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Mechanistically, PAX5 controls gene expression profiles, which are pivotal to cellular processes such as viability, proliferation, and differentiation. Given its crucial function in B-cell development, PAX5 aberrant expression also correlates with hallmark cancer processes leading to hematological and other types of cancer lesions. Despite the well-established association of PAX5 in the development, maintenance, and progression of cancer disease, the use of PAX5 as a cancer biomarker or therapeutic target has yet to be implemented. This may be partly due to the assortment of PAX5 expressed products, which layers the complexity of their function and role in various regulatory networks and biological processes. In this review, we provide an overview of the reported data describing PAX5 products, their regulation, and function in cellular processes, cellular biology, and neoplasm.<\/jats:p>","DOI":"10.3390\/ijms231710095","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T05:17:23Z","timestamp":1662441443000},"page":"10095","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Pleiotropy of PAX5 Gene Products and Function"],"prefix":"10.3390","volume":"23","author":[{"given":"Parinaz","family":"Nasri Nasrabadi","sequence":"first","affiliation":[{"name":"D\u00e9partement de Chimie et Biochimie, Universit\u00e9 de Moncton, Moncton, NB E1A 3E9, Canada"},{"name":"Atlantic Cancer Research Institute, Universit\u00e9 de Moncton, Moncton, NB E1C 8X3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danick","family":"Martin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chimie et Biochimie, Universit\u00e9 de Moncton, Moncton, NB E1A 3E9, Canada"},{"name":"Atlantic Cancer Research Institute, Universit\u00e9 de Moncton, Moncton, NB E1C 8X3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Gharib","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chimie et Biochimie, Universit\u00e9 de Moncton, Moncton, NB E1A 3E9, Canada"},{"name":"Atlantic Cancer Research Institute, Universit\u00e9 de Moncton, Moncton, NB E1C 8X3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5782-7899","authenticated-orcid":false,"given":"Gilles A.","family":"Robichaud","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chimie et Biochimie, Universit\u00e9 de Moncton, Moncton, NB E1A 3E9, Canada"},{"name":"Atlantic Cancer Research Institute, Universit\u00e9 de Moncton, Moncton, NB E1C 8X3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00439-020-02212-9","article-title":"Overview of pax gene family: Analysis of human tissue-specific variant expression and involvement in human disease","volume":"140","author":"Thompson","year":"2021","journal-title":"Hum. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1111\/j.1582-4934.2008.00427.x","article-title":"Pax genes in embryogenesis and oncogenesis","volume":"12","author":"Wang","year":"2008","journal-title":"J. Cell Mol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1615\/CritRevEukarGeneExpr.v22.i2.70","article-title":"Pax proteins and fables of their reconstruction","volume":"22","author":"Underhill","year":"2012","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nrc1778","article-title":"A panorama of pax genes in cancer and development","volume":"6","author":"Robson","year":"2006","journal-title":"Nat. Rev. Cancer."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1139\/o00-077","article-title":"Genetic and biochemical diversity in the pax gene family","volume":"78","author":"Underhill","year":"2000","journal-title":"Biochem. Cell Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1101\/gad.6.9.1589","article-title":"Pax-5 encodes the transcription factor bsap and is expressed in b lymphocytes, the developing cns, and adult testis","volume":"6","author":"Adams","year":"1992","journal-title":"Genes Dev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nature05690","article-title":"Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia","volume":"446","author":"Mullighan","year":"2007","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1182\/blood-2006-05-025221","article-title":"A novel pax5-eln fusion protein identified in b-cell acute lymphoblastic leukemia acts as a dominant negative on wild-type pax5","volume":"109","author":"Bousquet","year":"2007","journal-title":"Blood"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/onc.2010.554","article-title":"Pax5-pml acts as a dual dominant-negative form of both pax5 and pml","volume":"30","author":"Kurahashi","year":"2011","journal-title":"Oncogene"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/onc.2011.291","article-title":"Dominant-negative mechanism of leukemogenic pax5 fusions","volume":"31","author":"Kawamata","year":"2012","journal-title":"Oncogene"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1073\/pnas.93.12.6129","article-title":"Deregulation of pax-5 by translocation of the emu enhancer of the igh locus adjacent to two alternative pax-5 promoters in a diffuse large-cell lymphoma","volume":"93","author":"Busslinger","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"14670","DOI":"10.1038\/s41598-019-50864-z","article-title":"Circular rna differential expression in blood cell populations and exploration of circrna deregulation in pediatric acute lymphoblastic leukemia","volume":"9","author":"Gaffo","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"223-14","DOI":"10.4049\/jimmunol.204.Supp.223.14","article-title":"Characterization of new circular rna products from the pax-5 gene in b-cells","volume":"204","author":"Robichaud","year":"2020","journal-title":"J. Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"677-23","DOI":"10.1096\/fasebj.2018.32.1_supplement.677.23","article-title":"Discovery of novel non-coding products of the pax-5 gene and their clinical significance in lymphoid cancers","volume":"32","author":"Hannay","year":"2018","journal-title":"FASEB J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.1182\/blood.V100.13.4629","article-title":"Altered mrna expression of pax5 and blimp-1 in b cells in multiple myeloma","volume":"100","author":"Borson","year":"2002","journal-title":"Blood"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"10160","DOI":"10.1074\/jbc.272.15.10160","article-title":"The pax-5 gene is alternatively spliced during b-cell development","volume":"272","author":"Zwollo","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"49956","DOI":"10.1074\/jbc.M407171200","article-title":"Human pax-5 c-terminal isoforms possess distinct transactivation properties and are differentially modulated in normal and malignant b cells","volume":"279","author":"Robichaud","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Beauregard, A.