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The biggest advantages of hydrogel materials are the presence of a large amount of water and a polymeric structure that corresponds to the extracellular matrix, which allows to create healing conditions similar to physiological ones. The present work deals with the change in mechanical properties of sodium alginate mixed with gelatin containing Pygeum africanum. The work primarily concentrates on the evaluation of the mechanical properties of the hydrogel materials produced by the sol\u2013gel method. The antimicrobial activity of the hydrogels was investigated based on the population growth dynamics of Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923, as well as the degree of degradation after contact with urine using an innovative method with a urine flow simulation stand. On the basis of mechanical tests, it was found that sodium alginate-based hydrogels with gelatin showed weaker mechanical properties than without the additive. In addition, gelatin accelerates the degradation process of the produced hydrogel materials. Antimicrobial studies have shown that the presence of African plum bark extract in the hydrogel enhances the inhibitory effect on Gram-positive and Gram-negative bacteria. The research topic was considered due to the increased demand from patients for medical devices to promote healing of urethral epithelial injuries in order to prevent the formation of urethral strictures.<\/jats:p>","DOI":"10.3390\/ijms231810324","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T01:40:13Z","timestamp":1662601213000},"page":"10324","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Changes in the Mechanical Properties of Alginate-Gelatin Hydrogels with the Addition of Pygeum africanum with Potential Application in Urology"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2692-5311","authenticated-orcid":false,"given":"Jagoda","family":"Kurowiak","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, Institute of Material and Biomedical Engineering, Faculty of Mechanical Engineering, University of Zielona G\u00f3ra, Licealna 9 Street, 65-417 Zielona G\u00f3ra, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6410-6598","authenticated-orcid":false,"given":"Agnieszka","family":"Kaczmarek-Pawelska","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Safety, Institute of Mechanical Engineering, University of Zielona Gora, Licealna 9 Street, 65-417 Zielona G\u00f3ra, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3956-8483","authenticated-orcid":false,"given":"Agnieszka","family":"Mackiewicz","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Institute of Material and Biomedical Engineering, Faculty of Mechanical Engineering, University of Zielona G\u00f3ra, Licealna 9 Street, 65-417 Zielona G\u00f3ra, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8432-435X","authenticated-orcid":false,"given":"Katarzyna","family":"Baldy-Chudzik","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Biology, Collegium Medicum, University of Zielona G\u00f3ra, Licealna 9 Street, 65-417 Zielona G\u00f3ra, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6618-6616","authenticated-orcid":false,"given":"Justyna","family":"Mazurek-Popczyk","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Biology, Collegium Medicum, University of Zielona G\u00f3ra, Licealna 9 Street, 65-417 Zielona G\u00f3ra, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Zar\u0119ba","sequence":"additional","affiliation":[{"name":"Computer Center, University of Zielona G\u00f3ra, Licealna 9 Street, 65-417 Zielona G\u00f3ra, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Klekiel","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Institute of Material and Biomedical Engineering, Faculty of Mechanical Engineering, University of Zielona G\u00f3ra, Licealna 9 Street, 65-417 Zielona G\u00f3ra, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romuald","family":"B\u0119dzi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Institute of Material and Biomedical Engineering, Faculty of Mechanical Engineering, University of Zielona G\u00f3ra, Licealna 9 Street, 65-417 Zielona G\u00f3ra, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.actbio.2019.05.032","article-title":"Recent advances in high-strength and elastic hydrogels for 3D printing in biomedical applications","volume":"95","author":"Xu","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Cao, Z., Yuan, Z., Wu, R., Wu, H., Jin, B., Zheng, J., and Wu, J. 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