{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:02:47Z","timestamp":1790103767610,"version":"4.0.1"},"reference-count":36,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ditmanson Medical Foundation Chiayi Christian Hospital","award":["R109-009"],"award-info":[{"award-number":["R109-009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Secondary hyperparathyroidism (SHPT) is common in end-stage renal disease (ESRD) patients, and it can suppress erythropoiesis. We aimed to investigate the relationship between the consumption of erythropoiesis-stimulating agents (ESAs) and parathyroidectomy (PTX) in ESRD patients with SHPT and to determine the predictors for anemia improvement. The current standard of chronic kidney disease anemia therapy relies on the prescription of iron supplementation, and ESA. We retrospectively analyzed 81 ESRD patients with PTX at Ditmanson Medical Foundation Chiayi Christian Hospital from July 2004 to Dec 2018. The requirement of ESA therapy markedly declined from a dose of 41.6 (interquartile range [IQR], 0\u201391.2) to 10.3 (IQR, 0\u201359.5, p = 0.001) unit\/kg\/week. In addition, 63.7% of patients required iron replacement therapy preoperatively and the proportion reduced to 52.5% after PTX (p &lt; 0.001). The hemoglobin (Hb) level showed an insignificant change from a median value of 10.7 g\/dL (9.5\u201311.6 g\/dL) before PTX to 10.5 g\/dL (9.6\u201311.2 g\/dL) at 6 months after PTX. A preoperative Hb level \u2264 10 mg\/dL (odds ratio [OR], 20.1; 95% confidence interval [CI], 4.71\u2013125, p &lt; 0.001) and transferrin saturation (TSAT) &lt; 25% (OR, 12.8; 95% CI, 2.51\u2013129, p &lt; 0.001) were predictors for anemia improvement. Our study demonstrated that PTX markedly decreased the requirement of ESA. Patients with a low preoperative Hb level or low TSAT showed an increase in the Hb level after PTX. PTX may be considered not only for SHPT with refractory anemia but also for high ESA-dependent patients.<\/jats:p>","DOI":"10.3390\/ijms231810391","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T07:05:56Z","timestamp":1662620756000},"page":"10391","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Parathyroidectomy Improves the Consumption of Erythropoiesis-Stimulating Agents in Hemodialysis Patients"],"prefix":"10.3390","volume":"23","author":[{"given":"Yu-Ting","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan"},{"name":"Department of Biomedical Sciences, National Chung Cheng University, Min-Hsiung, Chiayi 621301, Taiwan"},{"name":"Epigenomics and Human Disease Research Center, National Chung Cheng University, Min-Hsiung, Chiayi 621301, Taiwan"},{"name":"Center for Innovative Research on Aging Society (CIRAS), National Chung Cheng University, Min-Hsiung, Chiayi 621301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Wen","family":"Tu","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kam-Hong","family":"Kam","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Liang","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Ho","family":"Kuo","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan"},{"name":"Min-Hwei Junior College of Health Care Management, Tainan 73658, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9139-5508","authenticated-orcid":false,"given":"Ming-Yang","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan"},{"name":"Min-Hwei Junior College of Health Care Management, Tainan 73658, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Yen","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan"},{"name":"Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1431-322X","authenticated-orcid":false,"given":"Michael W. Y.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, National Chung Cheng University, Min-Hsiung, Chiayi 621301, Taiwan"},{"name":"Epigenomics and Human Disease Research Center, National Chung Cheng University, Min-Hsiung, Chiayi 621301, Taiwan"},{"name":"Center for Innovative Research on Aging Society (CIRAS), National Chung Cheng University, Min-Hsiung, Chiayi 621301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5963-6981","authenticated-orcid":false,"given":"Peir-Haur","family":"Hung","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan"},{"name":"Department of Applied Life Science and Health, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0140-6736(09)60507-9","article-title":"Hyperparathyroidism","volume":"374","author":"Fraser","year":"2009","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"V2","DOI":"10.1093\/ndt\/gfh1049","article-title":"The clinical consequences of secondary hyperparathyroidism: Focus on clinical outcomes","volume":"19","year":"2004","journal-title":"Nephrol. 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