-P., Hannay, B., Gharib, E., Crapoulet, N., Finn, N., Guerrette, R., Ouellet, A., and Robichaud, G.A. (2021). Pax-5 protein expression is regulated by transcriptional 3\u2032utr editing. Cells, 11.","DOI":"10.3390\/cells11010076"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"14137","DOI":"10.1074\/jbc.M110.176289","article-title":"Histone acetyltransferase p300 acetylates pax5 and strongly enhances pax5-mediated transcriptional activity","volume":"286","author":"He","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6127","DOI":"10.4049\/jimmunol.1103039","article-title":"B cell receptor-erk1\/2 signal cancels pax5-dependent repression of blimp1 through pax5 phosphorylation: A mechanism of antigen-triggering plasma cell differentiation","volume":"188","author":"Yasuda","year":"2012","journal-title":"J. Immunol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.bbrc.2016.05.067","article-title":"Pax5 tyrosine phosphorylation by syk co-operatively functions with its serine phosphorylation to cancel the pax5-dependent repression of blimp1: A mechanism for antigen-triggered plasma cell differentiation","volume":"475","author":"Inagaki","year":"2016","journal-title":"Biochem. Biophys Res. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0165-4608(03)00054-2","article-title":"Three new cases of non-hodgkin lymphoma with t (9; 14)(p13; q32)","volume":"145","author":"Andrieux","year":"2003","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1101\/gad.4.5.849","article-title":"A novel b-cell lineage-specific transcription factor present at early but not late stages of differentiation","volume":"4","author":"Barberis","year":"1990","journal-title":"Genes Dev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"32841","DOI":"10.18632\/oncotarget.26003","article-title":"Pax5a and pax5b isoforms are both efficient to drive b cell differentiation","volume":"9","author":"Cresson","year":"2018","journal-title":"Oncotarget"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/1348-0421.12272","article-title":"Paired box gene 5 isoforms a and b have different functions in transcriptional regulation of b cell development-related genes in immature b cells","volume":"59","author":"Kikuchi","year":"2015","journal-title":"Microbiol. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1093\/nar\/gkn432","article-title":"Development of an isoform-specific gene suppression system: The study of the human pax-5b transcriptional element","volume":"36","author":"Robichaud","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1074-7613(01)00153-4","article-title":"Pax5\/bsap maintains the identity of b cells in late b lymphopoiesis","volume":"14","author":"Horcher","year":"2001","journal-title":"Immunity"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ni1454","article-title":"Pax5: The guardian of b cell identity and function","volume":"8","author":"Cobaleda","year":"2007","journal-title":"Nat. Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/bjh.15578","article-title":"Direct role of flt 3 in regulation of early lymphoid progenitors","volume":"183","author":"Zriwil","year":"2018","journal-title":"Br. J. Haematol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/333571a0","article-title":"Stimulation of b-cell progenitors by cloned murine interleukin-7","volume":"333","author":"Namen","year":"1988","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0952-7915(00)00215-6","article-title":"New views of bcr structure and organization","volume":"13","author":"Matsuuchi","year":"2001","journal-title":"Curr. Opin. Immunol."},{"key":"ref_32","first-page":"2662","article-title":"The promoter of the cd19 gene is a target for the b-cell-specific transcription factor bsap","volume":"12","author":"Kozmik","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1128\/MCB.23.6.1946-1960.2003","article-title":"Activation of the early b-cell-specific mb-1 (ig-alpha) gene by pax-5 is dependent on an unmethylated ets binding site","volume":"23","author":"Maier","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1002\/eji.200323974","article-title":"Ebf-regulating pax5 transcription is enhanced by stat5 in the early stage of b cells","volume":"33","author":"Hirokawa","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.4049\/jimmunol.180.3.1719","article-title":"Identification of pax5 target genes in early b cell differentiation","volume":"180","author":"Pridans","year":"2008","journal-title":"J. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.3389\/fimmu.2018.01264","article-title":"Pu.1 is required for the developmental progression of multipotent progenitors to common lymphoid progenitors","volume":"9","author":"Pang","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.4161\/cc.5.21.3396","article-title":"Pax5 maintains cellular identity by repressing gene expression throughout b cell differentiation","volume":"5","author":"Carotta","year":"2006","journal-title":"Cell Cycle"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S1074-7613(02)00418-1","article-title":"Control of pre-bcr signaling by pax5-dependent activation of the blnk gene","volume":"17","author":"Schebesta","year":"2002","journal-title":"Immunity"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/B978-0-12-800267-4.00004-3","article-title":"Signaling circuits in early b-cell development","volume":"122","author":"Reth","year":"2014","journal-title":"Adv. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s12032-014-0360-6","article-title":"The role of pax5 in leukemia: Diagnosis and prognosis significance","volume":"32","author":"Shahjahani","year":"2015","journal-title":"Med. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1084\/jem.20030802","article-title":"The balance between pax5 and id2 activities is the key to aid gene expression","volume":"198","author":"Gonda","year":"2003","journal-title":"J. Exp. