{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:22:06Z","timestamp":1792844526471,"version":"4.5.0"},"reference-count":172,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Rigshospitalet Research Fund","award":["R278-2018-804"],"award-info":[{"award-number":["R278-2018-804"]}]},{"name":"Lundbeck Foundation","award":["R278-2018-804"],"award-info":[{"award-number":["R278-2018-804"]}]},{"name":"Hjerteforeningen","award":["R278-2018-804"],"award-info":[{"award-number":["R278-2018-804"]}]},{"name":"Leducq","award":["R278-2018-804"],"award-info":[{"award-number":["R278-2018-804"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease is the most common form of dementia, and the prodromal phases of Alzheimer\u2019s disease can last for decades. Vascular dementia is the second most common form of dementia and is distinguished from Alzheimer\u2019s disease by evidence of previous stroke or hemorrhage and current cerebrovascular disease. A compiled group of vascular-related dementias (vascular dementia and unspecified dementia) is often referred to as non-Alzheimer dementia. Recent evidence indicates that preventing dementia by lifestyle interventions early in life with a focus on reducing cardiovascular risk factors is a promising strategy for reducing future risk. Approximately 40% of dementia cases is estimated to be preventable by targeting modifiable, primarily cardiovascular risk factors. The aim of this review is to describe the association between risk factors for atherosclerotic cardiovascular disease and the risk of Alzheimer\u2019s disease and non-Alzheimer dementia by providing an overview of the current evidence and to shed light on possible shared pathogenic pathways between dementia and cardiovascular disease. The included risk factors are body mass index (BMI); plasma triglyceride-, high-density lipoprotein (HDL) cholesterol-, low-density lipoprotein (LDL) cholesterol-, and total cholesterol concentrations; hypertension; diabetes; non-alcoholic fatty liver disease (NAFLD); physical inactivity; smoking; diet; the gut microbiome; and genetics. Furthermore, we aim to disentangle the difference between associations of risk factors in midlife as compared with in late life.<\/jats:p>","DOI":"10.3390\/ijms23179777","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T21:01:31Z","timestamp":1661806891000},"page":"9777","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Shared Risk Factors between Dementia and Atherosclerotic Cardiovascular Disease"],"prefix":"10.3390","volume":"23","author":[{"given":"Liv Tybj\u00e6rg","family":"Nordestgaard","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital\u2014Rigshospitalet, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6614-0899","authenticated-orcid":false,"given":"Mette","family":"Christoffersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital\u2014Rigshospitalet, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4084-5027","authenticated-orcid":false,"given":"Ruth","family":"Frikke-Schmidt","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital\u2014Rigshospitalet, 2100 Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The Diagnosis of Dementia Due to Alzheimer\u2019s Disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association Workgroups on Diagnostic Guidelines for Alzheimer\u2019s Disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia Prevention, Intervention, and Care: 2020 Report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"ref_3","unstructured":"World Health Organization (1993). ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research, World Health Organization."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"(2021). 2021 Alzheimer\u2019s Disease Facts and Figures. Alzheimer\u2019s Dement., 17, 327\u2013406.","DOI":"10.1002\/alz.12328"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jalz.2016.01.012","article-title":"Molecular Genetics of Early-Onset Alzheimer\u2019s Disease Revisited","volume":"12","author":"Cacace","year":"2016","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer \u2019 s Disease: The Amyloid Cascade Hypothesis Published by: American Association for the Advancement of Science Alzheimer \u2019 s Disease: The Amyloid Cascade Hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1056\/NEJMoa1304839","article-title":"Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer\u2019s Disease","volume":"370","author":"Salloway","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1056\/NEJMoa1705971","article-title":"Trial of Solanezumab for Mild Dementia Due to Alzheimer\u2019s Disease","volume":"378","author":"Honig","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1056\/NEJMc1402193","article-title":"Phase 3 Trials of Solanezumab and Bapineuzumab for Alzheimer\u2019s Disease","volume":"370","author":"Laske","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0140-6736(08)61075-2","article-title":"Long-Term Effects of A\u03b242 Immunisation in Alzheimer\u2019s Disease: Follow-up of a Randomised, Placebo-Controlled Phase I Trial","volume":"372","author":"Holmes","year":"2008","journal-title":"Lancet"},{"key":"ref_11","first-page":"1","article-title":"A Phase III Randomized Trial of Gantenerumab in Prodromal Alzheimer\u2019s Disease","volume":"9","author":"Ostrowitzki","year":"2017","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1212\/01.wnl.0000341273.18141.64","article-title":"Factors Associated with Resistance to Dementia despite High Alzheimer Disease Pathology","volume":"72","author":"Woltjer","year":"2009","journal-title":"Neurology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1212\/01.wnl.0000219668.47116.e6","article-title":"Neuropathology of Older Persons without Cognitive Impairment from Two Community-Based Studies","volume":"66","author":"Bennett","year":"2006","journal-title":"Neurology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1001\/archneur.58.11.1803","article-title":"Clinical and Pathological Diagnosis of Frontotemporal Dementia","volume":"58","author":"McKhann","year":"2001","journal-title":"Arch. Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and Management of Dementia with Lewy Bodies: Third Report of the DLB Consortium","volume":"65","author":"McKeith","year":"2005","journal-title":"Neurology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/MOL.0000000000000723","article-title":"Impact of Metabolic Dysfunction on Cognition in Humans","volume":"32","author":"Rasmussen","year":"2021","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/clinchem\/hvaa269","article-title":"Triglycerides as a Shared Risk Factor between Dementia and Atherosclerotic Cardiovascular Disease: A Study of 125 727 Individuals","volume":"67","author":"Nordestgaard","year":"2021","journal-title":"Clin. Chem."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Rasmussen, I.J., Rasmussen, K.L., Nordestgaard, B.G., Tybj\u00e6rg-Hansen, A., and Frikke-Schmidt, R. Impact of Cardiovascular Risk Factors and Genetics on 10-Year Absolute Risk of Dementia\u2014Risk Charts for Targeted Prevention. Eur. Heart J., 2020. in press.","DOI":"10.1016\/j.atherosclerosis.2020.10.079"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Iturria-Medina, Y., Sotero, R.C., Toussaint, P.J., Mateos-P\u00e9rez, J.M., Evans, A.C., Weiner, M.W., Aisen, P., Petersen, R., Jack, C.R., and Jagust, W. (2016). Early Role of Vascular Dysregulation on Late-Onset Alzheimer\u2019s Disease Based on Multifactorial Data-Driven Analysis. Nat. Commun., 7.","DOI":"10.1038\/ncomms11934"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neuroimage.2017.02.058","article-title":"Multifactorial Causal Model of Brain (Dis)Organization and Therapeutic Intervention: Application to Alzheimer\u2019s Disease","volume":"152","author":"Carbonell","year":"2017","journal-title":"Neuroimage"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/ca.980080612","article-title":"An English Translation of Alzheimer\u2019s 1907 Paper, \u201c\u00dcber Eine Eigenartige Erkankung Der Hirnrinde","volume":"8","author":"Stelzmann","year":"1995","journal-title":"\u201d Clin. Anat."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.43.10.2160","article-title":"Vascular Dementia: Diagnostic Criteria for Research Studies: Report of the NINDS-AIREN International Workshop Vascular Dementia: Diagnostic Criteria for Research Studies: Report of the NINDS-AIREN International Workshop 1993","volume":"43","author":"Roman","year":"1993","journal-title":"Neurology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/jnc.13932","article-title":"Hypoxia\/Ischemia Activate Processing of Amyloid Precursor Protein: Impact of Vascular Dysfunction in the Pathogenesis of Alzheimer\u2019s Disease","volume":"140","author":"Salminen","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1750-3639.1991.tb00661.x","article-title":"Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections","volume":"1","author":"Braak","year":"1991","journal-title":"Brain Pathol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/obr.12989","article-title":"Association of Anthropometry and Weight Change with Risk of Dementia and Its Major Subtypes: A Meta-Analysis Consisting 2.8 Million Adults with 57 294 Cases of Dementia","volume":"21","author":"Lee","year":"2020","journal-title":"Obes. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"\u00d8stergaard, S.D., Mukherjee, S., Sharp, S.J., Proitsi, P., Lotta, L.A., Day, F., Perry, J.R.B., Boehme, K.L., Walter, S., and Kauwe, J.S. (2015). Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study. PLoS Med., 12.","DOI":"10.1371\/journal.pmed.1001841"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1210\/jc.2017-00195","article-title":"Body Mass Index and Risk of Alzheimer\u2019s Disease: A Mendelian Randomization Study of 399,536 Individuals","volume":"102","author":"Nordestgaard","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/jnnp.73.4.371","article-title":"Changes in Appetite, Food Preference, and Eating Habits in Frontotemporal Dementia and Alzheimer\u2019s Disease","volume":"73","author":"Ikeda","year":"2002","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1192\/bjp.154.6.801","article-title":"Eating Habits in Dementia. A Descriptive Study","volume":"154","author":"Morris","year":"1989","journal-title":"Br. J. Psychiatry"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11357-015-9821-x","article-title":"Mechanisms of the Anorexia of Aging\u2014A Review","volume":"37","author":"Kostka","year":"2015","journal-title":"Age"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1161\/CIRCRESAHA.116.304846","article-title":"Remnant Cholesterol, Low-Density Lipoprotein Cholesterol, and Blood Pressure as Mediators from Obesity to Ischemic Heart Disease","volume":"116","author":"Varbo","year":"2015","journal-title":"Circ. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1001\/archneurol.2008.582","article-title":"Midlife and Late-Life Obesity and the Risk of Dementia: Cardiovascular Health Study","volume":"66","author":"Fitzpatrick","year":"2009","journal-title":"Arch Neurol"},{"key":"ref_33","first-page":"1","article-title":"BMI and Risk of Dementia in Two Million People over Two Decades: A Retrospective Cohort Study","volume":"8587","author":"Qizilbash","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jalz.2017.06.2637","article-title":"Obesity Trajectories and Risk of Dementia: 28 Years of Follow-up in the Whitehall II Study","volume":"14","author":"Dugravot","year":"2018","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.jalz.2015.05.015","article-title":"Genetically Predicted Body Mass Index and Alzheimer\u2019s Disease\u2013Related Phenotypes in Three Large Samples: Mendelian Randomization