{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T06:35:54Z","timestamp":1762065354096,"version":"build-2065373602"},"reference-count":163,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:00Z","timestamp":1661558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Interdisciplinary and Translation Research Training in NeuroHIV","award":["T32 MH079785"],"award-info":[{"award-number":["T32 MH079785"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Protein quality control allows eukaryotes to maintain proteostasis under the stress of constantly changing conditions. In this review, we discuss the current literature on PQC, highlighting flaws that must exist for malignancy to occur. At the nidus of PQC, the expression of BAG1-6 reflects the cell environment; each isoform directs proteins toward different, parallel branches of the quality control cascade. The sum of these branches creates a net shift toward either homeostasis or apoptosis. With an established role in ALP, Bag3 is necessary for cell survival in stress conditions including those of the cancerous niche (i.e., hypoxia, hypermutation). Evidence suggests that excessive Bag3\u2013HSP70 activity not only sustains, but also propagates cancers. Its role is anti-apoptotic\u2014which allows malignant cells to persist\u2014and intercellular\u2014with the production of infectious \u2018oncosomes\u2019 enabling cancer expansion and recurrence. While Bag3 has been identified as a key prognostic indicator in several cancer types, its investigation is limited regarding glioblastoma. The cochaperone HSP70 has been strongly linked with GBM, while ALP inhibitors have been shown to improve GBM susceptibility to chemotherapeutics. Given the highly resilient, frequently recurrent nature of GBM, the targeting of Bag3 is a necessary consideration for the successful and definitive treatment of GBM.<\/jats:p>","DOI":"10.3390\/ijms23179734","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T01:39:19Z","timestamp":1661737159000},"page":"9734","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protein Quality Control in Glioblastoma: A Review of the Current Literature with New Perspectives on Therapeutic Targets"],"prefix":"10.3390","volume":"23","author":[{"given":"Angela","family":"Rocchi","sequence":"first","affiliation":[{"name":"Center for Neurovirology and Gene Editing, Department of Microbiology, Immunology, and Inflammation, Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassen S.","family":"Wollebo","sequence":"additional","affiliation":[{"name":"Center for Neurovirology and Gene Editing, Department of Microbiology, Immunology, and Inflammation, Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamel","family":"Khalili","sequence":"additional","affiliation":[{"name":"Center for Neurovirology and Gene Editing, Department of Microbiology, Immunology, and Inflammation, Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.cell.2019.06.024","article-title":"An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma","volume":"178","author":"Neftel","year":"2019","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"The Cancer Genome Atlas Research Network (2008). Comprehensive genomic characterization defines human glioblastoma genes and core pathways. 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