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We hypothesized that specific microRNAs could target TIM-1, with potential implications for the management of patients suffering from coronavirus disease 2019 (COVID-19). By combining bioinformatic analyses and functional assays, we identified miR-142 as a specific regulator of TIM-1 transcription. Since TIM-1 has been implicated in the regulation of endothelial function at the level of the blood-brain barrier (BBB) and its levels have been shown to be associated with stroke and cerebral ischemia-reperfusion injury, we validated miR-142 as a functional modulator of TIM-1 in human brain microvascular endothelial cells (hBMECs). Taken together, our results indicate that miR-142 targets TIM-1, representing a novel strategy against cerebrovascular disorders, as well as systemic complications of SARS-CoV-2 and other viral infections.<\/jats:p>","DOI":"10.3390\/ijms231810242","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T20:52:51Z","timestamp":1662497571000},"page":"10242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["miR-142 Targets TIM-1 in Human Endothelial Cells: Potential Implications for Stroke, COVID-19, Zika, Ebola, Dengue, and Other Viral Infections"],"prefix":"10.3390","volume":"23","author":[{"given":"Urna","family":"Kansakar","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Gambardella","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahimeh","family":"Varzideh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Avvisato","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislovas S.","family":"Jankauskas","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6267-5845","authenticated-orcid":false,"given":"Pasquale","family":"Mone","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Matarese","sequence":"additional","affiliation":[{"name":"AORN \u201cAntonio Cardarelli\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7231-375X","authenticated-orcid":false,"given":"Gaetano","family":"Santulli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, NY 10461, USA"},{"name":"Department of Molecular Pharmacology, Institute for Neuroimmunology and Inflammation, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Fleischer Institute for Diabetes and Metabolism (FIDAM), Albert Einstein College of Medicine, New York, NY 10461, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-3-319-22380-3_4","article-title":"microRNAs Distinctively Regulate Vascular Smooth Muscle and Endothelial Cells: Functional Implications in Angiogenesis, Atherosclerosis, and In-Stent Restenosis","volume":"887","author":"Santulli","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Stavast, C.J., and Erkeland, S.J. (2019). The Non-Canonical Aspects of MicroRNAs: Many Roads to Gene Regulation. Cells, 8.","DOI":"10.3390\/cells8111465"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"van der Kwast, R., Quax, P.H.A., and Nossent, A.Y. (2019). An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization. Cells, 9.","DOI":"10.3390\/cells9010061"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"eaav9141","DOI":"10.1126\/scitranslmed.aav9141","article-title":"Exosomal microRNA: The revolutionary endogenous Innerspace nanotechnology","volume":"10","author":"Santulli","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Godlewski, J., Lenart, J., and Salinska, E. (2019). MicroRNA in Brain pathology: Neurodegeneration the Other Side of the Brain Cancer. Noncoding RNA, 5.","DOI":"10.3390\/ncrna5010020"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/apha.12416","article-title":"Application of microRNAs in diagnosis and treatment of cardiovascular disease","volume":"213","author":"Wronska","year":"2015","journal-title":"Acta Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Wong, W.K.M., Sorensen, A.E., Joglekar, M.V., Hardikar, A.A., and Dalgaard, L.T. (2018). Non-Coding RNA in Pancreas and beta-Cell Development. Noncoding RNA, 4.","DOI":"10.3390\/ncrna4040041"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Dama, E., Melocchi, V., Mazzarelli, F., Colangelo, T., Cuttano, R., Di Candia, L., Ferretti, G.M., Taurchini, M., Graziano, P., and Bianchi, F. (2020). Non-Coding RNAs as Prognostic Biomarkers: A miRNA Signature Specific for Aggressive Early-Stage Lung Adenocarcinomas. Noncoding RNA, 6.","DOI":"10.3390\/ncrna6040048"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/CIRCRESAHA.111.247452","article-title":"Circulating microRNAs: Novel biomarkers and extracellular communicators in cardiovascular disease?","volume":"110","author":"Creemers","year":"2012","journal-title":"Circ. Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Fay, E.J., and Langlois, R.A. (2018). MicroRNA-Attenuated Virus Vaccines. Noncoding RNA, 4.","DOI":"10.3390\/ncrna4040025"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1093\/cvr\/cvaa195","article-title":"Non-coding RNAs: Update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart","volume":"116","author":"Bar","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Slota, J.A., and Booth, S.A. (2019). MicroRNAs in Neuroinflammation: Implications in Disease Pathogenesis, Biomarker Discovery and Therapeutic Applications. Noncoding RNA, 5.","DOI":"10.3390\/ncrna5020035"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4103\/2229-3485.179431","article-title":"MicroRNA therapeutics: Discovering novel targets and developing specific therapy","volume":"7","author":"Christopher","year":"2016","journal-title":"Perspect Clin. Res."},{"key":"ref_14","unstructured":"Santulli, G. (2016). MicroRNA: From Molecular Biology to Clinical Practice, Springer Nature."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1210\/clinem\/dgaa538","article-title":"MicroRNA-15b Targets VEGF and Inhibits Angiogenesis in Proliferative Diabetic Retinopathy","volume":"105","author":"Yang","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e8046","DOI":"10.15252\/emmm.201708046","article-title":"miR-29 contributes to normal endothelial function and can restore it in cardiometabolic disorders","volume":"10","author":"Widlansky","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1002\/jcp.25276","article-title":"MicroRNAs and Endothelial (Dys) Function","volume":"231","author":"Santulli","year":"2016","journal-title":"J. Cell Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.devcel.2008.07.002","article-title":"The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis","volume":"15","author":"Wang","year":"2008","journal-title":"Dev. Cell"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Rafehi, H., and El-Osta, A. (2016). HDAC Inhibition in Vascular Endothelial Cells Regulates the Expression of ncRNAs. Noncoding RNA, 2.","DOI":"10.3390\/ncrna2020004"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1172\/JCI76069","article-title":"A selective microRNA-based strategy inhibits restenosis while preserving endothelial function","volume":"124","author":"Santulli","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12964-019-0417-4","article-title":"Inhibition of T cell immunoglobulin and mucin-1 (TIM-1) protects against cerebral ischemia-reperfusion injury","volume":"17","author":"Zheng","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41564-020-0740-y","article-title":"Exosome mimicry by a HAVCR1-NPC1 pathway of endosomal fusion mediates hepatitis A virus infection","volume":"5","author":"Costafreda","year":"2020","journal-title":"Nat. Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"561","DOI":"10.5604\/01.3001.0012.0917","article-title":"Relationship of Severity of Hepatitis A with Polymorphisms in Hepatitis A Virus Cellular Receptor 1 (HAVCR1) Gene","volume":"17","author":"Benjamin","year":"2018","journal-title":"Ann. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e0221221","DOI":"10.1128\/spectrum.02212-21","article-title":"TIM-1 Augments Cellular Entry of Ebola Virus Species and Mutants, Which Is Blocked by Recombinant TIM-1 Protein","volume":"10","author":"Zhang","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41598-018-36449-2","article-title":"Biomechanical characterization of TIM protein-mediated Ebola virus-host cell adhesion","volume":"9","author":"Dragovich","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"14682","DOI":"10.1073\/pnas.1508095112","article-title":"Virion-associated phosphatidylethanolamine promotes TIM1-mediated infection by Ebola, dengue, and West Nile viruses","volume":"112","author":"Richard","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e00093-18","DOI":"10.1128\/JVI.00093-18","article-title":"TIM-1 Mediates Dystroglycan-Independent Entry of Lassa Virus","volume":"92","author":"Brouillette","year":"2018","journal-title":"J. Virol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8426","DOI":"10.1073\/pnas.1019030108","article-title":"T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus","volume":"108","author":"Kondratowicz","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/j.celrep.2018.04.013","article-title":"TIM-1 Ubiquitination Mediates Dengue Virus