Analyses","volume":"11","author":"Mukherjee","year":"2015","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/HYPERTENSIONAHA.109.130005","article-title":"Does Greater Adiposity Increase Blood Pressure and Hypertension Risk?: Mendelian Randomization Using the FTO\/MC4R Genotype","volume":"54","author":"Timpson","year":"2009","journal-title":"Hypertension"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S0140-6736(14)61177-6","article-title":"Triglycerides and Cardiovascular Disease","volume":"384","author":"Nordestgaard","year":"2014","journal-title":"Lancet"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3233\/JAD-160826","article-title":"Updating the Evidence on the Association between Serum Cholesterol and Risk of Late-Life Dementia: Review and Meta-Analysis","volume":"56","author":"Anstey","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2337\/dc08-0272","article-title":"Metabolic Syndrome and Risk for Incident Alzheimer\u2019s Disease or Vascular Dementia","volume":"32","author":"Raffaitin","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_40","first-page":"135","article-title":"Relation of Plasma Lipids to Alzheimer\u2019s Disease and Vascular Dementia","volume":"10","author":"Reitz","year":"2005","journal-title":"Arch. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1515\/tnsci-2020-0098","article-title":"Plasma Cholesterol in Alzheimer\u2019s Disease and Frontotemporal Dementia","volume":"11","author":"Wang","year":"2020","journal-title":"Transl. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1373\/clinchem.2017.279463","article-title":"Remnant Cholesterol and Myocardial Infarction in Normal Weight, Overweight, and Obese Individuals from the Copenhagen General Population Study","volume":"64","author":"Varbo","year":"2018","journal-title":"Clin. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/joim.12713","article-title":"Chylomicronemia Risk Factors Ranked by Importance for the Individual and Community in 108 711 Women and Men","volume":"283","author":"Pedersen","year":"2018","journal-title":"J. Intern. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/ana.22384","article-title":"Nonfasting Triglycerides, Cholesterol, and Ischemic Stroke in the General Population","volume":"69","author":"Varbo","year":"2011","journal-title":"Ann. Neurol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS Guidelines for the Management of Dyslipidaemias: Lipid Modification to Reduce Cardiovascular Risk","volume":"41","author":"Mach","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1056\/NEJMoa1308027","article-title":"Loss-of-Function Mutations in APOC3 and Risk of Ischemic Vascular Disease","volume":"371","author":"Nordestgaard","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1001\/jamainternmed.2016.6875","article-title":"Nonfasting Mild-to-Moderate Hypertriglyceridemia and Risk of Acute Pancreatitis","volume":"176","author":"Pedersen","year":"2016","journal-title":"JAMA Intern. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/S0140-6736(10)60545-4","article-title":"Triglyceride-Mediated Pathways and Coronary Disease: Collaborative Analysis of 101 Studies","volume":"375","author":"Sarwar","year":"2010","journal-title":"Lancet"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1056\/NEJMoa1507652","article-title":"Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease","volume":"374","author":"Stitziel","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1093\/eurheartj\/ehs431","article-title":"Genetically Elevated Non-Fasting Triglycerides and Calculated Remnant Cholesterol as Causal Risk Factors for Myocardial Infarction","volume":"34","author":"West","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1161\/CIRCULATIONAHA.113.003008","article-title":"Elevated Remnant Cholesterol Causes Both Low-Grade Inflammation and Ischemic Heart Disease, Whereas Elevated Low-Density Lipoprotein Cholesterol Causes Ischemic Heart Disease without Inflammation","volume":"128","author":"Varbo","year":"2013","journal-title":"Circulation"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJMoa1612790","article-title":"Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease","volume":"377","author":"Dewey","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/CIRCRESAHA.115.306249","article-title":"Triglyceride-Rich Lipoproteins and Atherosclerotic Cardiovascular Disease: New Insights from Epidemiology, Genetics, and Biology","volume":"118","author":"Nordestgaard","year":"2016","journal-title":"Circ. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1161\/01.ATV.11.3.569","article-title":"Quantitative Studies of Transfer in Vivo of Low Density, Sf 12-60, and Sf 60-400 Lipoproteins between Plasma and Arterial Intima in Humans","volume":"11","author":"Shaikh","year":"1991","journal-title":"Arterioscler. Thromb."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1161\/01.ATV.15.4.534","article-title":"Selective Retention of VLDL, IDL, and LDL in the Arterial Intima of Genetically Hyperlipidemic Rabbits in Vivo: Molecular Size as a Determinant of Fractional Loss from the Intima-Inner Media","volume":"15","author":"Nordestgaard","year":"1995","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1001\/jama.292.18.2237","article-title":"The Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline","volume":"292","author":"Yaffe","year":"2016","journal-title":"JAMA"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1212\/WNL.59.5.788","article-title":"Cholesterol and Neuropathologic Markers of AD: A Population-Based Autopsy Study (Multiple Letters)","volume":"59","author":"Launer","year":"2002","journal-title":"Neurology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1093\/cvr\/cvab164","article-title":"Plasma High-Density Lipoprotein Cholesterol and Risk of Dementia: Observational and Genetic