{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:15:27Z","timestamp":1788412527685,"version":"build-2803163510"},"reference-count":46,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Republic of Turkey Ministry of National Education (Ph.D. studentship)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Body mass index (BMI) has been suggested to play an important role in the relationship between the APOLIPOPROTEIN (APO)E genotype and cardiovascular disease (CVD) risk. Using data from the BODYCON cross-sectional study (n = 360 adults) we assessed the association between body composition and CVD risk markers according to APOE genotype, with examination of the role of BMI. In this study cohort, the APOE2\/E3 group had lower fasting blood lipids than APOE4 carriers and APOE3\/E3 group (p \u2264 0.01). After stratifying the group according to BMI, APOE4 carriers in the normal BMI subgroup had a higher lean mass compared with the APOE3\/E3 group (p = 0.02) whereas in the overweight\/obese subgroup, the android to gynoid percentage fat ratio was lower in APOE4 carriers than APOE3\/E3 group (p = 0.04). Fasting lipid concentrations were only different between the APOE2\/E3 and other genotype groups within the normal weight BMI subgroup (p \u2264 0.04). This finding was associated with a lower dietary fibre and a higher trans-fat intake compared with APOE4 carriers, and a lower carbohydrate intake relative to the APOE3\/E3 group. Our results confirm previous reports that BMI modulates the effect of APOE on CVD risk markers and suggest novel interactions on body composition, with diet a potential modulator of this relationship.<\/jats:p>","DOI":"10.3390\/ijms23179766","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T03:34:56Z","timestamp":1661744096000},"page":"9766","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association between APOE Genotype with Body Composition and Cardiovascular Disease Risk Markers Is Modulated by BMI in Healthy Adults: Findings from the BODYCON Study"],"prefix":"10.3390","volume":"23","author":[{"given":"Ezgi","family":"Ozen","sequence":"first","affiliation":[{"name":"Hugh Sinclair Unit of Nutrition, Department of Food and Nutritional Sciences, and Institute for Cardiovascular and Metabolic Research and Institute for Food, Nutrition and Health, University of Reading, Whiteknights, Reading RG6 6DZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rada G.","family":"Mihaylova","sequence":"additional","affiliation":[{"name":"Hugh Sinclair Unit of Nutrition, Department of Food and Nutritional Sciences, and Institute for Cardiovascular and Metabolic Research and Institute for Food, Nutrition and Health, University of Reading, Whiteknights, Reading RG6 6DZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J.","family":"Lord","sequence":"additional","affiliation":[{"name":"Hugh Sinclair Unit of Nutrition, Department of Food and Nutritional Sciences, and Institute for Cardiovascular and Metabolic Research and Institute for Food, Nutrition and Health, University of Reading, Whiteknights, Reading RG6 6DZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7633-9455","authenticated-orcid":false,"given":"Julie A.","family":"Lovegrove","sequence":"additional","affiliation":[{"name":"Hugh Sinclair Unit of Nutrition, Department of Food and Nutritional Sciences, and Institute for Cardiovascular and Metabolic Research and Institute for Food, Nutrition and Health, University of Reading, Whiteknights, Reading RG6 6DZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0070-3203","authenticated-orcid":false,"given":"Kim G.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Hugh Sinclair Unit of Nutrition, Department of Food and Nutritional Sciences, and Institute for Cardiovascular and Metabolic Research and Institute for Food, Nutrition and Health, University of Reading, Whiteknights, Reading RG6 6DZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology","volume":"240","author":"Mahley","year":"1988","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/sj.ejhg.5200864","article-title":"The importance of plasma apolipoprotein E concentration in addition to its common polymorphism on inter-individual variation in lipid levels: Results from Apo Europe","volume":"10","author":"Haddy","year":"2002","journal-title":"Eur. 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