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1093\/emboj\/17.8.2319","article-title":"Identification of bsap (pax-5) target genes in early b-cell development by loss- and gain-of-function experiments","volume":"17","author":"Nutt","year":"1998","journal-title":"EMBO J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.immuni.2006.02.003","article-title":"Loss of pax5 promotes plasma cell differentiation","volume":"24","author":"Nera","year":"2006","journal-title":"Immunity"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1074-7613(02)00472-7","article-title":"Pax5 promotes b lymphopoiesis and blocks t cell development by repressing notch1","volume":"17","author":"Souabni","year":"2002","journal-title":"Immunity"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1128\/MCB.22.13.4771-4780.2002","article-title":"Blimp-1-dependent repression of pax-5 is required for differentiation of b cells to immunoglobulin m-secreting plasma cells","volume":"22","author":"Lin","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.coi.2007.01.003","article-title":"Terminal differentiation of lymphocytes depends on blimp-1","volume":"19","author":"Kallies","year":"2007","journal-title":"Curr. Opin. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.immuni.2006.01.012","article-title":"Gene repression by pax5 in b cells is essential for blood cell homeostasis and is reversed in plasma cells","volume":"24","author":"Delogu","year":"2006","journal-title":"Immunity"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e20200147","DOI":"10.1084\/jem.20200147","article-title":"Repression of the b cell identity factor pax5 is not required for plasma cell development","volume":"217","author":"Liu","year":"2020","journal-title":"J. Exp. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nature06159","article-title":"Conversion of mature b cells into t cells by dedifferentiation to uncommitted progenitors","volume":"449","author":"Cobaleda","year":"2007","journal-title":"Nature"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/44076","article-title":"Commitment to the b-lymphoid lineage depends on the transcription factor pax5","volume":"401","author":"Nutt","year":"1999","journal-title":"Nature"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s12185-010-0691-9","article-title":"Overexpression of pax5 induces apoptosis in multiple myeloma cells","volume":"92","author":"Proulx","year":"2010","journal-title":"Int. J. Hematol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1172\/JCI30842","article-title":"B cell activator pax5 promotes lymphomagenesis through stimulation of b cell receptor signaling","volume":"117","author":"Cozma","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1309\/XEC7-JMW9-YRM7-4RNO","article-title":"Pax-5 expression in nonhematopoietic tissues","volume":"126","author":"Torlakovic","year":"2006","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/gcc.20214","article-title":"Pax5\/igh rearrangement is a recurrent finding in a subset of aggressive b-nhl with complex chromosomal rearrangements","volume":"44","author":"Poppe","year":"2005","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1182\/blood.V92.4.1308","article-title":"Transcription factor b-cell-specific activator protein (bsap) is differentially expressed in b cells and in subsets of b-cell lymphomas","volume":"92","author":"Krenacs","year":"1998","journal-title":"Blood"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7345","DOI":"10.1158\/0008-5472.CAN-11-1874","article-title":"The pax-5 gene: A pluripotent regulator of b-cell differentiation and cancer disease","volume":"71","author":"Morin","year":"2011","journal-title":"Cancer Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1038\/s41467-018-06354-3","article-title":"Genome-wide discovery of somatic regulatory variants in diffuse large b-cell lymphoma","volume":"9","author":"Arthur","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature14666","article-title":"Non-coding recurrent mutations in chronic lymphocytic leukaemia","volume":"526","author":"Puente","year":"2015","journal-title":"Nature"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1182\/blood-2018-09-871418","article-title":"Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic burkitt lymphoma","volume":"133","author":"Grande","year":"2019","journal-title":"Blood"},{"key":"ref_60","first-page":"4666","article-title":"The paired box domain gene pax5 is fused to etv6\/tel in an acute lymphoblastic leukemia case","volume":"61","author":"Cazzaniga","year":"2001","journal-title":"Cancer Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1365-2141.2007.06731.x","article-title":"Identification of pml as novel pax5 fusion partner in childhood acute lymphoblastic leukaemia","volume":"139","author":"Nebral","year":"2007","journal-title":"Br. J. Haematol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1038\/leu.2009.135","article-title":"Pax5 mutations occur frequently in adult b-cell progenitor acute lymphoblastic leukemia and pax5 haploinsufficiency is associated with bcr-abl1 and tcf3-pbx1 fusion genes: A graall study","volume":"23","author":"Familiades","year":"2009","journal-title":"Leukemia"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/B978-0-12-385991-4.00005-2","article-title":"Pax5: A master regulator of b cell development and leukemogenesis","volume":"111","author":"Medvedovic","year":"2011","journal-title":"Adv. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"10357","DOI":"10.1073\/pnas.1721678115","article-title":"Pax5-eln oncoprotein promotes multistep b-cell acute lymphoblastic leukemia in mice","volume":"115","author":"Jamrog","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.devcel.2004.08.006","article-title":"Assembling a gene regulatory network for specification of the b cell fate","volume":"7","author":"Medina","year":"2004","journal-title":"Dev. Cell"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Okuyama, K., Strid, T., Kuruvilla, J., Somasundaram, R., Cristobal, S., Smith, E., Prasad, M., Fioretos, T., Lilljebj\u00f6rn, H., and Soneji, S. (2019). Pax5 is part of a functional transcription factor network targeted in lymphoid leukemia. PLoS Genet., 15.","DOI":"10.1371\/journal.pgen.1008280"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nature06866","article-title":"Bcr\u2013abl1 lymphoblastic leukaemia is characterized by the deletion of ikaros","volume":"453","author":"Mullighan","year":"2008","journal-title":"Nature"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature21076","article-title":"Metabolic gatekeeper function of b-lymphoid transcription factors","volume":"542","author":"Chan","year":"2017","journal-title":"Nature"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbcan.2012.12.004","article-title":"Expression of glucose transporters in cancers","volume":"1835","author":"Szablewski","year":"2013","journal-title":"Biochim. Biophys. Acta (BBA)-Rev. Cancer"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-pathol-061020-050135","article-title":"Metabolic gatekeepers of pathological b cell activation","volume":"16","author":"Sadras","year":"2021","journal-title":"Annu. Rev. Pathol."