{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T23:40:05Z","timestamp":1778283605097,"version":"3.51.4"},"reference-count":44,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22078246"],"award-info":[{"award-number":["22078246"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22178270"],"award-info":[{"award-number":["22178270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>To endow the polymeric prodrug with smart properties through a safe and simple method, matrix metalloproteinase (MMPs) responsive peptide GPLGVRGDG was introduced into the block copolymer to prepare TPGS3350-GPLGVRGDG-DOX&amp;DOX micelles, where TPGS3350 is D-\u03b1-tocopheryl polyethylene glycol 3350 succinate. During the doxorubicin delivery, the cleavage of the peptide chain triggers de-PEGylation, and the remaining VRGDG sequence was retained on the surface of the micelles, which can act as a ligand to facilitate cell uptake. Moreover, the cytotoxicity of TPGS3350-GPLGVRGDG-DOX&amp;DOX micelles against 4T1 cells was significantly improved, compared with TPGS3350-GPLGVRG-DOX&amp;DOX micelles and TPGS3350-DOX&amp;DOX micelles. During in vivo studies, TPGS3350-GPLGVRGDG-DOX&amp;DOX micelles exhibited good anticancer efficacy with long circulation in the body and more efficient accumulation at the tumor site. Therefore, TPGS3350-GPLGVRGDG-DOX&amp;DOX micelles have improved antitumor activity and reduced toxic side effects. This work opens new potential for exploring the strategy of drug delivery in clinical applications.<\/jats:p>","DOI":"10.3390\/ijms23179698","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T01:39:19Z","timestamp":1661737159000},"page":"9698","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Intelligent Drug Delivery by Peptide-Based Dual-Function Micelles"],"prefix":"10.3390","volume":"23","author":[{"given":"Dong","family":"Wan","sequence":"first","affiliation":[{"name":"School of Chemical Engineering and Technology, Tiangong University, Tianjin 300387, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujun","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology, Tiangong University, Tianjin 300387, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhao","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology, Tiangong University, Tianjin 300387, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry, Tiangong University, Tianjin 300387, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-6932","authenticated-orcid":false,"given":"Jie","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology, Tiangong University, Tianjin 300387, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"key":"ref_1","first-page":"359","article-title":"Cancer statistics","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J. 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