{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:40:24Z","timestamp":1791222024900,"version":"4.1.0"},"reference-count":256,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The peroxisome proliferator-activated receptor PPAR-\u03b3 is one of three PPAR nuclear receptors that act as ligand-activated transcription factors. In immune cells, the skin, and other organs, PPAR-\u03b3 regulates lipid, glucose, and amino acid metabolism. The receptor translates nutritional, pharmacological, and metabolic stimuli into the changes in gene expression. The activation of PPAR-\u03b3 promotes cell differentiation, reduces the proliferation rate, and modulates the immune response. In the skin, PPARs also contribute to the functioning of the skin barrier. Since we know that the route from identification to the registration of drugs is long and expensive, PPAR-\u03b3 agonists already approved for other diseases may also represent a high interest for psoriasis. In this review, we discuss the role of PPAR-\u03b3 in the activation, differentiation, and proliferation of skin and immune cells affected by psoriasis and in contributing to the pathogenesis of the disease. We also evaluate whether the agonists of PPAR-\u03b3 may become one of the therapeutic options to suppress the inflammatory response in lesional psoriatic skin and decrease the influence of comorbidities associated with psoriasis.<\/jats:p>","DOI":"10.3390\/ijms23179708","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T01:39:19Z","timestamp":1661737159000},"page":"9708","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["The Role of Transcription Factor PPAR-\u03b3 in the Pathogenesis of Psoriasis, Skin Cells, and Immune Cells"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4779-156X","authenticated-orcid":false,"given":"Vladimir V.","family":"Sobolev","sequence":"first","affiliation":[{"name":"Center for Theoretical Problems in Physico-Chemical Pharmacology, Russian Academy of Sciences, Moscow 109029, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Tchepourina","sequence":"additional","affiliation":[{"name":"Center for Theoretical Problems in Physico-Chemical Pharmacology, Russian Academy of Sciences, Moscow 109029, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina M.","family":"Korsunskaya","sequence":"additional","affiliation":[{"name":"Center for Theoretical Problems in Physico-Chemical Pharmacology, Russian Academy of Sciences, Moscow 109029, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia A.","family":"Geppe","sequence":"additional","affiliation":[{"name":"NF Filatov Clinical Institute of Children\u2019s Health at I.M. Sechenov First MSMU, Moscow 119435, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana N.","family":"Chebysheva","sequence":"additional","affiliation":[{"name":"NF Filatov Clinical Institute of Children\u2019s Health at I.M. Sechenov First MSMU, Moscow 119435, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-1933","authenticated-orcid":false,"given":"Anna G.","family":"Soboleva","sequence":"additional","affiliation":[{"name":"Center for Theoretical Problems in Physico-Chemical Pharmacology, Russian Academy of Sciences, Moscow 109029, Russia"},{"name":"Scientific Research Institute of Human Morphology, 3 Tsurupa Street, Moscow 117418, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Mezentsev","sequence":"additional","affiliation":[{"name":"Center for Theoretical Problems in Physico-Chemical Pharmacology, Russian Academy of Sciences, Moscow 109029, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Micali, G., Verz\u00ec, A.E., Broggi, G., Caltabiano, R., Musumeci, M.L., and Lacarrubba, F. 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