Entry","volume":"23","author":"Dejarnac","year":"2018","journal-title":"Cell Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.chom.2012.08.009","article-title":"The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry","volume":"12","author":"Meertens","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Niu, J., Jiang, Y., Xu, H., Zhao, C., Zhou, G., Chen, P., and Cao, R. (2018). TIM-1 Promotes Japanese Encephalitis Virus Entry and Infection. Viruses, 10.","DOI":"10.3390\/v10110630"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kirui, J., Abidine, Y., Lenman, A., Islam, K., Gwon, Y.D., Lasswitz, L., Evander, M., Bally, M., and Gerold, G. (2021). The Phosphatidylserine Receptor TIM-1 Enhances Authentic Chikungunya Virus Cell Entry. Cells, 10.","DOI":"10.3390\/cells10071828"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.placenta.2020.09.062","article-title":"TAM and TIM receptors mRNA expression in Zika virus infected placentas","volume":"101","author":"Nobrega","year":"2020","journal-title":"Placenta"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41586-020-2457-8","article-title":"Envelope protein ubiquitination drives entry and pathogenesis of Zika virus","volume":"585","author":"Giraldo","year":"2020","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/jmcb\/mjab003","article-title":"Kidney injury molecule-1 is a potential receptor for SARS-CoV-2","volume":"13","author":"Yang","year":"2021","journal-title":"J. Mol. Cell Biol."},{"key":"ref_36","unstructured":"Mori, Y., Fink, C., Ichimura, T., Sako, K., Mori, M., Lee, N.N., Aschauer, P., Padmanabha Das, K.M., Hong, S., and Song, M. (2022). KIM-1\/TIM-1 is a Receptor for SARS-CoV-2 in Lung and Kidney. medRxiv."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/s41564-021-00958-0","article-title":"Cellular host factors for SARS-CoV-2 infection","volume":"6","author":"Baggen","year":"2021","journal-title":"Nat. Microbiol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Havranek, K.E., Jimenez, A.R., Acciani, M.D., Lay Mendoza, M.F., Reyes Ballista, J.M., Diaz, D.A., and Brindley, M.A. (2020). SARS-CoV-2 Spike Alterations Enhance Pseudoparticle Titers and Replication-Competent VSV-SARS-CoV-2 Virus. Viruses, 12.","DOI":"10.3390\/v12121465"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Bohan, D., Van Ert, H., Ruggio, N., Rogers, K.J., Badreddine, M., Aguilar Briseno, J.A., Elliff, J.M., Rojas Chavez, R.A., Gao, B., and Stokowy, T. (2021). Phosphatidylserine receptors enhance SARS-CoV-2 infection. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1009743"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1161\/ATVBAHA.120.314269","article-title":"Association of TIM-1 (T-Cell Immunoglobulin and Mucin Domain 1) With Incidence of Stroke","volume":"40","author":"Song","year":"2020","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1177\/0271678X16630991","article-title":"In Vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use","volume":"36","author":"Helms","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41467-019-13896-7","article-title":"Microengineered human blood-brain barrier platform for understanding nanoparticle transport mechanisms","volume":"11","author":"Ahn","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Huang, L.Y., Stuart, C., Takeda, K., D\u2019Agnillo, F., and Golding, B. (2016). Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0160875"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Puerta-Guardo, H., Glasner, D.R., and Harris, E. (2016). Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005738"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e11892","DOI":"10.7717\/peerj.11892","article-title":"Influenza A virus infects pulmonary microvascular endothelial cells leading to microvascular leakage and release of pro-inflammatory cytokines","volume":"9","author":"Han","year":"2021","journal-title":"PeerJ"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2174\/1570161114666151202210221","article-title":"Vascular Endothelium and Hypovolemic Shock","volume":"14","author":"Gulati","year":"2016","journal-title":"Curr. Vasc. Pharm."},{"key":"ref_47","first-page":"57","article-title":"Systemic vascular leakage associated with dengue infections-the clinical perspective","volume":"338","author":"Trung","year":"2010","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.imlet.2007.08.003","article-title":"Immunopathogenesis of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome: Do CD8+ T cells trigger capillary leakage in viral hemorrhagic fevers?","volume":"113","author":"Terajima","year":"2007","journal-title":"Immunol. Lett."