},{"key":"ref_71","first-page":"300","article-title":"Antitumor effects of wnt2b silencing in glut1 overexpressing cisplatin resistant head and neck squamous cell carcinoma","volume":"5","author":"Li","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1080\/15592294.2017.1365207","article-title":"Pax5 gene as a novel methylation marker that predicts both clinical outcome and cisplatin sensitivity in esophageal squamous cell carcinoma","volume":"12","author":"Kurimoto","year":"2017","journal-title":"Epigenetics"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/hep.24124","article-title":"Paired box gene 5 is a novel tumor suppressor in hepatocellular carcinoma through interaction with p53 signaling pathway","volume":"53","author":"Liu","year":"2011","journal-title":"Hepatology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1038\/onc.2011.511","article-title":"Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients","volume":"31","author":"Li","year":"2012","journal-title":"Oncogene"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1158\/1541-7786.MCR-09-0368","article-title":"Pax5alpha enhances the epithelial behavior of human mammary carcinoma cells","volume":"8","author":"Vidal","year":"2010","journal-title":"Mol. Cancer Res. MCR"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.4161\/epi.29025","article-title":"Key tumor suppressor genes inactivated by \u201cgreater promoter\u201d methylation and somatic mutations in head and neck cancer","volume":"9","author":"Michailidi","year":"2014","journal-title":"Epigenetics"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/leu.2009.18","article-title":"Genome-wide profiling of genetic alterations in acute lymphoblastic leukemia: Recent insights and future directions","volume":"23","author":"Mullighan","year":"2009","journal-title":"Leukemia"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/ng.2754","article-title":"A recurrent germline pax5 mutation confers susceptibility to pre-b cell acute lymphoblastic leukemia","volume":"45","author":"Shah","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20101947","article-title":"Ebf1 or pax5 haploinsufficiency synergizes with stat5 activation to initiate acute lymphoblastic leukemia","volume":"208","author":"Willette","year":"2011","journal-title":"J. Exp. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ccr.2012.06.005","article-title":"Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia","volume":"22","author":"Roberts","year":"2012","journal-title":"Cancer Cell"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/S0140-6736(08)60457-2","article-title":"Acute lymphoblastic leukaemia","volume":"371","author":"Pui","year":"2008","journal-title":"Lancet"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"11921","DOI":"10.1073\/pnas.0711039105","article-title":"Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray","volume":"105","author":"Kawamata","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1182\/blood-2009-07-234229","article-title":"Wide diversity of pax5 alterations in b-all: A groupe francophone de cytogenetique hematologique study","volume":"115","author":"Coyaud","year":"2010","journal-title":"Blood"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"17050","DOI":"10.1073\/pnas.0803494105","article-title":"Variable breakpoints target pax5 in patients with dicentric chromosomes: A model for the basis of unbalanced translocations in cancer","volume":"105","author":"An","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/leu.2008.306","article-title":"Incidence and diversity of pax5 fusion genes in childhood acute lymphoblastic leukemia","volume":"23","author":"Nebral","year":"2009","journal-title":"Leukemia"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.3324\/haematol.2014.112193","article-title":"Three novel fusion transcripts of the paired box 5 gene in b-cell precursor acute lymphoblastic leukemia","volume":"100","author":"Fazio","year":"2015","journal-title":"Haematologica"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/leu.2012.281","article-title":"Pax5\/etv6 alters the gene expression profile of precursor b cells with opposite dominant effect on endogenous pax5","volume":"27","author":"Fazio","year":"2013","journal-title":"Leukemia"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"718","DOI":"10.15252\/embj.201695495","article-title":"Molecular role of the pax5-etv6 oncoprotein in promoting b-cell acute lymphoblastic leukemia","volume":"36","author":"Smeenk","year":"2017","journal-title":"EMBO J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1038\/emboj.2012.155","article-title":"The b-cell identity factor pax5 regulates distinct transcriptional programmes in early and late b lymphopoiesis","volume":"31","author":"Revilla","year":"2012","journal-title":"EMBO J."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1182\/blood.V88.11.4110.4110","article-title":"The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the pax-5 gene","volume":"88","author":"Iida","year":"1996","journal-title":"Blood"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1182\/blood-2006-03-009670","article-title":"Oncogenic role of pax5 in the t-lymphoid lineage upon ectopic expression from the immunoglobulin heavy-chain locus","volume":"109","author":"Souabni","year":"2007","journal-title":"Blood"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1093\/carcin\/bgh190","article-title":"The pax5 oncogene is expressed in n-type neuroblastoma cells and increases tumorigenicity of a s-type cell line","volume":"25","author":"Maag","year":"2004","journal-title":"Carcinogenesis"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1073\/pnas.92.12.5709","article-title":"Deregulated expression of pax5 in medulloblastoma","volume":"92","author":"Kozmik","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/labinvest.2008.168","article-title":"Pax5 is expressed in small-cell lung cancer and positively regulates c-met transcription","volume":"89","author":"Kanteti","year":"2009","journal-title":"Lab. Investig."