info":[{"award-number":["81730039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071653"],"award-info":[{"award-number":["82071653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017ZZ02015"],"award-info":[{"award-number":["2017ZZ02015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Municipal Medical and Health Discipline Construction Projects","award":["81730039"],"award-info":[{"award-number":["81730039"]}]},{"name":"Shanghai Municipal Medical and Health Discipline Construction Projects","award":["82071653"],"award-info":[{"award-number":["82071653"]}]},{"name":"Shanghai Municipal Medical and Health Discipline Construction Projects","award":["2017ZZ02015"],"award-info":[{"award-number":["2017ZZ02015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Iron is a vital element in nearly every living organism. During pregnancy, optimal iron concentration is essential for both maternal health and fetal development. As the barrier between the mother and fetus, placenta plays a pivotal role in mediating and regulating iron transport. Imbalances in iron metabolism correlate with severe adverse pregnancy outcomes. Like most other nutrients, iron exhibits a U-shaped risk curve. Apart from iron deficiency, iron overload is also dangerous since labile iron can generate reactive oxygen species, which leads to oxidative stress and activates ferroptosis. In this review, we summarized the molecular mechanism and regulation signals of placental iron trafficking under physiological conditions. In addition, we revealed the role of iron metabolism and ferroptosis in the view of preeclampsia and gestational diabetes mellitus, which may bring new insight to the pathogenesis and treatment of pregnancy-related diseases.<\/jats:p>","DOI":"10.3390\/ijms23169395","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T22:23:13Z","timestamp":1661120593000},"page":"9395","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Iron Metabolism and Ferroptosis in Physiological and Pathological Pregnancy"],"prefix":"10.3390","volume":"23","author":[{"given":"Yijun","family":"Zhang","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Maternal-Fetal Medicine, Department of Reproductive Immunology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Lu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal-Fetal Medicine, Department of Reproductive Immunology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Jin","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Maternal-Fetal Medicine, Department of Reproductive Immunology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0140-6736(07)61235-5","article-title":"Nutritional iron deficiency","volume":"370","author":"Zimmermann","year":"2007","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/humupd\/dmp025","article-title":"Role of micronutrients in the periconceptional period","volume":"16","author":"Cetin","year":"2009","journal-title":"Hum. 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