Studies","volume":"118","author":"Kjeldsen","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer\u2019s Disease in Late Onset Families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jalz.2017.05.006","article-title":"Plasma Apolipoprotein E Levels and Risk of Dementia: A Mendelian Randomization Study of 106,562 Individuals","volume":"14","author":"Rasmussen","year":"2018","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.jalz.2015.04.006","article-title":"Loss-of-Function Mutation in ABCA1 and Risk of Alzheimer\u2019s Disease and Cerebrovascular Disease","volume":"11","author":"Nordestgaard","year":"2015","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1093\/eurheartj\/ehz402","article-title":"Plasma Levels of Apolipoprotein E, APOE Genotype, and All-Cause and Cause-Specific Mortality in 105 949 Individuals from a White General Population Cohort","volume":"40","author":"Rasmussen","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1001\/jamacardio.2021.3728","article-title":"Long-Term Benefits and Harms Associated with Genetic Cholesteryl Ester Transfer Protein Deficiency in the General Population","volume":"7","author":"Nordestgaard","year":"2022","journal-title":"JAMA Cardiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.atherosclerosis.2020.03.005","article-title":"HDL Cholesterol and Apolipoprotein A-I Concentrations and Risk of Atherosclerotic Cardiovascular Disease: Human Genetics to Unravel Causality","volume":"299","year":"2020","journal-title":"Atherosclerosis"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Kjeldsen, E.W., Nordestgaard, L.T., and Frikke-Schmidt, R. (2021). Hdl Cholesterol and Non-Cardiovascular Disease: A Narrative Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094547"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000026249","article-title":"Relationships between Cholesterol, Apolipoprotein E Polymorphism and Dementia: A Cross-Sectional Analysis from the PAQUID Study","volume":"19","author":"Bonarek","year":"2000","journal-title":"Neuroepidemiology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1093\/eurheartj\/ehx665","article-title":"U-Shaped Relationship of HDL and Risk of Infectious Disease: Two Prospective Population-Based Cohort Studies","volume":"39","author":"Madsen","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1001\/archneurol.2010.297","article-title":"Association of Higher Levels of High-Density Lipoprotein Cholesterol in Elderly Individuals and Lower Risk of Late-Onset Alzheimer Disease","volume":"67","author":"Reitz","year":"2010","journal-title":"Arch. Neurol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"j1648","DOI":"10.1136\/bmj.j1648","article-title":"Low LDL Cholesterol, PCSK9 and HMGCR Genetic Variation, and Risk of Alzheimer\u2019s Disease and Parkinson\u2019s Disease: Mendelian Randomisation Study","volume":"357","author":"Benn","year":"2017","journal-title":"BMJ"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-24248-8","article-title":"Use of Statins and the Risk of Dementia and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis","volume":"8","author":"Chu","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1093\/eurheartj\/ehx144","article-title":"Low-Density Lipoproteins Cause Atherosclerotic Cardiovascular Disease. 1. Evidence from Genetic, Epidemiologic, and Clinical Studies. A Consensus Statement Fromthe European Atherosclerosis Society Consensus Panel","volume":"38","author":"Ference","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/eurheartj\/ehz962","article-title":"Low-Density Lipoproteins Cause Atherosclerotic Cardiovascular Disease: Pathophysiological, Genetic, and Therapeutic Insights: A Consensus Statement from the European Atherosclerosis Society Consensus Panel","volume":"41","author":"Krauss","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Mcguinness, B., Craig, D., Bullock, R., and Passmore, P. (2016). Statins for the Prevention of Dementia. Cochrane Database Syst. Rev., 2016.","DOI":"10.1002\/14651858.CD003160.pub3"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1001\/jama.2019.7437","article-title":"Associations of Amyloid, Tau, and Neurodegeneration Biomarker Profiles with Rates of Memory Decline among Individuals Without Dementia","volume":"321","author":"Jack","year":"2019","journal-title":"JAMA -J. Am. Med. Assoc."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jacl.2020.12.011","article-title":"Statins, Lipids and Dementia?","volume":"15","author":"Kuller","year":"2021","journal-title":"J. Clin. Lipidol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e11304","DOI":"10.1097\/MD.0000000000011304","article-title":"Statins Use and Risk of Dementia: A Dose\u2013Response Meta Analysis","volume":"97","author":"Zhang","year":"2018","journal-title":"Medicine"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1097\/HJH.0000000000000868","article-title":"Diuretic Antihypertensive Drugs and Incident Dementia Risk: A Systematic Review, Meta-Analysis and Meta-Regression of Prospective Studies","volume":"34","author":"Tully","year":"2016","journal-title":"J. Hypertens."