{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:23:06Z","timestamp":1785464586963,"version":"3.56.0"},"reference-count":41,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of The Ministry of Science, ICT &amp; Future Planning","award":["2021R1A2C1011916"],"award-info":[{"award-number":["2021R1A2C1011916"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The dynamics of uterine endometrium is important for successful establishment and maintenance of embryonic implantation and development, along with extensive cell differentiation and proliferation. The tissue event is precisely and complicatedly regulated as several signaling pathways are involved including two main hormones, estrogen and progesterone signaling. We previously showed a novel signaling molecule, Serine\/threonine protein kinase 3\/4 (STK3\/4), which is responded to hormone in the mouse uterine epithelium. However, the role and regulation of its target, YES-associated protein (YAP) remains unknown. In this study, we investigated the expression and regulation of YAP in mouse endometrium. We found that YAP was periodically expressed in the endometrium during the estrous cycle. Furthermore, periodic expression of YAP was shown to be related to the pathway under hormone treatment. Interestingly, estrogen was shown to positively modulate YAP via endometrial epithelial receptors. In addition, the knockdown of YAP showed that YAP regulated various target genes in endometrial cells. The knockdown of YAP down-regulated numerous targets including ADAMTS1, AMOT, AMOTL1, ANKRD1, CTNNA1, MCL1. On the other hand, the expressions of AREG and AXL were increased by its knockdown. These findings imply that YAP responds via Hippo signaling under various intrauterine signals and is considered to play a role in the expression of factors important for uterine endometrium dynamic regulation.<\/jats:p>","DOI":"10.3390\/ijms23179772","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T21:01:31Z","timestamp":1661806891000},"page":"9772","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Estrogen Regulates the Expression and Localization of YAP in the Uterus of Mice"],"prefix":"10.3390","volume":"23","author":[{"given":"Sohyeon","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ok-Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dental Regenerative Biotechnology, Seoul National University, Seoul 03080, Korea"},{"name":"Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4037-9222","authenticated-orcid":false,"given":"Byeongseok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinju","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dental Regenerative Biotechnology, Seoul National University, Seoul 03080, Korea"},{"name":"Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7120-464X","authenticated-orcid":false,"given":"Semi","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5869-9702","authenticated-orcid":false,"given":"Siyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-3754","authenticated-orcid":false,"given":"Giwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyukjung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9258-8304","authenticated-orcid":false,"given":"Hyuk","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"},{"name":"Institute of Advanced Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwonho","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"},{"name":"Institute of Advanced Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaejin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Dental Regenerative Biotechnology, Seoul National University, Seoul 03080, Korea"},{"name":"Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3862-4105","authenticated-orcid":false,"given":"Youngsok","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"},{"name":"Institute of Advanced Regenerative Biotechnology, Konkuk University, Seoul 05029, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5483\/BMBRep.2018.51.5.045","article-title":"Role of estrogen and RAS signaling in repeated implantation failure","volume":"51","author":"Hong","year":"2018","journal-title":"BMB Rep."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Moon, S., Hwang, S., Kim, B., Lee, S., Kim, H., Lee, G., Hong, K., Song, H., and Choi, Y. 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