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00441-014-1841-9","article-title":"Vascular events in viral hemorrhagic fevers: A comparative study of dengue and hantaviruses","volume":"355","author":"Srikiatkhachorn","year":"2014","journal-title":"Cell Tissue Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"101695","DOI":"10.1016\/j.jbc.2022.101695","article-title":"The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin alpha5beta1 and NF-kappaB signaling","volume":"298","author":"Robles","year":"2022","journal-title":"J. Biol. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3389\/fimmu.2020.00537","article-title":"Tim-4 in Health and Disease: Friend or Foe?","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.immuni.2007.11.008","article-title":"Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds","volume":"27","author":"Santiago","year":"2007","journal-title":"Immunity"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1161\/HYPERTENSIONAHA.122.19586","article-title":"SGLT2 Inhibition via Empagliflozin Improves Endothelial Function and Reduces Mitochondrial Oxidative Stress: Insights From Frail Hypertensive and Diabetic Patients","volume":"79","author":"Mone","year":"2022","journal-title":"Hypertension"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4103\/bc.bc_29_20","article-title":"Occludin regulation of blood-brain barrier and potential therapeutic target in ischemic stroke","volume":"6","author":"Yuan","year":"2020","journal-title":"Brain Circ."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3389\/fnins.2014.00392","article-title":"\u201cYou Shall Not Pass\u201d-tight junctions of the blood brain barrier","volume":"8","author":"Bauer","year":"2014","journal-title":"Front. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/S0002-9440(10)65511-3","article-title":"Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis","volume":"155","author":"Dallasta","year":"1999","journal-title":"Am. J. Pathol."},{"key":"ref_57","first-page":"733","article-title":"Endothelial cell dysfunction in viral hemorrhage and edema","volume":"5","author":"Mackow","year":"2014","journal-title":"Front. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Chanthick, C., Suttitheptumrong, A., Rawarak, N., and Pattanakitsakul, S.N. (2018). Transcytosis Involvement in Transport System and Endothelial Permeability of Vascular Leakage during Dengue Virus Infection. Viruses, 10.","DOI":"10.3390\/v10020069"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.coviro.2014.06.006","article-title":"Virus interactions with endothelial cell receptors: Implications for viral pathogenesis","volume":"7","author":"Dalrymple","year":"2014","journal-title":"Curr. Opin. Virol."},{"key":"ref_60","first-page":"992","article-title":"Association of Endothelial Glycocalyx and Tight and Adherens Junctions with Severity of Plasma Leakage in Dengue Infection","volume":"215","author":"Suwarto","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nrmicro3066","article-title":"Uncovering the mysteries of hantavirus infections","volume":"11","author":"Vaheri","year":"2013","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3389\/fcimb.2020.00477","article-title":"ERG-Associated lncRNA (ERGAL) Promotes the Stability and Integrity of Vascular Endothelial Barrier during Dengue Viral Infection via Interaction With miR-183-5p","volume":"10","author":"Zheng","year":"2020","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1473-3099(13)70286-X","article-title":"Pathogenesis of influenza-induced acute respiratory distress syndrome","volume":"14","author":"Short","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.1172\/JCI128426","article-title":"Dengue virus-elicited tryptase induces endothelial permeability and shock","volume":"129","author":"Rathore","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bj.2020.08.007","article-title":"Endothelial glycocalyx damage as a systemic inflammatory microvascular endotheliopathy in COVID-19","volume":"43","year":"2020","journal-title":"Biomed. J."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Pan, P., Li, G., Shen, M., Yu, Z., Ge, W., Lao, Z., Fan, Y., Chen, K., Ding, Z., and Wang, W. (2021). DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1008603"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Tramontini Gomes de Sousa Cardozo, F., Baimukanova, G., Lanteri, M.C., Keating, S.M., Moraes Ferreira, F., Heitman, J., Pannuti, C.S., Pati, S., Romano, C.M., and Cerdeira Sabino, E. (2017). Serum from dengue virus-infected patients with and without plasma leakage differentially affects endothelial cells barrier function in vitro. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0178820"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Tundup, S., Kandasamy, M., Perez, J.T., Mena, N., Steel, J., Nagy, T., Albrecht, R.A., and Manicassamy, B. (2017). Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species. PLoS Pathog., 13.","DOI":"10.1371\/journal.ppat.1006270"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1177\/1753425920954281","article-title":"Immune response and blood-brain barrier dysfunction during viral neuroinvasion","volume":"27","author":"Chen","year":"2021","journal-title":"Innate Immun."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"8327","DOI":"10.1128\/JVI.01025-13","article-title":"Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry","volume":"87","author":"Kondratowicz","year":"2013","journal-title":"J. Virol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s13054-021-03731-1","article-title":"Role of endothelial miR-24 in COVID-19 cerebrovascular events","volume":"25","author":"Gambardella","year":"2021","journal-title":"Crit. Care"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Sardu, C., Gambardella, J., Morelli, M.B., Wang, X., Marfella, R., and Santulli, G. (2020). Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence. J. Clin. Med., 9.","DOI":"10.20944\/preprints202004.0204.v1"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"8076","DOI":"10.7150\/thno.61810","article-title":"Endothelial cell infection and dysfunction, immune activation in severe COVID-19","volume":"11","author":"Qin","year":"2021","journal-title":"Theranostics"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1093\/eurheartj\/ehaa623","article-title":"COVID-19 is, in the end, an endothelial disease","volume":"41","author":"Libby","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41569-020-00469-1","article-title":"Thrombocytopathy and endotheliopathy: Crucial contributors to COVID-19 thromboinflammation","volume":"18","author":"Gu","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_76","first-page":"229","article-title":"Complement-mediated thrombogenic vasculopathy in COVID-19","volume":"60","year":"2020","journal-title":"Int J. Derm."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"e12718","DOI":"10.1111\/micc.12718","article-title":"Coronary microvascular dysfunction pathophysiology in COVID-19","volume":"28","author":"Yin","year":"2021","journal-title":"Microcirculation"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41577-020-0343-0","article-title":"COVID-19: The vasculature unleashed","volume":"20","author":"Teuwen","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1111\/jth.15660","article-title":"Non-severe COVID-19 is associated with endothelial damage and hypercoagulability despite pharmacological thromboprophylaxis","volume":"20","author":"Kelliher","year":"2022","journal-title":"J. Thromb. Haemost."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1186\/s13054-021-03803-2","article-title":"Peripheral microcirculatory alterations are associated with the severity of acute respiratory distress syndrome in COVID-19 patients admitted to intermediate respiratory and intensive care units","volume":"25","author":"Mesquida","year":"2021","journal-title":"Crit. Care"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"e151527","DOI":"10.1172\/jci.insight.151527","article-title":"Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19","volume":"6","author":"Schmaier","year":"2021","journal-title":"JCI Insight"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.amjms.2021.12.010","article-title":"Endothelial Dysfunction in COVID-19","volume":"363","author":"Otifi","year":"2022","journal-title":"Am. J. Med. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e276","DOI":"10.1016\/S1473-3099(20)30651-4","article-title":"COVID-19 and multisystem inflammatory syndrome in children and adolescents","volume":"20","author":"Jiang","year":"2020","journal-title":"Lancet Infect Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e2113874119","DOI":"10.1073\/pnas.2113874119","article-title":"Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells","volume":"119","author":"Amraei","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e161167","DOI":"10.1172\/JCI161167","article-title":"Long COVID endotheliopathy: Hypothesized mechanisms and potential therapeutic approaches","volume":"132","author":"Ahamed","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1093\/ehjcvp\/pvaa145","article-title":"What is linking COVID-19 and endothelial dysfunction? Updates on nanomedicine and bioengineering from the 2020 AHA Scientific Sessions","volume":"7","author":"Gambardella","year":"2021","journal-title":"Eur. Heart J. (Cardiovasc. Pharmacother.)"