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1474-4422(19)30393-X","article-title":"Antihypertensive Medications and Risk for Incident Dementia and Alzheimer\u2019s Disease: A Meta-Analysis of Individual Participant Data from Prospective Cohort Studies","volume":"19","author":"Ding","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1161\/HYPERTENSIONAHA.114.04257","article-title":"Hypertension and Alzheimer Disease: Another Brick in the Wall of Awareness","volume":"65","author":"Thorin","year":"2015","journal-title":"Hypertension"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1212\/WNL.0000000000005810","article-title":"Blood Pressure from Mid- to Late Life and Risk of Incident Dementia","volume":"91","author":"McGrath","year":"2018","journal-title":"Neurology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1093\/eurheartj\/ehy288","article-title":"Association between Systolic Blood Pressure and Dementia in TheWhitehall II Cohort Study: Role of Age, Duration, and Threshold Used to Define Hypertension","volume":"39","author":"Abell","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1212\/WNL.0000000000007543","article-title":"Blood Pressure and Dementia","volume":"92","author":"Peters","year":"2019","journal-title":"Neurology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.neulet.2018.02.027","article-title":"Calcium Channel Blocker Use Reduces Incident Dementia Risk in Elderly Hypertensive Patients: A Meta-Analysis of Prospective Studies","volume":"671","author":"Hussain","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/jamainternmed.2017.7023","article-title":"Blood Pressure Trajectories in the 20 Years before Death","volume":"178","author":"Delgado","year":"2018","journal-title":"JAMA Intern. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S1474-4422(19)30228-5","article-title":"Associations between Blood Pressure across Adulthood and Late-Life Brain Structure and Pathology in the Neuroscience Substudy of the 1946 British Birth Cohort (Insight 46): An Epidemiological Study","volume":"18","author":"Lane","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1001\/jama.2018.21442","article-title":"Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial","volume":"321","author":"Williamson","year":"2019","journal-title":"JAMA -J. Am. Med. Assoc."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Thomassen, J.Q., Tolstrup, J.S., Benn, M., and Frikke-Schmidt, R. (2020). Type-2 Diabetes and Risk of Dementia: Observational and Mendelian Randomisation Studies in 1 Million Individuals. Epidemiol. Psychiatr. Sci.","DOI":"10.1017\/S2045796020000347"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2337\/dc15-1588","article-title":"Type 2diabetes as a Risk Factor for Dementia in Women Compared with Men: A Pooled Analysis of 2.3 Million People Comprising More than 100,000 Cases of Dementia","volume":"39","author":"Chatterjee","year":"2016","journal-title":"Diabetes Care"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1001\/jamapsychiatry.2015.0082","article-title":"Effect of Depression and Diabetes Mellitus on the Risk for Dementia: A National Population-Based Cohort Study","volume":"72","author":"Katon","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2021.748888","article-title":"Liver Health and Dementia in an Italian Older Population: Findings From the Salus in Apulia Study","volume":"13","author":"Lampignano","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/imj.14709","article-title":"Non-Alcoholic Fatty Liver Disease: A Review of Epidemiology, Risk Factors, Diagnosis and Management","volume":"50","author":"Huang","year":"2020","journal-title":"Intern. Med. J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1007\/s10620-020-06644-1","article-title":"Incident Dementia in Elderly Patients with Nonalcoholic Fatty Liver Disease in Germany","volume":"66","author":"Labenz","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Shang, Y., Lidman, L., and Hagstr\u00f6m, H. (2022). Nonalcoholic Fatty Liver Disease and Risk of Dementia: A Population-Based Cohort Study. Neurology, Ahead of print.","DOI":"10.1212\/WNL.0000000000200853"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"100218","DOI":"10.1016\/j.jhepr.2020.100218","article-title":"Non-Alcoholic Fatty Liver Disease Does Not Increase Dementia Risk Although Histology Data Might Improve Risk Prediction","volume":"3","author":"Shang","year":"2021","journal-title":"JHEP Reports"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12035-020-02096-w","article-title":"Molecular Mechanisms of Metal Toxicity in the Pathogenesis of Alzheimer\u2019s Disease","volume":"58","author":"Kabir","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1007\/s12035-020-02211-x","article-title":"The Interplay of ABC Transporters in A\u03b2 Translocation and Cholesterol Metabolism: Implicating Their Roles in Alzheimer\u2019s Disease","volume":"58","author":"Behl","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"ref_97","first-page":"l1495","article-title":"Physical Inactivity, Cardiometabolic Disease, and Risk of Dementia: An Individual-Participant Meta-Analysis","volume":"365","author":"Pentti","year":"2019","journal-title":"BMJ"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Rasmussen, I.J., Rasmussen, K.L., Thomassen, J.Q., Schnohr, P., Frikke-schmidt, R., General, C., Study, P., Hospital, G., Copenhagen, T., and Heart, C. (2022). Physical Activity in Leisure Time and at Work and Risk of Dementia\u2014A Prospective Cohort Study of 117,616 Individuals. Atherosclerosis, 1\u201325.","DOI":"10.1016\/j.atherosclerosis.2022.08.004"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/S0140-6736(17)31363-6","article-title":"Dementia Prevention, Intervention, and Care","volume":"390","author":"Livingston","year":"2017","journal-title":"Lancet"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2018.00151","article-title":"Leisure-Time Physical Activity Is Associated with Reduced Risk of Dementia-Related Mortality in Adults with and without Psychological Distress: The Cohort of Norway","volume":"10","author":"Zotcheva","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"ref_101","first-page":"1","article-title":"Association of Ideal Cardiovascular Health at Age 50 with Incidence of Dementia: 25 Year Follow-up of Whitehall II Cohort Study","volume":"366","author":"Sabia","year":"2019","journal-title":"BMJ"},{"key":"ref_102","first-page":"e1298","article-title":"Midlife Cardiovascular Fitness and Dementia","volume":"90","author":"Johansson","year":"2018","journal-title":"Neurology"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/bjsports-2016-096587","article-title":"Exercise Interventions for Cognitive Function in Adults Older than 50: A Systematic Review with Meta-Analysis","volume":"52","author":"Northey","year":"2018","journal-title":"Br. J. Sports Med."