{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T02:22:33Z","timestamp":1781835753564,"version":"3.54.5"},"reference-count":44,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science &amp; ICT","award":["NRF-2019M3A9I3080263"],"award-info":[{"award-number":["NRF-2019M3A9I3080263"]}]},{"name":"Ministry of Science &amp; ICT","award":["NRF-2019M3A9I3080265"],"award-info":[{"award-number":["NRF-2019M3A9I3080265"]}]},{"name":"Ministry of Science &amp; ICT","award":["NRF-2019M3A9I3080266"],"award-info":[{"award-number":["NRF-2019M3A9I3080266"]}]},{"name":"Ministry of Science &amp; ICT","award":["2Z06661"],"award-info":[{"award-number":["2Z06661"]}]},{"name":"Korea Institute of Science &amp; Technology, Republic of Korea","award":["NRF-2019M3A9I3080263"],"award-info":[{"award-number":["NRF-2019M3A9I3080263"]}]},{"name":"Korea Institute of Science &amp; Technology, Republic of Korea","award":["NRF-2019M3A9I3080265"],"award-info":[{"award-number":["NRF-2019M3A9I3080265"]}]},{"name":"Korea Institute of Science &amp; Technology, Republic of Korea","award":["NRF-2019M3A9I3080266"],"award-info":[{"award-number":["NRF-2019M3A9I3080266"]}]},{"name":"Korea Institute of Science &amp; Technology, Republic of Korea","award":["2Z06661"],"award-info":[{"award-number":["2Z06661"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The activation and degranulation of immune cells play a pivotal role in allergic inflammation, a pathological condition that includes anaphylaxis, pruritus, and allergic march-related diseases. In this study, trifuhalol A, a phlorotannin isolated from Agarum cribrosum, inhibited the degranulation of immune cells and the biosynthesis of IL-33 and IgE in differentiated B cells and keratinocytes, respectively. Additionally, trifuhalol A suppressed the IL-33 and IgE-mediated activation of RBL-2H3 cells through the regulation of the TAK1 and MK2 pathways. Hence, the effect of trifuhalol A on allergic inflammation was evaluated using a Compound 48\/80-induced systemic anaphylaxis mouse model and a house dust mite (HDM)-induced atopic dermatitis (AD) mouse model. Trifuhalol A alleviated anaphylactic death and pruritus, which appeared as an early-phase reaction to allergic inflammation in the Compound 48\/80-induced systemic anaphylaxis model. In addition, trifuhalol A improved symptoms such as itching, edema, erythema, and hyperkeratinization in HDM-induced AD mice as a late-phase reaction. Moreover, the expression of IL-33 and thymic stromal lymphopoietin, inflammatory cytokines secreted from activated keratinocytes, was significantly reduced by trifuhalol A administration, resulting in the reduced infiltration of immune cells into the skin and a reduction in the blood levels of IgE and IL-4. In summarizing the above results, these results confirm that trifuhalol A is a potential therapeutic candidate for the regulation of allergic inflammation.<\/jats:p>","DOI":"10.3390\/ijms231710163","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T05:17:23Z","timestamp":1662441443000},"page":"10163","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Trifuhalol A Suppresses Allergic Inflammation through Dual Inhibition of TAK1 and MK2 Mediated by IgE and IL-33"],"prefix":"10.3390","volume":"23","author":[{"given":"Sim-Kyu","family":"Bong","sequence":"first","affiliation":[{"name":"Natural Products Research Institute, Korea Institute of Sceience and Technology (KIST), Gangneung 25451, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No-June","family":"Park","sequence":"additional","affiliation":[{"name":"Natural Products Research Institute, Korea Institute of Sceience and Technology (KIST), Gangneung 25451, Korea"},{"name":"Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul 02792, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Heon","family":"Lee","sequence":"additional","affiliation":[{"name":"Natural Products Research Institute, Korea Institute of Sceience and Technology (KIST), Gangneung 25451, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Natural Products Research Institute, Korea Institute of Sceience and Technology (KIST), Gangneung 25451, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron Taehwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Haizhibao Deutschland GmbH, Heiliggeistgasse 28, 85354 Freising, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Moo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Marine Food Science and Technology, Gangneung-Wonju National University, 7 Jukheon-gil, Gangneung 25457, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hye","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Pusan National University, Busan 46241, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6413-7538","authenticated-orcid":false,"given":"Yong Kee","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Sookmyung Women\u2019s University, Seoul 04310, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Nam","family":"Kim","sequence":"additional","affiliation":[{"name":"Natural Products Research Institute, Korea Institute of Sceience and Technology (KIST), Gangneung 25451, Korea"},{"name":"Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul 02792, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"ref_1","first-page":"79","article-title":"Understanding asthma pathophysiology","volume":"24","author":"Fireman","year":"2003","journal-title":"Allergy Asthma Proc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00130832-200406000-00004","article-title":"Mediators of inflammation in the early and the late phase of allergic rhinitis","volume":"4","author":"Hansen","year":"2004","journal-title":"Curr. 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