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1021\/acsinfecdis.0c00456","article-title":"Targeting Crucial Host Factors of SARS-CoV-2","volume":"6","author":"Tharappel","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1126\/science.abd2985","article-title":"Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity","volume":"370","author":"Ojha","year":"2020","journal-title":"Science"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3389\/fphys.2020.00989","article-title":"The Enigma of Endothelium in COVID-19","volume":"11","author":"Kaur","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Oxford, A.E., Halla, F., Robertson, E.B., and Morrison, B.E. (2020). Endothelial Cell Contributions to COVID-19. Pathogens, 9.","DOI":"10.3390\/pathogens9100785"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.jacbts.2020.09.010","article-title":"Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG\/CD147) Increases With Age in Endothelial Cells","volume":"5","author":"Vaja","year":"2020","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"598400","DOI":"10.3389\/fcvm.2020.598400","article-title":"Vascular Manifestations of COVID-19-Thromboembolism and Microvascular Dysfunction","volume":"7","author":"Roberts","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41581-020-00357-4","article-title":"Immunity, endothelial injury and complement-induced coagulopathy in COVID-19","volume":"17","author":"Perico","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1161\/ATVBAHA.120.314558","article-title":"Overcoming Barriers: The Endothelium As a Linchpin of Coronavirus Disease 2019 Pathogenesis?","volume":"40","author":"Gustafson","year":"2020","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1001\/jamainternmed.2020.3313","article-title":"Is a \u201cCytokine Storm\u201d Relevant to COVID-19?","volume":"180","author":"Sinha","year":"2020","journal-title":"JAMA Intern. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"22351","DOI":"10.1073\/pnas.2010229117","article-title":"IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome","volume":"117","author":"Kang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e0194","DOI":"10.1097\/CCE.0000000000000194","article-title":"Endothelial Injury and Glycocalyx Degradation in Critically Ill Coronavirus Disease 2019 Patients: Implications for Microvascular Platelet Aggregation","volume":"2","author":"Fraser","year":"2020","journal-title":"Crit. Care Explor."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"100639","DOI":"10.1016\/j.eclinm.2020.100639","article-title":"Thromboembolism risk of COVID-19 is high and associated with a higher risk of mortality: A systematic review and meta-analysis","volume":"29","author":"Malas","year":"2020","journal-title":"eClinicalMedicine"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1001\/jama.2020.23422","article-title":"Diagnosis, Management, and Pathophysiology of Arterial and Venous Thrombosis in COVID-19","volume":"324","author":"Piazza","year":"2020","journal-title":"JAMA"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"105427","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105427","article-title":"COVID-19 and Major Organ Thromboembolism: Manifestations in Neurovascular and Cardiovascular Systems","volume":"30","author":"Pillai","year":"2020","journal-title":"J. Stroke Cereb. Dis."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s40560-020-00483-y","article-title":"Thromboembolic disease in COVID-19 patients: A brief narrative review","volume":"8","author":"Mondal","year":"2020","journal-title":"J. Intensive Care"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1001\/jama.2020.13372","article-title":"Thrombosis in Hospitalized Patients With COVID-19 in a New York City Health System","volume":"324","author":"Bilaloglu","year":"2020","journal-title":"JAMA"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1161\/CIRCULATIONAHA.120.046702","article-title":"Deep Vein Thrombosis in Hospitalized Patients With COVID-19 in Wuhan, China: Prevalence, Risk Factors, and Outcome","volume":"142","author":"Zhang","year":"2020","journal-title":"Circulation"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1053\/j.ajkd.2021.05.013","article-title":"Plasma Kidney Injury Molecule 1 in CKD: Findings From the Boston Kidney Biopsy Cohort and CRIC Studies","volume":"79","author":"Schmidt","year":"2021","journal-title":"Am. J. Kidney Dis."