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ijnurstu.2018.01.002","article-title":"The Effectiveness of Physical Exercise on Cognitive and Psychological Outcomes in Individuals with Mild Cognitive Impairment: A Systematic Review and Meta-Analysis","volume":"79","author":"Song","year":"2018","journal-title":"Int. J. Nurs. Stud."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1093\/gerona\/glx234","article-title":"Exercise Training for Preventing Dementia, Mild Cognitive Impairment, and Clinically Meaningful Cognitive Decline: A Systematic Review and Meta-Analysis","volume":"73","author":"Demougeot","year":"2018","journal-title":"J. Gerontol. -Ser. A Biol. Sci. Med. Sci."},{"key":"ref_106","unstructured":"WHO (2019). Risk Reduction Of Cognitive Decline And Dementia, WHO."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A 2 Year Multidomain Intervention of Diet, Exercise, Cognitive Training, and Vascular Risk Monitoring versus Control to Prevent Cognitive Decline in at-Risk Elderly People (FINGER): A Randomised Controlled Trial","volume":"385","author":"Ngandu","year":"2015","journal-title":"Lancet"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2017.09.006","article-title":"Multidomain Lifestyle Intervention Benefits a Large Elderly Population at Risk for Cognitive Decline and Dementia Regardless of Baseline Characteristics: The FINGER Trial","volume":"14","author":"Rosenberg","year":"2018","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1161\/HYPERTENSIONAHA.116.08994","article-title":"Dose-Response Association between Physical Activity and Incident Hypertension: A Systematic Review and Meta-Analysis of Cohort Studies","volume":"69","author":"Liu","year":"2017","journal-title":"Hypertension"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1007\/s00125-010-1781-1","article-title":"Physical Activity, Obesity and Cardiometabolic Risk Factors in 9- to 10-Year-Old UK Children of White European, South Asian and Black African-Caribbean Origin: The Child Heart and Health Study in England (CHASE)","volume":"53","author":"Owen","year":"2010","journal-title":"Diabetologia"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S1474-4422(14)70136-X","article-title":"Potential for Primary Prevention of Alzheimer\u2019s Disease: An Analysis of Population-Based Data","volume":"13","author":"Norton","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/acn3.633","article-title":"Effect of Smoking Cessation on the Risk of Dementia: A Longitudinal Study","volume":"5","author":"Choi","year":"2018","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.atherosclerosis.2022.03.022","article-title":"Self-Reported and Genetically Predicted Coffee Consumption and Smoking in Dementia: A Mendelian Randomization Study","volume":"348","author":"Nordestgaard","year":"2022","journal-title":"Atherosclerosis"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/aje\/kwx377","article-title":"Secondhand Smoke and Women\u2019s Cognitive Function in China","volume":"187","author":"Pan","year":"2018","journal-title":"Am. J. Epidemiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/WAD.0b013e3182420b6e","article-title":"Smoking, Death, and Alzheimer\u2019s Disease: A Case of Competing Risks","volume":"26","author":"Chang","year":"2012","journal-title":"Alzheimer Dis Assoc Disord."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Coca, A. (2016). Hypertension and Brain Damage, Springer.","DOI":"10.1007\/978-3-319-32074-8"},{"key":"ref_117","unstructured":"Ahrens, J., Anthony, M., Asahara, T., Aviram, M., Bellosta, S., Bernini, F., and Bode, C. (2005). Atherosclerosis: Diet and Drugs, Springer."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Kjeldsen, E.W., Thomassen, J.Q., Rasmussen, K.L., Tybj\u00e6rg-Hansen, A., Nordestgaard, B.G., and Frikke-Schmidt, R. (2022). Adherence to Dietary Guidelines and Risk of Dementia: A Prospective Cohort Study of 94,184 Individuals. Epidemiol. Psychiatr. Sci., submitted.","DOI":"10.1017\/S2045796022000567"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/advances\/nmz054","article-title":"The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer\u2019s Disease-A Review","volume":"10","author":"Berendsen","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1001\/jama.2009.1146","article-title":"Adherence to a Mediterranean Diet, Cognitive Decline, and Risk of Dementia","volume":"302","author":"Samieri","year":"2009","journal-title":"JAMA -J. Am. Med. Assoc."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jalz.2015.04.011","article-title":"MIND Diet Slows Cognitive Decline with Ageing","volume":"11","author":"Morris","year":"2015","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_122","first-page":"921","article-title":"No Association between Dietary Patterns and Risk for Cognitive Decline in Older Women with Nine-Year Follow-up: Data from the Women\u2019s Health Initiative Memory Study","volume":"116","author":"Harring","year":"2016","journal-title":"Physiol. Behav."