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During aging and in Alzheimer\u2019s disease (AD), altered neurogenesis and neuroinflammation are evident both in C57BL\/6J, APPSwe\/PS1dE9 (Tg) mice and humans. AD pathology may slow down upon drug treatment, for example, in a previous study of our group P33, a putative neuroprotective agent was found to exert advantageous effects on the elevated levels of APP, A\u03b2, and neuroinflammation. In the present study, we aimed to examine longitudinal alterations in neurogenesis, neuroinflammation and AD pathology in a transgenic (Tg) mouse model, and assessed the putative beneficial effects of long-term P33 treatment on AD-specific neurological alterations. Hippocampal cell proliferation and differentiation were significantly reduced between 8 and 12 months of age. Regarding neuroinflammation, significantly elevated astrogliosis and microglial activation were observed in 6- to 7-month-old Tg animals. The amounts of the molecules involved in the amyloidogenic pathway were altered from 4 months of age in Tg animals. P33-treatment led to significantly increased neurogenesis in 9-month-old animals. Our data support the hypothesis that altered neurogenesis may be a consequence of AD pathology. Based on our findings in the transgenic animal model, early pharmacological treatment before the manifestation of AD symptoms might ameliorate neurological decline.<\/jats:p>","DOI":"10.3390\/ijms231810364","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T07:05:56Z","timestamp":1662620756000},"page":"10364","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Examination of Longitudinal Alterations in Alzheimer\u2019s Disease-Related Neurogenesis in an APP\/PS1 Transgenic Mouse Model, and the Effects of P33, a Putative Neuroprotective Agent Thereon"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9854-7340","authenticated-orcid":false,"given":"Titanilla","family":"Sz\u00f6gi","sequence":"first","affiliation":[{"name":"Department of Medical Chemistry, University of Szeged, D\u00f3m t\u00e9r 8, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Em\u0151ke","family":"Borb\u00e9ly","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, University of Szeged, D\u00f3m t\u00e9r 8, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildik\u00f3","family":"Schuster","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, University of Szeged, D\u00f3m t\u00e9r 8, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5713-3096","authenticated-orcid":false,"given":"Zsolt","family":"Bozs\u00f3","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, University of Szeged, D\u00f3m t\u00e9r 8, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"S\u00e1ntha","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Biological Research Centre, Temesv\u00e1ri Krt. 62., H-6726 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melinda E.","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Biological Research Centre, Temesv\u00e1ri Krt. 62., H-6726 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Botond","family":"Penke","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, University of Szeged, D\u00f3m t\u00e9r 8, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8010-0129","authenticated-orcid":false,"given":"L\u00edvia","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[{"name":"Department of Medical Chemistry, University of Szeged, D\u00f3m t\u00e9r 8, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/cne.901240303","article-title":"Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats","volume":"124","author":"Altman","year":"1965","journal-title":"J. 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