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1111\/j.1471-4159.2008.05678.x","article-title":"Tim-2 is the receptor for H-ferritin on oligodendrocytes","volume":"107","author":"Todorich","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1038\/s41598-020-59898-0","article-title":"H-Ferritin is essential for macrophages\u2019 capacity to store or detoxify exogenously added iron","volume":"10","author":"Mesquita","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1073\/pnas.0913192107","article-title":"Binding and uptake of H-ferritin are mediated by human transferrin receptor-1","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1182\/blood.V98.3.525","article-title":"H ferritin knockout mice: A model of hyperferritinemia in the absence of iron overload","volume":"98","author":"Ferreira","year":"2001","journal-title":"Blood"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1177\/0271678X18783372","article-title":"Endothelial cells are critical regulators of iron transport in a model of the human blood-brain barrier","volume":"39","author":"Chiou","year":"2019","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.immuni.2014.03.004","article-title":"TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity","volume":"40","author":"Angiari","year":"2014","journal-title":"Immunity"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Mone, P., Gambardella, J., Wang, X., Jankauskas, S.S., Matarese, A., and Santulli, G. (2021). miR-24 Targets the Transmembrane Glycoprotein Neuropilin-1 in Human Brain Microvascular Endothelial Cells. Noncoding RNA, 7.","DOI":"10.3390\/ncrna7010009"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/2045-8118-10-33","article-title":"Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC\/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies","volume":"10","author":"Eigenmann","year":"2013","journal-title":"Fluids Barriers CNS"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Mone, P., Gambardella, J., Pansini, A., de Donato, A., Martinelli, G., Boccalone, E., Matarese, A., Frullone, S., and Santulli, G. (2021). Cognitive Impairment in Frail Hypertensive Elderly Patients: Role of Hyperglycemia. Cells, 10.","DOI":"10.3390\/cells10082115"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Matarese, A., Gambardella, J., Lombardi, A., Wang, X., and Santulli, G. (2020). miR-7 Regulates GLP-1-Mediated Insulin Release by Targeting beta-Arrestin 1. Cells, 9.","DOI":"10.3390\/cells9071621"},{"key":"ref_115","first-page":"284","article-title":"Cardiomyocyte-derived exosomal microRNA-92a mediates post-ischemic myofibroblast activation both in vitro and ex vivo","volume":"7","author":"Wang","year":"2020","journal-title":"ESC Heart Fail."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Matarese, A., Gambardella, J., Sardu, C., and Santulli, G. (2020). miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19. Biomedicines, 8.","DOI":"10.3390\/biomedicines8110462"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Morelli, M.B., Shu, J., Sardu, C., Matarese, A., and Santulli, G. (2019). Cardiosomal microRNAs Are Essential in Post-Infarction Myofibroblast Phenoconversion. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010201"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1124\/jpet.121.000806","article-title":"A Retinoic Acid Receptor beta 2 Agonist Improves Cardiac Function in a Heart Failure Model","volume":"379","author":"Tang","year":"2021","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1073\/pnas.1513047112","article-title":"Mitochondrial calcium overload is a key determinant in heart failure","volume":"112","author":"Santulli","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1161\/HYPERTENSIONAHA.120.15130","article-title":"Role of Endothelial G Protein-Coupled Receptor Kinase 2 in Angioedema","volume":"76","author":"Gambardella","year":"2020","journal-title":"Hypertension"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/18\/10242\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:24:12Z","timestamp":1760142252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/23\/18\/10242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,6]]},"references-count":120,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["ijms231810242"],"URL":"https:\/\/doi.org\/10.3390\/ijms231810242","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,6]]}}}