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.atherosclerosis.2015.08.039","article-title":"A Mediterranean Diet and Risk of Myocardial Infarction, Heart Failure and Stroke: A Population-Based Cohort Study","volume":"243","author":"Tektonidis","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1056\/NEJMoa1800389","article-title":"Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts","volume":"378","author":"Estruch","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1474-4422(19)30356-4","article-title":"The Gut Microbiome in Neurological Disorders","volume":"19","author":"Cryan","year":"2020","journal-title":"Lancet Neurol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neurobiolaging.2016.08.019","article-title":"Association of Brain Amyloidosis with Pro-Inflammatory Gut Bacterial Taxa and Peripheral Inflammation Markers in Cognitively Impaired Elderly","volume":"49","author":"Cattaneo","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1009.e11","DOI":"10.1016\/j.neurobiolaging.2011.10.021","article-title":"Impact of Chronic Helicobacter Pylori Infection on Alzheimer\u2019s Disease: Preliminary Results","volume":"33","author":"Quadrio","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1007\/s12035-018-1188-4","article-title":"The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer\u2019s Disease\u2014A Critical Review","volume":"56","author":"Sochocka","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/db07-1403","article-title":"Changes in Gut Microbiota Control Metabolic Diet\u2013Induced Obesity and Diabetes in Mice","volume":"57","author":"Cani","year":"2008","journal-title":"Diabetes"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Aron, R.A.C., Abid, A., Vesa, C.M., Nechifor, A.C., Behl, T., Ghitea, T.C., Munteanu, M.A., Fratila, O., Andronie-Cioara, F.L., and Toma, M.M. (2021). Recognizing the Benefits of Pre-\/Probiotics in Metabolic Syndrome and Type 2 Diabetes Mellitus Considering the Influence of Akkermansia Muciniphila as a Key Gut Bacterium. Microorganisms, 9.","DOI":"10.3390\/microorganisms9030618"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nature11319","article-title":"Gut Microbiota Composition Correlates with Diet and Health in the Elderly","volume":"488","author":"Claesson","year":"2012","journal-title":"Nature"},{"key":"ref_132","unstructured":"Prince, M., and Jackson, J. (2009). World Alzheimer Report 2009, Alzheimer\u2019s Disease International."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ng0594-74","article-title":"Apolipoprotein E4 Allele in a Population\u2013Based Study of Early\u2013Onset Alzheimer\u2019s Disease","volume":"7","author":"Cruts","year":"1994","journal-title":"Nat. Genet."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/03014469800005512","article-title":"Anthropology of the Apolipoprotein e (Apo E) Gene: Low Frequency of Apo E4 Allele in Basques and in Tribal (Baiga) Populations of India","volume":"25","author":"Mastana","year":"1998","journal-title":"Ann. Hum. Biol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/mp.2015.131","article-title":"Whole-Genome Sequencing Suggests a Chemokine Gene Cluster That Modifies Age at Onset in Familial Alzheimer\u2019s Disease","volume":"20","author":"Lalli","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1474-4422(09)70127-9","article-title":"Cadasil","volume":"8","author":"Chabriat","year":"2009","journal-title":"Lancet Neurol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1008.e17","DOI":"10.1016\/j.neurobiolaging.2011.10.009","article-title":"Exome Sequencing Reveals an Unexpected Genetic Cause of Disease: NOTCH3 Mutation in a Turkish Family with Alzheimer\u2019s Disease","volume":"33","author":"Guerreiro","year":"2012","journal-title":"Neurobiol Aging."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/mp.2012.15","article-title":"High Frequency of Potentially Pathogenic SORL1 Mutations in Autosomal Dominant Early-Onset Alzheimer Disease","volume":"17","author":"Pottier","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pneurobio.2015.05.002","article-title":"The Epigenetics of Aging and Neurodegeneration","volume":"131","author":"Lardenoije","year":"2015","journal-title":"Prog Neurobiol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1001\/jama.2010.574","article-title":"Genome-Wide Analysis of Genetic Loci Associated With Alzheimer Disease","volume":"303","author":"Seshadri","year":"2010","journal-title":"J. Am. Med. Assoc."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer\u2019s Disease. Supplementary Information","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41588-019-0358-2","article-title":"Genetic Meta-Analysis of Diagnosed Alzheimer\u2019s Disease Identifies New Risk Loci and Implicates A\u03b2, Tau, Immunity and Lipid Processing","volume":"51","author":"Kunkle","year":"2019","journal-title":"Nat. Genet."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New Insights into the Genetic Etiology of Alzheimer\u2019s Disease and Related Dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat. Genet."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Karch, C.M., Jeng, A.T., Nowotny, P., Cady, J., Cruchaga, C., and Goate, A.M. (2012). Expression of Novel Alzheimer\u2019s Disease Risk Genes in Control and Alzheimer\u2019s Disease Brains. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0050976"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1474-4422(12)70259-4","article-title":"Genetic Insights in Alzheimer\u2019s Disease","volume":"12","author":"Bettens","year":"2013","journal-title":"Lancet Neurol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"137","DOI":"10.7326\/0003-4819-141-2-200407200-00013","article-title":"Meta-Analysis: Apolipoprotein E Genotypes and Risk for Coronary Heart Disease","volume":"141","author":"Song","year":"2004","journal-title":"Ann. Intern. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common Variants in ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP Are Associated with Alzheimer\u2019s Disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat. Genet."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 Associated with the Risk of Alzheimer\u2019s Disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 Variants in Alzheimer\u2019s Disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-018-1029-3","article-title":"Genetic Variation in Clusterin and Risk of Dementia and Ischemic Vascular Disease in the General Population\u2014Cohort Studies and Meta-Analyses of 362,338 Individuals","volume":"16","author":"Nordestgaard","year":"2018","journal-title":"BMC Med."