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.bbrc.2018.06.151","article-title":"Transactivation of ptgs2 by pax5 signaling potentiates cisplatin resistance in muscle-invasive bladder cancer cells","volume":"503","author":"Dong","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.1002\/j.1460-2075.1995.tb00251.x","article-title":"Loss of p53 function through pax-mediated transcriptional repression","volume":"14","author":"Stuart","year":"1995","journal-title":"EMBO J."},{"key":"ref_97","first-page":"207","article-title":"Pax5 expression correlates with increasing malignancy in human astrocytomas","volume":"1","author":"Stuart","year":"1995","journal-title":"Clin. Cancer Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e00129-19","DOI":"10.1128\/mSphere.00129-19","article-title":"Combined transcriptome and proteome analysis of immortalized human keratinocytes expressing human papillomavirus 16 (hpv16) oncogenes reveals novel key factors and networks in hpv-induced carcinogenesis","volume":"4","author":"Yang","year":"2019","journal-title":"mSphere"},{"key":"ref_99","first-page":"1003","article-title":"Overexpression of pax5 in oral carcinogenesis","volume":"16","author":"Norhany","year":"2006","journal-title":"Oncol. Rep."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1515\/cclm-2015-1198","article-title":"Aberrant methylation of tumour suppressor genes wt1, gata5 and pax5 in hepatocellular carcinoma","volume":"54","author":"John","year":"2016","journal-title":"Clin. Chem. Lab. Med. (CCLM)"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"12052","DOI":"10.18632\/oncotarget.14511","article-title":"Pax-5 is a potent regulator of e-cadherin and breast cancer malignant processes","volume":"8","author":"Benzina","year":"2017","journal-title":"Oncotarget"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"643","DOI":"10.2174\/187152011796817637","article-title":"Coordinated expression of pax-5 and fak1 in metastasis","volume":"11","author":"Crapoulet","year":"2011","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.7150\/jca.15200","article-title":"Breast cancer malignant processes are regulated by pax-5 through the disruption of fak signaling pathways","volume":"7","author":"Benzina","year":"2016","journal-title":"J. Cancer"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s12253-012-9498-8","article-title":"Epigenetic and copy number variation analysis in retinoblastoma by ms-mlpa","volume":"18","author":"Livide","year":"2012","journal-title":"Pathol. Oncol. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"7420","DOI":"10.18632\/oncotarget.1973","article-title":"Applicability of the methylated cpg sites of paired box 5 (pax5) promoter for prediction the prognosis of gastric cancer","volume":"5","author":"Deng","year":"2014","journal-title":"Oncotarget"},{"key":"ref_106","first-page":"142","article-title":"Immunohistochemical expression of pax5 and tdt by merkel cell carcinoma and pulmonary small cell carcinoma: A potential diagnostic pitfall but useful discriminatory marker","volume":"6","author":"Kolhe","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"246","DOI":"10.14712\/fb2012058060246","article-title":"Methylation analysis of tumour suppressor genes in ovarian cancer using ms-mlpa","volume":"58","author":"Chmelarova","year":"2012","journal-title":"Folia. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/path.2930","article-title":"Frequent promoter hypermethylation of brca2, cdh13, msh6, pax5, pax6 and wt1 in ductal carcinoma in situ and invasive breast cancer","volume":"225","author":"Moelans","year":"2011","journal-title":"J. Pathol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1177\/1947601911408889","article-title":"Mutations in the p53 tumor suppressor gene: Important milestones at the various steps of tumorigenesis","volume":"2","author":"Rivlin","year":"2011","journal-title":"Genes Cancer"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10911-010-9178-9","article-title":"Epithelial-mesenchymal transition in cancer: Parallels between normal development and tumor progression","volume":"15","author":"Micalizzi","year":"2010","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/1476-4598-9-179","article-title":"Breast carcinoma cells re-express e-cadherin during mesenchymal to epithelial reverting transition","volume":"9","author":"Chao","year":"2010","journal-title":"Mol. Cancer"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/jcp.21223","article-title":"Epithelial--mesenchymal and mesenchymal--epithelial transitions in carcinoma progression","volume":"213","author":"Hugo","year":"2007","journal-title":"J. Cell Physiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"11271","DOI":"10.1158\/0008-5472.CAN-06-2044","article-title":"Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2","volume":"66","author":"Chaffer","year":"2006","journal-title":"Cancer Res."},{"key":"ref_114","first-page":"12052","article-title":"Pax-5 is a potent transcriptional regulator of e-cadherin and breast cancer malignancy","volume":"8","author":"Benzina","year":"2015","journal-title":"Submitt. Mol. Cancer Res. MCR"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/35000025","article-title":"The transcription factor snail controls epithelial-mesenchymal transitions by repressing e-cadherin expression","volume":"2","author":"Cano","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2004.06.006","article-title":"Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis","volume":"117","author":"Yang","year":"2004","journal-title":"Cell"},{"key":"ref_117","first-page":"1613","article-title":"The slug zinc-finger protein represses e-cadherin in breast cancer","volume":"62","author":"Hajra","year":"2002","journal-title":"Cancer Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1038\/sj.onc.1208429","article-title":"Deltaef1 is a transcriptional repressor of e-cadherin and regulates epithelial plasticity in breast cancer cells","volume":"24","author":"Eger","year":"2005","journal-title":"Oncogene"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.bbrc.2009.04.051","article-title":"Molecular mechanisms controlling e-cadherin expression in breast cancer","volume":"384","author":"Baranwal","year":"2009","journal-title":"Biochem. Biophys Res. Commun."