{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T09:01:34Z","timestamp":1769763694869,"version":"3.49.0"},"reference-count":45,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health in Czech Republic\u2014conceptual development of the research organization (IKEM, IN 00023001), RVO VFN64165","award":["NV19-02-00118"],"award-info":[{"award-number":["NV19-02-00118"]}]},{"name":"Ministry of Health in Czech Republic\u2014conceptual development of the research organization (IKEM, IN 00023001), RVO VFN64165","award":["LX22NPO5104"],"award-info":[{"award-number":["LX22NPO5104"]}]},{"name":"National Institute for Research of Metabolic and Cardiovascular Diseases","award":["NV19-02-00118"],"award-info":[{"award-number":["NV19-02-00118"]}]},{"name":"National Institute for Research of Metabolic and Cardiovascular Diseases","award":["LX22NPO5104"],"award-info":[{"award-number":["LX22NPO5104"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>(1) Background: C1q TNF-related protein 3 (CTRP3) is an adipokine with anti-inflammatory and cardioprotective properties. In our study, we explored changes in serum CTRP3 and its gene expression in epicardial (EAT) and subcutaneous (SAT) adipose tissue in patients with and without coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) undergoing elective cardiac surgery. (2) Methods: SAT, EAT, and blood samples were collected at the start and end of surgery from 34 patients: (i) 11 without CAD or T2DM, (ii) 14 with CAD and without T2DM, and (iii) 9 with both CAD and T2DM. mRNA levels of CTRP3 were assessed by quantitative reverse transcription PCR. Circulating levels of CTRP3 and other factors were measured using ELISA and Luminex Multiplex commercial kits. (3) Results: Baseline plasma levels of TNF-\u03b1 and IL6 did not differ among the groups and increased at the end of surgery. Baseline circulating levels of CTRP3 did not differ among the groups and decreased after surgery. In contrast, baseline CTRP3 mRNA levels in EAT were significantly decreased in CAD\/T2DM group, while no differences were found for TNF-\u03b1 and IL6 gene expression. (4) Conclusions: Our data suggest that decreased EAT mRNA levels of CTRP3 could contribute to higher risk of atherosclerosis in patients with CAD and T2DM.<\/jats:p>","DOI":"10.3390\/ijms23179988","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T21:27:17Z","timestamp":1662067637000},"page":"9988","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Decreased Epicardial CTRP3 mRNA Levels in Patients with Type 2 Diabetes Mellitus and Coronary Artery Disease Undergoing Elective Cardiac Surgery: A Possible Association with Coronary Atherosclerosis"],"prefix":"10.3390","volume":"23","author":[{"given":"Zdenek","family":"Matloch","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Anaesthesia and Intensive Care, The James Cook University Hospital, Marton Road, Middlesbrough TS4 3BW, UK"},{"name":"First Faculty of Medicine, Charles University, Katerinska 32, 121 08 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milos","family":"Mraz","sequence":"additional","affiliation":[{"name":"Diabetes Centre, Institute for Clinical and Experimental Medicine, Videnska 1958\/9, 140 21 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4578-1093","authenticated-orcid":false,"given":"Barbora Judita","family":"Kasperova","sequence":"additional","affiliation":[{"name":"Diabetes Centre, Institute for Clinical and Experimental Medicine, Videnska 1958\/9, 140 21 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Kratochvilova","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, U Nemocnice 499\/2, 128 08 Prague, Czech Republic"},{"name":"Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Videnska 1958\/9, 140 21 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7297-4208","authenticated-orcid":false,"given":"Petr","family":"Svoboda","sequence":"additional","affiliation":[{"name":"Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Videnska 1958\/9, 140 21 Prague, Czech Republic"},{"name":"Department of Biochemistry and Microbiology, University of Chemistry and Technology Prague, Technicka 5, 166 28 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6894-1558","authenticated-orcid":false,"given":"Iveta","family":"Pleyerova","sequence":"additional","affiliation":[{"name":"Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Videnska 1958\/9, 140 21 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3710-3866","authenticated-orcid":false,"given":"Katerina","family":"Reznickova","sequence":"additional","affiliation":[{"name":"Diabetes Centre, Institute for Clinical and Experimental Medicine, Videnska 1958\/9, 140 21 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Norman","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, The James Cook University Hospital, Marton Road, Middlesbrough TS4 3BW, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8453-1666","authenticated-orcid":false,"given":"Daniel","family":"Hlavacek","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Institute for Clinical and Experimental Medicine, Videnska 1958\/9, 140 21 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9163-1881","authenticated-orcid":false,"given":"Jakub","family":"Mahrik","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Institute for Clinical and Experimental Medicine, Videnska 1958\/9, 140 21 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Ivak","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Institute for Clinical and Experimental Medicine, Videnska 1958\/9, 140 21 Prague, Czech Republic"},{"name":"Department of Physiology, Third Faculty of Medicine, Charles University, Ruska 87, 100 00 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdenka","family":"Lacinova","sequence":"additional","affiliation":[{"name":"Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, U Nemocnice 499\/2, 128 08 Prague, Czech Republic"},{"name":"Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Videnska 1958\/9, 140 21 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Netuka","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Institute for Clinical and Experimental Medicine, Videnska 1958\/9, 140 21 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Haluzik","sequence":"additional","affiliation":[{"name":"Diabetes Centre, Institute for Clinical and Experimental Medicine, Videnska 1958\/9, 140 21 Prague, Czech Republic"},{"name":"Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, U Nemocnice 499\/2, 128 08 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11906-019-0939-6","article-title":"Epicardial Adipose Tissue and Cardiovascular Disease","volume":"21","author":"Samson","year":"2019","journal-title":"Curr. 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