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10654-019-00498-2","article-title":"Blood\u2013Brain Barrier Transcytosis Genes, Risk of Dementia and Stroke: A Prospective Cohort Study of 74,754 Individuals","volume":"34","author":"Rasmussen","year":"2019","journal-title":"Eur. J. Epidemiol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.bbrc.2005.04.069","article-title":"Insertion\/Deletion Polymorphism in Clusterin Gene Influences Serum Lipid Levels and Carotid Intima-Media Thickness in Hypertensive Japanese Females","volume":"331","author":"Miwa","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/acn3.506","article-title":"ABCA7 and Risk of Dementia and Vascular Disease in the Danish Population","volume":"5","author":"Kjeldsen","year":"2018","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/ng.3246","article-title":"Loss-of-Function Variants in ABCA7 Confer Risk of Alzheimer\u2019s Disease","volume":"47","author":"Steinberg","year":"2015","journal-title":"Nat. Genet."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jns.2017.09.016","article-title":"A Complex Association between ABCA7 Genotypes and Blood Lipid Levels in Southern Chinese Han Patients of Sporadic Alzheimer\u2019s Disease","volume":"382","author":"Li","year":"2017","journal-title":"J. Neurol. Sci."},{"key":"ref_156","first-page":"1264","article-title":"Sequence Variations in in PCSK9, Low LDL, and Protection against Coronary Heart Disease","volume":"23","author":"Cohen","year":"2011","journal-title":"Hear. Dis."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1056\/NEJMoa1604304","article-title":"Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes","volume":"375","author":"Ference","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3233\/JAD-180004","article-title":"The Vascular Hypothesis of Alzheimer\u2019s Disease: A Key to Preclinical Prediction of Dementia Using Neuroimaging","volume":"63","year":"2018","journal-title":"J. Alzheimers. Dis."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S0140-6736(96)90608-X","article-title":"15-Year Longitudinal Study of Blood Pressure and Dementia","volume":"347","author":"Skoog","year":"1996","journal-title":"Lancet"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0140-6736(96)09328-2","article-title":"Atherosclerosis, Apolipoprotein E, and Prevalence of Dementia and Alzheimer\u2019s Disease in the Rotterdam Study","volume":"349","author":"Hofman","year":"1997","journal-title":"Lancet"},{"key":"ref_161","first-page":"125","article-title":"Myocardial Adaptations in Advanced Age","volume":"88","author":"Lakatta","year":"1993","journal-title":"Basic Res. Cardiol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.arr.2010.04.002","article-title":"Vascular Risk Factor Detection and Control May Prevent Alzheimer\u2019s Disease","volume":"9","year":"2010","journal-title":"Ageing Res. Rev."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0197-4580(00)00111-1","article-title":"Critically Attained Threshold of Cerebral Hypoperfusion: The CATCH Hypothesis of Alzheimer\u2019s Pathogenesis","volume":"21","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"De la Torre, J.C. (2016). Alzheimer\u2019s Turning Point A Vascular Approach to Clinical Prevention, Springer.","DOI":"10.1007\/978-3-319-34057-9"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/01.STR.20.5.620","article-title":"Ischemic Threshold of Brain Protein Synthesis after Unilateral Carotid Artery Occlusion in Gerbils","volume":"20","author":"Xie","year":"1989","journal-title":"Stroke"},{"key":"ref_166","unstructured":"Prince, M.J., Wimo, A., Guerchet, M.M., Ali, G.C., Wu, Y.T., and Prina, M. (2015). World Alzheimer Report 2015: The Global Impact of Dementia|Alzheimer\u2019s Disease International, Alzheimer\u2019s Disease International. World Alzheimer\u2019s Report;."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jalz.2018.07.222","article-title":"Vascular Dysfunction\u2014The Disregarded Partner of Alzheimer\u2019 s Disease. Alzheimer\u2019 s and Dementia","volume":"15","author":"Sweeney","year":"2019","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.jalz.2019.01.006","article-title":"Dementia: Paradigm Shifting into High Gear","volume":"15","author":"Hachinski","year":"2019","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0140-6736(99)02355-7","article-title":"Cerebrovascular Disease and Threshold for Dementia in the Early Stages of Alzheimer\u2019s Disease","volume":"354","author":"Esiri","year":"1999","journal-title":"Lancet"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3233\/JAD-190654","article-title":"Alzheimer\u2019s\/Vascular Spectrum Dementia: Classification in Addition to Diagnosis","volume":"73","author":"Emrani","year":"2020","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1159\/000094973","article-title":"Rethinking the Dementia Diagnoses in a Population-Based Study: What Is Alzheimer\u2019s Disease and What Is Vascular Dementia? A Study from the Kungsholmen Project","volume":"22","author":"Kivipelto","year":"2006","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1177\/1533317513494457","article-title":"Vascular Risk Factors: A Ticking Time Bomb to Alzheimer\u2019s Disease","volume":"28","year":"2013","journal-title":"Am. J. Alzheimers. Dis. Other Demen."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/17\/9777\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:19:24Z","timestamp":1760141964000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/17\/9777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":172,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["ijms23179777"],"URL":"https:\/\/doi.org\/10.3390\/ijms23179777","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,29]]}}}