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s10585-008-9167-1","article-title":"E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas","volume":"25","author":"Wells","year":"2008","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1083\/jcb.200308162","article-title":"Autoregulation of e-cadherin expression by cadherin-cadherin interactions: The roles of beta-catenin signaling, slug, and mapk","volume":"163","author":"Simcha","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10585-008-9232-9","article-title":"A gene expression signature that defines breast cancer metastases","volume":"26","author":"Ellsworth","year":"2009","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e13087","DOI":"10.7554\/eLife.13087","article-title":"Transcription-coupled genetic instability marks acute lymphoblastic leukemia structural variation hotspots","volume":"5","author":"Heinaniemi","year":"2016","journal-title":"eLife"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.3390\/cancers13133270","article-title":"Enhancing b-cell malignancies-on repurposing enhancer activity towards cancer","volume":"13","author":"Kasprzyk","year":"2021","journal-title":"Cancers"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/hdy.2010.54","article-title":"Epigenetics and gene expression","volume":"105","author":"Gibney","year":"2010","journal-title":"Heredity"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/or.2016.5236","article-title":"Non-coding rnas as regulators in epigenetics (review)","volume":"37","author":"Wei","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2003.tb05957.x","article-title":"Epigenetics in cancer prevention: Early detection and risk assessment: Introduction","volume":"983","author":"Dunn","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s12016-015-8494-7","article-title":"Epigenetic control of b cell development and b-cell-related immune disorders","volume":"50","author":"Bao","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000337290","article-title":"A methyl-deficient diet modifies early b cell development","volume":"79","author":"Kurogi","year":"2012","journal-title":"Pathobiology"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.biochem.74.010904.153721","article-title":"Eukaryotic cytosine methyltransferases","volume":"74","author":"Goll","year":"2005","journal-title":"Annu. Rev. Biochem."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/cbic.201000195","article-title":"Structure and function of mammalian DNA methyltransferases","volume":"12","author":"Jurkowska","year":"2011","journal-title":"Chembiochem"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.exphem.2010.12.004","article-title":"Tet genes: New players in DNA demethylation and important determinants for stemness","volume":"39","author":"Mohr","year":"2011","journal-title":"Exp. Hematol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.it.2013.03.006","article-title":"Epigenetics of the antibody response","volume":"34","author":"Li","year":"2013","journal-title":"Trends Immunol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fimmu.2014.00156","article-title":"The interplay between chromatin and transcription factor networks during b cell development: Who pulls the trigger first?","volume":"5","author":"Choukrallah","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"8467","DOI":"10.1073\/pnas.150218497","article-title":"V(d)j recombination is not activated by demethylation of the kappa locus","volume":"97","author":"Cherry","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e18290","DOI":"10.7554\/eLife.18290","article-title":"Tet2 and tet3 cooperate with b-lineage transcription factors to regulate DNA modification and chromatin accessibility","volume":"5","author":"Lio","year":"2016","journal-title":"eLife"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/ni1119","article-title":"Early b cell factor cooperates with runx1 and mediates epigenetic changes associated with mb-1 transcription","volume":"5","author":"Maier","year":"2004","journal-title":"Nat. Immunol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"11258","DOI":"10.1073\/pnas.0809485106","article-title":"Opposing effects of swi\/snf and mi-2\/nurd chromatin remodeling complexes on epigenetic reprogramming by ebf and pax5","volume":"106","author":"Gao","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1038\/emboj.2011.140","article-title":"The transcription factor pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed b cells","volume":"30","author":"McManus","year":"2011","journal-title":"EMBO J."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0161-5890(02)00003-2","article-title":"DNA methylation dominates transcriptional silencing of pax5 in terminally differentiated b cell lines","volume":"38","author":"Danbara","year":"2002","journal-title":"Mol. Immunol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3389\/fimmu.2014.00642","article-title":"Epigenetic function of activation-induced cytidine deaminase and its link to lymphomagenesis","volume":"5","author":"Dominguez","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","article-title":"Class switch recombination and hypermutation require activation-induced cytidine deaminase (aid), a potential rna editing enzyme","volume":"102","author":"Muramatsu","year":"2000","journal-title":"Cell"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/35085588","article-title":"Hypermutation of multiple proto-oncogenes in b-cell diffuse large-cell lymphomas","volume":"412","author":"Pasqualucci","year":"2001","journal-title":"Nature"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/cmi.2017.133","article-title":"Epigenetic regulation in b-cell maturation and its dysregulation in autoimmunity","volume":"15","author":"Wu","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.leukres.2010.11.015","article-title":"Epigenetic regulation of pax5 expression in acute t-cell lymphoblastic leukemia","volume":"35","author":"Kaiser","year":"2011","journal-title":"Leuk. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/j.seminhematol.2008.09.005","article-title":"Global genomic characterization of acute lymphoblastic leukemia","volume":"46","author":"Mullighan","year":"2009","journal-title":"Semin. Hematol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13148-014-0039-z","article-title":"DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia","volume":"7","author":"Nordlund","year":"2015","journal-title":"Clin. Epigenet."},{"key":"ref_148","first-page":"4620","article-title":"Aberrant promoter methylation of the transcription factor genes pax5 \u03b1 and \u03b2 in human cancers","volume":"63","author":"Palmisano","year":"2003","journal-title":"Cancer Res."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/CM9.0000000000002018","article-title":"Paired box 5 increases the chemosensitivity of esophageal squamous cell cancer cells by promoting p53 signaling activity","volume":"135","author":"Zhang","year":"2022","journal-title":"Chin. Med. J."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.bbagrm.2014.03.001","article-title":"Interpreting the language of histone and DNA modifications","volume":"1839","author":"Rothbart","year":"2014","journal-title":"Biochim. Biophys Acta"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1101\/gad.240416.114","article-title":"Pax5 loss imposes a reversible differentiation block in b-progenitor acute lymphoblastic leukemia","volume":"28","author":"Liu","year":"2014","journal-title":"Genes Dev."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1038\/s41598-021-81000-5","article-title":"Ebf1 drives hallmark b cell gene expression by enabling the interaction of pax5 with the mll h3k4 methyltransferase complex","volume":"11","author":"Bullerwell","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1128\/MCB.20.7.2592-2603.2000","article-title":"Transcriptional repression by blimp-1 (prdi-bf1) involves recruitment of histone deacetylase","volume":"20","author":"Yu","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/ni1046","article-title":"Prdi-bf1 recruits the histone h3 methyltransferase g9a in transcriptional silencing","volume":"5","author":"Gyory","year":"2004","journal-title":"Nat. Immunol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.immuni.2015.10.015","article-title":"The foxo1 transcription factor instructs the germinal center dark zone program","volume":"43","author":"Kung","year":"2015","journal-title":"Immunity"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/ni.1891","article-title":"A global network of transcription factors, involving e2a, ebf1 and foxo1, that orchestrates b cell fate","volume":"11","author":"Lin","year":"2010","journal-title":"Nat. Immunol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"S497","DOI":"10.1177\/09603271211051601","article-title":"Cyclophosphamide inhibits pax5 methylation to regulate the growth of retinoblastoma via the notch1 pathway","volume":"40","author":"Jin","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mrfmmm.2006.08.015","article-title":"Mechanisms of atp dependent chromatin remodeling","volume":"618","author":"Gangaraju","year":"2007","journal-title":"Mutat. Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"7132","DOI":"10.1158\/0008-5472.CAN-07-0750","article-title":"Identification of pax5 as a target of mta1 in b-cell lymphomas","volume":"67","author":"Balasenthil","year":"2007","journal-title":"Cancer Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nrg3863","article-title":"Rna-mediated epigenetic regulation of gene expression","volume":"16","author":"Holoch","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2217\/epi.15.79","article-title":"Regulatory rnas and control of epigenetic mechanisms: Expectations for cognition and cognitive dysfunction","volume":"8","author":"Butler","year":"2016","journal-title":"Epigenomics"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12943-018-0765-5","article-title":"Nuclear functions of mammalian micrornas in gene regulation, immunity and cancer","volume":"17","author":"Liu","year":"2018","journal-title":"Mol. Cancer"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s00018-017-2688-5","article-title":"Molecular roles and function of circular rnas in eukaryotic cells","volume":"75","author":"Holdt","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1093\/carcin\/bgy191","article-title":"Mirnas 484 and 210 regulate pax-5 expression and function in breast cancer cells","volume":"40","author":"Harquail","year":"2019","journal-title":"Carcinogenesis"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Rothe, F., Ignatiadis, M., Chaboteaux, C., Haibe-Kains, B., Kheddoumi, N., Majjaj, S., Badran, B., Fayyad-Kazan, H., Desmedt, C., and Harris, A.L. (2011). Global microrna expression profiling identifies mir-210 associated with tumor proliferation, invasion and poor clinical outcome in breast cancer. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0020980"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.molcel.2009.09.006","article-title":"Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation","volume":"35","author":"Huang","year":"2009","journal-title":"Mol. Cell"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1756-9966-33-50","article-title":"Multiple functions of hypoxia-regulated mir-210 in cancer","volume":"33","author":"Qin","year":"2014","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/iub.427","article-title":"Mir-210: More than a silent player in hypoxia","volume":"63","author":"Devlin","year":"2011","journal-title":"IUBMB Life"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.molmed.2010.03.004","article-title":"Mir-210--micromanager of the hypoxia pathway","volume":"16","author":"Huang","year":"2010","journal-title":"Trends Mol. Med."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10911-018-9404-4","article-title":"Pax-5 inhibits nf-kappab activity in breast cancer cells through ikkepsilon and mirna-155 effectors","volume":"23","author":"Harquail","year":"2018","journal-title":"J. Mammary Gland. Biol. Neoplasia"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1084\/jem.20140338","article-title":"The mir-155\u2013pu.1 axis acts on pax5 to enable efficient terminal b cell differentiation","volume":"211","author":"Lu","year":"2014","journal-title":"J. Exp. Med."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.immuni.2007.11.010","article-title":"Microrna-155 function in b cells","volume":"27","author":"Calame","year":"2007","journal-title":"Immunity"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.dci.2013.06.008","article-title":"Alternative splicing of the trout pax5 gene and identification of novel b cell populations using pax5 signatures","volume":"41","author":"MacMurray","year":"2013","journal-title":"Dev. Comp. Immunol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.4049\/jimmunol.166.4.2617","article-title":"Reduction in DNA binding activity of the transcription factor pax-5a in b lymphocytes of aged mice","volume":"166","author":"Anspach","year":"2001","journal-title":"J. Immunol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1365-2141.2009.07859.x","article-title":"Multiple isoforms of pax5 are expressed in both lymphomas and normal b-cells","volume":"147","author":"Arseneau","year":"2009","journal-title":"Br. J. Haematol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1365-2141.2006.06425.x","article-title":"Expression and production of aberrant pax5 with deletion of exon 8 in b-lineage acute lymphoblastic leukaemia of children","volume":"136","author":"Sadakane","year":"2007","journal-title":"Br. J. Haematol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.tcb.2009.06.001","article-title":"To localize or not to localize: Mrna fate is in 3\u2019utr ends","volume":"19","author":"Andreassi","year":"2009","journal-title":"Trends Cell Biol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/0955-0674(90)90161-7","article-title":"The role of poly(a) in the translation and stability of mrna","volume":"2","author":"Sachs","year":"1990","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/nar\/gki158","article-title":"A large-scale analysis of mrna polyadenylation of human and mouse genes","volume":"33","author":"Tian","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1126\/science.1155390","article-title":"Proliferating cells express mrnas with shortened 3\u2019 untranslated regions and fewer microrna target sites","volume":"320","author":"Sandberg","year":"2008","journal-title":"Science"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cell.2009.06.016","article-title":"Widespread shortening of 3\u2032utrs by alternative cleavage and polyadenylation activates oncogenes in cancer cells","volume":"138","author":"Mayr","year":"2009","journal-title":"Cell"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Salzman, J., Gawad, C., Wang, P.L., Lacayo, N., and Brown, P.O. (2012). Circular rnas are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0030733"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41544-019-0046-5","article-title":"Circular rna: Functions, applications and prospects","volume":"2","author":"Lu","year":"2020","journal-title":"ExRNA"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.ymthe.2019.07.001","article-title":"Circular rnas: A novel class of functional rna molecules with a therapeutic perspective","volume":"27","author":"Santer","year":"2019","journal-title":"Mol. Ther."},{"key":"ref_185","first-page":"67","article-title":"Circular rnas act as mirna sponges","volume":"1087","author":"Panda","year":"2018","journal-title":"Circ. RNAs"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"8591","DOI":"10.3390\/ijms21228591","article-title":"Circular rna, the key for translation","volume":"21","author":"Prats","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/cr.2017.31","article-title":"Extensive translation of circular rnas driven by n6-methyladenosine","volume":"27","author":"Yang","year":"2017","journal-title":"Cell Res."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"617281","DOI":"10.3389\/fcell.2021.617281","article-title":"Insights into the role of circrnas: Biogenesis, characterization, functional, and clinical impact in human malignancies","volume":"9","author":"Nisar","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.3390\/cancers13133154","article-title":"New molecular mechanisms and clinical impact of circrnas in human cancer","volume":"13","author":"Fontemaggi","year":"2021","journal-title":"Cancers"},{"key":"ref_190","first-page":"670","article-title":"Regulation of marginal zone b-cell differentiation by microrna-146a","volume":"7","author":"King","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"12207","DOI":"10.1038\/ncomms12207","article-title":"Regulation of b-cell development and tolerance by different members of the mir-17 approximately 92 family micrornas","volume":"7","author":"Lai","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1182\/blood-2012-12-473090","article-title":"The myc-mir-17-92 axis amplifies b-cell receptor signaling via inhibition of itim proteins: A novel lymphomagenic feed-forward loop","volume":"122","author":"Psathas","year":"2013","journal-title":"Blood"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"19381","DOI":"10.18632\/oncotarget.4574","article-title":"The myc\/mir-17-92 axis in lymphoproliferative disorders: A common pathway with therapeutic potential","volume":"6","author":"Bomben","year":"2015","journal-title":"Oncotarget"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"16752","DOI":"10.1074\/jbc.M001551200","article-title":"Bsap (pax5)-importin alpha 1 (rch1) interaction identifies a nuclear localization sequence","volume":"275","author":"Kovac","year":"2000","journal-title":"J. Biol Chem."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"7399","DOI":"10.1158\/0008-5472.CAN-04-1865","article-title":"Pax5 expression in acute leukemias: Higher b-lineage specificity than cd79a and selective association with t(8;21)-acute myelogenous leukemia","volume":"64","author":"Tiacci","year":"2004","journal-title":"Cancer Res."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bcmd.2011.04.003","article-title":"Pax5 deletion is common and concurrently occurs with cdkn2a deletion in b-lineage acute lymphoblastic leukemia","volume":"47","author":"Kim","year":"2011","journal-title":"Blood Cells Mol. Dis."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1182\/blood.V80.7.1825.1825","article-title":"Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, aml1\/eto, with similarity to drosophila segmentation gene, runt","volume":"80","author":"Erickson","year":"1992","journal-title":"Blood"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1182\/blood-2007-07-092015","article-title":"T(6;14)(p22;q32): A new recurrent igh@ translocation involving id4 in b-cell precursor acute lymphoblastic leukemia (bcp-all)","volume":"111","author":"Russell","year":"2008","journal-title":"Blood"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/17\/10095\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:23:01Z","timestamp":1760142181000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/17\/10095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,3]]},"references-count":198,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["ijms231710095"],"URL":"https:\/\/doi.org\/10.3390\/ijms231710095","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,3]]}}}